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management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis muñoz de Nova Jorge Hernando miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva maría Triviño Ibáñez maría isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena martín-Pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and Nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Pathology Universidad Autónoma de MadridMadrid 28029Spain Department of Nuclear medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and Nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy Neoplasm grading Treatment outcome

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Ultrasound Promoted Synthesis and Antimicrobial Evaluation of Novel Seven and Eight-membered 1,3-Disubstituted Cyclic Amidinium Salts

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Open Journal of medicinal Chemistry 2020年第4期10卷 139-152页

作者： maría m. Blanco maría A. Reamírez maría C. Caterina isabel A. Perillo Guido A. Oppezzo maría S. Shmidt Gabriel O. Gutkind José Di Conza Alejandra Salerno Departamento de Química Orgánica Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Buenos Aires Argentina Departamento de microbiología Inmunología y Biotecnología Facultad de Farmacia y Bioquímica Universidad de Buenos Aires Buenos Aires Argentina

Series of 1,3-dibenzyl-1H-4,5,6,7-tetrahydro-1,3-diazepinium and 1,4,5,6,7,8-hexahydro-1,3-diazocinium salts derivatives were efficiently synthesized in excellent yields by dehydrogenation of the corresponding N,N'-dibenzyl aminals employing N-bromosuccinimide (NBS) as dehydrogenating agent under ultrasound irradiation. The present methodology has proven to be simple, efficient and environmentally benign. All novel compounds were identified and characterized by 1H and 13C NMR spectra. The synthesized compounds were screened for their antimicrobial activities.

关键词： medium Ring Amidinium Salts Ultrasonic Assisted Synthesis Antimicrobial Green Chemistry

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将欧洲的生物多样性研究与政策联系起来

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AmBIO－人类环境杂志 2008年第2期37卷 132-134页

作者： Carsten Nesshver Rainer müssner Klaus Henle isabel Sousa Pinto 丁莉 UFZ-Helmholtz Centre for Environmental Research Department of Conservation Biology German Aerospace Centre Project management Agency Centre for marine and Environmental Research and Department of Botany Faculty of Sciences University of Porto

人类对生物资源的可持续利用以及生物多样性保护是对社会、科学家和决策者的一项挑战。各个领域的科学家必须精诚合作为社会和政策提供有关环境问题以及生物多样性保护和可持续利用的可靠反应。尽管对以事实为基础的环境政策的需要越来... 详细信息

人类对生物资源的可持续利用以及生物多样性保护是对社会、科学家和决策者的一项挑战。各个领域的科学家必须精诚合作为社会和政策提供有关环境问题以及生物多样性保护和可持续利用的可靠反应。尽管对以事实为基础的环境政策的需要越来越受到重视，科学家和决策者之间的信息流动是非常有限的，而且，正因如此，研究的结果并没有得到充分的利用，也没有在决策中加以考虑。

关键词：生物多样性保护可持续利用欧洲决策者科学家生物资源环境问题环境政策

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A self-employed taxpayer experimental study on trust,power,and tax compliance in eleven countries

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Financial Innovation 2022年第1期8卷 2588-2610页

