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Sparing effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response( MAC-BAR) of sevoflurane in dogs.

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畜牧与兽医 2012年第S2期44卷 33-33页

作者： Fukui S tamura J Itami t ishizuka t Miyoshi K Yamashita K Department of Small Animal Clinical Sciences Rakuno Gakuen University

Robenacoxib is a newer non-steroidal anti-inflammatory drug (NSAID) and effective for the management of perioperative pain and inflammation. A preoperative administration of robenacoxib is approved in many countries. the preoperative administration of NSAIDs (carprofen or meloxicam) reduces the minimum alveolar concentration (MAC) of sevoflurane during noxious stimulation in dogs (Yamashita et al. 2008). the purpose of this study was to evaluate the effect of robenacoxib on the MAC for blunting adrenergic response (MAC-BAR) of sevoflurane in *** adult healthy beagle dogs were anesthetized to determine the MAC-BAR of sevoflurane on 2-ocassions at least 1-week intervals. In each occasion,the dogs received a subcutaneous injection (SC) of saline (0. 1 ml/kg) or robenacoxib (2 mg/kg) before the MAC-BAR determination. MAC-BAR determination started at 60 minutes after the administration of saline or robenacoxib. MAC-BAR was determined in duplicate for each dog using electrical stimulus applied to the gingival (50 V,50 Hz,10 ms). During the MAC determination,all dogs were mechanically ventilated to maintain the end-tidal CO2within 35 to 40 mmHg and kept warm to maintain esophageal temperature within 37. 5 to 38. 5 ℃. Data were compared between groups using a paired t-test. the level of significance was set at P taneous robenacoxib significantly decreased the sevoflurane MAC-BAR by 17% (2. 84 ± 0. 77%,P = 0. 039).Robenacoxib decreased the sevoflurane MAC-BAR when it was administered at the approved preoperative dose (2mg/kg: SC) to dogs. It is expected that the use of robenscoxib as premedication may provide a clinically relevant anesthetic sparing effect similar to carprofen and meloxicam in dogs (Yamashita et al. 2008).

关键词： dogs MAC-BAR robenacoxib sevoflurane sparing effects

Sparing effect of an antiemetic dose of maropitant on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs.

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畜牧与兽医 2012年第S2期44卷 42-42页

作者： tamura J Itami t ishizuka t Fukui S Miyoshi K Yamashita K Department of Small Animal Clinical Sciences Rakuno Gakuen University

Maropitant a neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug in dogs by blockade of substance P/NK-1 receptor binding in the vomiting center and chemoreceptor trigger zone in the central nervous system. In addition,substance P and NK-1 receptors have been isolated in nociceptive pathways. therefore,it is expected that maropitant provides analgesic effect and its sparing effect of minimum alveolar concentration (MAC) has been reported in dogs. the purpose of this study was to evaluate the sparing effect of an approved antiemetic dose of maropitant on the MAC for blunting adrenergic response (MAC-BAR) of sevoflurane in *** adult healthy beagle dogs were anesthetized to determine the MAC-BAR of sevoflurane on 2-ocassions at least 1-week intervals. In each occasion,the dogs received a subcutaneous injection (SC) of saline (0. 1 ml/kg) or maropitant (1 mg/kg) before the MAC-BAR determination. MAC-BAR determination started at 60 min after the administration of saline or maropitant. MAC-BAR was determined in duplicate for each dog using electrical stimulus applied to the gingival (50 V,50 Hz,10 ms). During the MAC determination,all dogs were mechanically ventilated to maintain the endtidal CO2within 35 to 40 mmHg and kept warm to maintain esophageal temperature within 37. 5 to 38. 5 ℃. Data were compared between groups using a paired t-test. the level of significance was set at P taneous maropitant significantly decreased the sevoflurane MAC-BAR by 17% (2. 88 ± 0. 74%,P = 0. 037).Maropitant decreased the sevoflurane MAC-BAR when administered at the approved antiemetic dose (1 mg/kg:SC) to dogs. It is expected that a preoperative administration of maropitant may produce anesthetic sparing effect in addition to antiemetic effect in dogs.

关键词： maropitant MAC sevoflurane dog

Effects of controlled ventilation and positioning on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-tIVA)

