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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán cristina Jiménez-Luna isabel rodriguez Elisabeth Maza Carlos García-Collado Antonio rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUnD Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Ecological succession of benthic organisms on niche-type artificial reefs

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Ecological Processes 2020年第1期9卷 433-442页

作者： María-isabel Toledo Pamela Torres cristina Díaz Victor Zamora Jesús López Germán Olivares Escuela de Ciencias del Mar Facultad de Ciencias del Mar y GeografíaPontificia Universidad Católica de ValparaísoValparaísoChile

As part of efforts to restore fishery resources and recover damaged coastal ecosystems,artificial reefs are often anchored on the seafloor in coastal zones,to provide new habitats for marine *** aim of the study was to describe the structure of a community of benthic invertebrates colonising a niche-type artificial reef(AATn in Spanish).nine structures were anchored at depths of 16±1.5 m for 99 weeks(22 months)in the Area of Benthic Resource Management and Exploitation(AMERB)in coastal waters of the Region of Bio Bio,*** results showed that,at 3 months from submersion of the nTAR,much of the artificial substrate remained bare and there were only low levels of specimens of Balanus ***,showing mean coverage of 11.26%,and even lower proportions of Rhodophyta,with mean coverage of 0.34%.At 6 months,the presence of hydrozoans was seen,decreasing the coverage of the barnacles,which was aided further at 8 months with the arrival of barnacle predatory *** 8 months,new benthic invertebrates appeared and competed for the *** included sponges and *** 99 weeks,the hydrozoans dominated the substrate,followed by barnacles and Rhodophyta,the first colonising organisms,leading to colonisation by motile macro-invertebrates,mainly consisting of crustaceans,echinoderms and *** AATn artificial system provides an ideal substrate for the development of early ecological succession and the use of this technology should be feasible in the recovery process of habitat damaged by anthropogenic actions and climate change.

关键词： Artificial reefs Ecological succession Colonisation Benthic organisms Balanus sp. Rhodophyta Hydrozoans

Influence of Blueberry and Jaboticaba Agroindustrial Residue Particle Size on Color Change of Corn Starch Based Films Submitted to Different pH Values Solutions

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Journal of Renewable Materials 2019年第3期7卷 235-243页

作者： Cláudia Leites Luchese Julia Menegotto Frick Pavoni Jordana Corralo Spada isabel cristina Tessaro Laboratory of Packaging Technology and Membrane Development(LATEM) Department of Chemical Engineering-Federal University of Rio Grande do Sul(UFRGS)Street Ramiro Barcelos2777.Porto Alegre/RS-ZC:90035-007-Brazil

Corn starch,glycerol and agroindustrial residues were used to produce films by ***-products from juice processing,blueberry and jaboticaba in powder with different particle sizes were added in the filmogenic matrix to evaluate its potential as a colorimetric *** and jaboticaba peels are commonly discarded although contain high amount of important compounds as *** compounds have the ability to color change after immersion in different pH values,demonstrating its potential for the intelligent packaging *** were performed in a colorimeter after films immersion in different buffer *** color changes were perceived;reddish and bluish color in acidic and basic pH values,*** of the particle size,theΔE* values were greater than 5,showing visually perceptible change to the human *** results indicate the potential of use of these residues as a pH indicator for the development of renewable and biodegradable sensor of food deterioration.

关键词： Blueberry jaboticaba anthocyanin casting colorimetric analysis

Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study

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Infectious Diseases of Poverty 2021年第5期10卷 14-27页

