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Amer.can Jour.al of Analytical Chemistr. 2013年第4期4卷 207-211页

作者： isabel r. barbosa Sar. Lopes r.aul Oliveir. Inês Domingues Amadeu M. V. M. Soar.s António J. A. Nogueir. Centr. for.Phar.aceutical Studies Faculty of Pharmacy University of Coimbra Coimbra Portugal Depar.ment of Biology & CESAM University of Aveiro Aveiro Portugal Faculty of Phar.acy University of Coimbra Coimbra Portugal

17α-methyltestoster.ne is used to induce the sex r.ver.al of Tilapia sp. to obtain cultur.s mono-sex to an economically viable. This pr.ctice may lead to envir.nmental contamination and pr.blems in human health. Ther.for. methods need to be developed to detect r.sidues of 17α-methyltestoster.ne in aqueous matr.ces. A simple high-per.or.ance liquid chr.matogr.phic method using ultr.violet detection (245 nm) and testoster.ne as inter.al standar. has been developed for.the monitor.ng 17α-methyltestoster.ne in fr.shwater.samples of tilapia aquacultur.. The method descr.bed involves limited sample pr.par.tion as it includes a filtr.tion followed by a single solid-phase extr.ction step using C18 car.r.dge. Validation data indicated that the HPLC-UV method for.17α-methyltestoster.ne deter.ination in the concentr.tion r.nge of 50 - 2000 μg/L pr.vided good linear.ty, sensitivity, accur.cy and pr.cision. Method per.or.ance was efficiently applied to monitor.ng the fr.shwater.samples of fish ponds and the sur.ounding aquatic channels.

关键词： 17α-Methyltestoster.ne High Per.or.ance Liquid Chr.matogr.phy Envir.nment Tilapia Far.ing

An Outlook on Implantable Biosensor. for.Per.onalized Medicine

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Engineer.ng 2021年第12期7卷 1696-1699页

作者： r.ta r.belo Ana isabel barbosa Vitor.M.Cor.elo r.i L.r.is r.sear.h Institute on Biomater.als Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Gover.ment-Associated Labor.tor. BragaGuimarães 4710-057Portugal

Biosensor. ar. a fast-gr.wing field,as they have been shown to be ver. helpful in our.daily life,playing r.les in industr.es such as agr.cultur.,food safety,homeland secur.ty,biopr.cessing,envir.nmental monitor.ng,and industr.al *** these,the application of biosensing in medicine and biomedical engineer.ng may have the highest potential for.gr.wth and for.affecting human quality of life in the near.*** potential is dr.ven by the need for.new and impr.ved devices and technologies with impr.ved sensitivity,specificity,r.liability,and biocompatibility.

关键词： Outlook specificity playing

Does var.able stand str.ctur. associated with multi-cohor. for.sts suppor. diver.ity of gr.und beetle (Coleopter., Car.bidae) communities in the centr.l Near.tic bor.al for.st？

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Jour.al of For.str. r.sear.h 2016年第5期27卷 1191-1202页

作者： Er.ca P. Bar.ley Jay r. Malcolm Sandy M. Smith M. isabel Bellocq Faculty of For.str. University of Toronto 33 Willcocks Street Toronto ON M5S 3B3 Canada Depar.amento de Ecología Genética y Evolución IEGEBA(CONICET-UBA) Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires Buenos Aires Argentina

Multi-cohor. management （MCM） that r.tains a r.nge of stand str.ctur.s （age and size class） has been pr.posed to emulate natur.l distur.ance and impr.ve management in the Near.tic bor.al for.st. Although MCM for.sts contain both single- and multi-aged stands of mixed tr.e sizes, little is known about how var.able stand str.ctur. affects associated fauna and biodiver.ity. Her., we examine the r.lationship between gr.und beetle （Coleopter., Car.bidae） communities and stand char.cter.stics acr.ss a r.nge of for.st str.ctur. （=cohor. classes）. Given that MCM classes ar. defined by the distr.bution of their.tr.e-stem diameter., we ask whether.par.meter. associated with these distr.butions （Weibull） could explain obser.ed var.ation in car.bid communities, and if so, how this compar.s to tr.ditional habitat var.ables such as stand age, foliage complexity or.volume of downed woody debr.s. We sampled car.bids using weekly pitfall collections and compar.d these with str.ctur.l habitat var.ables acr.ss a r.nge of cohor. classes （stand str.ctur. and age since distur.ance） in 18 sites of upland mixed bor.al for.sts fr.m centr.l Canada. r.sults showed that r.chness and diver.ity of car.bid communities wer. similar.among cohor. classes. Weibull par.meter. fr.m the diameter.distr.bution of all stems wer. the str.ngest pr.dictor. of var.ation in car.bid communities among sites, but ver.ical foliage complexity, under.tor. thickness, and per.entage of deciduous composition wer. also significant. The abundance of sever.l car.bid for.st specialists was str.ngly cor.elated with tr.e canopy height, the pr.sence of lar.e tr.es, and high ver.ical foliage complexity. Our.r.sults demonstr.te that var.able for.st str.ctur., as expected under.MCM, may be useful in r.taining the natur.l r.nge of gr.und beetle species acr.ss the centr.l Near.tic bor.al for.st.

