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The versatility of Fe(Ⅱ) in the synthesis of uniform citrate-stabilized plasmonic nanoparticles with tunable size at room temperature

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Nano Research 2020年第9期13卷 2351-2355页

作者： Carlos Fernández-Lodeiro Javier Fernández-Lodeiro Enrique Carbó-Argibay Carlos Lodeiro Jorge Pérez-Juste isabel Pastoriza-santos CINBIO Universidade de VigoCampus universitario LagoasMarcosende36310 VigoSpain Galicia sur Health Research Institute(IIs Galicia sur) SERGAS-UVIGO36312 VigoSpain BIOsCOPE Group LAQV@REQUIMTEChemistry DepartmentNOVA School of Science and TechnologyNOVA University LisbonCaparica Campus2829-516 CaparicaPortugal PROTEOMAss scientific society Rua dos InventoresMadam ParqueCaparica Campus2829-516 CaparicaPortugal International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/n4715-330 BragaPortugal

A highly versatile seed-mediated approach for the synthesis of citrate-stabilized gold,silver and palladium nanoparticles(NPs)with size control is *** use of iron(Ⅱ)as a reducing agent enables the fabrication of monodisperse NPs in a wide range of sizes(from 15 nm to at least 120 nm(90 nm for Pd))at room *** citrate as capping ligand on the NPs surface facilitates its further surface modification with proteins and thiolated molecules.

关键词： plasmonic nanoparticles gold silver palladium citrate-stabilized Fe(Ⅱ)

Autoimmune hepatitis and eosinophilia:A rare case report

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World Journal of Hepatology 2023年第2期15卷 311-317页

作者： isabel Garrido susana Lopes Elsa Fonseca Fátima Carneiro Guilherme Macedo Department of Gastroenterology and Hepatology Centro Hospitalar Universitário de São JoãoWorld Gastroenterology Organization Porto Training CenterFaculty of Medicine of the University of PortoPortoPortugal Department of Pathology Centro Hospitalar Universitário de São JoãoInstituto de Investigação e Inovação em Saúde(i3S)and Institute of Molecular Pathology and ImmunologyUniversity of Porto(Ipatimup)Faculty of Medicine of the University of PortoPortoPortugal

BACKGROUND Autoimmune hepatitis consists of a chronic liver disease whose etiology is *** is comprised of relevant immunological aspects and of immunemediated liver *** may be a considerable feature,particularly happening in male *** sUMMARY We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia,circulating autoantibodies and elevated transaminase *** also had significant peripheral eosinophilia and elevated immunoglobulin E levels at *** pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic *** This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow,described in a patient with Crohn’s disease.

关键词： Autoimmune hepatitis Eosinophilia Bone marrow Crohn’s disease Case report

Risk factors associated with the development of ischemic colitis

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World Journal of Gastroenterology 2010年第36期16卷 4564-4569页

作者： Joaquín Cubiella Fernández Luisa Núez Calvo Elvira González Vázquez Maria Jesús García García Maria Teresa Alves Pérez isabel Martínez silva Javier Fernández seara Department of Gastroenterology Complexo Hospitalario de Ourense32005 OurenseSpain Department of Internal Medicine Complexo Hospitalario de Ourense32005 OurenseSpain Department of Internal Medicine Fundación Pública Hospitalaria de Verín32600 VerinSpain Research support Unit Complexo Hospitalario de Orense32005 OurenseSpain Biostatistic Unit University of Santiago de Compostela15703 Santiago de CompostelaSpain

AIM:To ascertain the role of cardiovascular risk factors,cardiovascular diseases,standard treatments and other diseases in the development of ischemic colitis(IC).METHODs:A retrospective,case-control study was designed,using matched data and covering 161 incident cases of IC who required admission to our hospital from 1998 through *** was diagnosed on the basis of endoscopic findings and diagnostic or compatible *** were randomly chosen from a cohort of patients who were admitted in the same period and required a colonoscopy,excluding those with diagnosis of *** were matched with controls(ratio 1:2),by age and sex.A conditional logistic regression was ***:A total of 483 patients(161 cases,322 con-trols)were included;mean age 75.67±10.03 years,55.9%*** principal indications for colonos-copy in the control group were lower gastrointestinal hemorrhage(35.4%),anemia(33.9%),abdominal pain(19.9%)and diarrhea(9.6%).The endoscopic findings in this group were hemorrhoids(25.5%),diverticular disease(30.4%),polyps(19.9%)and colorectal cancer(10.2%).The following variables were associated with IC in the univariate analysis:arterial hypertension(P= 0.033);dyslipidemia(Ps mellitus(P =0.025);peripheral arterial disease(P=0.004);heart failure(P=0.026);treatment with hypotensive drugs(P=0.023);angiotensin-converting enzyme inhibitors;(P=0.018);calcium channel antagonists(P=0.028);and acetylsalicylic acid(AsA)(Ps were independently associated with the development of IC:diabetes mellitus[odds ratio(OR)1.76,95%confidence interval(CI):1.001-3.077,P=0.046];dyslipidemia(OR 2.12,95%CI:1.26-3.57,P=0.004);heart failure(OR 3.17,95%CI:1.31-7.68,P=0.01);peripheral arterial disease(OR 4.1,95%CI:1.32-12.72,P=0.015);treatment with digoxin(digitalis)(OR 0.27,95%CI:0.084-0.857,P=0.026);and AsA(OR 1.97,95%CI:1.16-3.36,P=0.012).CONCLUsION:The development of an episode of IC was independently associat

