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Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock

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Journal of Geriatric Cardiology 2020年第10期17卷 604-611页

作者： Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual isaac llaó Oriol Alegre Angel Cequier Javier Elola Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Hospital Clínico Universitario San Carlos MadridSpain Hospital Universitario 12 de Octubre MadridSpain

Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains *** information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with *** aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older *** Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data *** were classified according to their availability of *** outcome measured was in-hospital *** A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 *** impact of DM on in-hospital mortality was different among age *** in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older *** availability of ICCU and revascularization were associated with better outcomes in these complex patients.

关键词： Cardiogenic shock Diabetes mellitus Myocardial infarction Revascularization The elderly

Usefulness of Impella support in different clinical settings in cardiogenic shock

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Journal of Geriatric Cardiology 2022年第2期19卷 115-124页

作者： María Isabel Barrionuevo-Sánchez Albert Ariza-Solé Daniel Ortiz-Berbel JoséGonzález-Costello Joan Antoni Gómez-Hospital Victòria Lorente Oriol Alegre isaac llaó JoséCarlos Sánchez-Salado Josep Gómez-Lara Arnau Blasco-Lucas Josep Comin-Colet Cardiology Department Intensive Cardiac Care UnitBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain Cardiac Surgery Department Heart Disease InstituteBellvitge University HospitalL’Hospitalet de LlobregatBarcelonaSpain

BACKGROUND The Impella pump has emerged as a promising tool in patients with cardiogenic shock(CS).Despite its attractive properties,there are scarce data on the specific clinical setting and the potential role of Impella devices in CS patients from routine clinical *** This is an observational,retrospective,single center,cohort *** consecutive patients with diagnosis of CS and undergoing support with Impella 2.5?,Impella CP?or Impella 5.0?from April 2015 to December 2020 were *** characteristics,management and outcomes were assessed according to CS severity,age and cause of *** outcome measured was in-hospital *** A total of 50 patients were included(median age:59.3±10 years).The most common cause of CS was acute coronary syndrome(ACS)(68%),followed by decompensation of previous cardiomyopathy(22%).A total of 13 patients(26%)had profound *** patients(54%)improved pulmonary congestion at 48 h after Impella support.A total of 19 patients(38%)presented significant ***-hospital mortality was 42%.Among patients with profound CS(n=13),five patients were previously supported with venoarterial extracorporeal membrane oxygenation.A total of eight patients(61.5%)died during the admission,and no patient achieved ventricular *** patients(≥67 years,n=10)had more comorbidities and the highest mortality(70%).Among patients with ACS(n=34),35.3%of patients had profound CS;and in most cases(52.9%),Impella support was performed as a bridge to *** contrast,only one patient from the decompensated cardiomyopathy group(n=11)presented with profound *** 90.9%of these cases,Impella support was used as a bridge to cardiac *** were no cases of *** In this cohort of real-life CS patients,Impella devices were used in different settings,with different clinical profiles and *** a significant rate of complications,mortality was acceptable and lower than those observed

关键词： Impella clinical routine

Classifying rockburst with confidence:A novel conformal prediction approach

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International Journal of Mining Science and Technology 2024年第1期34卷 51-64页

作者： Bemah Ibrahim isaac Ahenkorah University of South Australia UniSA STEMSA 5000Australia

The scientific community recognizes the seriousness of rockbursts and the need for effective mitigation *** literature reports various successful applications of machine learning(ML)models for rockburst assessment;however,a significant question remains unanswered:How reliable are these models,and at what confidence level are classifications made?Typically,ML models output single rockburst grade even in the face of intricate and out-of-distribution samples,without any associated confidence *** the susceptibility of ML models to errors,it becomes imperative to quantify their uncertainty to prevent consequential *** address this issue,we propose a conformal prediction(CP)framework built on traditional ML models(extreme gradient boosting and random forest)to generate valid classifications of rockburst while producing a measure of confidence for its *** proposed framework guarantees marginal coverage and,in most cases,conditional coverage on the test *** CP was evaluated on a rockburst case in the Sanshandao Gold Mine in China,where it achieved high coverage and efficiency at applicable confidence ***,the CP identified several“confident”classifications from the traditional ML model as unreliable,necessitating expert verification for informed *** proposed framework improves the reliability and accuracy of rockburst assessments,with the potential to bolster user confidence.

