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Smooth muscle AKG/OXGR1 signaling regulates epididymal fluid acid–base balance and sperm maturation

Life Metabolism 2022年第1期1卷 67-80页

作者： Chang Xu Yexian Yuan Cha Zhang Yuchuan Zhou Jinping Yang Huadong Yi ishwari gyawali Jingyi Lu Sile Guo Yunru Ji Chengquan Tan Songbo Wang Yongliang Zhang Qingyan Jiang Gang Shu Guangdong Laboratory for Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine Industry and Guangdong Province Key Laboratory of Animal Nutritional RegulationCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouGuangdongChina International Peace Maternity and Child Health Hospital Shanghai Key Laboratory of Embryo Original DiseasesSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory for Aquatic Economic AnimalsSchool of Life SciencesSun Yat-Sen UniversityGuangzhouChina

Infertility is a global concern attributed to genetic defects,lifestyle,nutrition,and any other factors that affect the local metabolism and niche microenvironment of the reproductive system.2-Oxoglutarate receptor 1(OXGR1)is abundantly expressed in the testis;however,its cellular distribution and biological function of OXGR1 in the male reproductive system remain *** the current study,we demonstrated that OXGR1 is primarily expressed in epididymal smooth muscle cells(SMCs).Aging and heat stress significantly reduced OXGR1 expression in the *** OXGR1 global knockout and epididymal-specific OXGR1 knockdown models,we revealed that OXGR1 is essential for epididymal sperm maturation and fluid acid–base *** ofα-ketoglutaric acid(AKG),the endogenous ligand of OXGR1,effectively reversed epididymal sperm maturation disorders caused by aging and heat ***,in vitro studies showed that AKG markedly stimulated the release of instantaneous intracellular calcium from epididymal SMCs and substantially reduced the pH_(i) value in the epididymal SMCs via ***,we discovered that AKG/OXGR1 considerably increased the expression of Na^(+)/HCO_(3)^(−)cotransporter(NBCe1)mRNA in the epididymal SMCs,mediated by intracellular calcium *** local AKG/OXGR1 system changed the epididymal fluid pH value and HCO_(3)^(−)concentration,thereby regulating sperm maturation via intracellular calcium signaling and NBCe1 mRNA *** study for the first time reveals the crucial role of OXGR1 in male fertility and sheds light on the applicability of metabolic intermediates in the nutritional intervention of reproduction.

关键词： AKG OXGR1 epididymis acid-base balance sperm maturation

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AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle

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Life Metabolism 2022年第3期1卷 285-297页

作者： Jinping Yang Guli Xu Yiming Xu Pei Luo Yexian Yuan Lin Yao Jingjing Zhou Yunlong Zhu ishwari gyawali Chang Xu Jinlong Feng Zewei Ma Yuxian Zeng Songbo Wang Ping Gao Canjun Zhu Qingyan Jiang Gang Shu Guangdong Laboratory for Lingnan Modern Agriculture and Guangdong Province Key Laboratory of Animal Nutritional Regulation South China Animal Nutrition and Feed Science Observation and Experimental StationCollege of Animal ScienceSouth China Agricultural University483 Wushan RoadTianhe DistrictGuangzhouGuangdong 510642China School of Basic Medical Sciences The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511518China South China Research Center for Acupuncture and Moxibustion Medical College of Acu-Moxi and RehabilitationGuangzhou University of Chinese MedicineGuangzhouGuangdong 510006China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhouGuangdong 510006China

In response to contraction during exercise,skeletal muscle growth and metabolism are dynamically regulated by nerve action,blood flow,and metabolic feedback.α-Ketoglutarate(AKG),a bioactive intermediate in the tricarboxylic acid cycle released during exercise,has been shown to promote skeletal muscle ***,the underlying mechanism of AKG in regulating skeletal muscle development and metabolism is still less known.2-Oxoglutarate receptor 1(OXGR1),the endogenous AKG receptor,is found to be distributed in the vascular smooth muscle(VSM)of skeletal ***1 knockout results in skeletal muscle atrophy,accompanied by decreased expression of myosin heavy chain I(MyHC I),capillary density,and endurance exercise ***,the study found that dietary AKG supplementation increased mice endurance exercise distance,MyHC I/MyHC IIb ratio,arteriole,and capillary densities in skeletal ***,acute AKG administration gradually increased the blood flow in the lower ***,by using OXGR1 global knockout and OXGR1 VSM-specific(MYH11-Cre×OXGR1-FloxP)knockdown models,we found that OXGR1 in VSM is essential for AKG-induced improvement of skeletal muscle *** to the in vitro study,AKG expanded the cell area in VSM with a decreased intracellular pH by *** results demonstrated a novel role of AKG/OXGR1 in VSM of skeletal muscle to regulate blood flow and then enhance slow muscle fiber conversion and *** findings provide a theoretical basis for the AKG/OXGR1 signaling pathway to maintain human muscle function and improve meat production and livestock and poultry meat quality.