作者： Violeta Ramos‑Sesma Miriam navarro Jara Llenas‑García Concepción Gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑Jorgensen María García‑López Concepción Amador‑Prous María‑Paz Ventero‑Martín Pedro Guevara‑Hernández Ana Garijo‑Saiz Ares Sanchez‑Sanchez cristina Bernal‑Alcaraz Ana‑isabel Pujades‑Tarraga Roser Muñoz‑Perez María Flores‑Chávez José‑Manuel Ramos‑rincón Internal Medicine Service HLA Inmaculada HospitalGranadaSpain Public Health Science History and Gynecology DepartmentUniversidad Miguel Hernández de ElcheAlicanteSpain Epidemiology Unit Public Health Center of Elche AlicanteSpain Internal Medicine Department Hospital Vega Baja de Orihuela(AlicanteSpain)-Foundation for the Promotion of Health and Biomedical Research of the Valencia Region(FISABIO)AlicanteSpain Clinical Medicine Department University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine Department Hospital Marina BaixaLa Vila Joiosa(AlicanteSpain)-FISABIOAlicanteSpain Internal Medicine Department General University Hospital of Alicante–Biomedical and Health Research Institute of Alicante(ISABIAL)AlicanteSpain Parasitology Area University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine Department University Hospital of Sant Joan(Sant Joan d’AlacantSpain)–FISABIOAlicanteSpain Microbiology Service General University Hospital of Alicante–ISABIALAlicanteSpain Pediatric Department General University Hospital of Alicante–ISABIALAlicanteSpain Digestive Service General University Hospital of Alicante–ISABIALAlicanteSpain Reference and Research Laboratory in Parasitology National Center of Microbiology/Mundo Sano FoundationMadridSpain

Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration *** carriers may host the parasite for years,without knowing they are *** aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening ***:Three community-based campaigns were performed in Alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi *** completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and *** seroposi‑tive for *** underwent diagnostic confrmation by two diferent *** were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aORs),adjusting for age,sex,and time in ***:A total of 596 participants were included in the study;17%were aged under 18 *** in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among *** but one case were in *** was independently associated with having been born in Bolivia(aOR:102,95%CI:13–781)and a primary school-level education(aOR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received *** analysis showed that coming from Argentina(aOR:13,95%CI:1.61–1188)or Bolivia(aOR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aOR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the *** primary level studies(aOR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aOR:4.63,95%CI:2.52–847)were independently associated with a lower level of ***:Community-based interventions are a good strategy for diagnosi

关键词： Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening

Methane production and small intestinal bacterial overgrowth in children living in a slum

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World Journal of Gastroenterology 2012年第41期18卷 5932-5939页

作者： Carolina Santos Mello Soraia Tahan Lígia cristina FL Melli Mirian Silva do Carmo rodrigues Ricardo Martin Pereira de Mello isabel cristina Affonso Scaletsky Mauro Batista de Morais Pediatric Gastroenterology Division Federal University of Sao Paulo04039-031 Sao PauloBrazil Center Foundation Institute of Education for Osasco 06020-190 Sao PauloBrazil Infectology Division Federal University of Sao Paulo04025-010 Sao PauloBrazil Microbiology Immunology and Parasitology DivisionFederal University of Sao Paulo 04023-062 Sao PauloBrazil

AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath ***:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,*** characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were *** data was obtained in children from both *** children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ***:Children from the slum group had worse living conditions and lower nutritional indices than children from the private *** was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P nd in the colon(P ng the children from the slum group with SIBO when compared to children from the slum group without *** production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P ne production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the *** production of hydrogen was lower in methaneproducing children(P = 0.017).COnCLUSIOn:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane *** is a substrate for methane production in the colon.

关键词： Bacterial overgrowth Breath test Children Colon Hydrogen Methane Small intestine

Autoimmune gastritis presenting as iron deficiency anemia in childhood

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World Journal of Gastroenterology 2014年第42期20卷 15780-15786页

作者： cristina Gon?alves Maria Emília Oliveira Ana M Palha Anabela Ferr?o Anabela Morais Ana isabel Lopes Gastroenterology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre Pathology Department University Hospital Santa Maria Lisbon Academic Medical Centre Hematology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre

AIM: To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anemia investigation.

