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Blackberry jam fruit(Randia formosa(Jacq.)***):An Amazon superfruit with in vitro neuroprotective properties

Food Bioscience 2022年第6期50卷 944-953页

作者： Giovanna Nascimento de Mello e Silva Edson Silvio Batista Rodrigues isaac yves lopes de macêdo Henric Pietro Vicente Gil Hericles Mesquita Campos Paulo César Ghedini Lidya Cardozo da Silva Erica Aparecida Batista Giovanna lopes de Araújo Boniek Gontijo Vaz Tânia Aparecida Pinto de Castro Ferreira Renê Oliveira do Couto Eric de Souza Gil LAFAM – Laboratory for Pharmaceutical and Environmental Analysis Faculdade de FarmáciaUniversidade Federal de GoiásGoiâniaGoiásBrazil DFar – Pharmacology department Instituto de Ciências BiológicasUniversidade Federal de GoiásGoiâniaGoiásBrazil LaCEM – Laboratory of Chromatography and Mass Spectometry Instituto de QuímicaUniversidade Federal de GoiásGoiâniaGoiásBrazil LANAL – Laboratory of Nutrition and Food Analysis Faculdade de NutriçãoUniversidade Federal de GoiásGoiâniaGoiásBrazil Universidade Federal de São João del-Rei (UFSJ) Campus Centro-Oeste Dona Lindu (CCO)DivinópolisMinas GeraisBrazil

We report on the bromatological profile,the preliminary phytochemical composition,the antioxidant capacity,and the in vitro neuroprotective effects of Blackberry Jam *** were the major macronutrients(20 g/100 g)in both pulp and seeds(36.5 g/100g),that also possess a low lipid content(0.1 g/100 g and 0.7 g/100,and 86 Kcal/100 g,respectively).Eleven compounds including a diterpenoid dimmer,a lactone,coumarins,sphingosines,and flavonoids have been identified for the first time in the pulp and seeds of *** by mass *** electrochemical index of the hydroalcoholic extract of the pulp(BJFp respectively)and an appreciable energy value(89 Kcal/100 g)was around 6.8μA/V and two reversible cathode peaks were observed up to 0.5 V,thus shedding light to its antioxidant capacity,which was also evidenced by the DPPH•and ABTS+radical scavenging assays(IC50 of 3.30±0.23μg/mL and 18.17±1.21μg/mL,respectively).The BJFp protected against oxidative stress in vitro by significantly decreasing both the lipid peroxidation and contents of carbonyl proteins in a dose-dependent manner in murine brain cells treated with ***,the BJFp increased the superoxide dismutase(EC50 of 11.99±0.35μg/mL)and catalase(EC50 of 69.53±0.43μg/mL)*** BJFp markedly decreased both the in vitro acetylcholinesterase(IC50 of 227.9±0.34μg/mL)and butyrylcholinesterase(IC50 of 8.77±0.40μg/mL)***,besides being a great source of energy,this Amazon superfruit may be promising for enhancing the treatment outcomes of ailments related to oxidative stress,which require further in vivo investigation.

关键词： Antioxidants Cholinesterase inhibitors Electrochemistry Functional foods Phenolic compounds

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African eggplant(Solanum anguivi Lam.)fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca^(2+)-induced mitochondrial swelling

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 757-766页

作者： Olusola Olalekan Elekofehinti Jean Paul Kamdem Aline Augusti Bolingon Margareth Linde Athayde Seeger Rodrigo lopes Emily Pansera Waczuk Ige Joseph Kade isaac Gbadura Adanlawo Joao Batista Teixeira Rocha department of Biochemistry Adekunle Ajasin UniversityAkungbaOndo StateNigeria Postgraduate Programme in Biochemical Toxicology Department of ChemistryCCNE.Federal University of Santa Maria.Campus CamobiSanta MariaRS.97105-900Brazil Postgraduate Programme in Pharmaceutical Sciences Federal University of Santa MariaCampus CamohiSanta MariaRS97105-900.Brazil Toxicologia de Produtos Naturais e Sinteticos.Universidade Federal do Pampa CEP 97500-970 UruguaianaRSBrazil department of Biochemistry Federal University of TechnologyAkureOndo StateNigeria department of Biochemistry University of Ado EkitiEkiti State.Nigeria

Objective:To evaluate the antioxidant and radical scavenging activities of Solanum anguivi fruit(SAG)and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential(△Ψ_m)isolated from rat ***:Antioxidant activity of SAG was assayed by using 2,2-diphenyl-1-picrylhydrazyl(DPPH),reducing power,iron chelation and ability to inhibit lipid peroxidation in both liver and brain homogenate of ***,the effect of SAG on mitochondrial membrane potential and mitochondrial swelling were *** and quantification of bioactive polyphenolics was done by ***:SAG exhibited potent and concentration dependent free radical-scavenging activity(IC_(50)/DPPH=275.03±7.8μg/mL).Reductive and iron chelation abilities also increase with increase in SAG *** also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative *** protected against Ca^(2+)(110μmol/L)-induced mitochondrial swelling and maintained the△Ψ_*** analysis revealed the presence of gallic acid[(17.54±0.04)mg/g],chlorogenic acid(21.90±0.02 mg/g),caffeic acid(16.64±0.01 mg/g).rutin[(14.71±0.03)mg/g]and quercetin[(7.39±0.05)mg/g].Conclusions:These effects could be attributed to the bioactive polyphenolic compounds present in the *** results suggest that SAG extract is a potential source of natural antioxidants that may be used not only in pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress.

关键词： Solanum anguivi fruit Antioxidant activity Oxidative stress Mitochondrial swelling HPLC Polyphenolic compounds MPTP

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Evaluation of Sleep Quality in Undergraduated Medical Students

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Journal of Behavioral and Brain Science 2024年第10期14卷 265-275页

作者： isaac Filipe Melo de Freitas Poliana Pinheiro Pascoal Rafaela Cruz Sampaio Carla Maria de Lima Barbosa João Pedro Palmeira lopes Diêgo Lucas Ramos e Silva Gabriel Arthur Gomes Cavalcante Milton Vieira Costa Euclides Mauricio Trindade Filho department of Physiological Sciences State University of Health Sciences of Alagoas Macei Brazil University Center CESmac Macei Brazil Uninassau Faculty Arapiraca Brazil

Objective: The aim of this study was to evaluate the sleep quality of medical students to identify the main factors that affect sleep patterns. Methods: According to the methodology, 154 students participated in the research, attending from the first to the sixth year of the course. The Pittsburg Sleep Quality Index questionnaire and the Epworth sleepiness scale were applied. descriptive statistics techniques were applied and demonstrated in the form of tables and graphs. The comparison of variables was carried out using statistical tests. Results: The results showed that most students do not sleep very well. It was observed that 68.83% of a total of 106 students are bad sleepers. Conclusion: It is concluded that medical students sleep a low number of hours by period, which could interfere in impairment of attention, learning and memory formation, interfering in academic performance. On the other hand, they showed greater daytime sleepiness compared to the general population.

关键词： Sleep Quality Daytime Sleepiness Medical Students

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