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The 2024 M_(j) 7.6 Noto Peninsula, Japan earthquake caused by the fluid flow in the crust

Earthquake Research Advances 2024年第3期4卷 1-6页

作者： Yuzo ishikawa Ling Bai Center for Integrated Research and Education of Natural Hazards Shizuoka UniversityShizuoka422-8529Japan state Key Laboratory of Tibetan Plateau Earth system Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China University of Chinese Academy of sciences Beijing100049China

On January 1, 2024 at 16:10:09 JsT, an M_(j) 7.6 earthquake struck the Noto Peninsula in the southern part of the sea of Japan. This location has been experiencing an earthquake swarm for more than three years. Here, we provide an overview of this earthquake, focusing on the slip distribution of the mainshock and its relationship with the preceding swarm. We also reexamined the source areas of other large earthquakes that occurred around the sea of Japan in the past and compared them with the Matsushiro earthquake swarm in central Japan from1964 to 1968. The difference between the Matsushiro earthquake swarm and the Noto earthquake swarm is the surrounding stress field. The Matsushiro earthquake swarm was a strike-slip stress field, so the cracks in the crust were oriented vertically. This allowed fluids seeped from the depths to rise and flow out to the surface. On the other hand, the Noto area was a reverse fault stress field. Therefore, the cracks in the earth's crust were oriented horizontally. Fluids flowing underground in deep areas could not rise and spread over a wide area in the horizontal plane. This may have caused a large amount of fluid to accumulate underground, triggering a large earthquake. Although our proposed mechanism does not take into account other complex geological conditions into consideration, it may provide a simple way to explain why the Noto swarm is followed by a large earthquake while other swarms are not.

关键词： The M 7.6 Noto Peninsular earthquake Earthquake swarm Fluid triggering strike-slip fault Reverse fault

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The 2023 Turkey earthquake doublet: Earthquake relocation, seismic tomography, and stress field inversion

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Earth and Planetary Physics 2024年第3期8卷 535-548页

作者： HuiLi Zhan Ling Bai Bagus Adi Wibowo ChaoYa Liu Kazuo Oike Yuzo ishikawa state Key Laboratory of Tibetan Plateau Earth system Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of sciences Beijing 100049China Center of Earthquake and Tsunami Agency of MeteorologyClimatology and GeophysicsJakarta 10610Indonesia University of shizuoka Shizuoka 422-8526Japan shizuoka University Shizuoka 422-8529Japan

On February 6,2023,two earthquakes with magnitudes of M_(W) 7.8 and M_(W) 7.5 struck southeastern Turkey,causing significant casualties and economic *** seismic events occurred along the East Anatolian Fault Zone,a convergent boundary between the Arabian Plate and the Anatolian *** this study,we analyze the M_(W) 7.8 and M_(W) 7.5 earthquakes by comparing their aftershock relocations,tomographic images,and stress field *** earthquakes were localized in the upper crust and exhibited steep dip ***,the aftershocks occurred either close to the boundaries of low and high P-wave velocity anomaly zones or within the low P-wave velocity anomaly *** East Anatolia Fault,associated with the M_(W) 7.8 earthquake,and the sürgüFault,related to the M_(W) 7.5 earthquake,predominantly experienced shear ***,their western sections experienced a combination of strike-slip and tensile stresses in addition to shear *** ruptures of the M_(W) 7.8 and M_(W) 7.5 earthquakes appear to have bridged a seismic gap that had seen sparse seismicity over the past 200 years prior to the 2023 Turkey earthquake sequence.

关键词： Turkey earthquake doublet earthquake relocation seismic tomography stress field seismicity

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High Concentration Er-Doped Fiber for Efficient L-Band Amplification with short Length

High Concentration Er-Doped Fiber for Efficient L-Band Ampli...

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亚太地区通信会议暨光电子通信会议

作者： s.Endo s.ishikawa M.Kakui M.Nishimura Y.Makio sumitomo Electric Industries Ltd.1 Taya-cho sakae-ku Yokohama 244-8588 Japan sumitomo Electric Industries Ltd.1 Taya-cho sakae-ku Yokohama 244-8588 Japan sumitomo Electric Industries Ltd.1 Taya-cho sakae-ku Yokohama 244-8588 Japan sumitomo Electric Industries Ltd.1 Taya-cho sakae-ku Yokohama 244-8588 Japan sumitomo Electric Industries Ltd.1 Taya-cho sakae-ku Yokohama 244-8588 Japan

High concentration(-3500ppm)Ex-doped fiber has been developed to shorten the fiber length necessary for *** exhibits gain per unit length as high as 1.58dB/m and no significant degradation of conversionefficiency.