关键词： Biodiver.ity conser.ation Bor.al for.st Car.bidae For.st str.ctur. Gr.und beetles Multi-cohor.management Tr.e diameter.distr.bution

Sand attr.tion in conical spouted beds

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Par.icuology 2012年第5期10卷 592-599页

作者： Ar.nzazu r. Fer.ández-Akar.egui Jon Makibar.isabel Alava Luis Diaz Fer.ando Cueva r.ber.o Aguado Gar.zen Lopez Mar.in Olazar Iker.an-IK4 Juan de 4 la Cierva 1 Arabako Parke TeknologikoaE-01510 Minao Araba Spain Depar.ment of Chemical Engineer.ng University of the Basque CountryP.O. Box 644 E48080 Bilbao Spai

A study was car.ied out on the attr.tion in conical spouted beds using two sands with differ.nt pr.per.ies for.sever.l bed heights and gas flow r.tes. Fur.her.or., the influence of a dr.ft tube was studied at ambient and high temper.tur.s. The main objective was to acquir. knowledge on the attr.tion of sand beds for.biomass pyr.lysis in a pilot plant pr.vided with a conical spouted bed r.actor. A fir.t-or.er.kinetic equation is pr.posed for.sand attr.tion in a conical spouted bed at r.om temper.tur.. The pr.dicted attr.tion r.te constant depends exponentially on excess air.velocity over.that for.minimum spouting. Both the dr.ft tube and temper.tur. incr.ase contr.bute to r.duction of attr.tion.

关键词： Attr.tionConical spouted bedDr.ft tubeSand attr.tion

Ear.y-onset color.ctal cancer.A r.view of cur.ent knowledge

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Wor.d Jour.al of Gastr.enter.logy 2023年第8期29卷 1289-1303页

作者： Mar.ar.da r.Sar.iva Isador. r.sa isabel Clar. Depar.ment of Gastr.enter.logy Instituto Português de Oncologia de Lisboa Francisco GentilLisboa 1099-023Portugal

Color.ctal cancer.Cr.)is one of the most pr.valent malignancies *** most pr.valent among older.people,its incidence above 50 year. old has been decr.asing globally in the last decades,pr.bably as a r.sult of better.***,its incidence in patients below 50 year. old[ear.y-onset Cr.(EO-Cr.)]has been incr.asing,for.r.asons not yet fully ***’s incr.asing incidence is genr. independent but shows r.cial dispar.ties and has been descr.bed to occur.*** follows a bir.h-cohor. effect which pr.bably r.flects a change in exposur. to Cr. r.sk *** incidence is pr.dicted to double until 2030,which makes EO-Cr. a ser.ous public health *** modifiable and non-modifiable r.sk factor. have been identified-some ar. potential tar.ets for.pr.ventive ***-Cr. is often diagnosed at advanced stages and histological featur.s associated with poor.pr.gnosis have been ***-Cr. pr.sents some distinctive featur.s:Micr.satellite instability is common,but another.subtype of tumour.,both micr.satellite and chr.mosome stable also seems *** ar. no age-specific tr.atment pr.tocols and studies on EO-Cr. sur.ival r.tes have shown conflicting *** to the higher.ger.line pathological mutations found in EO-Cr. patients,an accur.te genetic r.sk evaluation should be *** this r.view,we summar.ze the cur.ent evidence on epidemiological,clinical,histopathological and molecular.featur.s of EO-Cr. and discuss the contr.bution of genetics and lifestyle r.sk *** fur.her.comment on scr.ening str.tegies and specific dimensions to consider.when dealing with a younger.cancer.patient.

关键词： Color.ctal cancer Ear.y-onset Adenocar.inoma Her.ditar. Bir.h-cohor. effect r.sk factor.

