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Person Authentication Using a New Feature Vector of the Brain Wave

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维普期刊数据库

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通讯和计算机（中英文版） 2012年第1期9卷 101-105页

作者： isao nakanishi Sadanao Baba Chisei Miyamoto Shignag Li Graduate School of Engineering Tottori University Tottori 680-8552 Japan

Homology Modeling of Human Alpha-Glucosidase Catalytic Domains and SAR Study of Salacinol Derivatives

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Open Journal of Medicinal Chemistry 2012年第3期2卷 50-60页

作者： Shinya Nakamura Kazunori Takahira Genzoh Tanabe Osamu Muraoka isao nakanishi Department of Pharmaceutical Sciences Kinki University Kinki Japan

Maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) belong to human intestinal alpha-glucosidase and their N-terminal side catalytic domains are called NtMGAM and NtSI, and their C-terminal side catalytic domains are called CtMGAM and CtSI. As an antidiabetic, alpha-glucosidase inhibitor is required to bind to all of these domains to inhibit disaccharides hydrolysis. Salacinol and kotalanol isolated from Salacia reticulata are novel seed compounds for al-pha-glucosidase inhibitor. Even though the complex structures of NtMGAM or NtSI have been determined experimen-tally, those of CtMGAM and CtSI have not been revealed. Thus, homology modeling for CtMGAM and CtSI has been performed to predict the binding mode of salacinol and its derivatives for each domain. The binding affinities for these compounds were also calculated to explain the experimental structure-activity relationships (SARs). After a docking study of the derivatives to each catalytic domain, the MM/PBSA method has been applied to predict the binding affinities. The predicted binding affinities were almost consistent with the experimental SARs. The comparison of the complex structures and binding affinities provided insights for designing novel compounds, which inhibit all catalytic domains.

关键词： Homology Modeling Docking Study MM/PBSA Alpha-Glucosidase Salacinol Kotalanol

Computational Study on the Comparative Differences in the Activity of Inhibitors of Human versus Rat Alpha-Glucosidase

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Open Journal of Medicinal Chemistry 2017年第2期7卷 19-28页

作者： Shinya Nakamura Kazuko Shimada Genzoh Tanabe Osamu Muraoka isao nakanishi Department of Pharmaceutical Sciences Kindai University Higashiosaka Japan

Differences between the inhibitory activities of specific compounds on analogous enzymes isolated from different animal species are one of the critical issues to evaluate when exploring structure-activity relationships. The activity of acarbose is about ten times stronger in rat than in human, and that of neosalacinol is similar in both species. Binding affinities of acarbose and neosalacinol to four catalytic domains of alpha-glucosidases in human and rat were compared to investigate the cause of activity differences among species. Species difference was brought about complicatedly by the balance of interaction with four domains, and the result was indicated that larger ligand would show larger species difference in activity.

关键词： Homology Modeling MM/PBSA Alpha-Glucosidase Salacinol Acarbose Species Difference

Estimating effects from trapped magnetic fluxes in superconducting magnetic levitation measurement

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仪器仪表学报 2008年第3期29卷 449-452页

作者： Masakazu nakanishi Metrology Institute of Japan National Institute of Advanced Industrial Science and Technology 1-1-1 Umezono Tsukuba-shi Ibaraki 305-8563 Japan

Superconducting magnetic levitation measurement is one of the most promising approaches to define mass standard based on the fundamental physical constants. However, the present system has unknown factors causing error larger than 50 ppm. We examined the effects of magnetic fluxes trapped in the superconducting coil and the superconducting floating body. When fluxes were trapped in either coil or floating body, their effects were able to be cancelled by reversing polarities of current and magnetic field, as had been believed. However, fluxes trapped in both coil and body induced an attractive force between them and caused error. In order to reduce the fluxes, the coil and the floating body should be cooled in low magnetic field in magnetic and electromagnetic shields.

关键词：截留磁通量超导电磁飘浮测量基本物理常量

Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging

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Neural Regeneration Research 2020年第1期15卷 25-29页

作者： Hiroshi nakanishi Department of Pharmacology Faculty of Pharmacy Yasuda Women’s University

Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent *** microglia are the main cellular source of interleukin-1βin the *** B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the *** leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial ***,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain *** active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.

