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Coin-structured tunable beam shaping assembly design for accelerator-based boron neutron capture therapy for tumors at different depths and sizes

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Nuclear Science and Techniques 2023年第12期34卷 66-76页

作者： Zhao‑Peng Qiao Yao‑Cheng Hu Quan‑Xu Jiang Jing‑Jing Fan isao murata Rui‑Rui Liu Bo Wang Sheng Wang Department of Nuclear Science and Technology School of Energy and Power EngineeringXi’an Jiao-Tong UniversityNo.28Xianning West RoadXi’an 710049China XJTU-Huzhou Neutron Science Laboratory Science Valley Medium‑Sized Building#1Huzhou 313000China RIKEN Center for Advanced Photonics RIKENWakoSaitama 351‑0198Japan Division of Sustainable Energy and Environmental Engineering Graduate School of EngineeringOsaka UniversitySuitaOsaka 565‑0871Japan Department of Radiation Oncology and Winship Cancer Institute Emory UniversityAtlantaGAUSA School of Mathematics and Statistics NingBo UniversityNo.818 Fenghua RoadNingbo 315211China

In the past decade,boron neutron capture therapy utilizing an accelerator-based neutron source(ABNS)designed primarily for producing epithermal neutrons has been implemented in the treatment of brain tumors and other *** specifications for designing an epithermal beam are primarily based on the IAEA-TECODC-1223 report,issued in 2001 for reactor neutron *** on this report,the latest perspectives and clinical requirements,we designed an ABNS capable of adjusting the average neutron beam *** design was based on a 2.8 MeV,20 mA proton beam bombarding a lithium target to produce neutrons that were subsequently moderated and tuned through a tunable beam shaping assembly(BSA)which can modify the thicknesses and materials of the coin-shaped moderators,back reflectors,filters,and *** simulation results demonstrated that epithermal neutron beams for deep seated tumor treatment,which were generated by utilizing magnesium fluoride with lengths ranging between 28 and 36 cm as the moderator,possessed a treatment depth of 5.6 cm although the neutron flux peak shifts from 4.5 to 1.0 *** utilizing a thinner moderator,a less accelerated beam power can meet the treatment ***,higher powers reduced the treatment *** contrast,employing a thick moderator can reduce the skin *** scenarios that required relatively low energy neutron beams,the removal of the thermal neutron filter can raise the thermal neutron flux at the beam *** the depth of the dose rate peak could be adjusted between 0.25 and 2.20 cm by combining magnesium fluoride and polyethylene coins of different ***,this device has a better adaptability for the treatment of superficial ***,the tunable BSA provides greater flexibility for clinical treatment than common BSA designs that can only adjust the port size.

关键词： Boron neutron capture therapy(BNCT) Accelerator-based neutron source(ABNS) Beam shaping assembly(BSA) Treatment depth

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Long-lived neutron-induced radioisotopes in OKTAVIAN facility concrete wall after 38 year-operation

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辐射防护 2020年第6期40卷 577-582页

作者： Fajar Panuntun Shingo Tamaki Sachie Kusaka Fuminabo Sato isao murata Graduate School of Engineering Osaka UniversityYamadaoka 2-1SuitaOsaka565-0871Japan

An intense 14 MeV neutron source facility named OKTAVIAN was installed in the A15 building,Osaka University in *** the operation period,new radioisotopes with various half-life have been produced as neutron activation products in its concrete wall *** this work,we investigated the concrete wall in the heavy irradiation room of OKTAVIAN using gamma spectrometry method to discover the presence of radioisotope having large half-life value(long-lived radioisotope)as neutron activation *** simulations were performed prior to measurement to predict the presence of long-lived radioisotopes by employing MCNP5 and FISPACT codes.A pre-calibrated Germanium detector with high energy resolution was employed to measure the *** long-lived activation products have been observed such as 152 Eu,54 Mn,65 Zn,22 Na and 60 *** activity of each radioisotope was derived after estimating the detector efficiency using *** a result of the measurement and analysis,the followings are concluded:(1)Though presence of activation products represents radiological risk to everyone who performs an experimental activity in the irradiation room of the OKTAVIAN facility,the present result shows that past experiments were carried out safely without any significant additional exposure dose coming from the wall for the last 38 years.(2)The approximated total fluence of D-T neutrons to the wall was successfully estimated from the produced radioisotope,152 Eu,because it has the longest half-life of 13.5 years among the observed radioisotopes.(3)From the results of(1)and(2),it could be possible to estimate the total activity of the concrete wall in the OKTAVIAN facility,which is very essential and important information,because this would be very valuable for decommissioning or disposal of the facility in the future.

