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Delineation of Well Head Protection Areas for the Public Wells in the Ferizaj Region (Kosovo) with Limited Data Availability

第三届全球华人眼科学术大会暨中华医学会第十一届全国眼科学术大会

作者： Jost B．Jonas Wido m．Budde Andrea Stroux isabel m．Oberacher-Velten Department of Ophthalmology Faculty of Clinical medicine mannheim University of HeidelbergMannheimGermany

Purpose. To evaluate whether iris colour influences size and shape of the optic nerve head and risk for glaucoma progression. methods. The hospital - based observational study included 1973 eyes of 1012 Caucasian subjects with ocular hypertension or chronic open - angle glaucoma. For all patients, colour stereo optic disc photographs were evaluated,

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Journal of Environmental Protection 2022年第2期13卷 204-219页

作者： Argjend Hajra mario Roidt Stephanie isabel Lobensteiner Randolf Rausch Community Development Initiatives Pr. Nak Berisha Nr. 12 Pristina Kosovo Dorsch International Consultants GmbH Landsbergerstr. 368 M&uuml nchen Germany Rottenburg University of Applied Forest Sciences Department of Water Resources Management Schadenweilerhof Rottenburg am Neckar Germany Technische Universit&auml t Darmstadt Institute of Applied Geosciences Schnittspahnstr. 9 Darmstadt Germany

The Swiss Agency for Development and Cooperation (SDC) has funded the Rural Water and Sanitation Support Programme (RWSSP) that has increased the access to public water supply throughout Europe’s youngest state—Kosovo—in the past ten years. The Programme, implemented by Dorsch International Consultants GmbH and Community Development Initiatives has, among other activities, implemented groundwater protection methods. Nevertheless, groundwater protection remains a challenge in Kosovo. The water law describes that water source protection is similar to German rules, yet modelling-based planning of water source protection zones remains challenging. In the present study, the development of the hydrogeological and the mathematical groundwater model for the technical delineation of the well head protection area for the Ferizaj well fields under limited data availability is described in detail. The study shows that even when not all data are available, it is possible and necessary to use mathematical groundwater models to delineate well head protection areas.

关键词： Water-Resources Conservation Groundwater Protection Numerical modeling Limited Data Availability Kosovo

Gracilariopsis lemaneiformis(Gracilariaceae,Rhodophyta)in the mexican Coasts:A Case of Disjunct Distribution?

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American Journal of Plant Sciences 2020年第2期11卷 111-124页

作者： Oscar E.Hernandez Kurt m.Dreckmann maria Luisa Nunez-Resendiz martha isabel Vilchis Abel Senties Doctorado en Ciencias Biológicas y de la Salud Universidad Autónoma Metropolitana-IztapalapaMexico CityMéxico Departamento de Hidrobiología Universidad Autónoma Metropolitana-IztapalapaMexico CityMéxico

Gracilariopsis lemaneiformis is a widely reported species of marine red algae, with records from around the world. Particularly in mexico, it has been recorded along the coasts of the Gulf of mexico and the mexican Caribbean as well as the Tropical mexican Pacific;so, its current distribution on the mexican coasts is disjunct. From its molecular characterization with COI-5P and rbcL sequences of specimens collected at sites in mexico where this species has been most frequently recorded, our aim was to re-evaluate the current distribution of Gp. lemaneiformis on the mexican coasts and discuss the taxonomic implications. Phylogenetic analysis, supported by DNA species delimitation methods, genetic distances and morphological comparisons, showed that the current disjunct distribution of Gp. lemaniformis in mexico is a consequence of taxonomic misidentifications. From our results, Gp. lemaneiformis is the only species of the genus with a distribution in the Tropical mexican Pacific, whereas Gp. tenuifrons is the only species with a distribution in the Gulf of mexico and the mexican Caribbean. Also, we propose that Gp. cata-luziana is to be merged with Gp. tenuifrons, while Gp. costarisensis is to be merged with Gp. lemaneiformis.

关键词： COI-5P Cosmopolitan morphological Variation rbcL Species Delimitation

English and Black Walnut Phenolic Antioxidant Activity <i>in Vitro</i>and Following Human Nut Consumption

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Food and Nutrition Sciences 2011年第3期2卷 193-200页

作者： Jacki m Rorabaugh Ajay P Singh isabel m Sherrell michelle R Freeman Nicholi Vorsa Peter Fitschen Christopher malone margaret A maher Ted Wilson 不详