关键词： Rockburst Machine learning Uncertainty quantification Conformal prediction

(Sm/Eu/Tm)^(3+) doped tantalum semiconductor system for photovoltaic and electrochemical functionality amplification

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Journal of Rare Earths 2024年第8期42卷 1586-1594,I0007页

作者： Shaan Bibi Jaffri Khuram Shahzad Ahmad isaac Abrahams Ibrahim A.A Materials and Environmental Chemistry Lab Lab-E21Department of Environmental SciencesFatima Jinnah Women UniversityRawalpindiPakistan School of Physical and Chemical Sciences Queen Mary University of LondonLondonUnited Kingdom Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

This work reports the synthesis,characterization,and energy focused applications of the novel lanthanides co-doped tantalum pentoxide hetero-system(Sm^(3+)-Eu^(3+)-Tm^(3+):Ta_(2)O_(5)).Ln^(3+)-doped Ta_(2)O_(5) express excellent opto-electronic features reflected by the narrow band gap energy of 3.87 *** vibrations confirm the presence of Ta-O-Ta and Ta-O *** synthesized system possesses orthorhombic geometry with 59.46 nm particle *** the smoother and compact morphology,the synthesized material succeeds in augmenting the performance of different systems aimed at energy *** ambient perovskite solar cell device fabricated with the Ln^(3+)-doped Ta_(2)O_(5) as an electron transport layer excels in achieving an efficiency and fill factor of 14.17% and 76% under artificial *** device was marked by the negligible hysteresis behavior showing profound photovoltaic *** electrochemical activity of the Ln^(3+)-doped Ta_(2)O_(5) decorated electrode was evaluated for electrical charge storage potential with pseudocapacitive behavior,With the highest specific capacitance of 355.39 F/g and quicker ionic diffusion rate,the designed electrode excels conventionally used ***-catalysis of water with Ln^(3+)-doped Ta_(2)O_(5) material indicates its capacity for H_(2) production with the lowest overpotential and Tafel slope values of 148 and 121.2 mV/dec,while the O_(2) generation is comparatively *** the stable electrochemical output,this rare earth modified material has the potential to replace conventionally used environmentally perilous and costly materials.

关键词： Lanthanide doping Rare earth materials Perovskite solar cells Supercapacitors Water splitting

5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

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Oncology Research 2024年第6期32卷 1047-1061页

作者： KIMBERLY FENECH isaac MICALLEF BYRON BARON Centre for Molecular Medicine and Biobanking University of MaltaMsidaMSD 2080Malta Department of Tumor Genetics and Biology Graduate School of Medical SciencesFaculty of Life SciencesKumamoto UniversityKumamoto860-8556Japan

Background:Colorectal cancer(CRC)is one of the most frequently diagnosed *** many cases,the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil(5-FU).The epithelial-to-mesenchymal transition(EMT)and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many *** study looked into the effect of 5-FU dose escalation on EMT and protein methylation in *** and Methods:HCT-116,Caco-2,and DLD-1 CRC cell lines were exposed to dose escalation treatment of *** motility and invasive potentials of the cells before and after treatment with 5-FU were investigated through wound healing and invasion *** was followed by aWestern blot which analyzed the protein expressions of the epithelial marker E-cadherin,mesenchymal marker vimentin,and the EMT transcription factor(EMTTF),the snail family transcriptional repressor 1(Snail)in the parental and desensitized *** blotting was also conducted to study the protein expressions of the protein methyltransferases(PMTs),Euchromatic histone lysine methyltransferase 2(EHMT2/G9A),protein arginine methyltransferase(PRMT5),and SET domain containing 7/9(SETD7/9)along with the global lysine and arginine methylation ***:The dose escalation method generated 5-FU desensitized CRC cells with distinct morphological features and increased tolerance to high doses of *** 5-FU desensitized cells experienced a decrease in migration and invasion when compared to the parental *** was reflected in the observed reduction in E-cadherin,vimentin,and Snail in the desensitized cell ***,the protein expressions of EHMT2/G9A,PRMT5,and SETD7/9 also decreased in the desensitized cells and global protein lysine and arginine methylation became dysregulated with 5-FU ***:This study showed that continuous,dose-escalation treatment of 5-FU in CRC cells generated 5-FU

关键词： Chemoresistance Epithelial-to-mesenchymal transition Protein methylation Protein methyltransferases

Large porewater exchange reshapes saltmarsh carbon and greenhouse gas budgets on local and global scales

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Science China Earth Sciences 2024年第7期67卷 2195-2209页

作者： Xiaogang CHEN isaac RSANTOS Lucheng ZHAN Yu Yan YAU Yan ZHANG Ling LI Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China Department of Marine Sciences University of GothenburgGothenburg 41319Sweden College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210024China

Saltmarshes are carbon-rich ecosystems that play a role in climate regulation by efficiently sequestrating atmospheric CO_(2).Climate change is a major threat to saltmarshes and will impact saltmarsh carbon ***,porewater-derived carbon outwelling emerges as a crucial pathway for carbon sequestration,but it has been largely overlooked in ***,we assessed the drivers of dissolved carbon exports and greenhouse gas emissions in a saltmarsh and placed those observations into a global *** our study site,porewater exchange(PEX)was the major process controlling dissolved carbon and greenhouse gas *** our results with 33 other studies in saltmarshes worldwide,porewater-derived carbon fluxes were equivalent to~48% of average global saltmarsh primary productivity and 2.2 times greater than global organic carbon ***,our local observations and global upscaling demonstrate the major role played by PEX in saltmarsh carbon *** part of dissolved inorganic carbon returns to the atmosphere as CO_(2),the remaining bicarbonate fraction is stored in the ocean over long time *** findings strengthen global blue carbon assessments and build arguments for the use of saltmarshes as nature-based solutions for global climate change.

