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Relationship between chromatin organization, mRNAs profile and human male gamete quality

Asian Journal of Andrology 2007年第5期9卷 587-592页

作者： isabelle Galeraud-Denis Sophie Lambard Serge Carreau UPRES EA 2608-USC INRA Université de Caen 14032-CAEN France Biology of Reproduction CHU-Caen Avenue G. Clemeanceau 14033-CAEN France Hospital St Antoine 184 Rue Fg St Antoine 75571-PARIS France

Spermiogenesis is a complex process leading to the formation of motile spermatozoa characterized by a highly stable chromatin compaction that transfers the paternal genome into the oocyte. It is commonly held that these haploid cells are devoid of transcriptional and translational activities and that the transcripts represent remnants of stored mRNAs. Recently, the chromatin organization of mature spermatozoa has been revisited as a double nucleoprotamine-nucleohistone structure possessing less-condensed regions sensitive to nuclease activity, which could be implicated in the expression of genes involved in the early embryo development. The existence of a complex population of mRNAs in human sperm is well-documented, but their role is not yet elucidated. Evidence for a latent transcriptional capacity and/or a potential de novo translation in mature spermatozoa from fertile men are essential for understanding the last steps of sperm maturation, such as capacitation and acrosome reaction. As such, we have documented the relationship between sperm quality and the distribution of sperm RNAs by showing divergent levels of transcripts encoding for proteins involved in either nuclear condensation （protamines 1 and 2） or in capacitation （eNOS and nNOS, c-myc） or in motility and sperm survival （aromatase） between low and high motile sperm issued from the same sample. Therefore, analyzing the profile of mRNAs could be helpful either as a diagnostic tool for evaluating male fertility after spermatogenesis or for prognosis use for fertilization.

关键词： chromatin fertility gamete quality man spermatozoa transcripts

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Chiral supramolecular gold-cysteine nanoparticles: Chiroptical and nonlinear optical properties

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Progress in Natural Science:Materials International 2016年第5期26卷 455-460页

作者： isabelle Russier-Antoine Franck Bertorelle Alexander Kulesza Antonin Soleilhac Amina Bensalah-Ledoux Stephan Guy Philippe Dugourd Pierre-Fran?ois Brevet Rodolphe Antoine Univ Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière

Cysteine is a sulfur-containing amino acid that easily coordinates to soft metal ions and grafts to noble metal surfaces. We report a simple synthetic approach for the production of chiral gold-cysteine polymeric nanoparticles soluble in water. Conjugation of cysteine with gold in a polymeric way, leading to;0 nm diameter nanoparticles, resulted in the generation of new characteristic circular dichroism（CD） signals in the region of 250–400 nm, whereas no CD signal changes were found with cysteine alone. We also investigate their nonlinear optical properties after two-photon absorption. Two-photon emission spectra and first hyperpolarizabilities, as obtained by the hyper-Rayleigh scattering technique, of these particles are presented.

关键词： Gold Cysteine Supramolecular chemistry Nanoparticles Chirality Nonlinear optics

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Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males

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Asian Journal of Andrology 2013年第5期15卷 626-629页

作者： Nathalie Sermondade Charlotte Dupont Celine Faure Marouane Boubaya isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy Service d'Histologie-Embryologie-Cytogenetique-Biologie de la Reproduction-CECOS Hopital Jean Verdier (AP-HP) HUPSSD Bondy 93143 France INSERM U557 INRA U 1125 CNAM EA3200 Univ Paris 13 CRNH IdF Unite de Recherche en Epidemiologie Nutritionnelle Bobigny 93017 France INRA UMR1198 Biologie du Developpement et Reproduction Jouy-en-Josas 78352 France Unite de Recherche Clinique Hopital Avicenne Bobigny 93009 France Service d'Assistance Medicale a la Procreation Hopital Jean Verdier (AP-HP) Bondy 93143 France

Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index （BMI） and sperm-zona pellucida binding ability assessed according to the zona binding （ZB） test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization （IVF） ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated.

