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Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of parsley(petroselinum crispum)

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phyton-International Journal of Experimental Botany 2023年第10期92卷 2807-2823页

作者： Laura isabel Arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli Analytical Laboratory National Technological Institute of MexicoTuxtla Gutierrez CampusTuxtla GutierrezMexico plant Biotechnology Laboratory Instrumental Analysis LaboratoryPlant Biochemistry LaboratoryNational Technological Institute of MexicoTlajomulco de ZunigaMexico Department of Cellular Biology and Genetics Faculty of Biological SciencesAutonomous University of Nuevo LeonSan Nicolas delos GarzaMexico

In recent years,there has been a growing interest in exploring alternative treatments for bone *** tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone *** our study,we specifically investigated the extract of petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and *** objective was to compare the total flavonoid content(TFC)and their accumulation in different *** obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell *** TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell ***,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,*** findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive *** results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing.

关键词： parsley(petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts

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Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 234-243页

作者： João Gramaça isabel Gomes Fernandes Carolina Trabulo Joana Gonçalves Rita Gameiro dos Santos Adriano Baptista Idília pina Centro Hospitalar Barreiro Montijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical Oncology Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGROUND In patients with metastatic colorectal cancer(mCRC),the treatment options are limited and have been proved to be affected by rat sarcoma virus(RAS)mutational *** RAS wild-type(wt)patients,the combination of antiepidermal growth factor receptor(EGFR)monoclonal antibodies with chemotherapy(CT)is more effective than CT *** the other hand,RAS-mutated patients are not eligible for treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May *** the time of cell-free DNA determination,five patients had undergone one CT line,five patients had undergone two CT lines,and one patient had undergone three CT lines(all in combination with bevacizumab).At the second and third treatment lines[second line(2L),third line(3L)],patients with neo-RAS wt received a combination of CT and *** neo-RAS wt patients treated with anti-EGFR,our findings indicated an increase in progression-free survival for both 2L and 3L(14.5 mo,p=0.119 and 3.9 mo,p=0.882,respectively).Regarding 2L overall survival,we registered a slight increase in neo-RAS wt patients treated with anti-EGFR(33.6 mo vs 32.4 mo,p=0.385).At data cut-off,two patients were still alive:A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR(ongoing).CONCLUSION Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.

关键词： Metastatic colorectal cancer Rat sarcoma virus mutational status Liquid biopsy Rat sarcoma virus wild-type Neo-rat sarcoma virus wild-type Anti-epidermal growth factor receptor therapy Case report

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Cirrhotic cardiomyopathy:Isn't stress evaluation alwaysrequired for the diagnosis?

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World Journal of Hepatology 2016年第3期8卷 200-206页

作者： mara barbosa joana guardado carla marinho bruno rosa isabel quelhas antónio lourenco josécotter Gastroenterology Department Centro Hospitalar do Alto Ave4835 GuimarãesPortugal

AIM:To describe the proportion of patients with cirrhotic cardiomyopathy(CCM) evaluated by stress echocardiography and investigating its association with the severity of liver ***:A cross-sectional study was *** patients without risk factors for cardiovascular disease were *** regarding etiology and severity of liver disease(Child-pugh score and model for end-stage liver disease),presence of ascites and gastroesophageal varices,pro-brain natriuretic peptide(proBNp) and corrected QT(QTc) interval were *** stress echocardiography(conventional and tissue Doppler imaging) was *** was considered present when diastolic and/or systolic dysfunction was diagnosed at rest or after pharmacological *** interfering with cardiovascular system was suspended 24 h before the ***:Twenty-six patients were analyzed,17(65.4%) Child-pugh A,mean model for end-stage liver disease(MELD) score of *** global proportion of patients with CCM was 61.5%.At rest,only 2(7.7%)patients had diastolic dysfunction and none of the patients had systolic *** stress echocardiography revealed the presence of diastolic dysfunction in more 6(23.1%) patients and of systolic dysfunction in 10(38.5%) *** interval prolongation was observed in 68.8%of the patients and increased pro-BNp levels in 31.2%of *** was no association between the presence of CCM and liver impairment assessed by Child-pugh score or MELD(p= 0.775,p= 0.532,respectively).patients with QTc interval prolongation had a significant higher rate of gastroesophageal varices comparing with those without QTc interval prolongation(95.0%vs 50.0%,p= 0.028).CONCLUSION:CCM is a frequent complication of cirrhosis that is independent of liver *** evaluation should always be performed,otherwise it will remain an underdiagnosed condition.

