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An in vitro Anti-urolithiasis Activity of a Herbal Formulation:Spinacia oleracea *** Coriandrum sativum L.

Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 76-84页

作者： Sumathy Raj Monica Shree Gnana Soundara Rajan Suganthi Ramasamy Rimal isaac Rajamony Suthies Goldy Ramathilaga Ariyamuthu Monisha Sudhagar Sakthivel Gandhi Prakash Shoba Manikandan Gurusamy School of Biotechnology Dr.G.R.Damodaran College of ScienceCoimbatoreTamil NaduIndia Department of Biotechnology Dr.N.G.P Arts and Science CollegeCoimbatoreTamil NaduIndia Department of Nanotechnology Noorul Islam Centre for Higher EducationKumaracoilThuckalayKanyakumari DistrictTamil NaduIndia PG and Research Department of Biochemistry Kongunadu Arts and Science CollegeCoimbatoreTamil NaduIndia Department of Biological and Chemical Engineering Mekelle UniversityMekelleEthipoia Department of Zoology Holy Cross College(Autonomous)NagercoilTamilnaduIndia Department of Pharmaceutical Sciences Tshwane University of TechnologyArcadia CampusPretoriaSouth Africa

Background:Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones.A complicated chain of physicochemical events,including hyper saturation,nucleation,growth,aggrega-tion,and retention in the urinary tract,leads to urolithiasis,the third most prevalent urinary tract *** traditional medications and therapies are less successful in treating urolithiasis and frequently cause ***:The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from Spinacia oleracea *** Coriandrum sativum ***:To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from *** and *** seeds against oxalate crystals by employing an in vitro inhibition,aggregation,and nucleation assay,employing a spectrophotometer followed by microscopic observation,and further monitored by egg semiperme-able membrane model,using cystone as a standard ***:In the present work,the alkaloids,glycosides,flavonoids,glycosides,phenols,saponins,steroids,tannins,terpenoids,and triterpenoids were found in the extracts of *** and *** in vitro assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation,growth and *** aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization ***:It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.

关键词： Urolithiasis Polyherbal Egg membrane Spinacia oleracea Coriandrum sativum

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Publisher’s Erratum to:Metamaterial-based graphene thermal emitter

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Nano Research 2024年第6期17卷 5753-5753页

作者： Cheng Shi Nathan H.Mahlmeister isaac J.Luxmoore Geoffrey R.Nash College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeterEX44QFUK

The article"Metamaterial-based graphene thermal emitter",written by Cheng Shi,Nathan ***,***,and Geoffrey ***,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on December 6th 2017 without open *** the author(s)’decision to opt for Open Choice the copyright of the article changed in February 2018 to©The Author(s)2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License(http://***/licenses/by/4.0/),which permits use,duplication,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license and indicate if changes were *** original article has been corrected.

关键词： emitter license creative

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Assessment of Past and Future Land Use/Land Cover Dynamics of the Old Kumasi Metropolitan Assembly and Atwima Nwabiagya Municipal Area, Ghana

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Journal of Geoscience and Environment Protection 2023年第3期11卷 44-69页

作者： Addo Koranteng Bernard fosu Frimpong isaac Adu-Poku Jack Nti Asamoah Tomasz Zawiła-Niedźwiecki Kumasi Technical University Institute of Research Innovation and Development Kumasi Ghana Department of Hydrology Brandenburg University of Technology Cottbus Germany Kwame Nkrumah University of Science and Technology Geomatic Engineering Department Kumasi Ghana Kumasi Technical University Department of Civil Engineering Faculty of Engineering and Technology Kumasi Ghana Coordination Centre for Environmental Projects Warszawa Poland

Ghana like all countries in Sub-Saharan region of Africa have long been undergoing intense land use land cover changes (LULCC) which have given rise to extensive forest loss (deforestation and degradation), loss of arable land and land degradation. This study assessed the past LULCC in the Atwima Nwabiagya which contains the Barekese and Owabi Headworks) and the old Kumasi Local Assemblies’ areas in Ghana and projected the scenario in 2040 for business-as-usual (BAU). The synergies of satellite imagery of 1990, 2000, 2010 and 2020 were classified with an overall accuracy of 90%. Markov Cellular-Automata method was used to forecast the future LULC pattern after detecting main driving forces of LULCC. The findings showed an extensive increase in built up areas from 11% in 1990 to 39% in 2020 owing largely to 23% decrease in forest cover and 6% decrease in agricultural lands within the past 30 years (1990-2020). The projected LULC under the BAU scenario for 2040 showed built-up surge from 39% to 45% indicating additional forest loss from 43% in 2020 to 40% and decreasing agricultural land from 17% to 14%. The main driver for the LULCC is clearly anthropogenic driven as the human population in the study area keeps rising every censual year. This study exemplifies the fast-tracked forest loss, loss of arable land and challenges on ecosystem sustainability of the Barekese-Owabi-Kumasi landscape. The current and projected maps necessitate the apt implementation of suitable interventions such as reforestation, protection measures and policy decision in deliberate land use planning to mitigate further loss of forest cover and safeguard the Barekese and Owabi headworks.