关键词： OXGR1 AKG smooth muscle cell skeletal muscle blood flow metabolism

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禽源贝莱斯芽孢杆菌发酵玉米粉对白羽肉鸡生产性能和肠道健康的影响

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中国家禽 2022年第11期44卷 26-36页

作者：曾宇贤李金成周静静王雨君朱云龙 ishwari gyawali 岑颖谊冀云茹张海军张丽江青艳束刚华南农业大学动物科学学院广东省动物营养调控重点实验室岭南现代农业科学与技术广东省实验室广东广州510642 中国农业科学院饲料研究所农业农村部饲料生物技术重点实验室北京100080 广州朴成生物科技有限公司广东广州511300

试验旨在研究禽源贝莱斯芽孢杆菌发酵玉米粉对白羽肉鸡生产性能和肠道健康的影响。将180只1日龄白羽肉鸡公鸡随机分为3组,每组6个重复,每个重复10只。对照组饲喂基础饲粮,抗生素组、发酵玉米粉组分别饲喂添加15 g/t维吉尼亚霉素、2 kg/... 详细信息

试验旨在研究禽源贝莱斯芽孢杆菌发酵玉米粉对白羽肉鸡生产性能和肠道健康的影响。将180只1日龄白羽肉鸡公鸡随机分为3组,每组6个重复,每个重复10只。对照组饲喂基础饲粮,抗生素组、发酵玉米粉组分别饲喂添加15 g/t维吉尼亚霉素、2 kg/t发酵玉米粉的基础饲粮。试验期42 d。结果显示:与对照组相比,贝莱斯芽孢杆菌发酵玉米粉可显著降低1~21日龄肉鸡料重比(P<0.05);抗生素显著提高1~21日龄肉鸡的平均日增重(P<0.05),并显著降低1~21和1~42日龄肉鸡料重比(P<0.05)。与抗生素组相比,发酵玉米粉组肉鸡血清活性氧和谷草转氨酶水平显著降低(P<0.05);与对照组相比,发酵玉米粉组肉鸡十二指肠IL-10、空肠IL-10、ZO-1和Claudin-1及回肠sIgA水平显著提高(P<0.05)。饲粮添加发酵玉米粉有提高盲肠微生物数目的趋势,并显著提高免疫系统相关菌群基因的富集(P<0.05)。与对照组相比,添加发酵玉米粉显著提高乳杆菌属(Lactobacillus)、Ileibacterium和Muribaculum丰度(P<0.05);与抗生素组相比,发酵玉米粉显著降低Anaerostipes丰度(P<0.05)。结果表明,日粮添加2 kg/t贝莱斯芽孢杆菌发酵玉米粉可降低肉鸡死淘率,维持肠道屏障完整性并调节盲肠微生物组成。

关键词：禽源贝莱斯芽孢杆菌白羽肉鸡发酵玉米粉生产性能肠道炎症肠道屏障损伤微生物区系

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社会主义运动的复杂现实与新前景

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世界社会主义研究 2024年第2期9卷 56-59页

作者：普拉迪普·库马尔·贾瓦里唐芳芳中国社会科学院马克思主义研究院

一、社会主义运动面临的复杂形势与挑战经济全球化的力量以各种前所未有的方式将我们的世界交织在一起，创造了一幅超越地理边界的互联互通的锦绣画卷。经济全球化虽然促进了经济增长，加强了贸易往来，推动了知识、技术与文化的交流，... 详细信息

一、社会主义运动面临的复杂形势与挑战经济全球化的力量以各种前所未有的方式将我们的世界交织在一起，创造了一幅超越地理边界的互联互通的锦绣画卷。经济全球化虽然促进了经济增长，加强了贸易往来，推动了知识、技术与文化的交流，但也加剧了现存的不平等，扩大了社会差距和经济差距，并带来了环境恶化、政治不稳定等新挑战。跨国公司的崛起引发了人们对以更新、更复杂的形式出现的劳动剥削的担忧，以及对破坏环境造成的致命代价的忧虑。

关键词：社会主义运动人类命运共同体尼泊尔共产党

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Electrodeposited Ni-W-TiC Composite Coatings:Effect of TiC Reinforcement on Microstructural and Tribological Properties

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Acta Metallurgica Sinica(English Letters) 2020年第4期33卷 573-582页