关键词： Dobutamine stress echocardiography Cirrhotic cardiomyopathy Cirrhosis Corrected QT interval prolongation Liver impairment

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Aquaglyceroporins but not orthodox aquaporins are involved in the cryotolerance of pig spermatozoa

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Journal of Animal Science and Biotechnology 2020年第1期11卷 20-31页

作者： Ariadna Delgado-Bermúdez Marc Llavanera Leira Fernández-Bastit Sandra Recuero Yentel Mateo-Otero Sergi Bonet isabel Barranco Beatriz Fernández-Fuertes Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Unit of Cell BiologyDepartment of BiologyFaculty of SciencesInstitute of Food and Agricultural TechnologyUniversity of GironaC/Maria Aurèlia Campany69Campus MontiliviE-17003 GironaSpain

Background:Aquaporins(AQps)are a family of transmembrane water channels that includes orthodox AQps,aquaglyceroporins(GLps)and super ***3,AQp7,AQp9 and AQp11 have been identified in boar sperm,and they are crucial for sperm maturation and *** exchange is an important event in cryopreservation,which is the most efficient method for long-term storage of ***,the freezethaw process leads to sperm damage and a loss of fertilizing *** that the quality of frozenthawed sperm partially depends on the regulation of osmolality variations during this process,AQps might play a crucial role in boar semen *** this context,the aim of this study was to unravel the functional relevance of the different groups of AQps for boar sperm cryotolerance through three different ***:Inhibition of different groups of AQps was found to have different effects on boar sperm *** the use of 1,3-propanediol(pDO),an inhibitor of orthodox AQps and GLps,decreased total motility(ppost-thaw sperm viability,lowered membrane lipid disorder and increased mitochondrial membrane potential(MMp)(pps,the effects on post-thaw sperm quality were restricted to a mild increase in MMp in the presence of the intermediate concentration at 30 min post-thaw and an increase in superoxide levels(pphloretin(pHL),a GLp inhibitor,had detrimental effects on post-thaw total and progressive sperm motilities,viability and lipid membrane disorder(pps rather than orthodox AQps are relevant for boar sperm ***,the positive effect of pDO on sperm quality suggests a cryoprotective role for this molecule.

关键词： Acetazolamide Aquaporins Boar phloretin propanediol Sperm

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XEN^(■) implant and trabeculectomy medium-term quality of life assessment and comparison of results

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1941-1944页

作者： Ana Luisa Basilio Nuno Moura-Coelho Ines passos Mariana Sa Cardoso isabel Domingues Maria Reina Rita Flores Teresa Gomes Ophthalmology Department Central Lisbon Hospital Center Lisbon 1169050Portugal

AIM: To evaluate and compare the quality of life of patients submitted to XEN~? implant or trabeculectomy and the relationship with potentially involved ***: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN~?(group 1) and trabeculectomy(group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure(IOp). The quantification of the quality of life was attained through the Glaucoma Symptom Scale(GSS) questionnaire. RESULTS: Totally 34 eyes(34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8(median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0(median, 43; p25, 36.5; p75, 47.0; p=0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups(r=-0.88, pp=0.01, respectively) and a moderate negative correlation with IOp in group 1(r=-0.50, p=0.03).CONCLUSION: The analysis demonstrates the noninferiority of medium-term quality of life of one group in relation to the other(XEN~? implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOp negatively influenced the quality of life.

关键词： quality of life XEN^(■) trabeculectomy

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Cutaneous leishmaniasis control in Alta Verapaz (northern Guatemala): evaluating current efforts through stakeholders' experiences

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Infectious Diseases of poverty 2021年第3期10卷 14-25页

作者： Renata Mendizabal-Cabrera isabel perez Victor Becerril Montekio Freddy perez Erick Duran Mei L.Trueba Center for Health Studies(CHS) Universidad del Valle de Guatemala(UVG)18 Avenida 11-95zona 15V.H.3Guatemala CityGuatemala Instituto Nacional de Salud publica(INSp) CuernavacaMexico Communicable Diseases and Environmental Determinants of Health Department Pan American Health OrganizationWashingtonDCUSA. Leishmaniasis Sub-program National Ministry of Health of GuatemalaGuatemala CityGuatemala Department of Global Health and Infection(GHI) Brighton and Sussex Medical School(BSMS)University of SussexBrightonUK.

Background:Cutaneous leishmaniasis(CL),endemic in Guatemala,mostly affects poor people living in the northern region.A national control program that ineludes surveillanee,diagnose,and treatment offered free of cost by the Ministry of Health(MoH)has been in place since ***,the incidence is increasing and treatment rates are not optimal,suggesting that current efforts are not being *** study aimed to understand barriers and facilitators of CL control in Guatemala as experienced and perceived by key stakeholders in order to comprehend what works well and does not and suggest evidence-informed ***:The study was conducted in the Coban municipality,the most endemic of Guatemala,situated in the Department of Alta *** were collected during May and June 2019 via focus groups and semi-structured interviews with key stakeholders,including local and national health personnel and residents of four communities of the endemic *** and content analysis of the collected data was conducted using ***:Three overarching issues hamper the effectiveness of current CL efforts:resource scarcity,treatment challenges,and knowledge-action *** economic resources from the MoH and community residents negatively impact incidence,detection of cases and treatment rates in that preventive action is insufficient and healthcare access is *** addition,local health workers often lack specialized CL training and access to the national CL control *** regards to the population living in the study area,misunderstanding of disease causation,shame associated with CL lesions,treatment pain fear,and long(often uncertain)waiting times for diagnose and treatment negatively affect people's willingness to seek help,treatment adherence,and their trust on the healthcare ***:Culturally sensitive CL preventive action must be *** the scarce economic resources available for CL control in the country,the