关键词： Coastal carbon Global carbon budget Carbon neutrality Nature-based solutions Coastal wetlands Submarine groundwater discharge

Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units

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Journal of Geriatric Cardiology 2020年第1期17卷 35-42页

作者： Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez isaac llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Hospital Unversitari Josep Trueta GironaSpain Hospital Universitari Germans Trias i Pujol Badalona BarcelonaSpain Hospital de la Santa Creu i Sant Pau Instituto de Investigación Biomedica IIB Sant PauUniversitat Autonoma de Barcelona(UAB)BarcelonaSpain Hospital Universitari de la Vall d’Hebron BarcelonaSpain Hospital Clinic i Provicial BarcelonaSpain Hospital Arnau de Vilanova LleidaSpain Hospital Joan XXIII TarragonaSpain the Grup de Treball de Cures Agudes Cardiologiques de la Societat Catalana de Cardiologia

Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical *** All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively *** was defined as hemoglobin<130 g/L in men and<120 g/L in *** association between anemia and mortality or readmission at six months was assessed by the Cox regression *** A total of 629 patients were *** age was 66.6 years.A total of 197 patients(31.3%)had *** angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score *** with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement *** ICCU and hospital stay were significantly longer in patients with *** the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had *** patients underwent coronary *** was independently associated to poorer outcomes at 6 months.

关键词： Acute coronary syndromes Anemia Intensive cardiac care units Prognosis

Optimization of gas lift system for well performance improvement in Asmari formation:A techno-economic perspective

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Petroleum Research 2024年第1期9卷 115-124页

作者： Hari Sreenivasan Jash Patel Dev Jain Setu Patel isaac Wilson Shanker Krishna Drilling Cementing&Stimulation(DCS)Research CentreDepartment of Petroleum EngineeringSchool of Energy Technology(SoET)Pandit Deendayal Energy University(PDEU)Knowledge CorridorRaysanGandhinagarGujarat382426India

Well productivity in the Asmari carbonate formation of southwest Iran has decreased in recent years as a result of production *** production rate must be maintained below 1500 STB/day to prevent water *** this study,a gas lift well is modeled using data from one of the producing wells of this *** analysis is performed using lift-gas injection rates and wellhead pressures at different reservoir pressures and water cut conditions to optimize *** aspects are considered to optimize the artificial gas injection rates at different tubing head pressures and water cut *** the lift-gas injection rate from 0.4 MMscf/day to 1 MMscf/day enhances the oil production rate by 37.71%and 43.89%for 10%and 30%water cut conditions,*** injection rates of 5.2 MMscf/day and 5.4 MMscf/day are determined to be economically optimal for 30%water cut with tubing head pressures of 260 psig and 270 psig,respectively.

关键词： Production enhancement Artificial lift Gas lift Asmari carbonate formation Techno-economic analysis Well productivity

DeepRice: A deep learning and deep feature based classification of Rice leaf disease subtypes

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Artificial Intelligence in Agriculture 2024年第1期11卷 34-49页

作者： P.isaac Ritharson Kumudha Raimond X.Anitha Mary Jennifer Eunice Robert Andrew J Department of CSE Karunya Institute of Technology and Sciences CoimbatoreTamilnaduIndia Department of Robotics Engineering Karunya Institute of Technology and SciencesCoimbatoreIndia Department of Mechatronics Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Computer Science and Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India

Rice stands as a crucial staple food globally,with its enduring sustainability hinging on the prompt detection of rice leaf ***,efficiently detecting diseases when they have already occurred holds paramount importance for solving the cost of manual visual identification and chemical *** the recent past,the identification of leaf pathologies in crops predominantly relies on manual methods using specialized equipment,which proves to be time-consuming and *** study offers a remedy by harnessing Deep Learning(DL)and transfer learning techniques to accurately identify and classify rice leaf diseases.A comprehensive dataset comprising 5932 self-generated images of rice leaves was assembled along with the benchmark datasets,categorized into 9 classes irrespective of the extent of disease spread across the *** classes encompass diverse states including healthy leaves,mild and severe blight,mild and severe tungro,mild and severe blast,as well as mild and severe brown *** meticulous manual labelling and dataset segmentation,which was validated by horticulture experts,data augmentation strategies were implemented to amplify the number of *** datasets were subjected to evaluation using the proposed tailored Convolutional Neural Networks *** performance are scrutinized in conjunction with alternative transfer learning approaches like VGG16,Xception,ResNet50,DenseNet121,Inception ResnetV2,and Inception *** effectiveness of the proposed custom VGG16 model was gauged by its capacity to generalize to unseen images,yielding an exceptional accuracy of 99.94%,surpassing the benchmarks set by existing state-of-the-art ***,the layer wise feature extraction is also visualized as the interpretable AI.

关键词： Rice leaf disease Deep learning CNN Crop yield Agriculture Food security