关键词： body mass index (BMI) fertilization ability obesity semen quality zona binding test

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Complete remission of gastric Burkitt's lymphoma after eradication of Helicobacter pylori

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World Journal of Gastroenterology 2009年第45期15卷 5746-5750页

作者： isabelle Baumgaertner Christiane Copie-Bergman Michael Levy Corinne Haioun Antoine Charachon Maryse Baia Iradj Sobhani Jean-Charles Delchier Department of Gastroenterology AP-HP Henri Mondor Hospital Paris 12 University 51 avenue du maréchal de Lattre de Tassigny Créteil 94000 France Department of Pathology AP-HP Henri Mondor Hospital Paris 12 University 51 avenue du maréchal de Lattre de Tassigny Créteil 94000 France Department of Hematology AP-HP Henri Mondor Hospital Paris 12 University 51 avenue du maréchal de Lattre de Tassigny Créteil 94000 France

Burkitt＇s lymphoma is a highly aggressive non-Hodgkin lymphoma, often presenting in extra-nodal sites. It generally has a poor spontaneous outcome and needs aggressive treatment with systemic and intrathecal chemotherapy. Occurrence at the gastric site is rare. We report the case of a 39-year old woman who presented with a prominent ulcerated lesion of the antrum corresponding histologically to a Burkitt＇s lymphoma associated with He/icobacter py/ori （H pylori） infection. Interphase fluorescence in situ hybridization （FISH） demonstrated c-MYC gene rearrangement in tumour cells without BCL2 or BCL6 gene translocations. Ulcer healing and tumour regression with a complete histological response were obtained 8 wk after Hpylori eradication. In spite of this complete remission, taking into account the high risk of recurrence, the patient received systemic and intrathecal chemotherapy. Two years later, the patient remained in complete remission. This is the first report of a gastric Burkitt＇s lymphoma responding to Hpylori eradication. These findings raise the question of the potential role of H pylori in the pathogenesis of some gastric Burkitt＇s lymphomas, and show the importance of searching for and eradicating the bacteria in combination with conventional chemotherapy regimens.

关键词： Burkitt's lymphoma Gastric lymphoma Helicobacter pylori Therapy

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Population assessment and habitat associations of the Visayan Hornbill(Penelopides panini)in Northwest Panay,Philippines

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Avian Research 2021年第4期12卷 612-622页

作者： Holly isabelle Mynott David Charles Lee Rhea Aranas Santillan Christian Jürgen Schwarz Benjamin Tacud Arcel Dryden Fernandez Daphne Kerhoas Bristol Zoological Society Bristol Zoo GardensCollege RoadCliftonBristol BS83HAUK School of Applied Sciences University of South WalesAlfred Russel Wallace BuildingUpper Glyntaff CampusPontypridd CF374BBUK PhilinCon L.A.Dioso Memorial Public LibraryIloilo-Antique Road5712 PandanPhilippines PhilinCon Germany Ruhr-Universität BochumUniversitätsstraße 150ND 1/3144801 BochumGermany

Background:Seven out of ten hornbill species in the Philippines are threatened with *** these is the endangered Visayan Hornbill(Penelopides panini),found on the islands of Panay and *** by habitat loss and hunting,its population size is thought to have declined from 1800 individuals 20 years ago to less than ***,a recent study on Negros estimated 3564 individuals across three core forest *** study aims to quantify the Visayan Hornbill population size in and around the Northwest Panay Peninsula Natural Park(NWPPNP)on Panay,the largest contiguous low-elevation forest landscape remaining across its range,and its broad habitat associations across a gradient of environmental ***:Hornbills were surveyed using 10-min distance sampling point counts(n=367)along transects(average length 1.1 km).Environmental variables were recorded along transects,while habitat was classified into primary forest,secondary forest,plantation,or open *** software was used to estimate population densities stratified by habitat,with the overall population estimate taken as a mean of habitat density estimates weighted by habitat *** generalized linear mixed models,hornbill occurrence was modelled using combinations of nine environmental variables as main and two-way fixed ***:Surveys covered 204.4 km^(2) of the 374.8 km^(2) Northwest Panay *** were not recorded in plantations or open *** density was significantly higher in primary forest(17.8 individuals/km~2±26.9%CV)than in secondary forest(3.7 individuals/km^(2)±33.2%CV;z=15.212,P<0.001).The overall population estimate for the NWPPNP and environs is 2109 individuals,and 2673 individuals for the entire Northwest Panay *** presence was best explained by a model including distance from the Park boundary alongside five interaction effects and transect as a random ***,and the interaction between distance