关键词： brain aging caspase-1 cathepsin B inflammatory brain diseases interleukin-1β microglia mitochondrial transcription factor A neuroinflammation nuclear factor-κB oxidative stress

Hierarchically porous monoliths based on low-valence transition metal (Cu, Co, Mn) oxides:gelation and phase separation

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National Science Review 2020年第11期7卷 1656-1666页

作者： Xuanming Lu Kazuyoshi Kanamori Kazuki nakanishi Department of Chemistry Graduate School of ScienceKyoto University Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto University Division aof Materials Research Institute of Materials and Systems for Sustainability Nagoya University

Hierarchically porous monoliths based on copper (Cu), cobalt (Co) and manganese (Mn) oxides with three-dimensionally (3D) interconnected macropores and open nanopores were prepared using metal bromides as precursors via a sol–gel process accompanied by phase separation. The difficulty of gelation for low-valence metal cation was overcome by introducing a highly electronegative Br atom near to the metal atom to control the rates of hydrolysis and polycondensation. The 3D interconnected macropores were obtained using appropriate polymers to induce phase separation. The domain sizes of macropores and skeletons can be controlled by reaction parameters such as concentration and/or average molecular weight of polymers, and the amount of hydrochloric acid. The crystalline metal oxide monoliths with their 3D interconnected macroporous structure preserved were obtained after heat treatment in air.

关键词： hierarchically porous monolith low-valence transition metal oxide 3D interconnected macropore sol–gel process phase separation

Sintering Formation of Low Temperature Phase MnBi and Its Disordering in Mechanical Milling

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Journal of Materials Science & Technology 1996年第5期12卷 335-341页

作者： Yin, FX Gu, NJ Shigematsu, T nakanishi, N KONAN UNIV FAC SCIDEPT CHEMKOBE 658JAPAN

With X-ray diffraction and DSC analysis, it is found that 4 cycles of sintering at 593 K are necessary for the complete production of the low-temperature phase (LTP) MnBi. The c/a of the fabricated LTP MnBi is 1.4286. Metastable phase MnBip formed in primary sintering stage of LTP MnBi has the similar crystal structure and lattice constant with the quenched high-temperature phase (HTP) Mn1.08Bi. The structural differences between MnBip phase and Mn1.08Bi phase are discussed. The LTP MnBi phase is unstable for strong mechanical milling as Bi appears after milling over 7200 s in the present milling condition. Strains caused by the mechanical attrition are difficult to accumulate in the MnBi crystals, and the crystal size of the milled MnBi is only 30 nm before the presence of grains coalescence. The whole milling process can be classified into 3 stages indicated by the structural changes. Based on the structural parameter calculation, the changes of atomic configurations in every stage have been discussed. The existence of Bi equivalent vacancy site is considered to play an important role in the disordering processes of Mn and Bi atoms.

关键词： Binary alloys

Non-Contact Measurements of Water Jet Spreading Width with a Laser Instrument

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Journal of Thermal Science 2016年第4期25卷 349-354页

作者： Yuki Funami Ryo Hasuya Kotaro Tanabe Yuji nakanishi Kanagawa University: 3-27-1 Rokkakubashi Kanagawa-ku Yokohama Kanagawa 221-8686 Japan

Jet spreading width is one of the important characteristics of water jets discharging into the *** researchers have dealt with measuring this width,and contact measuring methods on the water jet surface were employed in a lot of the *** order to avoid undesirable effects caused by the contact on the jet surface,we introduce non-contact measuring methods with a laser instrument to the measurements of jet spreading *** measurements,a transmitter emits sheet-like laser beam to a *** water jet between the transmitter and the receiver interrupts the laser beam and makes a *** minimum and maximum values of the shadow width are *** addition,pictures of the water jet are taken with a scale,and the shadow width is measured from the *** experiments on various needle strokes were *** kinds of width consistent with the jet structure were *** the results,it can be concluded that our non-contact measuring methods are *** data of jet spreading widths and jet taper were obtained and are useful for future applications.

关键词： Water jet Jet spreading width Jet taper Non-contact measurement Laser instrument

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

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World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： Koki nakanishi Mitsuro Kanda Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication