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A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy

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Chinese Journal of Cancer Research 2020年第1期32卷 105-114页

作者： Ho Kyoung Hwang Keita Wada Ha Yan Kim Yuichi Nagakawa Yosuke Hijikata Yota kawasaki Yoshiharu Nakamura Lip Seng Lee Dong Sup Yoon Woo Jung Lee Chang Moo Kang Division of HBP Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Korea Pancreatobiliary Cancer Clinic Yonsei Cancer CenterSeverance HospitalSeoul 03722Korea Department of Surgery Teikyo University School of MedicineTokyo 173-8605Japan Biostatistician Biostatistics Collaboration UnitDepartment of Biomedical Systems InformaticsYonsei University College of MedicineSeoul 03722Korea Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 160-8402Japan Department of Digestive Surgery Breastand Thyroid SurgeryGraduate School of Medical SciencesKagoshima UniversityKagoshima 890-0065Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 890-0065Japan Department of General Surgery Changi General HospitalSingapore 529889Singapore

Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. However, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term ***: The medical records of patients who underwent pancreatectomy following neoadjuvant treatment from January 2005 to December 2016 at Severance Hospital were retrospectively reviewed. Medical records were collected from five international institutions from Japan and Singapore for external ***: A total of 113 patients were enrolled. The nomogram for predicting 1-year disease-specific survival was created based on 5 clinically detectable preoperative parameters as follows: age(year), symptom(no/yes), tumor size at initial diagnostic stage(cm), preoperative serum carbohydrate antigen(CA) 19-9 level after neoadjuvant treatment(<34/≥34 U/m L), and planned surgery [pancreaticoduodenectomy(PD)(pylorus-preserving PD)/distal pancreatectomy(DP)/total pancreatectomy]. Model performance was assessed for discrimination and *** calibration plot showed good agreement between actual and predicted survival probabilities;the the Greenwood-Nam-D’Agostino(GND) goodness-of-fit test showed that the model was well calibrated(χ~2=8.24,P=0.5099). A total of 84 patients were used for external validation. When correlating actual disease-specific survival and calculated 1-year disease-specific survival, there were significance differences according to the calculated probability of 1-year survival among the three groups(P=0.044).Conclusions: The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of p

关键词： Pancreatic cancer neoadjuvant treatment pancreatectomy survival nomogram

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THE REFINERY MAINTENANCE ACTIVITIES WHILE TREATING MIDDLE EAST CRUDE TO RUN THE PLANT DURING 4 YEARS

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石油学报（石油加工） 2001年第1期17卷 63-69页

作者： Katsumi MASUDA (Engineering Integrity Service section, Engineering Department, kawasaki Refinery, Showa Shell Sekiyu K.K.18 1 Ohgimachi, kawasaki Ward, kawasaki City, Kanagawa, Japan) Engineering Integrity Service section Engineering Department Kawasaki Refinery 日本

Middle East crude oil is known to be a higher sulfur and metal containing crude than Far East crude. To treat higher sulfur crude requires appropriate procedures on refinery maintenance since corrosion environment of equipment can be affected by sulfur content. This paper introduces our experiences and measures in running the plant while facing corrosion and degradation by Middle East crude.

关键词：中东地区原油资源硫含量金属含量加氢精制

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Formation and UV-laser induced desorption of Cl-containing species on/from GaAs(100) surface

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Progress in Natural Science:Materials International 1996年第1期 77-85页

作者：宋真,吕日昌,Satoshi Shogen,Masahiro kawasaki,Ikuo Suemune China Research Institute for Electonic Science Hokkaido University Sapporo 060 Japan Research Institute for Electonic Science Hokkaido University Sapporo 060 Japan Research Institute for Electonic Science Hokkaido University Sapporo 060 Japan State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023

XPS was used to analyse the GaAs(100) substrate before and after concentrated HO treatment. The untreated RTO GaAs(100) surface has a 0.17nm thick oxide overlayer on it. HC1 treatment canremove this oxide layer and form a layer of Cl-contaimng species——GaClx. The 355 nm and 193 nm laserwas tried to study the 'laser induced desorption of GaCl,. XPS was also used to monitor the change of Cl quantity by laser irradiation. The results show that the 355 nm laser induces a thermal desorption of GaClx. By the behavior of the thermal desorption, we conclude that the GaClx on the HC1 treated GaAs(100) surface may be GaCl. The 193 nm laser can dissociate GaCl and induce a photo dissociation desorption of Cl.

关键词： HC1 solution etching laser induced desorption GaAs.

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Synchrotron-Infrared Microscopy Analysis of Amyloid Fibrils Irradiated by Mid-Infrared Free-Electron Laser

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American Journal of Analytical Chemistry 2014年第6期5卷 384-394页

作者： Takayasu kawasaki Toyonari Yaji Takayuki Imai Toshiaki Ohta Koichi Tsukiyama IR Free Electron Laser Research Center Research Institute for Science and Technology (RIST) Tokyo University of Science Noda Japan SR Center Research Organization of Science and Engineering Ritsumeikan University Kusatsu Japan

Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer’s disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease in the toxicity of the fibrils in cells, the fibril structure is robust under physiological conditions. We have irradiated amyloid fibrils with a free-electron laser (FEL) tuned to mid-infrared frequencies to induce dissociation of the aggregates into monomer forms. We have previously succeeded in dissociating fibril structures of a short peptide of the thyroid hormone by tuning the oscillation frequency to the amide I band, but the detailed structural changes of the peptide have not yet been determined at a high spatial resolution. Synchrotron-radiation infrared microscopy (SR-IRM) is a powerful tool for in situ analysis of minute structural changes of various materials, and in this study, the feasibility of SR-IRM for analyzing the microscopic conformational changes of amyloid fibrils after FEL irradiation was investigated. Reflection spectra of the amyloid fibril surface showed that the amide I peaks shifted to higher wave numbers after the FEL irradiation, indicating that the initial β-sheet-rich structure transformed into a mixture of non-ordered and turn-like peptide conformations. This result demonstrates that conformational changes of the fibril structure after the FEL irradiation can be observed at a high spatial resolution using SR-IRM analysis and the FEL irradiation system can be useful for dissociation of amyloid aggregates.

关键词： Amyloid Fibrils Free-Electron Laser Infrared Microscopy Synchrotron Radiation

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Shadow free texture acquisition of a large scale scene for city modeling

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重庆邮电学院学报（自然科学版） 2004年第5期16卷 121-128页

作者： Thanda Oo OIKE Jiro MIYAMOTO Mitsunori kawasaki Hiroshi OHSAWA Yutaka Department of Information and Computer Science Faculty of Engineering Saitama UniversityJapanDepartment of Information and Computer Science Faculty of Engineering Saitama UniversityJapanDepartment of Information and Computer Science Faculty of Engineering Saitama UniversityJapanDepartment of Information and Computer Science Faculty of Engineering Saitama UniversityJapanDepartment of Information and Computer Science Faculty of Engineering Saitama UniversityJapan

Texture acquisition of a large scale scene is one of the critical research areas in computer vision and can be used in other application areas such as computer graphics (CG), the intelligent transportation system (ITS) and the 3D geographic information system (GIS). Moreover, to acquire texture without noise (e.g., a shadow, an obstacle body) is vital for such work. Although obstacles can be removed by using 3D geometric data, shadow elimination is still a difficult problem and strongly required for the CG and ITS community, especially for city modeling and simulation purposes. In this paper, we propose an automatic multiple image fusion technique and an efficient and simple shadow removing technique to retrieve high quality texture images of an urban area. The image fusion can be efficiently achieved by epipolar plane image (EPI) analysis, and the shadow elimination can be successfully carried out by an illumination independent color clustering technique. The strength of this algorithm is that we can successfully fuse multiple images and eliminate shadows from the fused single image, especially in low dynamic range images, which have proven difficult using previous techniques.

关键词：场景阴影计算机图象平面图象建模

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Magnetic Sensorless Control of Plasma Position and Shape in a Tokamak

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Plasma Science and Technology 2006年第1期8卷 80-83页

作者： K.NAKAMURA 罗家融王华忠季振山王华王枫齐娜 K.N.SATO K.HANADA M.SAKAMOTO H.IDEI M.HASEGAWA S.kawasaki H.NAKASHIMA A.HIGASHIJIMA Research Institute for Applied Mechanics Kyushu UniversityFukuoka816-8580Japan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityFukuoka816-8580Japan

Magnetic sensorless sensing and control experiments with the plasma horizontal position have been carried out in the superconducting tokamak HT-7. The sensing is made to focus on the ripple frequency component of the power supply with thyristor and directly from them without time integration. There is no drift problem with the integrator of wagnetic sensors. Two kinds of control experiments have been carried out： to keep the position constant and swing the position in a triangular waveform, And magnetic sensorless sensing of plasma shape is discussed.

关键词： sensorless control drift problem HT-7 shape control EAST

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JNK-Mediated FOXO Expression Plays a Critical Role in EGFR Tyrosine Kinase Inhibitor-Induced BIM Expression and Apoptosis

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Journal of Cancer Therapy 2012年第4期3卷 424-434页

作者： Kenji Takeuchi Anh Ho Viet Katsumi kawasaki Kazuto Nishio Fumiaki Ito Department of Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Osaka Japan Department of Genome Biology Kinki University School of Medicine Osaka Japan

BIM, a key proapoptotic member of the BCL-2 family of proteins, is essential for apoptosis triggered by tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR). However, the precise molecular mechanism by which EGFR-TKIs induce BIM expression has remained unclear. A previous study of ours showed that the activetion of c-Jun NH2-terminal kinase (JNK) is critical for the TKI-induced apoptosis in PC-9 cells, a gefitinib-sensitive human NSCLC cell line. In this study, we therefore examined the effect of JNK activation on BIM expression and further investigated the mechanism responsible for TKI-induced apoptosis in PC-9 cells. Northern blotting analysis revealed that the TKI AG1478 induced a substantial increase in the level of BIM mRNA. However, this TKI-induced increase was not observed in dominant-negative JNK overexpressing cell line J12A5 or in the TKI-resistant cell line HP-5R, in which JNK is not activated in response to AG1478. Therefore, JNK activation was correlated with the up-regulation of BIM expression. BIM is known to be a downstream target of forkhead box protein O (FOXO) transcription factors. Immunoblot analysis indicated that the levels of FOXO1, FOXO3a, and FOXO4 transcription factors increased after AG1478 treatment of PC-9 cells but that they were not increased in either J12A5 or HP-5R cells, indicating that FOXO was increased in PC-9 cells through JNK activation. FOXO1 knockdown in PC-9 cells decreased EGFR-TKI-induced BIM expression and apoptosis. These findings provide evidence that JNK activation and subsequent increased FOXO expression play a critical role in EGFR-TKI-induced BIM expression and apoptosis.

关键词： EGFR-TKI FOXO BIM JNK NSCLC

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晶粒尺寸对大塑性变形的两相合金超塑性的影响（英文）

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材料与冶金学报 2015年第4期14卷 255-262,304页

作者：张念先 Megumi kawasaki 黄毅 Terence G.Langdon 南安普顿大学工程与环境学院英国南安普顿S0171BJ 汉阳大学材料与工程学院韩国首尔133-791 南加州大学航空航天机械工程与材料科学学院美国洛杉矶CA90089-1453

在室温下对共晶铅锡合金(Pb-62%Sn)进行了高压扭转变形(HPT).采用不同时间的自退火制备不同晶粒尺寸的样品.最长的自退火时间为12天.通过研究这些样品在室温下不同的拉伸行为,从而获得了关于超塑性性能的结果.之后,本文通过将这些结果... 详细信息

在室温下对共晶铅锡合金(Pb-62%Sn)进行了高压扭转变形(HPT).采用不同时间的自退火制备不同晶粒尺寸的样品.最长的自退火时间为12天.通过研究这些样品在室温下不同的拉伸行为,从而获得了关于超塑性性能的结果.之后,本文通过将这些结果与等通道挤压(ECAP)获得的样品进行比较,不仅证明了所有样品都具有良好的超塑性,而且具有小晶粒尺寸的样品更容易在大应变速率的条件下获得超塑性.

