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River management system development in Asia based on Data Integration and Analysis System(DIAS) under GEOSS

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Science China Earth Sciences 2015年第1期58卷 76-95页

作者： Toshio KOIKE petra KOUDELOVA Patricia Ann JARANILLA-SANCHEZ Asif Mumtaz BHATTI Cho Thanda NYUNT Katsunori TAMAGAWA Department of Civil Engineering River and Environmental Engineering Laboratorythe University of Tokyo Department of Civil and Environmental Engineering Hydraulic Engineering LaboratoryHiroshima University

This paper introduces the process of development and practical use implementation of an advanced river management system for supporting integrated water resources management practices in Asian river basins under the framework of GEOSS Asia water cycle initiative （AWCI）. The system is based on integration of data from earth observation satellites and in-situ networks with other types of data, including numerical weather prediction model outputs, climate model outputs, geographical infor- mation, and socio-economic data. The system builds on the water and energy budget distributed hydrological model （WEB-DHM） that was adapted for specific conditions of studied basins, in particular snow and glacier phenomena and equipped with other functions such as dam operation optimization scheme and a set of tools for climate change impact assess- ment to be able to generate relevant information for policy and decision makers. In situ data were archived for 18 selected ba- sins at the Data Integration and Analysis System （DIAS） of Japan and demonstration projects were carded out showing poten- tial of the new system. It included climate change impact assessment on hydrological regimes, which is presently a critical step for sound management decisions. Results of such three case studies in Pakistan, Philippines, and Vietnam are provided here.

关键词： integrated water resources management tools climate change impact assessment Asian river basins Asian Water Cycle Initiative

Multimodal imaging of experimental choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 886-893页

作者： Ioanna Tsioti Xuan Liu petra Schwarzer Martin S.Zinkernagel Despina Kokona Department of Ophthalmology InselspitalBern University Hospitaland Department of BioMedical ResearchUniversity of BernBern 3010Switzerland Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To compare choroidal neovascularization(CNV)lesion measurements obtained by in vivo imaging modalities,with whole mount histological preparations stained with isolectin GS-IB4,using a murine laser-induced CNV ***:B6 ***-Tg(Csf1 r-EGFP)1 Hume/J heterozygous adult mice were subjected to laser-induced CNV and were monitored by fluorescein angiography(FA),multicolor(MC)fundus imaging and optical coherence tomography angiography(OCTA)at day 14 after CNV *** pigment epithelium(RPE)whole mounts were prepared at the end of the experiment and were stained with isolectin *** areas were measured in all different imaging modalities at day 14 after CNV from three independent raters and were compared to choroidal-RPE whole *** correlation coefficient(ICC)type 2(2-way random model)and its 95%confidence intervals(CI)were calculated to measure the correlation between different raters’***’s rank correlation coefficient(Spearman’s r)was calculated for the comparison between FA,MC and OCTA data and histology ***:FA(early and late)and MC correlates well with the CNV measurements ex vivo with FA having slightly better correlation than MC(FA early Spearman’s r=0.7642,FA late Spearman’s r=0.7097,and MC Spearman’s r=0.7418),while the interobser ver reliability was good for both techniques(FA early ICC=0.976,FA late ICC=0.964,and MC ICC=0.846).In contrast,OCTA showed a poor correlation with ex vivo measurements(Spearman’s r=0.05716)and high variability between different raters(ICC=0.603).CONCLUSION:This study suggests that FA and MC imaging could be used for the evaluation of CNV areas in vivo while caution must be taken and comparison studies should be performed when OCTA is employed as a CNV monitoring tool in small rodents.