关键词： Distance sampling Endangered species GLMM Hornbill Point count Population size Protected area

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Cardio-thoracic imaging and COVID-19 in the pediatric population:A narrative review

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World Journal of Radiology 2021年第4期13卷 94-101页

作者： Paolo Ferrero isabelle Piazza ACHD Unit–Pediatric and Adult Congenital Heart Centre IRCCS-Policlinico San DonatoSan Donato Milanese 20097MilanItaly Department of Emergency Medicine ASST Papa Giovanni XXIIIBergamo 24127Italy

Worldwide experience about coronavirus disease 2019(COVID-19)pandemics suggests that symptomatic disease is significantly less frequent in the pediatric age ***,multi-system inflammatory syndrome has been consistently reported in children and has been associated with severe acute respiratory syndrome coronavirus 2 *** this paper we give an overview of the multimodality chest imaging of pediatric patients with suspected COVID-19,focusing on relevant differences with adults.

关键词： COVID-19 Radiology Imaging Chest Pediatric SARS-CoV-2

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Application of an Analytical Method to Locate a Mixing Plane in a Supersonic Compressor

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Journal of Energy and Power Engineering 2015年第1期9卷 91-101页

作者： Emmanuel Benichou isabelle Trebinjac Turbomeca Groupe SAFRAN Bordes 64511 France Laboratoire de Mecanique des Fluides et d'Aeoustique UMR CNRS 5509 Ecole Centrale de Lyon Ecully Cedex 69134 France

In order to achieve greater pressure ratios, compressor designers have the opportunity to use transonic configurations. In the supersonic part of the incoming flow, shock waves appear in the front part of the blades and propagate in the upstream direction. In case of multiple blade rows, steady simulations have to impose an azimuthal averaging （mixing plane） which prevents these shock waves to extend upstream. In the present paper, several mixing plane locations are numerically tested and compared in a supersonic configuration. An analytical method is used to describe the shock pattern. It enables to take a critical look at the CFD （computational fluid dynamics） steady results. Based on this method, the shock losses are also evaluated. The good agreement between analytical and numerical values shows that this method can be useful to wisely forecast the mixing plane location and to evaluate the shift in performances due to the presence of the mixing plane.

关键词： Supersonic compressor shock wave pressure loss RANS mixing plane

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Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation

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Cellular & Molecular Immunology 2018年第4期15卷 367-376页

作者： Stéphanie Bussières-Marmen Valérie Vinette Jeremy Gungabeesoon isabelle Aubry Luis Alberto Pérez-Quintero Michel L Tremblay Department of Biochemistry McGill UniversityMontréalQuébecCanada Rosalind and Morris Goodman Cancer Research Centre MontréalQuébecCanada Department of Microbiology and Immunology McGill UniversityMontréalQuébecCanada