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畜牧与兽医 2012年第S2期44卷 34-34页

作者： ishizuka t Itami t tamura J Fukui S Miyoshi K Yamashita K Department of Small Animal Clinical Sciences Rakuno Gakuen University

the purpose of this study was to evaluate effects of controlled ventilation and positioning on cardiopulmonary function in horses anesthetized with total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-tIVA).Five healthy adult horses were anesthetized with MLBP-tIVA for 2-hours on 3-occasions at 4-week interval. In each occasion,horses were anesthetized in lateral recumbency with (CV-LR-group) or without controlled ventilation (SB-LRgroup) or in dorsal recumbency with controlled ventilation (CV-DR-group). Anesthesia was induced with lidocaine (1mg/kg: IV) and propofol (3 mg/kg: IV) following premedications with medetomidine (0. 005 mg/kg: IV) and butorphanol (0. 02 mg/kg: IV),and then maintained by constant rate infusions of propofol (6 mg/kg/hr),medetomidine (0. 0035 mg/kg/h),lidocaine (3 mg/kg/h) and butorphanol (0. 024 mg/kg/h). All horses breathed 100% oxygen during anesthesia. In the CV-groups,horses were mechanically ventilated to maintain arterial CO2pressure (PaCO2)within 40 ~ 50 mmHg. Cardiopulmonary parameters were compared between groups using repeated-measures *** level of significance was set at P < 0. *** the SB-LR group,cardiovascular parameters were maintained within acceptable ranges (heart rate: 37 ~ 39beats/min,mean arterial blood pressure: 109 ~ 115 mmHg,mean pulmonary arterial pressure [MPAP]: 28 ~ 29 mmHg,mean right atrial pressure [MRAP]: 19 ~ 21 mmHg,cardiac output: 27 ~ 30 L/min) but severe hypercapnia with insufficient oxygenation (PaCO283 ~ 103 mmHg,arterial O2pressure [PaO2]155 ~171 mmHg) was observed. Cardiopulmonary parameters were maintained with acceptable ranges in the both CV groups. In the CV-LR group,significant decreases in heart rate (29 ~ 31 beats/min,P = 0. 020),cardiac output (17 ~ 21 L/min,P = 0. 005) and PaCO2 (42 ~50 mmHg,P =0. 001) and a significant increase in PaO2 (395 ~419 mmHg,P =0. 005) were observed compared to the SB-group. In the CV-DR group,MPAP

关键词： cardiopulmonary function intravenous anesthesia MLBP-tIVA horse

Evaluation of cardiopulmonary effects of total intravenous anesthesia using a drug combination of medetomidine,lidocaine,butorphanol and propofol (MLBP-tIVA) with or without controlled ventilation and effect of positioning in mechanically ventilated horses

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畜牧与兽医 2012年第S2期44卷 35-35页

作者： ishizuka t Nagaro t Sudo K Itami t tamura J Fukui S Miyoshi K Yamashita K. Rakuno Gakuen University

the purpose of this study was to evaluate cardiopulmonary effects of MLBP-tIVA with or without controlled ventilation in horses and to determine effects of positioning on cardiovascular function in mechanically ventilated *** healthy adult horses were anesthetized with MLBP-tIVA for 2-hours on 3-occasions at 4-week interval with (CMV-group) or without controlled mechanical ventilation (SB-group) and in lateral (LR-group) or dorsal (DRgroup) *** was induced with lidocaine (1 mg/kg: IV) and propofol (3 mg/kg: IV) following premedications with medetomidine (0.005 mg/kg: IV) and butorphanol (0.02 mg/kg: IV),and then maintained by propofol infusion combined with constant rate infusions of medetomidine (0.0035 mg/kg/h),lidocaine (3 mg/kg/h)and butorphanol (0.024 mg/kg/h).Data were compared between groups using repeated-measures *** level of significance was set at P < *** parameters were maintained within acceptable ranges in ***,severe hypercapnia with insufficient oxygenation was observed (PaCO2: 83 ~103 mmHg,arterial O2pressure [PaO2]: 155 ~171 mmHg).In CMV-group,significant decreases in heart rate (29 ~ 31 beats/min,P = 0.020),cardiac output (17 ~ 21 L/min,P= 0.005) and PaCO2 (42 ~ 50 mmHg,P = 0.001) and a significant increase in PaO2 (395 ~ 419 mmHg,P =0.005) were observed compared to *** pulmonary arterial pressure and mean atrial blood pressure were significantly decreased in DR-group compared to LR-group (18 ~ 20 mmHg vs 27 ~ 31 mmHg,P = 0.001 and 8 ~ 9 mmHg vs 15 ~ 17 mmHg,P = 0.003,respectively).Arterial O2pressure was significantly lower in DR-group than in LR-group (171 ~301 mmHg vs 385 ~416 mmHg,P =0.043).Cardiovascular functions were maintained within acceptable range during MLBP-tIVA in *** ventilation is useful for improving hypercapnia and ***,MLBP-tIVA provides a preservation of cardiovascular function leading to compensation for decreased preload in hors

关键词： butorphanol cardiopulmonary effects horses lidocaine medetomidine propofol tIVA

Experimental Study of High-spin States in 127I1

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IMP & HIRFL Annual Report 2001年 37-37页

作者： Y.Sasaki,K.Yamada,H.Ohshima,S.Yokose,M.ishizuka,t.Komatsubara,K.Furuno Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan. Institute of Physics and tandem Accelerator Center University of tsukuba Ibaraki Japan.