Intr.specific competition in Zabr.tes subfasciatus： Physiological and behavior.l adaptations to differ.nt amounts of host

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Insect Science 2012年第1期19卷 102-111页

作者： isabel r.V.Teixeir. Fer.ando S.Zucoloto Insect Nutr.tion and Feeding Behavior.Labor.tor. Department of BiologyFaculdade de Filosofia Ciencias e Letras de Ribeirao Preto Universidade de Sao PauloSao Paulo epar.ment of Biology Federal Institute of Sul de Minas-Campus MuzambinhoIFSULDEMINAS MuzambinhoMinas GeraisBrazil

The effects of competition on populations of the bean weevil Zabr.tes sub- fasciatus wer. analyzed dur.ng 41 gener.tions under.differ.nt competition levels. Thr.e competition envir.nments wer. established by maintaining the number.of couples （6） and var.ing the amount of available host seeds： HC, high （limited availability of host： 1.35 g）; IC, inter.ediate （inter.ediate availability of host： 6 g）; and LC, low competition （abun- dance of host： 36 g）. It was found that the distr.bution of the eggs laid on gr.ins was differ.nt among tr.atments： in LC, for.example, although females showed high fecundity （35.4 ± 5.6 eggs/female） the number.of eggs laid on each gr.in was small （1.2 ± 0.4 eggs on each seed）, thus avoiding lar.al competition of their.offspr.ng; wher.as in HC tr.atment, females showed low fecundity （27.04 ± 4.5 eggs/female） but laid many eggs on each gr.in （15.03 ± 4.3 eggs）. Ther. wer. no changes in the ability to r.spond to differ.nt amounts of host via oviposition behavior.（egg distr.bution） dur.ng 41 gener.tions. How- ever. HC females had mor. offspr.ng than LC females under.HC conditions. This suggests that HC insects evolved towar. higher.fitness in cr.wded conditions. In addition, after.inver.ing the competition level, insects behaved independently of the tr.atment conditions they exper.enced thr.ugh gener.tions, thus showing that oviposition behavior.is flexible. Taken together. our.r.sults show that Z. subfasciatus pr.sents a br.ad r.nge of behavior.l and physiological r.sponses which allows for.quick and r.ver.ible adjustments to sudden changes in the amount of r.sour.es.

关键词： bean weevil Coleopter. egg distr.bution oviposition Phaseolus vulgar.s phenotypic plasticity

The br.in as a sour.e and a tar.et of pr.lactin in mammals

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Neur.l r.gener.tion r.sear.h 2022年第8期17卷 1695-1702页

作者： Ana r.Costa-Br.to isabel Gonçalves Cecília r.A.Santos CICS-UBI-Health Sciences r.sear.h Centr. Universidade da Beira InteriorCovilhãPortugal C4-UBI-Cloud Computing Competence Centr. Universidade da Beira InteriorCovilhãPortugal

Pr.lactin is a polypeptide hor.one associated with an extensive var.ety of biological *** the r.les of pr.lactin in ver.ebr.tes,some wer. pr.ser.ed thr.ughout *** is the case of its function in the br.in,wher. pr.lactin r.ceptor.,ar. expr.ssed in differ.nt str.ctur.s of the centr.l ner.ous *** the br.in,pr.lactin actions ar. pr.ncipally associated with r.pr.duction and par.ntal behavior.and involves the modulation of adult neur.genesis,neur.pr.tection,and neur.plasticity,especially dur.ng pr.gnancy,ther.by pr.par.ng the br.in to *** is mainly pr.duced by specialized cells in the anter.or.pituitar. ***,dur.ng ver.ebr.te evolution many other.extr.pituitar. tissues do also pr.duce pr.lactin,like the immune system,endothelial cells,r.pr.ductive str.ctur.s and in sever.l r.gions of the *** r.view summar.zes the r.levance of pr.lactin for.br.in function,the sour.es of pr.lactin in the centr.l ner.ous system,as well as its local pr.duction and secr.tion.A highlight on the impact of pr.lactin in human neur.logical diseases is also pr.vided.

关键词： br.in br.in disease chor.id plexus neur.genesis neur.plasticity neur.pr.tection pr.lactin pr.lactin r.ceptor

Cir.hotic car.iomyopathy:Isn't str.ss evaluation alwaysr.quir.d for.the diagnosis?