关键词： Cutaneous leishmaniasis Control effort Qualitative evaluation Stakeholders'experiences Alta Verapaz Guatemala

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plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications

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Molecular plant 2022年第1期15卷 104-124页

作者： Javier paz-Ares Maria isabel puga Monica Rojas-Triana Iris Martinez-Hevia Sergio Diaz Cesar poza-Carrión Miguel Mi(n)ambres Antonio Leyva Department of plant Molecular Genetics Centro Nacional de Biotecnología(CNB-CSIC)Darwin 3Campus Universidad Autónoma28049 MadridSpain Institute of plant Biochemistry Institute of Synthetic Biology and CEPLASUniversity of Düsseldorf40225 DüsseldorfGermany

phosphorus(p)is an essential nutrient for plant growth and *** preferentially absorb p as orthophosphate(pi),an ion that displays low solubility and that is readily fixed in the soil,making p limita-tion a condition common to many soils and pi fertilization an inefficient *** cope with pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the pi starvation rescue system(pSR),aimed to improve pi acquisition and use efficiency(pUE)and protect from pi-starvation-induced *** research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the pSR in *** we review the results of this research effort that have led to the identification and characterization of several core pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis *** also refer to recent results revealing the existence of intricate signaling interplays between pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient ***,we discuss advances toward improving pUE and future research priorities.

关键词： inositol pyrophosphate plant nutrient pHR1 transcription factor pUE(phosphorus acquisition and use efficiency) SpX sensor and STOp1 transcription factor

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Evolution of radical hysterectomy for cervical cancer along the last two decades: single institution experience

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Chinese Journal of Cancer Research 2016年第2期28卷 215-220页

作者： Claudia Arispe Ana isabel pomares Javier De Santiago Ignacio Zapardiel Gynecologic Oncology Department La Paz University Hospital

Background： The radical hysterectomy （RH） surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoseopy at our institution. Methods： We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery： 1990-1999, 2000-2009 and 2010-2013. patients＇ characteristics, pathologic details, intraoperative and postoperative complications were analyzed and comoared throughout the time periods. Results： A total of 102 cases of RH were performed at our center during the study period. Among all data collected, the presence of necrosis, age, number of lymph nodes, surgery route, operating time, hospital stay, blood loss and transfusion requirement were statistically significant different among groups. Conversion to laparotomy rate was 19% for the second period compared to the absence of cases in the last one. No significant differences （p=0.124） were observed in the adjuvant treatment received among the three different groups. At the time of the last contact the patients free of disease were 12 （85.7%）, 53 （91.3%） and 26 （86.6%） respectively （p=0.406）. Regarding the disease-free interval, we found significant better outcomes in the group of laparotomy compared to laparoscopy （p=0.015）.Conclusions： Laparoscopic RH is an acceptable surgery with advantages like magnified vision of the operation＇s field, lower surgical complications, shorter hospital stay and earlier resumption to daily activities.

关键词： Gynaecological cancer radical hysterectomy (RH) laparoscopy cervical cancer

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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

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World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia isabel Comino Ana Florencia Costa Roberto puebla María paz Temprano Sonia isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of Microbiology and parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant *** To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-pEp)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of two AN-pEp capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIp)between the run-in and end of treatments and between AN-pEp and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of *** samples were collected for GIp testing by ELISA every Tuesday and Friday during run-ins and *** Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(ples,and no differences between treatment arms were *** 0.5%of samples had GIp concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal *** GIp concentration in the AN-pEp arm was 44.7%lower than in the run-in ***-third of patients exhibiting GIp>0.08μg/g during run-in had lower or undetectable GIp after AN-pEp *** with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-pEp arm was significantly lower(ppEp did not result in changes in specific *** This exploratory study conducted in a real-life setting revealed high adherence to the *** AN-pEp treatment did not significantly reduce the overall GIp stool ***,given the observation of a significantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

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Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

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World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis Muñoz de Nova Jorge Hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena Martín-pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and Nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of pathology Universidad Autónoma de MadridMadrid 28029Spain Department of Nuclear Medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and Nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy Neoplasm grading Treatment outcome

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