关键词： choroidal neovascularization in vivo imaging fluorescein angiography multicolor fundus imaging optical coherence tomography angiography

Effects of Organic Matter-Rich Amendments on Selenium Mobility in Soils

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Pedosphere 2019年第6期29卷 740-751页

作者： petra SMAZíKOVá Luká? PRAUS Jirina SZáKOVá Jana TREMLOVá Ale? HANC Pavel TLUSTOS Department of Agro-Environmental Chemistry and Plant Nutrition Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Prague

Soil organic matter (SOM) plays an important role in the Se dynamics in soil. The potential effects of vermicompost and digestate as important sources of SOM on selenium (Se) mobility were assessed in this study. Three soils differing in their physicochemical parameters, fluvisol, chernozem, and luvisol, were chosen, and three types of vermicomposts based on various bio-waste materials as digestate (vermicompost 1), kitchen waste with woodchips (vermicompost 2), and garden bio-waste (vermicompost 3) were used due to their high organic matter content. Additionally, digestate samples alone were applied. To evaluate the potential effect of vermicompost application on sorption characteristics of soils, batch sorption experiments were performed. The results showed a predominant effect on Se species in the soils, where selenite sorbed more intensively compared to selenate, regardless of the soil and ameliorative material applied. In the control, the soil sorption ability of selenite tended to decrease in the order: fluvisol > luvisol > chernozem. However, these differences were not significant. Moreover, the effects of the ameliorative materials depended on both soil and amendment used. In fluvisol, all the amendment applications resulted in a decrease in distribution coefficient ( K d values) of Se, whereas in chernozem, this effect was observed only for the digestate-based vermicompost 1. Increasing K d levels were reported in luvisol treated with digestate;the application of garden bio-waste-based vermicompost 3 tended to decrease the K d values. Further studies are required on long-term effects of these amendments on Se mobility in soils and the role of individual organic matter fractions in this context.

关键词： Batch sorption experiments Bio-waste material Selenite Selenate Sorption isotherms Vermicompost

Importance of genetic polymorphisms in liver transplantation outcomes

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World Journal of Gastroenterology 2020年第12期26卷 1273-1285页

作者： Tomislav Kelava petra Turcic Antonio Markotic Ana Ostojic Dino Sisl Anna Mrzljak Laboratory for Molecular Immunology Croatian Institute for Brain ResearchUniversity of ZagrebSchool of MedicineZagreb 10000Croatia Department of Pharmacology Faculty of Pharmacy and Biochemistry of University of ZagrebZagreb 10000Croatia Center for Clinical Pharmacology University Clinical Hospital MostarMostar 88000Bosnia and Herzegovina Department of Medicine Merkur University HospitalZagreb 10000Croatia Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

Although,liver transplantation serves as the only curative treatment for patients with end-stage liver diseases,it is burdened with complications,which affect survival *** addition to clinical risk factors,contribution of recipient and donor genetic prognostic markers has been extensively studied in order to reduce the burden and improve the *** of single nucleotide polymorphisms(SNPs)is one of the most important tools in development of personalized transplant *** provide a better insight in recent developments,we review the studies published in the last three years that investigated an association of recipient or donor SNPs with most common issues in liver transplantation:Acute cellular rejection,development of new-onset diabetes mellitus and non-alcoholic fatty liver disease,hepatocellular carcinoma recurrence,and tacrolimus concentration *** studies confirmed previously established SNP prognostic factors,such as PNPLA3 rs738409 for nonalcoholic fatty liver disease development,or the role of CYP3A5 rs776746 in tacrolimus concentration *** also identified several novel SNPs,with a reasonably strong association,which have the potential to become useful predictors of post-transplant ***,as the studies were typically conducted in one center on relatively low-to-moderate number of patients,verification of the results in other centers is warranted to resolve these ***,of 29 reviewed studies,28 used gene candidate approach and only one implemented a genome wide association *** wide association multicentric studies are needed to facilitate the development of personalized transplant medicine.

关键词： Single nucleotide polymorphisms Liver transplantation Acute rejection Non-alcoholic fatty liver disease New-onset diabetes mellitus Hepatocellular carcinoma Tacrolimus

Tuberculous cervical lymphadenitis in a patient with suspected neck recurrence

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Chinese Medical Journal 2012年第9期125卷 1667-1668页

作者： Doh-jeing Yong Hailani iskandar Mohd-Yunus Mohd Razif Department of Otorhinolaryngology Hospital Kuala Lumpur50586Malaysia Department of Otorhinolaryngology Universiti Kebangsaan Malaysia Medical Centre56000Malaysia

The significance of metastastic disease in the cervical lymph nodes has long been appreciated. The rich lymphatics of the upper aerodigestive tract explained the high incidence of cervical metastasis, occasional bilaterally spread. Even with appropriate treatment, cervical recurrences do occur. Nonetheless, with the resurgence of tuberculosis, the differential of tuberculous cervical lymphadenitis should be excluded. Appropriate modalities should be employed in making the appropriate diagnosis possible.