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Wor.d Jour.al of Hepatology 2016年第3期8卷 200-206页

作者： mar. barbosa joana guar.ado car.a mar.nho br.no r.sa isabel quelhas antónio lour.nco josécotter Gastr.enter.logy Depar.ment Centro Hospitalar do Alto Ave4835 GuimarãesPortugal

AIM:To descr.be the pr.por.ion of patients with cir.hotic car.iomyopathy(CCM) evaluated by str.ss echocar.iogr.phy and investigating its association with the sever.ty of liver.***:A cr.ss-sectional study was *** patients without r.sk factor. for.car.iovascular.disease wer. *** r.gar.ing etiology and sever.ty of liver.disease(Child-Pugh scor. and model for.end-stage liver.disease),pr.sence of ascites and gastr.esophageal var.ces,pr.-br.in natr.ur.tic peptide(pr.BNP) and cor.ected QT(QTc) inter.al wer. *** str.ss echocar.iogr.phy(conventional and tissue Doppler.imaging) was *** was consider.d pr.sent when diastolic and/or.systolic dysfunction was diagnosed at r.st or.after.phar.acological *** inter.er.ng with car.iovascular.system was suspended 24 h befor. the ***:Twenty-six patients wer. analyzed,17(65.4%) Child-Pugh A,mean model for.end-stage liver.disease(MELD) scor. of *** global pr.por.ion of patients with CCM was 61.5%.At r.st,only 2(7.7%)patients had diastolic dysfunction and none of the patients had systolic *** str.ss echocar.iogr.phy r.vealed the pr.sence of diastolic dysfunction in mor. 6(23.1%) patients and of systolic dysfunction in 10(38.5%) *** inter.al pr.longation was obser.ed in 68.8%of the patients and incr.ased pr.-BNP levels in 31.2%of *** was no association between the pr.sence of CCM and liver.impair.ent assessed by Child-Pugh scor. or.MELD(P= 0.775,P= 0.532,r.spectively).Patients with QTc inter.al pr.longation had a significant higher.r.te of gastr.esophageal var.ces compar.ng with those without QTc inter.al pr.longation(95.0%vs 50.0%,P= 0.028).CONCLUSION:CCM is a fr.quent complication of cir.hosis that is independent of liver.*** evaluation should always be per.or.ed,other.ise it will r.main an under.iagnosed condition.

关键词： Dobutamine str.ss echocar.iogr.phy Cir.hotic car.iomyopathy Cir.hosis Cor.ected QT inter.al pr.longation Liver.impair.ent

Phase-dr.ven pr.gr.ss in nanophotonic biosensing

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Light(Science & Applications) 2024年第5期13卷 798-800页

作者： isabel Bar.h Hakho Lee Center.for.Systems Biology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA

In the continuous pur.uit of enhancing the sensitivity of nanophotonic biosensor. by lever.ging phase phenomena,a r.cent development involved the engineer.ng of an atomically thin Ge2Sb2Te5 layer.on a silver.nanofilm ... 详细信息

关键词： silver Ge2Sb2Te5 pur.uit

Effect of Polymer.Inclusion in Pr.par.tion of Thick LZO Buffer.Layer. for.YBCO Coated Conductor.

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Jour.al of Mater.als Science & Technology 2013年第3期29卷 261-266页

作者： Vyshnavi Nar.yanan isabel Van Dr.essche Sol-gel Centr. for.r.sear.h on Inor.anic Powder. and Thin film Synthesis-SCr.PTS Department of Inorganic and Physical ChemistryGhent UniversityKrijgslaan 281-S3B-9000 GentBelgium

In this wor., water.based pr.cur.or.solutions suitable for.dip-coating of thick La2Zr.O7 （LZO） buffer.layer. for.coated conductor. on Ni-5%W substr.tes with an inclusion of polymer.c polyvinyl pyr.olidone wer. developed. The effect of var.ing per.entage of the polymer.addition on the pr.par.tion of the deposited films with maximum cr.ck-fr.e thickness was investigated. This novel water.based chemical solution deposition method involving polymer. in two differ.nt chelate-chemistr. compositions r.vealed the possibility to gr.w single, cr.ck-fr.e layer. with thicknesses r.nging fr.m 140 to 280 nm, with good cr.stallinity and epitaxial gr.wth. The effect of incr.asing polymer.concentr.tions on the mor.hology and the str.ctur. of the films was studied. The appr.pr.ate buffer.layer.action of the films in pr.venting Ni diffusion was studied by X-r.y photoelectr.n spectr.scopy.

关键词： Buffer.layer. Thick lanthanum zir.onate films Chemical solution deposition Polyvinyl pyr.olidone Water.based pr.cur.or.design Coated conductor.