Study of in-bearn γ-ray spectroscopy o127I has been carried out by using124Sn（7Li,4n）127I ***7Li beam was delivered by the tandem Accelerator in the University of tsukuba,*** target was an enriched self-supporting124Sn metallic foil of 4 mg/cm2thickness.A γ-ray detector array composed of one planar detector and 9 BGO-Compton-suppressed Ge detectors was *** Ge detectors were positioned at

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Experimental Observation of High Spin States in 135La Nucleus

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IMP & HIRFL Annual Report 2003年 41-41页

High spin states of 135La have been experimentally studied by 128te(10B, 3n)135La reaction. the 10B beam was provided by the tandem accelerator laboratory in the University of tsukuba, Japan. Based on the γ-γ coincidence relationships, relative intensities and ADO ratios, a level scheme of 135La has been established.

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In-beam γ-ray Spectroscopy of Level Structure in 134Ba

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IMP & HIRFL Annual Report 2003年 42-42页

Excited states of 134Ba, populated via the heavy-ion induced 128te(10B, lp3n)134Ba reaction at 46 MeV beam energy, have been studied to medium and high spins by in-beam γ-ray spectroscopy techniques. the experiment w...

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Landscape gradient of autumn photosynthetic decline in Abies sachalinensis seedlings

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Journal of Forestry Research 2023年第1期34卷 187-195页

作者： tetsuto Sugai Wataru ishizuka toshihiro Watanabe Hokkaido Research Center Forestry and Forest Products Research InstituteHitsujigaoka 7Sapporo 062-8516Japan Plant Nutrition Laboratory Research Faculty of AgricultureHokkaido UniversitySapporo 060-8689Japan Forest Research Institute Hokkaido Research OrganizationBibaiHokkaido 079-0198Japan

Understanding what environmental factors are genetically linked to a phenologic al event is critical for predicting responses to climate *** synthetic phenology often varies among a species of evergreen conifers due to local ***,few empirical studies have revealed relevant relationships between climatic factors in provenance environments and photosynthetic *** study evaluated the effects of environmental conditions of the growing site and seed source provenance on the seasonal changes in maximal photochemical quantum yield of photo systemⅡ(Fv/Fm)in a common garden experiment with 2-year-old seedlings of Sakhalin fir(Abies sachalinensis),a representative species with local adaptation,from four seed source provenances.A logistic model was constructed to explain the seasonal variation of Fv/Fmfrom July to October and the relationships between the estimated model parameters and representative factors featuring provenance environments were *** landscape gradient of the detected model parameters responsible for the provenance environments was visualized in a map of the distribution *** lowest temperature was the most plausible factor in the growing environment to explain the seasonal changes of Fv/*** the representative meteorological factors of provenance environments,the lowest temperatures in July showed significant relationships with two model parameters,explaining the lower limit of Fv/Fmand the higher sensitivity of autumn Fv/*** estimated spatial maps of model parameters consistently showed that the higher the lowest temperature in July in the provenance environment,the lower the Fv/Fmin October and the greater the decrease in the autumn Fv/***,the lowest summer temperature could be associated with the local adaptation of autumn photosynthetic phenology in ***.

关键词： Phenology Local adaptation Genetic cline Lowest temperature

topographical and hydrological effects on meso-scale vegetation in desert steppe, Mongolia

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Journal of Arid Land 2017年第1期9卷 132-142页

作者： Batdelger GANtSEtSEG Masahide ishizuka Yasunori KUROSAKI Masao MIKAMI Information and Research Institute of Meteorology Hydrology and Environment Ulaanbaatar 15160 Mongolia Faculty of Engineering Kagawa University Takamatsu 761-03 96 Japan Arid Land Research Center Tottori University Tottori 680-0001 Japan Japan Meteorological Business Support Center Tokyo 101-0054 Japan

this study investigated the seasonal variations of the normalized difference vegetation index（NDVI） and its relationships with climatic variables and topography in a small-scale（20 km×20 km） area（i.e., tsogt-Ovoo village） within the desert steppe zone of Mongolia using in-situ observed climate data and satellite remote sensing data. We found that the topography is very important for vegetation growth in the desert steppe although the summer precipitation is the constraining factor. the unexpectedly high NDVI（up to 0.56）, as well as the high aboveground biomass, in the valley bottom was primarily resulted from the topography-modulated redistribution of overland flow after relatively heavy precipitation events during the growing season. this makes the valley bottoms in desert steppes not only reliable feeding resources for livestock but also heavens for wild lives. But, the detected large standard deviation of annual maximum NDVI（NDVI_（max）） from 2000 to 2013 in the valley bottom in response to rather variable precipitation implies that the valley bottoms under desert steppe climates are more vulnerable to climatic change.

关键词： topography climatic variable desert valley vegetation soil moisture terra-MODIS NDVI