关键词： Ischemic colitis Diabetes mellitus Dyslipidemia Acetylsalicylic acid Peripheral arterial disease Digoxin

Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction

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Acta Pharmaceutica sinica B 2021年第12期11卷 3685-3726页

作者： Antonio segovia-Zafra Daniel E.Di Zeo-sanchez Carlos Lopez-Gomez Zeus Perez-Valdes Eduardo Garcıa-Fuentes Raul J.Andrade M.isabel Lucena Marina Villanueva-Paz Unidad de Gestio´n Clı´nica de Gastroenterologı´a Servicio de Farmacologıa ClınicaInstituto de Investigacio´n Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalaga 29071Spain Centro de Investigacion Biomedica en Red en el Area Tematica de Enfermedades Hepaticas y Digestivas(CIBERehd) Madrid 28029Spain Platform IsCIII de Ensayos Clınicos UICEC-IBIMAMalaga 29071Spain Unidad de Gestion Clınica de Aparato Digestivo Instituto de Investigacion Biomedica de Malaga(IBIMA)Hospital Universitario Virgen de la VictoriaMalaga 29010Spai

Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the *** remains a major public health problem and a major cause of drug *** the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is *** of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant ***,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI ***,there are many gaps for explaining all the complexity of iDILI susceptibility and ***,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug ***,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI *** also comment about in silico approaches and the increasing relevance of patient-derived cellular models.

关键词： Drug-induced liver injury Preclinical models Mechanisms Oxidative stress Mitochondrial damage Immune response Personalized medicine

Cantharellus(Cantharellales,Basidiomycota)revisited in Europe through a multigene phylogeny

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Fungal Diversity 2017年第2期83卷 263-292页

作者： Ibai Olariaga Gabriel Moreno Jose Luis Manjon isabel salcedo Valerie Hofstetter Diego Rodrıguez Bart Buyck Department of Life sciences(Botany) University of Alcala28805 Alcalade HenaresMadridSpain Department of Plant Biology and Ecology(Botany) University of the Basque Country(UPV/EHU)Apdo 64448080 BilbaoSpain Department of Plant Protection Agroscope ChanginsWadenswil Research StationACWRte de Duiller1260 NyonSwitzerland Kherdzmari st.Microdistrict 11.Block 58 Flat 69TemkaTbilisiGeorgia Departement systematique et Evolution CP 39ISYEBUMR 7205 CNRS MNHN UPMC EPHEMuseum National d’Histoire Naturelle12 Rue Buffon75005 ParisFrance

Resolving species delimitation issues of European Cantharellus is crucial to correctly name chanterelles around the *** names referring to Cantharellus *** been described in Europe,some of which are used in other *** on combined analyses of ITs2,LsU,RPB2 and TEF-1,merely eight species are here recognized in Europe applying the genealogical concordance phylogenetic species recognition criteria,one of which,***,is described as ***logical characters used in species delimitation are mapped and their variability *** colour of the hymenophore in young specimens is found to be a rather constant morphological character of taxonomic *** species of Cantharellus are morphologically distinguished by unique combinations of characters,such as the presence of a pink pileal coating,pileus and hymenophore colour when young,and in some cases,the mean spore length and *** type specimens from Europe are *** on revised species concepts sixteen novel taxonomic synonyms are here proposed for European chanterelles:***(=***,***,***),***(=*** ***,*** ***,***),***(=*** ***,***),***(=*** ***),***(=***),***(=*** ***,*** ***,***),and ***sianus(=***,***,***nesianus ***).The type of Cantharellus,***,is ***,colour illustrations and a key to all European species are provided.

关键词： Cantharelloid clade Cantharellaceae Epitype Edible fungi Genealogical concordance species delimitation

Coupons in the digital age

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China International Business 2010年第6期 26-28页

作者： isabel DING

isa Li spent RMB 20 （UsD 3） last month to buy a new Velo card while she was with a friend at the Ginza Center in Beijing. ＂Actually, I had a free one before, but it＇s not my favorite style. If I spend RMB 20 I can... 详细信息

关键词：数字化时代人民币个人消费

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E-tail Wars

China International Business 2011年第2期 30-31页

作者： isabel DING RETAILERs BATTLE TO WOO CHINEsE CONsUMERs ONLINE

The biggest fight on China＇s Internet these days doesn＇t involve players in the World of Warcraft online game. Instead,

关键词：零售在线游戏互联网

Real Estate Land＇s End

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China International Business 2007年第11期 34-35页

作者： isabel DING

As property prices and stock valuations rise, real estate companies are snapping up ever greater chunks of land

关键词：中国地产行业企业管理经济状态

The first step towards a global currency

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China International Business 2009年第6期 36-37页

作者： isabel Ding

On April 9, China＇s state Council announced a pilot program, allowing importers and exporters in five major cities, shanghai, Guangzhou, shenzhen, Zhuhai and Dongguan,to settle their cross-border trade in RMB. This move -- besides giving Chinese companies more control over currency risk during the current financial crisis -- is the first expansion of the Chinese currency＇s use in international trade in over ten years.

关键词：全球货币人民币汇率中国国务院试点项目边界贸易国际贸易金融危机货币风险