Background: Walnut consumption may reduce the risk of cardiovascular disease by providing antioxidant protection to low density lipoproteins (LDL). Aim: This study compared the phenolic profile and antioxidant activity of English ver- sus black walnuts. methods: Nuts were extracted in methanol or acetone prior to analysis with HPLC/LC-mS-mS for phenolic identification and quantitation. The ability to prevent oxidation of LDL was examined in vitro using walnut extracts and ex vivo after walnut consumption for 28 days. Results: Flavonoids identified/quantified with HPLC/LC- mS-mS included the phenolic acids 5-caffeoylquinic acid, 3-caffeoylquinic acid (black walnut only), 4-caffeoylquinic acid, and the flavonol glycosides quercetin-3-rutinoside, quercetin-3-galactoside, quercetin-3-pentoside, quercetin-3- arabinoside, quercetin-3-rhamnoside, and the aglycone quercetin (English walnut only). Total phenolic yield of acetone extracts were 166.1 and 24.2 μg/g for English and black walnut respectively, and yield for methanol extracts were 147.6 and 4.1 μg/g for English and black walnut respectively. In vitro LDL oxidation by Cu++ with English walnut ex- tracts significantly extended oxidation lag-time (A234) in a dose dependent manner at 1.0 and 0.1 μg/ml and reduced TBARS formation (1.0 μg/ml). Black walnut extracts reduced TBARS significantly but had no effect on A234. Human consumption of English or black walnuts (30 g nuts/day) for 28 days resulted in no differences in LDL antioxidant ca- pacity (A234) between groups or within groups. Conclusion: This study suggests that the English walnuts have a pheno- lic profile and in vitro antioxidant capacity that is better than black walnuts, but that walnut consumption for 28 days does not improve LDL resistance to oxidation.

关键词： Walnut Lipoprotein Oxidation Antioxidant Phenolic Flavonol

T cell immune responses to SARS-CoV-2 and variants of concern(Alpha and Delta)in infected and vaccinated individuals

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Cellular & molecular Immunology 2021年第11期18卷 2554-2556页

作者： Stanley C.Jordan Bong-Ha Shin Terry-Ann m.Gadsden maggie Chu Anna Petrosyan Catherine N.Le Rachel Zabner Jillian Oft isabel Pedraza Susan Cheng Ashley Vo Noriko Ammerman Jasmine Plummer Shili Ge max Froch Anders Berg mieko Toyoda Ruan Zhang Comprehensive Transplant Center Transplant Immunology LaboratoryCedars-Sinai Medical CenterLos AngelesCAUSA Division of Infectious Diseases Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Cardiology Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Bioinformatics&Functional Genomics Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Pathology&Laboratory medicine Cedars-Sinai Medical CenterLos AngelesCAUSA

Our understanding of immune responses to SARS-CoV-2 and variants of concern(VOCs)has been primarily acquired through analysis of Spike-specific IgG ***,a more comprehensive understanding of the breadth and longevity of immune responses after infection and vaccination requires analysis of cellular ***,we report on T cell immunity in infected and vaccinated individuals,identifying CD4+/CD8+T cell cytokine responses to SARS-CoV-2 and variant peptides(Alpha,B.1.1.7 and Delta,B.1.617.2).

关键词： Alpha infected immunity

Wnt genes in colonic polyposis predisposition

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Genes & Diseases 2023年第3期10卷 753-757页

作者： isabel Quintana mariona Terradas Pilar mur Iris B.A.Wte Paske Sophia Peters isabel Spier Verena Steinke-Lange Claudia maestro David Torrents montserrat Puiggròs Romina Royo Raul Tonda Genís Parra Davide Piscia Sergi Beltrán matilde Navarro Virginia Piñol Joan Brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda mde Voer Stefan Aretz Gabriel Capellá Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) Madrid 28029Spain Department of Human Genetics Radboud Institute for Molecular Life SciencesRadboud University Medical CenterGA Nijmegen 6525the Netherlands member of SOLVE-RD ERN-GENTURIS Institute of Human Genetics Medical FacultyUniversity of BonnBonn 53127Germany National Center for Hereditary Tumor Syndromes University Hospital BonnBonn 53127Germany medizinische Klinik Und Poliklinik IV Campus InnenstadtKlinikum Der Universität MünchenMunich 80336Germany mGZ-medizinisch Genetisches Zentrum Munich 80335Germany Life Sciences Department Barcelona Supercomputing Center(BSC)Barcelona 08034Spain ICREA Barcelona 08010Spain CNAG-CRG Centre for Genomic Regulation(CRG)Barcelona Institute of Science and TechnologyBarcelona 08028Spain Universitat Pompeu Fabra(UPF) Barcelona 08002Spain Department of Genetics Microbiology and StatisticsSchool of BiologyUniversitat de Barcelona(UB)Barcelona 08028Spain Gastroenterology Unit Hospital Universitario de Girona Dr Josep TruetaGirona 17007Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Department of Gastroenterology and Hepatology Radboud University Medical CenterGA Nijmegen 6525the Netherlands Department of Human Genetics Radboud University Medical CenterGA Nijmegen 6525the Netherlands

much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains *** germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-catenin signaling pathway,have been causally linked to some SP cases(most known hereditary CRC and polyposis genes affect DNA repair,BmP/TGF-β,or Wnt signaling,being the latter associated with adenomatous and serrated polyposis phenotypes.2 Based on this observation,we evaluated the presence and role of germline variants in those pathways in unsolved polyposis patients.