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高效耐用的聚合物滤网

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国际纺织导报 2007年第5期35卷 4-7页

作者： s. ishikawa 胡吉永（译）李毓陵（校） Kansai丝网公司（日本）不详

由Kansai丝网公司开发的新型褶皱滤网能防止滤网边缘聚合物液体的渗漏和滤网褶皱结构的变形。在合成纤维纺丝过程中已证实以下优势:使用寿命延长,生产中断、生产损耗和滤网损耗减少,相应降低了生产成本,有使用更细的滤网的可能性,因而... 详细信息

由Kansai丝网公司开发的新型褶皱滤网能防止滤网边缘聚合物液体的渗漏和滤网褶皱结构的变形。在合成纤维纺丝过程中已证实以下优势:使用寿命延长,生产中断、生产损耗和滤网损耗减少,相应降低了生产成本,有使用更细的滤网的可能性,因而产品质量得到改进。

关键词：聚合物滤网纺丝

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saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?

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Neural Regeneration Research 2021年第3期16卷 489-495页

作者： Takao ishikawa Department of Molecular Biology Institute of BiochemistryFaculty of BiologyUniversity of WarsawWarsawPoland

The baker's yeast saccharomyces(s.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life *** a unicellular organism,*** has some evident limitations in application to ***,yeast prions are extensively studied and they are known to share some hallmarks with mammalian prion protein or other amyloidogenic proteins found in the pathogenesis of Alzheimer's,Parkinson's,or Huntington's ***,the yeast *** has been widely used for basic research on aggregation properties of proteins in cellulo and on their ***,a yeast-based study revealed that some regions of mammalian prion protein and amyloidβ1–42 are capable of induction and propagation of yeast *** is one of the examples showing that evolutionarily distant organisms share common mechanisms underlying the structural conversion of prion proteins making yeast cells a useful system for studying mammalian prion *** has also been used to design novel screening systems for anti-prion compounds from chemical *** assays are cheap in maintenance and safe for the researcher,making them a very good choice to perform preliminary screening before further characterization in systems engaging mammalian cells infected with *** this review,not only classical red/white colony assay but also yeast-based screening assays developed during last year are *** analysis and research carried out using yeast prions force us to expect that prions are widely present in ***,the last few years brought us several examples indicating that the mammalian prion protein is no more peculiar protein–it seems that a better understanding of prion proteins nature-wide may aid us with the treatment of prion diseases and other amyloid-related medical conditions.

关键词： amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay

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Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering （sERs） and basic applications of sERs biological sensing

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Frontiers of physics 2014年第1期9卷 31-46页

作者： Yuko s. Yamamoto Mitsuru ishikawa Yukihiro Ozaki Tamitake Itoh Nano-Bioanalysis Research Group Health Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Takamatsu Kagawa 761-0395 Japan Department of Chemistry Josai University Itado Saitama 350-0295 Japan Department of Chemistry School of Science and Technology Kwansei Gakuin University Sanda Hyogo 669-1337 Japan

We review recent our results in the fundamental study of surface-enhanced Raman scattering （sERs） with emphasis on experiments that attempted to identify the enhancement and blinking mechanism using single Ag nanoparticle dimers attached to dye molecules. These results are quantitatively discussed in the framework of electromagnetic mechanism. We also review recent our results in basic sERs applications for biological sensing regarding detections of cell surface molecules and distinction of disease marker molecules under single cell and single molecule level.

关键词： plasmonics surface-enhanced Raman scattering (sERs) surface-enhanced fluorescence,Ag nanoparticle

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Early administration of branched-chain amino acid granules

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World Journal of Gastroenterology 2012年第33期18卷 4486-4490页

作者： Toru ishikawa Department of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital Niigata 950-1104 Japan

The effect of malnutrition on survival in patients with decompensated liver cirrhosis has not been well defined. Nutritional intervention with branched-chain amino acid (BCAA) can increase serum albumin concentration in patients with decompensated cirrhosis but its effects on survival are unclear. The BCAA to tyrosine ratio (BTR) is a surrogate marker (the normal range of BTR is between 4.41 and 10.05, and a Fischer's ratio of 1.8 corresponds to a BTR of 3.5) in patients with decompensated liver cirrhosis, and BCAA inhibits hepatic carcinogenesis in patients with compensated cirrhosis. This review discusses data regarding the effect of early administration of BCAA granules based on the ratio of BCAA to BTR on prognosis in patients with cirrhosis.