作者： Jin Hyuk Choi Gobinda gyawali Dhani Ram Dhakal Bhupendra Joshi Soo Wohn Lee Department of Materials Metal Engineering Sun Moon University31460 AsanSouth Korea Department of Fusion Science and Technology Sun Moon UniversityTangjeong Myeon31460 AsanChungnamSouth Korea Department of Environmental and Bio-Chemical Engineering Sun Moon University31460 AsanSouth Korea

Ni-W-TiC composite coatings were prepared via electrodeposition technique by dispersing the different amount of TiC particles into the plating *** Ni-W and Ni-W-TiC composite coatings containing different concentrations of TiC particles were characterized by using the scanning electron microscope,X-ray diffraction technique,Vickers microhardness test,surface roughness test,and tribology *** results show that the Ni-W coatings containing reinforced TiC particles have shown a typical FCC Ni-W crystal structure with significantly higher Vickers *** amount of dispersed TiC particles into the plating bath considerably affected codeposition weight percent of TiC into the Ni-W matrix,as revealed by the EDS ***-W-TiC samples demonstrated the decreased abrasive wear as compared to Ni-W coating and no characteristic features observed for the adhesive ***,an improvement in coefficient of friction was observed in Ni-W-TiC composite coating as compared to Ni-W coating.

关键词： Ni-W alloy Composite coating Microhardness Wear Coefficient of friction

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The effect of laser surface texturing on the tribological performance of different Sialon ceramic phases

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Progress in Natural Science:Materials International 2016年第4期26卷 415-421页

作者： Bhupendra Joshi Khagendra Tripathi Gobinda gyawali Soo Wohn Lee Research Center for Eco Multifunctional Nano Materials Sun Moon University

A tribological performance was carried out on different types of hot press Sialon ceramics regarding the phases, i.e., the α-Sialon phase, the β-Sialon phase, and the α/β-Sialon composite phase. The different phases of Sialon ceramics were analyzed by XRD patterns. For the tribological performance, the Sialon ceramics were laser textured and the starved lubrication method was applied with different dimple pitches under a load of 10 N at room temperature. The material having a dimple pitch of 200 mm shows the lowest coefficient of friction. The α/β-Sialon composite phase shows the least coefficient of friction i.e. 0.04 and 0.1 for the textured and polished(without being textured) samples, respectively. The Sialon ceramics show mild wear and therefore, the wear rate of the steel ball(mating partner) was taken into account for the wear analysis. The α-Sialon phase having a higher hardness shows the least wear in comparison to the α/β-Sialon composite phase and the β-Sialon phase.

关键词： Sialon Hot press Laser surface texturing Coefficient of friction Wear

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Highly photostable nanogels for fluorescence-based theranostics

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Bioactive Materials 2018年第1期3卷 39-47页

作者： Dipendra gyawali Jimin P.Kim Jian Yang Department of Bioengineering The University of Texas at ArlingtonArlingtonTX 76010USA Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of The Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

A novel photo-crosslinkable nanogel is prepared from a biodegradable polymer template with intrinsic photoluminescence and high *** fluorescent nanogels display excellent biodegradability and cytocompatibility owed to the facile synthesis scheme involving a solvent-and surfactant-free onepot reaction,derived entirely from biocompatible monomers citric acid,maleic acid,L-cysteine,and poly(ethylene glycol).The resultant nanogels are less than 200 nm in diameter with a narrow size distribution and monodispersity,and demonstrate long-term structural stability in biological buffer for two *** gauge potential in theranostic applications,the fluorescent nanogels were surface functionalized with biologically active RGD peptides and encapsulated with active anti-cancer drug Doxorubicin,resulting in a pH-responsive controlled drug release in acidic pH resembling tumor *** strong fluorescence of the nanogels enabled tracking of targeted drug delivery,showing that drug-loaded nanogels homed into the cytoplasmic regions of prostate cancer cells to significantly induce cell *** photo-crosslinkable and biodegradable nanogels pose as a strong candidate for theranostic medicine,demonstrating versatile functionalization,high stability in biological buffers,and capacity for real-time fluorescence-based monitoring of targeted drug delivery.