关键词： tuberculosis metastases lymph nodes

All Roads Lead to Susceptibility: The Many Modes of Action of Fungal and Oomycete Intracellular Effectors

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Plant Communications 2020年第4期1卷 1-12页

作者： Qin He Hazel McLellan petra C.Boevink Paul R.J.Birch Key Laboratory of Horticultural Plant Biology(HZAU) Ministry of EducationKey Laboratory of Potato Biology and Biotechnology(HZAU)Ministry of Agriculture and Rural AffairsHuazhong Agricultural UniversityWuhanHubei 430070China Division of Plant Sciences School of Life SciencesUniversity of Dundee(at JHI)InvergowrieDundee DD25DAUK Cell and Molecular Sciences James Hutton InstituteInvergowrieDundee DD25DAUK These authors contributed equally to this article.

The ability to secrete effector proteins that can enter plant cells and manipulate host processes is a key determinant of what makes a successful plant ***,we review intracellular effectors from filamentous(fungal and oomycete)phytopathogens and the host proteins and processes that are targeted to promote *** cover contrasting virulence strategies and effector modes of *** pathogen effectors alter the fates of host proteins that they target,changing their stability,their activity,their location,and the protein partners with which they *** effectors inhibit target activity,whereas others enhance or utilize it,and some target multiple host *** discuss the emerging topic of effectors that target negative regulators of immunity or other plant proteins with activities that support *** also highlight the commonly targeted host proteins that are manipulated by effectors from multiple pathogens,including those representing different kingdoms of life.

关键词： effectors fungi oomycete immunity defense susceptibility factor

Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment

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World Journal of Gastroenterology 2007年第2期13卷 228-235页

作者： Shi-He Guan Mengji Lu petra Grünewald Michael Roggendorf Guido Gerken Joerg F Schlaak Department of Gastroenterology and Hcpatology University Hospital of Esscn Esscn Germany Institute of Virology University Hospital of Essen Essen Germany Department of Laboratory Medicine the first Affiliated Hospital of Anhui Medical University China

AIM：To characterize the IFN-response and its modulation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS： HepG2.2.15 and HepG2 cells were stimulated with various concentrations of IFN-α 2a in the presence or absence of lamivudine. Then, total RNA was extracted and analysed by customised cDNA arrays and northern blot for interferon-inducible genes （ISGs）. In addition, cellular proteins were extracted for EMSA and western blot. HBV replication was assessed by southern blot or ELISAs for HBsAg and HBeAg. RESULTS： Two genes （MxA, CigS） with completely abolished and 4 genes （IFITM1, -2, -3, and 6-16） with partially reduced IFN-responses were identified in HepG2.2.15 cells. In 2 genes （IFITM1, 6-16）, the response to IFN-α could be restored by treatment with lamivudine. This effect could not be explained by a direct modulation of the Jak/Stat signalling pathway since EMSA and western blot experiments revealed no suppression of Statl activation and ISGF3 formation after stimulation with IFN-α in HepG2.2.15 compared to HepG2 cells. CONCLUSION： These results are consistent with the assumption that chronic hepatitis B may specifically modulate the cellular response to IFN by a selective blockage of some ISGs. Antiviral treatment with lamivudine may partially restore ISG expressionby reducing HBV gene expression and replication.