关键词： Branched-chain amino acid to tyrosine ratio Branched-chain amino acid granules Liver cirrhosis Nutritional intervention Malnutrition Quality of life Albumin Cancer onset

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Branched-chain amino acids to tyrosine ratio value as a potential prognostic factor for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第17期18卷 2005-2008页

作者： Toru ishikawa Department of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital280-7 TerajiNiigata 950-1104Japan

The prognosis of hepatocellular carcinoma(HCC) depends on tumor extension as well as hepatic *** functional reserve is recognized as a factor affecting survival in the treatment of HCC;the ChildPugh classif ication system is the most extensively used method for assessing hepatic functional reserve in patients with chronic liver disease,using serum albumin level to achieve accurate assessment of the status of protein ***,insuff icient attention has been given to the status of amino acid(AA) metabolism in chronic liver disease and ***'s ratio is the molar ratio of branched-chain AAs(BCAAs:leucine,valine,isoleucine) to aromatic AAs(phenylalanine,tyrosine) and is important for assessing liver metabolism,hepatic functional reserve and the severity of liver *** this ratio is diff icult to determine in clinical situations,BCAAs/tyrosine molar concentration ratio(BTR) has been proposed as a simpler *** correlates with various liver function examinations,including markers of hepatic f ibrosis,hepatic blood flow and hepatocyte function,and can thus be considered as reflecting the degree of hepatic *** manuscript examines the literature to clarify whether BTR can serve as a prognostic factor for treatment of HCC.

关键词： Branched-chain amino acids to tyrosine ratio Fischer's ratio Prognostic factor Hepatocellular carcinoma

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Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue

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World Journal of stem Cells 2017年第5期9卷 77-88页

作者： Tetsuya ishikawa Cell Biology Core Facilities for Research and Innovative MedicineNational Cancer Center Research InstituteTokyo 104-0045Japan Central Animal Division Fundamental Innovative Oncology Core CenterNational Cancer Center Research InstituteTokyo 104-0045Japan

AIM To investigate genotype variation among induced pluripotent stem cell(iPsC) lines that were clonally generated from heterogeneous colon cancer tissues using next-generation sequencing. METHODs Human iPsC lines were clonally established by selecting independent single colonies expanded from heterogeneous primary cells of s-shaped colon cancer tissues by retroviral gene transfer(OCT3/4, sOX2, and KLF4). The ten iPsC lines, their starting cancer tissues, and the matched adjacent non-cancerous tissues were analyzed using nextgeneration sequencing and bioinformatics analysis using the human reference genome hg19. Non-synonymous single-nucleotide variants(sNVs)(missense, nonsense,and read-through) were identified within the target region of 612 genes related to cancer and the human kinome. All sNVs were annotated using dbs NP135, CCDs, Refseq, GENCODE, and 1000 Genomes. The sNVs of the iPsC lines were compared with the genotypes of the cancerous and non-cancerous tissues. The putative genotypes were validated using allelic depth and genotype quality. For final confirmation, mutated genotypes were manually curated using the Integrative Genomics Viewer. REsULTs In eight of the ten iPsC lines, one or two non-synonymous sNVs in EIF2AK2, TTN, ULK4, TssK1 B, FLT4, sTK19, sTK31, TRRAP, WNK1, PLK1 or PIK3R5 were identified as novel sNVs and were not identical to the genotypes found in the cancer and non-cancerous tissues. This result suggests that the sNVs were de novo or pre-existing mutations that originated from minor populations, such as multifocal pre-cancer(stem) cells or pre-metastatic cancer cells from multiple, different clonal evolutions, present within the heterogeneous cancer tissue. The genotypes of all ten iPsC lines were different from the mutated ERBB2 and MKNK2 genotypes of the cancer tissues and were identical to those of the noncancerous tissues and that found in the human reference genome hg19. Furthermore, two of the ten iPsC lines did not have any confir

关键词： Colon cancer Next-generation sequencing single-nucleotide variant Genotype Heterogeneous cancer tissue Cancer associated fibroblast Pre-cancer cell Induced pluripotent stem cell single cell Clonal evolution

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Epigenetic Programming： The Challenge to species Hybridization

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Molecular Plant 2009年第4期2卷 589-599页

作者： Ryo ishikawa Tetsu Kinoshita Plant Reproductive Genetics GCOE Research Group Graduate School of Biological Science Nara Institute of Science and Technology 8916-5 Takayama IkomaNara 630-0192 Japan

In many organisms, the genomes of individual species are isolated by a range of reproductive barriers that act before or after fertilization. successful mating between species results in the presence of different genomes within a cell （hybridization）, which can lead to incompatibility in cellular events due to adverse genetic interactions. In addition to such genetic interactions, recent studies have shown that the epigenetic control of the genome, silencing of transposons, control of non-additive gene expression and genomic imprinting might also contribute to reproductive barriers in plant and animal species. These genetic and epigenetic mechanisms play a significant role in the prevention of gene flow between species. In this review, we focus on aspects of epigenetic control related to hybrid incompatibility during species hybrid- ization, and also consider key mechanism（s） in the interaction between different genomes.

关键词： Endosperm epigenetics genomic imprinting species hybridization transposon.

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