关键词： OKTAVIAN concrete wall shielding long-lived neutron-induced product total fluenced D-T neutron

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Development of beta ray scanner for imaging foliar uptake of radiocesium

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Radiation Detection Technology and Methods 2017年第2期1卷 76-80页

作者： Fuminobu Sato Tomonori Okumura Yushi Kato isao murata Toshiyuki Iida Graduate School of Engineering Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

Large quantities of radionuclides were released from the Fukushima Daiichi Nuclear Power Plant(FDNPP)into the atmosphere,which then contaminated the soil and vegetation surrounding the *** research on radiocesium contamination of agricultural products and wild plants is ***,we developed a simple beta ray scanner to obtain radiographs of the transport and foliar uptake of *** simple beta ray scanner comprised a beta ray detector,a motorized sample stage,a shielding box,and a personal *** rays released from radiocesium were detected effectively using a plastic scintillator plate coupled to multipixel photon counter *** spatial resolving power was approximately 6 mm×4 mm(FWHM).In a preliminary experiment,a drop of radiocesium solution was placed on the upper surface of a radish ***-lapse images of radiocesium in the leaf were obtained by the beta ray *** of isotope transport in the leaf were successfully obtained with the beta ray *** beta ray scanner will be used in our future research on the mechanism of the foliar uptake of radiocesium.

关键词： Beta ray scanner Multipixel photon counter Foliar uptake of radiocesium Artificial climate germination box

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Detecting Communities in K-Partite K-Uniform (Hyper)Networks

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Journal of Computer Science & Technology 2011年第5期26卷 778-791页

作者：刘欣 Tsuyoshi murata Department of Computer Science Tokyo Institute of Technology

In social tagging systems such as Delicious and Flickr,users collaboratively manage tags to annotate ***,a social tagging system can be modeled as a （user,tag,resource） hypernetwork,where there are three different types of nodes,namely users,resources and tags,and each hyperedge has three end nodes,connecting a user,a resource and a tag that the user employs to annotate the *** how can we automatically cluster related users,resources and tags,respectively？ This is a problem of community detection in a 3-partite,3-uniform *** generally,given a K-partite K-uniform （hyper）network,where each （hyper）edge is a K-tuple composed of nodes of K different types,how can we automatically detect communities for nodes of different types？ In this paper,by turning this problem into a problem of finding an efficient compression of the （hyper）network＇s structure,we propose a quality function for measuring the goodness of partitions of a K-partite K-uniform （hyper）network into communities,and develop a fast community detection method based on *** method overcomes the limitations of state of the art techniques and has several desired properties such as comprehensive,parameter-free,and *** compare our method with existing methods in both synthetic and real-world datasets.

关键词： community detection bipartite graph tripartite hypergraph clustering social tagging

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Three-Dimensional Leaf Edge Reconstruction Combining Two-and Three-Dimensional Approaches

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Plant Phenomics 2024年第3期6卷 532-546页

作者： Hidekazu murata Koji Noshita Department of Biology Kyushu UniversityFukuokaFukuoka 819-0395Japan Plant Frontier Research Center Kyushu UniversityFukuokaFukuoka 819-0395Japan

Leaves,crucial for plant physiology,exhibit various morphological traits that meet diverse functional *** leaf morphology quantification,largely 2-dimensional(2D),has not fully captured the 3-dimensional(3D)aspects of leaf *** improvements in 3D data acquisition,accurately depicting leaf morphologies,particularly at the edges,is *** study proposes a method for 3D leaf edge reconstruction,combining 2D image segmentation with curve-based 3D *** deep-learning-based instance segmentation for 2D edge detection,structure from motion for estimation of camera positions and orientations,leaf correspondence identification for matching leaves among images,and curve-based 3D reconstruction for estimating 3D curve fragments,the method assembles 3D curve fragments into a leaf edge model through B-spline curve *** method's performances were evaluated on both virtual and actual leaves,and the results indicated that small leaves and high camera noise pose greater challenges to *** developed guidelines for setting a reliability threshold for curve fragments,considering factors occlusion,leaf size,the number of images,and camera error;the number of images had a lesser impact on this threshold compared to *** method was effective for lobed leaves and leaves with fewer than 4 ***,challenges still existed when dealing with morphologies exhibiting highly local variations,such as *** nondestructive approach to 3D leaf edge reconstruction marks an advancement in the quantitative analysis of plant *** is a promising way to capture whole-plant architecture by combining 2D and 3D phenotyping approaches adapted to the target anatomical structures.

关键词： edge leaf approaches combining dimensional reconstruction three

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Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases

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Acta Pharmacologica Sinica 2007年第3期28卷 439-445页

作者： Nobuo murata Tatsuo YAMAKAWA Department of Surgery Mini-invasive surgery CenterTeikyo University Mizonokuchi HospitalKawasaki 213-8507Japan

Aim:To provide experimental data for further research on the signal transductionof apoptosis in lung adenocarcinoma cells,we examined the effects of exogenousC2-ceramide administration on several members of the mitogen-activated proteinkinase(MAPK)superfamily and caspase-3 in A549 ***:Cell viabilityand apoptosis were analyzed by cell counting kit-8 assay and flow *** MAPK and caspase-3 proteins were detected by Western ***:C2-ceramide selectively altered the phosphorylation state &members ofthe MAPK superfamily,causing hyperphosphorylation ofmitogen-activated pro-tein kinase kinase(MEK)1/2 and the p38 MAPK,but not affecting the phosphory-lation ofextracellular signal-regulated kinase 1/2 and the c-Jun N-terminal ***-203580(a p38 MAPK inhibitor)and p38 siRNA,but not U0126(a MEKinhibitor),partially rescued cell death induced by C2-ceramide.C2-ceramide promoted theactivation of ***:Exogenous C2-ceramide induced apoptosisin human lung adenocarcinoma A549 *** activation of MAPK and caspase-3were involved in the mechanisms ofC2-ceramide-induced apoptosis in A549 cells.