关键词：等通道转角挤压高压扭转铅锡合金自退火超塑性

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Introduction of Education Systems for Clinical Engineers in Japan

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中国医疗设备 2016年第9期31卷 1-4页

作者： Jun Yoshioka Keiko Fukuta Hiroki Igeta Takeshi Ifuku Tadayuki kawasaki Department of Clinical Engineering Yamagata University Hospital Yamagata 990-9585 Japan International Exchange Committee Japan Association for Clinical Engineers Japan

Japanese clinical engineer(CE) is a significant and unique profession compared with other nations with its dual clinical and technology focus and national licensing. The CE system of licensing was established in May 1987 under the Clinical Engineers Act. CEs are required to complete 3 to 4 years in designated schools and pass a national examination. It is a professional medical position responsible for the operation and maintenance of life-support and non-life-support medical device systems under the direction of physicians. Currently approximately 70 educational institutes- including technical colleges and universities- provide diverse and wide-ranging curricula from engineering to various clinical disciplines to produce CEs. Since clinical practice training is mandatory as a part of institute work, an important approach for CEs is gained by working in hospitals. The comprehensive curricula and the licensing system in Japan together serve to keep the appropriate quantity and quality of CEs. The Japan Association for Clinical Engineers(JACE) was established in February 1990; one of its aims is to support improvement of CEs throughout their careers through various lectures, seminars, on-the-job trainings, workshops, and an annual member meeting. New CEs can now take advantage of video e-learning. For junior CEs, there are seminars for hyperbaric oxygen therapy, blood purification, heart-lung bypass, respiratory therapy, operating room, intensive care unit, arrhythmia and aphaeresis related devices, as well as healthcare technology management(HTM). Also, the institutes provide a leadership seminar alongside this clinical practice training. Besides the licensing process, a proper certification system for CEs is a critical element in the clinical field. This enhances the ability of CEs to engage in more extensive duties and develop specialties, as well as to provide better healthcare. Associated societies provide certification with technology qualifications in dialysis,

关键词： Japanese clinical engineer Japan Association for Clinical Engineers national license certification system

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Effects of Hyperventilation on Venous-Arterial Bicarbonate Concentration Difference: A Possible Pitfall in Venous Blood Gas Analysis

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International Journal of Clinical Medicine 2014年第2期5卷 76-80页

作者： Akira Umeda Kazuteru kawasaki Tadashi Abe Tateki Yamane Yasumasa Okada Department of Internal Medicine International University of Health and Welfare Shioya Hospital Yaita Japan Department of Respiratory Medicine National Center for Child Health and Development Tokyo Japan Division of Internal Medicine Murayama Medical Center Musashimurayama Japan Division of Respiratory Medicine Department of Medicine Tokai University School of Medicine Isehara Japan

Objectives: Recent reports on venous blood gas analysis have shown that venous bicarbonate concentration is useful in the evaluation of the body acid-base status. Most of these reports have been based on the Bland-Altman analysis comparing arterial and venous blood gas values. We intended to elucidate any factors that decrease the agreement between venous and arterial bicarbonate concentrations, which might impair the usefulness of venous blood gas analysis. Methods: Healthy volunteers and patients with various diseases (n = 141) were evaluated by simultaneous arterial and venous blood sampling and Bland-Altman analysis. The venous-arterial bicarbonate concentration difference was compared between healthy volunteers and untreated respiratory alkalosis patients. Intentional hyperventilation (30 or 60 breaths/min, for 3 min) was also performed on 6 healthy volunteers and the venous-arterial bicarbonate concentration difference was evaluated. Results: The relative average bias in bicarbonate concentration was 2.00 mEq/l with venous bicarbonate higher than arterial bicarbonate with 95% limits of agreement of ±4.15 mEq/l. Hyperventilation challenges increased the venous-arterial bicarbonate concentration difference in an intensity-dependent manner. The venous-arterial bicarbonate concentration difference was higher in untreated respiratory alkalosis patients than in healthy volunteers (P Conclusion: Although venous bicarbonate may be useful to evaluate the body acid-base status, hyperventilation increases the venous-arterial bicarbonate concentration difference. Physicians should keep this phenomenon in mind.

关键词： Hyperventilation Bicarbonate Bland-Altman Analysis Venous Blood Gas Analysis

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