关键词： polyposis suppressor colorectal

The safety,efficacy and pharmaceutical quality of male enhancement nutraceuticals bought online:Truth versus claim

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Journal of Integrative medicine 2021年第3期19卷 232-242页

作者： mohamed Ismail Nounou Heba AEassa Nada AHelal Khaled Aboul Fotouh Ihab mansoor isabel KLatz Cindy Zheng Hadeer AEassa Dina mohamed Diana mHuynh Abigail RWiss Jessica Sweeney monica TOakes mark mmikhail Nadine Amine Harshvir Kaur Natalia Echeverry Kamila Orzechowski Doreen Szollosi Department of Pharmaceutical Sciences School of Pharmacy&Physician Assistant Studies(SOPPAS)University of Saint Joseph(USJ)HartfordConnecticut 06103USA Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyAL-Azhar UniversityCairo 11651Egypt Pharmaceutical Sciences Department Irma Lerma Rangel College of PharmacyTexas A&M Health Science CenterTexas A&M UniversityCollege StationTexas 77843USA Division of molecular Pharmaceutics and Drug Delivery College of PharmacyThe University of Texas at AustinTexas 78712USA Department of Pharmaceutics Faculty of PharmacyAssiut UniversityAssiut 71526Egypt Department of Pharmaceutics Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt Department of Public Health Sciences College of Health SciencesThe University of Texas at El PasoTX 79968USA Genetic Engineering and Biotechnology Research Institute University of Sadat CitySadat 32897Egypt Department of Industrial Pharmacy Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Objective:Nutraceutical products are widely used for their claimed therapeutic ***,falsified or adulterated nutraceuticals present a major health threat to *** study investigates the pharmaceutical quality,safety and anti-inflammatory effects of six male enhancement nutraceuticals that claim to be 100%***:Three batches of six male enhancement products were tested to detect the presence and levels of adulterants via high-performance liquid chromatography(HPLC).The pharmaceutical quality of the selected nutraceuticals was tested with near infrared spectroscopy(NIR)and Se De *** cytotoxic effects of these products on HepG2 cells were determined through cell proliferation(XTT)and lactate dehydrogenase(LDH)cytotoxicity ***,the in vitro inflammatory effects of these products were investigated using murine J774 macrophages through cytokine release ***:HPLC analysis detected the presence of sildenafil citrate,a vasodilator,and the active ingredient in Viagra and Revatio,in all batches of the products we *** of sildenafil citrate ranged from 0.45 mg to 51.85 mg among different *** assessment showed inter-and intra-batch heterogeneity in product *** of the XTT and LDH assays showed significant cytotoxic effects of the analyzed *** analysis revealed that the viability of HepG2 treated with tested products varied from 27.57%to 41.43%.Interestingly,the male enhancement products also showed anti-inflammatory ***:Despite their labeling as 100%natural,all products tested in this study contained levels of sildenafil citrate,which was not reported on the *** was a lack of pharmaceutical uniformity among products of the same batch and across different ***,the products we tested had cytotoxic *** study findings highlight the adulteration,poor quality and hazard of these ***,strict regulation of these product

关键词： Nutraceuticals Adulteration Erectile dysfunction Sildenafil citrate Online market

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana m.Gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.Costa Lima Salette Reis Angela Fernandes isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for medicines(imed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de montanha(CImO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for marine Sciences(CCmar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/mS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEm and spherical polymeric nanoparticles with a smooth surface were *** and DSC were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

Evaluation of a culturally adapted cognitive behavior therapy-based,third-wave therapy manual

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World Journal of Psychiatry 2023年第1期13卷 15-35页

作者： Peter Phiri isabel Clarke Lydia Baxter Yu-Tian Zeng Jian-Qing Shi Xin-Yuan Tang Shanaya Rathod mustafa G Soomro Gayathri Delanerolle Farooq Naeem Research&Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Department of Italk Southern Health NHS Foundation TrustSouthampton SO509FHUnited Kingdom Department of Italk Step 3 Southern Health NHS Foundation TrustSouthampton SO519FHUnited Kingdom Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055Guangdong ProvinceChina National Center for Applied mathematics Shenzhen Shenzhen 518055Guangdong ProvinceChina Nuffield Department of Primary Health Care Science University of OxfordOxford OX37JXUnited Kingdom Centre for Addition and mental Health University of TorontoToronto ON M5SCanada

BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United *** use of CBT for severe mental illness is now more common *** To investigate the feasibility and acceptability of a culturally adapted,CBT-based,third-wave therapy manual using the Comprehend,Cope,and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare *** A pilot study was used to assess the feasibility and acceptability of the manualised *** measures were evaluated at baseline,post-intervention and 12 wk-follow up.32 participants with mental health conditions aged 20-53 years were *** were completed at three time points,using Clinical Outcomes in Routine Evaluation(CORE),Hospital Anxiety and Depression Scale(HADS),Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0(WHODAS).The Patient Experience Questionnaire was completed *** Repeated measures of analysis of variance associated with HADS depression,F(2,36)=12.81,Pmanual intervention among minoritized groups with moderate effect *** levels and acceptability were highly *** viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.

关键词： Cognitive behavioral therapy Comprehend Cope Connect Ethnicity Culture