关键词： Autoimmune gastritis Iron deficiency anemia Children

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor cristina Roca-Oporto nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores navarro-Amuedo Dolores nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain neurology and Clinical neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFn-α).In COVID-19 there is a deficit in DC numbers and IFn-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV

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World Journal of Pediatrics 2019年第5期15卷 492-498页

作者： isabel Cuéllar-Flores Talís Saínz Carlos Velo María isabel González-Tomé cristina García-navarro Caroclina Fernández-Mcphee Sara Guillén JoséTomás Ramos Pilar Miralles Rafae Rubio JoséIgnacio Bernardino Luis Prieto Pablo Rojo Santiago Jiménez de Ory Maria Luisa navarro CoRiSpe(FARO and neuroCoRISpeS projects,RITIP-Traslational Research network in Pediatric Infectious Diseases) Pediatric Department Hospital Clínico San CarlosMadridSpain Infectious Diseases Service Paed DepartmentHospital La PazMadridSpain La Paz Research Institute(IdiPAZ) MadridSpain Infectious Diseases Service Paed DepartmentHospital 12 de OctubreMadridSpain Infectious Diseases Service Paed DepartmentH.Gregorio MaranónMadridSpain Paed Department Hospital de GetafeMadridSpain Infectious Diseases Service H.Gregorio MaranónMadridSpain HIV Service Hospital 12 de OctubreMadridSpain Infectious Diseases Service Hospital La PazMadridSpain Instituto de Investigación Sanitaria Hospital Gregorio Maranón(IiSGM) MadridSpain Universidad Complutense de Madrid MadridSpain Translational Research network in Pediatric Infectious Diseases(RITIP) MadridSpain 不详

Background Studies investigating health-related quality of life(HRQoL)in youth with perinatally acquired HIV(PHIV+)are *** study aimed to compare HRQoL of PHIV+to sociodemographic-matched youth not living with HIV(HIV-),Spanish general youth population,and to explore associations between sociodemographic variables,drug consumption,and *** PHIV+youth were randomly selected from CoRISpe database(Cohort of the Spanish Pediatric HIV network).HRQoL was evaluated by *** Thirty-nine PHIV+youth(mean age:23.36 years,SD=3.83)and thirty-nine HIV-youth(mean age:22.97 years,SD=3.80)participated in this ***+obtained lower scores in SF-12 physical health subscale(PCS)than HIV-(P=0.001)and Spanish general youth population(P=0.006).PHIV+had lower scores on the mental health subscale(MCS)than the Spanish general youth population(Pned better scores than those were not at ***+youth who had used cocaine and cannabis had lower scores in MCS(P=0.002).Conclusions There is a need for HRQoL management in the associated medical follow-up.

关键词： Drug consumption Health-related quality of life Mental health Perinatally acquired HIV youth

Methadone Maintenance Treatment Program in Portuguese Community Pharmacies

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Journal of Health Science 2015年第2期3卷 85-94页

作者： isabel JACInTO Anabela MADEIRA cristina SAnTOS Joao GOULAO Jose PADUA Department of Pharmacy Services National Association of Pharmacies (ANF) Lisboa 1249-069 Portugal Advisory Board Institute on Drugs and Drug Addiction I.P. (IDT I.P.) Lisboa 1700-036 Portugal

MMT （Methadone maintenance treatment） is an effective way to treat opioid dependence. In Portugal, an MMT program has been available in pharmacies since January 1998, when a formal agreement was signed by the IDT, I.P. （Institute on Drugs and Drug Addiction）, the PPS （Portuguese Pharmaceutical Society）, and the AnF （national Association of Pharmacies）. In January 2004, the InFARMED （national Authority of Medicine and Health Products） became a partner of the program. The possibility of continuing the treatment at a community pharmacy was restricted to patients receiving a stabilized dose of methadone at IDT, I.P. treatment centers. Pharmacists joining the MMT were given mandatory training. Patients on the MMT program received daily doses of methadone solution under directly observed therapy, and were followed up by trained pharmacists. From January 1998 to January 2013, 3,090 patients underwent MMT in Portuguese community pharmacies. The delivery of MMT at community pharmacy level is feasible. This strategy improves access and adherence to methadone treatment, thus helping to reduce the use of illegal opioids. Community pharmacists fully demonstrated their ability to perform extended roles in public health and harm-reduction strategies. Interaction and close cooperation between the different health professionals and organizations involved were crucial to achieve adequate support to the patients.

关键词： Community pharmacy directly observed therapy methadone pharmaceutical services Portugal