关键词： Nanogels Fluorescent polymer Drug delivery Cellular imaging Bioconjugation

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Quantification of hookworm ova from wastewater matrices using quantitative PCR

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Journal of Environmental Sciences 2017年第7期29卷 231-237页

作者： Pradip gyawali Warish Ahmed Jatinder P.Sidhu Paul Jagals Simon Toze CSIRO Land and Water Ecosciences Precinct School of Public Health The University of Queensland

A quantitative PCR（q PCR） assay was used to quantify Ancylostoma caninum ova in wastewater and sludge *** estimated the average gene copy numbers for a single ovum using a mixed population of *** average gene copy numbers derived from the mixed population were used to estimate numbers of hookworm ova in *** seeded and unseeded wastewater and sludge *** newly developed qP CR assay estimated an average of3.7 × 10~3 gene copies per ovum,which was then validated by seeding known numbers of hookworm ova into treated *** qP CR estimated an average of（1.1 ± 0.1）,（8.6 ± 2.9）and（67.3 ± 10.4） ova for treated wastewater that was seeded with（1 ± 0）,（10 ± 2） and（100 ± 21）ova,*** further application of the q PCR assay for the quantification of *** ova was determined by seeding a known numbers of ova into the wastewater *** qP CR results indicated that 50%,90% and 67% of treated wastewater（1 L）,raw wastewater（1 L）and sludge（~4 g） samples had variable numbers of *** gene *** conversion of the q PCR estimated gene copy numbers to ova for treated wastewater,raw wastewater,and sludge samples,had an average of 0.02,1.24 and 67 ova,*** result of this study indicated that qP CR can be used for the quantification of hookworm ova from wastewater and sludge samples;however,caution is advised in interpreting qP CR generated data for health risk assessment.

关键词： Wastewater matrices Quantitative PCR Hookworm ova Health risks

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Fabrication of a TiO2-P25/(TiO2-P25+TiO2 nanotubes) junction for dye sensitized solar cells

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Progress in Natural Science:Materials International 2016年第4期26卷 375-379页

作者： Nguyen Huy Hao Gobinda gyawali Tohru Sekino Soo Wohn Lee Research Center for Eco-multifunctional Nano Materials Sun Moon University Department of Environmental and Bio-chemical Engineering Sun Moon University The Institute of Scientific and Industrial Research (ISIR-SANKEN) Osaka University

The dye sensitized solar cell(DSSC), which converts solar light into electric energy, is expected to be a promising renewable energy source for today’s world. In this work, dye sensitized solar cells, one containing a single layer and one containing a double layer, were fabricated. In the double layer DSSC structure, the under-layer was TiO-P25 film, and the top layer consisted of a mixture of TiO-P25 and TiOnanotubes. The results indicated that the efficiency of the DSSC with the double layer structure was a significant improvement in comparison to the DSSC consisting of only a single film layer. The addition of TiO-P25 in the top layer caused an improvement in the adsorption of dye molecules on the film rather than on the TiOnanotubes only. The presence of the TiOnanotubes together with TiO-P25 in the top layer revealed the enhancement in harvesting the incident light and an improvement of electron transport through the film.

关键词： TiO2 nanotube Hydrothermal method DSSC Efficiency Double layer

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Efficient inactivation of Staphylococcus aureus by silver and copper loaded photocatalytic titanate nanotubes

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Progress in Natural Science:Materials International 2018年第2期28卷 15-23页

作者： Bhupendra Joshi Chhabilal Regmi Dipesh Dhakal Gobinda gyawali Soo Wohn Lee Division of Basic Science Basic Engineering Sun Moon University Department of Environment and Bio-Chemical Engineering Sun Moon University Department of Life Science and Bio-Chemical Engineering Sun Moon University

One dimensional titanate nanotubes(TNTs) were synthesized by microwave assisted alkaline hydrothermal process. The process was followed by UV-photodeposition of Ag and Cu on the surface of TNTs to enhance the photocatalytic activity in visible light spectrum. The loading of Ag and Cu(single and combination mode)offered a new insight to inactivate multi-drug resistant micro-organisms. The antibacterial properties of these samples were studied on Gram positive bacteria, Staphylococcus aureus(S. aureus) using well diffusion *** TNTs with Ag and Cu loading showed a clear zone of inhibition after overnight incubation of S. aureus. The bacterial inactivation efficiency of nanoparticles in the visible light was further analyzed by kill kinetics. TNTs with Ag and/or Cu loading showed a significant reduction in bacterial growth. Cu co-loaded with Ag sample showed the highest inactivation efficiency within 90 min of visible light irradiation. To elucidate the mechanism of bactericidal properties of samples under visible light irradiation, the formation of reactive oxygen species(ROS), particularly, superoxide radical anion was determined by nitro blue tetrazolium(NBT) assay and the protein degradation by each samples were measured. Based on overall results, it was observed that the Cu coloaded with Ag on TNTs samples were found to be more effective as compared to either Ag or Cu loaded TNTs. It provides new avenues for utilizing the combination of Cu and Ag for enhancing the antimicrobial efficacies for different nanoparticles.

关键词： Titante nanotubes Staphylococcus aureus Antibacterial Photocatalytic inactivation Reactive oxygen species

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