关键词： Forest Loss Random Forest Classifier Change Detection Urbanization Markov-Cellular Automata

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Lipopolysaccharide mouse models for Parkinson's disease research:a critical appraisal

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Neural Regeneration Research 2022年第11期17卷 2413-2417页

作者： isaac Deng Larisa Bobrovskaya Health and Biomedical Innovation Clinical and Health SciencesUniversity of South AustraliaAdelaideAustralia

Parkinson's disease,the most common movement disorder,has a strong neuroinflammatory *** is evident by increased pro-inflammatory cytokines in the serum,and the presence of activated microglial cells,and inflammatory cytokines in the substantia nigra of post-mortem brains as well as cerebrospinal fluid of Parkinson's disease *** central and peripheral neuroinflammatory aspects of Parkinson's disease can be investigated in vivo via administration of the inflammagen lipopolysaccharide,a component of the cell wall of gram-negative *** this mini-review,we will critically evaluate different routes of lipopolysaccharide administration(including intranasal systemic and ste reotasic),their relevance to clinical Parkinson's disease as well as the recent findings in lipopolysaccharide mouse *** will also share our own expe riences with systemic and intrastriatal lipopolysaccharide models in C57BL/6 mice and will discuss the usefulness of lipopolysaccharide mouse models for future research in the field.

关键词： C57BL/6 mice intranasal models lipopolysaccharide models neuroinflammation Parkinson's disease stereotaxic models substantia nigra systemic models

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Urbanization and Other Land Use Land Cover Change Assessment in the Greater Kumasi Area of Ghana

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Journal of Geoscience and Environment Protection 2023年第5期11卷 363-383页

作者： Addo Koranteng isaac Adu-Poku Bernard fosu Frimpong Jack Nti Asamoah John Agyei Tomasz Zawiła-Niedźwiecki Institute of Research Innovation and Development Kumasi Technical University Kumasi Ghana Geomatic Engineering Department Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Hydrology Brandenburg University of Technology Cottbus Germany Department of Civil Engineering Faculty of Engineering and Technology Kumasi Technical University Kumasi Ghana Coordination Centre for Environmental Projects Warszawa Poland

Urbanization posits the expression of urban expanse expansion due to population growth, rise in built-up areas, high population density and its correspondingly urban way of life. Unrestrained impetus of development and land use land cover change (LULCC) portent several issues such as unlawful urban sprawl, loss of agricultural land, forest loss and other associated complications. This study analyzed the dynamics of urbanization and other LULCC in Ghana’s Greater Kumasi area via Landsat images (TM 1986, OLI 2013 and OLI 2023) using ERDAS Imagine, Idrisi and ArcGIS software. Implementing supervised classification technique, the Maximum Likelihood Classifier (MLC) procedure was employed to categories the study area into five LULC classes. Accuracy assessment undertaken on the resultant LULC maps was deemed very satisfactory. The results from 1986-2023 pointed to an upsurge in a built-up extent as of 8% to 41%, a decrease in Closed Forest from 9% to 4%, another decrease in Open Forests from 64% to 33%, a slight increase from 16% to 20% in farmlands and a stable level of water share. Further analysis indicated that the study area had undergone LULCC within the periods 1986-2013 and 2013-2023 at 60% and 37% respectively. The findings showed uncontrolled urban sprawling along major roads and forest loss as deforestation outside protected areas and degradation in protected forest. The monitoring of urbanization and other LULCC is important for local, and national governments and other bodies charged with the implementation of programs and policies that manage and utilize natural resources. Development adapts to mitigate the effect on the environment.