T-cell protein tyrosine phosphatase(TC-PTP)has a critical role in the development of the immune system and has been identified as a negative regulator of ***-nucleotide polymorphisms in the TC-PTP locus have been associated with increased susceptibility to inflammatory bowel diseases(IBDs)in *** further understand how TC-PTP is related to IBDs,we investigated the role of TC-PTP in maintaining the intestinal epithelial barrier using an in vivo genetic *** epithelial cell(IEC)-specific deletion of TC-PTP was achieved in a mouse model at steady state and in the context of dextran sulphate sodium(DSS)-induced ***(KO)of TC-PTP in IECs did not result in an altered intestinal ***,upon DSS treatment,IECspecific TC-PTP KO mice displayed a more severe colitis phenotype with a corresponding increase in the immune response and inflammatory cytokine *** absence of TC-PTP caused an altered turnover of IECs,which is further explained by the role of the tyrosine phosphatase in colonic stem cell(CoSC)*** results suggest a novel role for TC-PTP in regulating the homeostasis of CoSC *** supports the protective function of TC-PTP against IBDs,independently of its previously demonstrated role in intestinal immunity.

关键词： Colonic stem cells DSS-induced colitis intestinal epithelial barrier TC-PTP

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Consequences of gestational and pregestational diabetes on placental function and birth weight

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World Journal of Diabetes 2011年第11期2卷 196-203页

作者： Anne Vambergue isabelle Fajardy EA 4489 "Perinatal Environment and Fetal Growth" Department of Diabetology EA 4489 "Perinatal Environment and Fetal Growth" Biology and Pathology Center

Maternal diabetes constitutes an unfavorable environment for embryonic and fetoplacental development. Despite current treatments, pregnant women with pregestational diabetes are at increased risk for congenital malformations, materno-fetal complications, placental abnormalities and intrauterine malprogramming. The complications during pregnancy concern the mother (gravidic hypertension and/or preeclampsia, cesarean section) and the fetus (macrosomia or intrauterine growth restriction, shoulder dystocia, hypoglycemia and respiratory distress). The fetoplacental impairment and intrauterine programming of diseases in the offspring's later life induced by gestational diabetes are similar to those induced by type 1 and type 2 diabetes mellitus. Despite the existence of several developmental and morphological differences in the placenta from rodents and women, there are similarities in the alterations induced by maternal diabetes in the placenta from diabetic patients and diabetic experimental models. From both human and rodent diabetic experimentalmodels, it has been suggested that the placenta is a compromised target that largely suffers the impact of maternal diabetes. Depending on the maternal metabolic and proin ammatory derangements, macrosomia is explained by an excessive availability of nutrients and an increase in fetal insulin release, a phenotype related to the programming of glucose intolerance. The degree of fetal damage and placental dysfunction and the availability and utilisation of fetal substrates can lead to the induction of macrosomia or intrauterine growth restriction. In maternal diabetes, both the maternal environment and the genetic background are important in the complex and multifactorial processes that induce damage to the embryo, the placenta, the fetus and the offspring. Nevertheless, further research is needed to better understand the mechanisms that govern the early embryo development, the induction of congenital anomalies and fetal overgrow

关键词： Maternal diabetes Placental function Birth weight Macrosomia Intrauterine growth retardation

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Inflamed phenotype of splenic marginal zone B-cell lymphomas with expression of PD-L1 by intratumoral monocytes/macrophages and dendritic cells

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Cellular & Molecular Immunology 2019年第6期16卷 621-624页

作者： Christelle Vincent-Fabert isabelle Soubeyran Valérie Velasco Marie Parrens Robin Jeannet Emilie Lereclus Nathalie Gachard Jean Feuillard Nathalie Faumont CNRS-UMR 7276 INSERM U1262 CRIBL University of Limogesand Hematology Laboratory of Dupuytren Hospital University Center(CHU)of LimogesLimogesFrance Laboratory of Pathology Institut BergoniéBordeauxFrance Pathology Department Hospital University Center of BordeauxBordeauxFrance

Splenic marginal zone lymphoma(SMZL)is an incurable indolent small B-cell lymphoma that primarily involves the spleen and arises in elderly patients,who have a median age of 65 years old at diagnosis.1 Splenomegaly is... 详细信息

关键词： lymphoma spleen patients

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