作者： Larissa m.Batrancea Anca Nichita Ruggero De Agostini Fabricio Batista Narcizo Denis Forte Samuel de Paiva Neves mamede Ana maria Roux-Cesar Bozhidar Nedev LeošVitek József Pántya Aidin Salamzadeh Eleanya K.Nduka Janusz Kudła mateusz Kopyt Luis Pacheco isabel maldonado Nsubili Isaga Serkan Benk Tamer Budak Department of Business Babeş-Bolyai University7 Horea Street400174 Cluj-NapocaRomania Faculty of Economics “1 Decembrie 1918”University of Alba Iulia15-17 Unirii Street510009 Alba IuliaRomania Department of Psychol-ogy University of YorkHeslingtonYork YO105DDUK BPP Education Group Department of PsychologySchool of BusinessBPP University137 Stamford StreetLondon SE19NNUK Department of Computer Science IT University of CopenhagenRued Langgards Vej 72300 CopenhagenDenmark Office of CTO GN Audio As(Jabra)Lautrupbjerg 72750 BallerupDenmark Business management Graduate Program Strategic Finance DepartmentMackenzie Pres-byterian University163 Rua Maria AntôniaSão Paulo 01302-907Brazil Center for Applied Social Sciences Mackenzie Presbyterian University930 Rua da ConsolaçãoSão Paulo 01302-907Brazil Department of Finance and Accounting Faculty of Economics and Business AdministrationSofia University“St.Kliment Ohridski”125 Tsarigradsko Shose Blvd.Block 31113 SofiaBulgaria Department of Public Finance Faculty of Finance and AccountingPrague University of Economics and BusinessWinston Churchill Sq.13067 Prague 3Czech Republic Department of Social Psychology Institute of PsychologyELTE Eötvös Loránd UniversityEgyetem tér 1-3Budapest 1053Hungary Faculty of manage-ment University of TehranJalal-Ale-Ahmad StreetNasr BridgeTehran ***Iran Department of Economics University of NigeriaNsukkaEnugu StateNigeria Faculty of Economic Sciences University of Warsaw44/50 Długa Street00-241 WarsawPoland Department of Economics and management/REmIT Portucalense UniversityRua Dr.António Bernardino de Almeida541-6194200-072 PortoPortugal School of Business Mzumbe UniversityMzumbeP.O.Box 6MorogoroTanzania Department of Public Finance Faculty of Economics and Administrative StudiesInonu University44280 BattalgaziMalatyaTurkey Department of Public Finance Faculty of EconomicsAdministrative and Social SciencesAlanya Alaaddin Keykubat University07400 AlanyaAntalyaTurkey

The slippery slope framework explains tax compliance along two main dimensions,trust in authorities and power of authorities,which influence taxpayers’compliance *** frequentist and Bayesian analyses,we investigated the framework’s assumptions on a sample of 2786 self-employed taxpayers from eleven post-communist and non-post-communist countries doing business in five economic *** using scenarios that experimentally manipulated trust and power,our results confirmed the framework’s assumptions regarding the attitudes of the self-employed taxpayers;trust and power fostered intended tax compliance and diminished tax evasion,trust boosted voluntary tax compliance,whereas power increased enforced tax ***,self-employed taxpayers from post-communist countries reported higher intended tax compliance and lower tax evasion than those from non-post-communist *** results offer tax authorities insights into how trust and power may contribute to obtaining and maintaining high tax compliance levels amid global economic challenges,downturns,and increasing tax compliance costs.

关键词： Self-employed taxpayers Slippery slope framework Voluntary tax compliance Enforced tax compliance Tax evasion

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The influence of obesity on operating room time and perioperative complications in cochlear implantation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 231-234页

作者： Jonathan L.Hatch isabel m.Boersma Forest W.Weir michael J.Bauschard meredith A.Holcomb Paul R.Lambert Ted A.meyer Department of Otorhinolaryngology Head and Neck Surgery Medical University of South Carolina SC 29425 USA

Objective:The rising incidence of obesity in the United States is associated with increased healthcare expenditures and resource *** has been associated with prolonged operating times during surgical *** primary objective of this study is to compare body mass index (BmI) to length of surgery during cochlear ***:A retrospective case control study from a tertiary academic referral center was *** included were adults who underwent primary,single-sided cochlear implantation with documented BmI and operating room (OR) times from January 2009 to July *** following data were collected:BmI,total operating room time (TORT),surgical operating room time (SORT),ASA status,perioperative and postoperative complications,age,and ***:Two hundreds and thirty-four patients were included and stratified into obese (BmI ＞30)and non-obese (BmI ＜ 30) *** analysis was performed comparing TORT against the obesity category along with other *** sample t-test demonstrated that obesity increases TORT and SORT by 16.8 min (P ＝ 0.0002) and 9.3 min (P ＝ 0.03),respectively,compared to the non-obese *** linear regression analysis demonstrated no statistically significant impact of gender,or ASA status on total operating or surgical *** was associated with increased perioperative complications (odds ratio [OR],6.21;95％ CI,1.18-32.80;P ＝ 0.03) and postoperative complications (OR,3.97;95％ CI,1.29-12.26;P ＝ 0.02).Conclusions:Obesity leads to longer TORT and SORT during primary cochlear implant *** is also associated with increased perioperative and postoperative complications compared to non-obese *** data have implications with utilization of operating room resources.