关键词： Hepatitis B IFN-α Gene expression Larnivudine

Smart-Fragile Authentication Scheme for Robust Detecting of Tampering Attacks on English Text

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Computers, Materials & Continua 2022年第5期71卷 2497-2513页

作者： Mohammad Alamgeer Fahd N.Al-Wesabi Huda G.iskandar Imran Khan Nadhem Nemri Mohammad Medani Mohammed Abdullah Al-Hagery Ali Mohammed Al-Sharafi Department of Information Systems King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia Department of Computer Science King Khalid UniversityMuhayel AseerKingdom of Saudi Arabia Faculty of Computer and IT Sana’a UniversitySana’aYemen School of Computing Faculty of EngineeringUniversiti Teknologi MalaysiaMalaysia Department of Electrical Engineering University of Engineering and Technology PeshawarPakistan Department of Computer Science College of ComputerQassim UniversitySaudi Arabia Department of Computer Science College of Computers and Information TechnologyUniversity of BishaKSA

Content authentication,integrity verification,and tampering detection of digital content exchanged via the internet have been used to address a major concern in information and communication *** this paper,a text zero-watermarking approach known as Smart-Fragile Approach based on Soft Computing and Digital Watermarking(SFASCDW)is proposed for content authentication and tampering detection of English text.A first-level order of alphanumeric mechanism,based on hidden Markov model,is integrated with digital zero-watermarking techniques to improve the watermark robustness of the proposed *** researcher uses the first-level order and alphanumeric mechanism of Markov model as a soft computing technique to analyze English ***,he extracts the features of the interrelationship among the contexts of the text,utilizes the extracted features as watermark information,and validates it later with the studied English text to detect any *** has been implemented using PHP with VS code *** robustness,effectiveness,and applicability of SFASCDW are proved with experiments involving four datasets of various lengths in random locations using the three common attacks,namely insertion,reorder,and *** SFASCDW was found to be effective and could be applicable in detecting any possible tampering.

关键词： Watermarking soft computing text analysis hidden Markov model content authentication

Non-invasive prediction of persistent villous atrophy in celiac disease

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World Journal of Gastroenterology 2020年第26期26卷 3780-3791页

作者： Barbora Packova petra Kovalcikova Zdenek Pavlovsky Daniel Bartusek Jitka Prokesova Jiri Dolina Radek Kroupa Department of Gastroenterology and Internal Medicine University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic Institute of Biostatistics and Analyses Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Pathology University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Radiology and Nuclear Medicine University Hospital BrnoFaculty of MedicineMasaryk UniversityBrno 62500Czech Republic

BACKGROUND Celiac disease(CD)is an immune-mediated enteropathy that is primarily treated with a gluten-free diet(GFD).Mucosal healing is the main target of the ***,duodenal biopsy is the only way to evaluate mucosal healing,and noninvasive markers are *** elevation of anti-tissue transglutaminase antibodies(aTTG)is not an ideal predictor of persistent villous atrophy(VA).Data regarding prediction of atrophy using anti-deamidated gliadin peptide antibodies(aDGP)and abdominal ultrasonography are *** To evaluate the ability of aTTG,aDGP,small bowel ultrasonography,and clinical and laboratory parameters in predicting persistent VA determined using *** Patients with CD at least 1 year on a GFD and available follow-up duodenal biopsy,levels of aTTG and aDGP,and underwent small bowel ultrasonography were included in this retrospective cohort *** evaluated the sensitivity,specificity,and positive and negative predictive values of aTTG,aDGP,small bowel ultrasonography,laboratory and clinical parameters to predict persistent VA.A receiver operating characteristic(ROC)curve analysis of antibody levels was used to calculate cut off values with the highest accuracy for atrophy *** Complete data were available for 82 patients who were followed up over a period of four years(2014-2018).Among patients included in the analysis,women(67,81.7%)were predominant and the mean age at diagnosis was 33.8 *** biopsy revealed persistent VA in 19 patients(23.2%).The sensitivity and specificity of aTTG using the manufacturer’s diagnostic cutoff value to predict atrophy was 50%and 85.7%,respectively,while the sensitivity and specificity of aDGP(using the diagnostic cutoff value)was 77.8%and 75%,*** of an optimal cutoff value using ROC analysis(13.4 U/mL for aTTG IgA and 22.6 U/mL for aDGP IgA)increased the accuracy and reached 72.2%[95%confidence interval(CI):46.5-90.3]sensitivity and 90%(9

关键词： Celiac disease Villous atrophy Anti-tissue transglutaminase antibodies Antideamidated gliadin peptide antibodies Abdominal ultrasound Gluten-free diet