关键词： ceramide apoptosis mitogen-activated protein kinases A549 cells

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Applicability of LIVE/DEAD BacLight stain with glutaraldehyde fixation for the measurement of bacterial abundance and viability in rainwater

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Journal of Environmental Sciences 2017年第1期29卷 202-213页

作者： Wei Hu Kotaro murata Daizhou Zhang Faculty of Environmental and Symbiotic Sciences Prefectural University of KumamotoKumamoto 862-8502Japan

Rainwater contains substantial bacteria and rain is an efficient pathway for the dissemination of bacteria from the atmosphere to land and water ***,quantitative information on rainwater bacteria is very limited due to the lack of a reliable *** this study,the epifluorescence microscopy enumeration with the LIVE/DEAD BacLight Bacterial Viability Kit stain was verified to quantify the abundance of viable and non-viable bacterial cells in rainwater,with the 4＇,6-diamidino-2-phenylindole（DAPI） stain for the reference of total cell *** showed that the total counts of bacterial cells by LIVE/DEAD BacLight staining were consistent with those by DAPI staining,and the average detection efficiency was（109 ± 29）%.The ratio of cell count with glutaraldehyde fixation to that without fixation was（106 ± 5）%on *** bacterial concentration in negative control was usually an order of magnitude lower than that in rainwater ***,in case of small precipitation,the abundance in negative control could be more than that in rainwater *** results indicate that the enumeration with LIVE/DEAD BacLight bacterial viability assay coupled with glutaraldehyde fixation and careful negative control investigation is an approach applicable to the measurement of the concentration and viability of bacterial cells in rainwater.

关键词： Bacterial abundance Viability Rainwater LIVE/DEAD BacLight stain Fluorescent enumeration

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Physiological significance of Rag1 in retinal ganglion cell death

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Neural Regeneration Research 2015年第2期10卷 192-194页

作者： Takuma Hayashi Toshinori murata Department of Immunology and Infectious Disease Shinshu University Graduate School of Medicine Department of Ophthalmology Shinshu University Graduate School of Medicine

Although the transcription factor, nudear factor-κB （NF-κB） is known to regulate cell death and survival, its precise role in cell death within the central nervous system （CNS） remains unknown. We previously reported that mice with a homozygous deficiency for NF-κBp50 spon- taneously developed optic neuropathy. We examined the expression and activation of pro-apoptotic factor（s） that mediate optic neuropathy in p50-/- mice. Recombination activating gene 1 （Ragl） is known to regulate the recombination of immunoglobulin V（D）J.

关键词： RGCs Physiological significance of Rag1 in retinal ganglion cell death cell

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An Electronic Approach to Materials Design

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Journal of Materials Science & Technology 2003年第Z1期19卷 73-76页

作者： Masahiko MORINAGA Yoshinori murata Hiroshi YUKAWA Department of Materials Science and Engineering Graduate School of Engineering Nagoya UniversityNagoya 464-8603 Japan Department of Materials Science and Engineering Graduate School of Engineering Nagoya UniversityNagoya 464-8603 Japan Department of Materials Science and Engineering Graduate School of Engineering Nagoya UniversityNagoya 464-8603 Japan

A molecular orbital approach to materials design has recently made great progress. This approach is based onthe electronic structure calculations by the DV-Xα cluster method. In this paper recent progress in this approachis reviewed. In particular, it is stressed that New PHACOMP approach is useful for predicting the formation oftopologically close-packed (TCP) phases (e.g., σ phase andμ phase ) in nickel based superalloys. Compared to thecurrent PHACOMP, New PHACOMP provides a better tool for designing those alloys which are free from such TCPprecipitates at service temperatures. In addition, the d-electrons concept is shown for alloy design and development.

关键词： High temperature materials, Ni based superalloys, Alloy design, Molecular orbital method

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Optimal calibration scheme for map-based control of diesel engines

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Science China(Information Sciences) 2018年第7期61卷 68-81页

作者： Yui NISHIO Yutaka murata Yukihisa YAMAYA Masato KIKUCHI Automobile R & D Center Honda R & D Co. Ltd.

Map-based control has the advantage of a simple control structure. However, in the case of a complex plant, calibrating the map is difficult. Calibration methodology using plant model is increasing in engine calibration industries. However, the models are for steady-state operation and cannot simulate at transient operation well. This study introduces the dynamic empirical model and applies the transient corrective function of an electronic control unit to simulate more realistic behavior. The optimization problem for calibrating maps of diesel engines is constructed, and the formulation of cost function and constraints is discussed. Consequently, the proposed calibration scheme can find an optimal map in satisfied ***, the optimized maps are validated using mass production diesel engines.

关键词： optimization Gaussian SQP Diesel engine calibration DoE

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