关键词： Cochlear implant Body mass index Operating time Perioperative complications

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Synthesis and Structure of Novel Cyclohistidinopeptide Box

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有机化学 2004年第Z1期24卷 377-页

作者： ZHOU,Cheng-He WU,Jun YUAN,Yong BAI,Xue Juan F.miravet m.isabel Burguete Santiago V.Luis School of Pharmaceutical Sciences Chongqing Medical University Chongqing 400016 School of Chemistry and Chemical Engineering Southwest China Normal University Chongqing 400715 School of Pharmaceutical Sciences Chongqing Medical University Chongqing 400016 School of Pharmaceutical Sciences Chongqing Medical University Chongqing 400016 School of Chemistry and Chemical Engineering Southwest China Normal University Chongqing 400715 Department of Inorganic and Organic Chemistry Universitat Jaume I. Castellon 12080 Spain Department of Inorganic and Organic Chemistry Universitat Jaume I. Castellon 12080 Spain Department of Inorganic and Organic Chemistry Universitat Jaume I. Castellon 12080 Spain

　　A novel tetra-histidine cyclopeptide was prepared through multi-step reactions from histidine and naphthalene diamine (Scheme 1). All new compounds were characterized by 1H, 13C, 1H-15N and 1H-13C HETCOR spectra.……

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红树植物内生真菌Penicillium sp.中两个甾体化合物的研究

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天然产物研究与开发 2007年第3期19卷 420-422页

作者：李想孙光芝郑毅男林文翰 isabel Sattler 吉林农业大学中药材学院北京大学天然药物与仿生药物国家重点实验室 Hans-Knll-Institute for Natural Product Research Beutenbergstraβe 11D-07745JenaGermany

从红树植物内生真菌Penicillium sp.的发酵液中分离纯化了两个甾体类化合物,通过各种波谱实验(1D-NmR,2D-NmR,ESI-mS)确定为:麦角甾-4,6,8(14),22-四烯-3-酮(1)和麦角甾-5,7,22-三烯-3-醇(2),1对于3α-HSD脱氢酶在250μm浓度下有较弱的... 详细信息

从红树植物内生真菌Penicillium sp.的发酵液中分离纯化了两个甾体类化合物,通过各种波谱实验(1D-NmR,2D-NmR,ESI-mS)确定为:麦角甾-4,6,8(14),22-四烯-3-酮(1)和麦角甾-5,7,22-三烯-3-醇(2),1对于3α-HSD脱氢酶在250μm浓度下有较弱的活性。

关键词：红树植物内生真菌 Penicillium sp. 甾体化合物

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Perfect Single Qubit mirroring Effects on Two and Three maximally Entangled Qubits

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Communications in Theoretical Physics 2013年第1期59卷 7-10页

作者： m.Avila Centro Universitario UAEm Valle de Chalco UAEMex Mar' a IsabelValle de ChalcoEstado de M'exicoCP 56615Mexico

Perfect quantum state mirroring in a chain of N spins is defined as the condition in which the state 丨i 丨of the chain is swapped into the state 丨N - i丨 within a time evolution interval r. Such a phenomenon is an interesting way of transfering entanglement. An expressions for the perfect mirroring of a single qubit contained in a spin chain were proposed in the past. We exploit such an expressions for calculating the evolution times in chains of both two and three spins. In the case of a chain of two qubits, we derive conditions under which the associated four Bell states diagonalize the Hamiltonian. It is found that for the two Bell states 丨Ф＋） and 丨Ф-）, perfect mirroring does not occur （i.e. entanglement is not preserved under swapping）. On the other hand, perfect single qubit mirror effect （entanglement preservation） indeed occurs for the other two Bell states 丨ψ＋） and 丨ψ-） which are mapped into 丨Ф＋） and 丨Ф-） respectively. For the case of a chain of three qubits, the effects of a perfect single qubit mirroring on a set of four maximally entangled three qubit states ψl, ψ2, X1, and X2are studied. Due to the fact that quantum mirroring preserves maximal entanglement, the states ψ1 and ψ2 are not altered. However, quantum mirroring changes the states X1 and X2 only if we apply perfect quantum state mirroring in the site a = 1 of the three qubits spin chain. The above constrains the preservation of maximal entanglement under qubit mirroring of such a state. Due to the fact that swapping has already been experimentally tested, a posible, experimental implementations of single qubit mirroring is possible.

