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Healing effect on gastric and oral ulcers of tannic extract obtained from Pinus caribaeae Morelet bark and preclinical toxicology tests

Healing effect on gastric and oral ulcers of tannic extract ...

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第十五届国际药理学大会

作者： Alicia Lagarto Pedro Barzaga Viviana Bueno Jorge Luis Santana isbel guerra Sara Agüero Odalys Valdés Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 MSc. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Lic. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Dra. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Dr. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Téc. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Téc. Drag Research and Development Center. Biologic Control Laboratory. Ave. 26 No.1605. Nuevo Vedado. Plaza. Havana. Cuba. CP 10600 Téc.

＜正＞ The study examines the healing effect on gastric and oral ulcers of tannic extract obtained from Pinus caribaeae Morelet and preclinical toxicology tests. The protective effect on gastric mucous was evaluated in lesions induced by ethanol in Wistar rats at dose of 5 mg/kg. Oral mucous healing effect was evaluated in lesions induced by acetic acid in Golden Syrian hamster at 3 dose levels:64,80 and 100 mg/ml. Oral acute toxicity was conduced at dose of 2000 mg/kg and subchronic doses of 1,2.5 and 5 mg/kg/day were used for 90 days exposure in Wistar rats. Tannic extract causes significant decrease of gastric lesions. Ulcers number and lesions index decreased in 47 and 35 % respectively. Oral mucous dosing causes significant acceleration of scaring. Epithelial regeneration and own sheet maturation were accelerate in treated group. There were no mortality and signs of toxicity in acute toxicity assay. In subchronic exposure signs of toxicity were observed and body weight gain was significantly increased. Some of the blood and biochemical elements were affected. The histopathological examination showed abnormalities in liver, kidney, stomach and nasal cavity organs at doses of 1.0 and 5.0 mg/kg/day.

关键词： gastric and oral mucous healing oral acute toxicity oral subchronic toxicity

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