关键词： time evolution of a state perfect quantum state mirroring of a single qubit Bell states Gisinstates quantum mirroring of Bell states quantum mirroring of Gisin states entanglement preset-vation

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Optimization and Validation of a method for Heavy metals Quantification in Soil Samples by Inductively Coupled Plasma Sector Field mass Spectrometry(ICP-SFmS)

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American Journal of Analytical Chemistry 2013年第10期4卷 9-15页

作者： Héctor Hernández-mendoza marcos mejuto Ana isabel Cardona Avelino García-Alvarez Rocio millán Abel Yllera Instituto Nacional de Investigaciones Nucleares Carretera México-TolucaLa Marquesa OcoyoacacMéxico Departamento de medio Ambiente Centro de Investigaciones EnergéticasMedioambientales y Tecnológicas(CIEMAT)AvdaMadridEspana

In this work, a method for quantification of heavy metals Inductively Coupled Plasma Sector Field mass Spectrometry (ICP-SFmS) in soil samples of El Bierzo district (Spain) has been optimized and validated. Optimization was carried out for elements: Cr, mn, Co, Ni, Cu, Zn, Se, As, Cd, Hg, Pb and U. Validation of the method was performed with Certified and Standard Reference materials (CRms and SRms);SRm2709, CRm020-051 and CRm050-051. Results obtained under optimized conditions can be summarized as follows: a) the Limits of Detection (LODs) were in the order of sub fg·g-1 for Cr, mn, Cu, Co, As, Cd, Hg, Pb and U, and few fg·g-1for Ni, Zn and Se;b) precision measurement, in terms of relative standard deviation (RSD), was been below 5%;c) the average recovery of CRm was between 81.3% and 98%. In conclusion, the method offers several advantages: fast, good accuracy, very low values of Limits of Quantification (LOQs) and high sensitivity on measurement of heavy metal.

关键词： Soil Heavy metal ICP-SFmS

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Factors Associated to the Presence of Pneumothorax in Cystic Fibrosis Patients in the City of madrid

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International Journal of Clinical medicine 2011年第3期2卷 212-217页

作者： Prados Concepción Carpio Carlos martínez maría Teresa máiz Luis Girón Rosa Barrio isabel Salcedo Antonio García Hernández Gloria Gómez Carrera Luis álvarez-Sala Rodolfo Prados Sánchez Concepción Department of Pneumology La Paz University Hospital Madrid

Background: To identify risk factors associated with pneumothorax and to determine the prognosis of cystic fibrosis patients following an episode of pneumothorax in the city of madrid. methods: Records of 17 patients (10 males;age 24.4 ± 17.5 years) and 32 controls, and a total of 44 pneumothorax episodes were studied. We have analyzed the characteristics of the pneumothorax, the microbiology, the lung function tests (LFT) and the prognosis of patients. Two controls with cystic fibrosis and without pneumothorax matched for sex and age were selected. Results: Eight male and three female patients with pneumothorax were older than 18 years. The mean age of the first pneumothorax episode was 18.3 years (±9.6). The group with pneumothorax had a mean body mass index of 19.2(±2.42 kg/m2) and in the control group it was 26.5 (±1.98 kg/m2). Pseudomonas aeruginosa was present in fourteen patients (82%) with pneumothorax and in eleven patients (34.4%) in the control group (p = 0.002). Pneumothorax predominantly occurred in the coldest seasons. There was a significant drop in both forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) after the pneumothorax. In the same way, FEV1 and FVC were greater in the control group. Six patients (35.4%) with pneumothorax and two patients in the control group have died (p mothorax are more likely to have P. aeruginosa colonization. LFT drop after an episode of pneumohorax. Patients with pneumothorax have worse LFT than patients without pneumothorax. mortality is greater in patients with pneumothorax.

关键词： Cystic Fibrosis Pleural Disease Pneumothorax

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