关键词： Urbanization Maximum Likelihood Classifier (MLC) Urban Sprawl Change Detection Forest Loss

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Anthropogenic land use substantially increases riverine CO_(2) emissions

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Journal of Environmental Sciences 2022年第8期34卷 158-170页

作者： Shijie Gu Siyue Li isaac R.Santos School of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Key Laboratory of Reservoir Aquatic Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing School University of Chinese Academy of SciencesChongqing 400714China Research Center for Environmental Ecology and Engineering Institute of Changjiang Water Environment and Ecological SecuritySchool of Environmental Ecology and Biological EngineeringKey Laboratory for Green Chemical Process of Ministry of EducationKey Laboratory of Novel Reactor and Green Chemical Technology of Hubei ProvinceEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationWuhan Institute of TechnologyWuhan 430205China Department of Marine Sciences University of GothenburgGothenburg 41296Sweden National Marine Science Centre Southern Cross UniversityCoffs HarbourNSW 2450Australia

Carbon dioxide(CO_(2)) emissions from inland waters to the atmosphere are a pivotal component of the global carbon budget. Anthropogenic land use can influence riverine CO_(2) emissions, but empirical data exploring cause-effect relationships remain limited. Here, we investigated CO_(2) partial pressures(pCO_(2)) and degassing in a monsoonal river(Yue River)within the Han River draining to the Yangtze in China. Almost 90% of river samples were supersaturated in CO_(2) with a mean ± standard deviation of 1474 ± 1614 μatm, leading to emissions of 557-971 mmol/m^(2)/day from river water to the atmosphere. Annual CO_(2) emissions were 1.6-2.8 times greater than the longitudinal exports of riverine dissolved inorganic and organic carbon. pCO_(2) was positively correlated to anthropogenic land use(urban and farmland), and negatively correlated to forest cover. p CO_(2) also had significant and positive relationships with total dissolved nitrogen and total dissolved phosphorus. Stepwise multiple regression models were developed to predict p CO_(2) . Farmland and urban land released nutrients and organic matter to the river system, driving riverine p CO_(2) enrichment due to enhanced respiration in these heterotrophic rivers. Overall, we show the crucial role of land use driving riverine pCO_(2) , which should be considered in future large-scale estimates of CO_(2) emissions from streams. Land use change can thus modify the carbon balance of urban-river systems by enhancing river emissions, and reforestation helps carbon neutral in rivers.

关键词： River carbon Inland waters Greenhouse gases Climate change Water quality Headwater streams

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Laboratory investigation into the use of soundless chemical demolitions agents for the breakage of hard rock

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International Journal of Coal Science & Technology 2022年第5期9卷 71-80页

作者： Kelly‑Meriam Habib isaac Vennes Hani Mitri Department of Mining and Material Engineering McGill UniversityMontrealCanada

The method of drilling and blasting with explosives is widely used in rock fragmentation applications in the mining industry for mine development and ore ***,the use of explosives is associated with rigorous safety and environmental constraints as blasting creates toxic fumes,ground vibrations,and *** study is focused on the use of Soundless Chemical Demolition Agents(SCDA)as a more environmentally friendly method for rock breakage and a potential replacement of *** this paper,the results of a series of experimental tests are reported to identify the efect of SCDA on hard rock breakage under no load and under uniaxial loading *** granite prismatic specimens of 152.4 mm(6″)×152.4–203.2 mm(6–8″)×406.4 mm(16″)are used to test the infuence of borehole size on the time to fracturing with SCDA borehole size of 25.4 mm(1″),31.75 mm(1.25″)and 38.1 mm(1.5″).It is shown that the fracturing time decreases with increasing borehole *** is also shown that specimens subjected to uniaxial compression of 5 MPa fracture as early as 7 h after SCDA mixing.A borehole spacing to borehole diameter ratio of 12.8 to 14.6 is suggested for practical applications.

关键词： Explosive-free Hard rock fragmentation Soundless chemical demolition agents Uniaxial loading

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Assessment of Ti-6Al-4V particles as a reinforcement for AZ31 magnesium alloy-based composites to boost ductility incorporated through friction stir processing

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Journal of Magnesium and Alloys 2022年第4期10卷 979-992页

作者： isaac Dinaharan Shuai Zhang Gaoqiang Chen Qingyu Shi IDM-Joint Lab Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China The State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Poor ductility is the primary concern of magnesium matrix composites(MMCs)inflicted by non-deformable ceramic particle *** particles which melt at elevated temperature can be used as reinforcement to improve the deformation ***-6Al-4V particles reinforced AZ31 MMCs were produced through friction stir processing(FSP)which was carried out in a traditional vertical milling *** microstructural features as well as the response to external tensile load were explored.A homogenous distribution of Ti-6Al-4V was achieved at every part of the stir *** was no chemical decomposition of ***,Ti-6Al-4V did not react with Al and Zn present in AZ31 alloy to form new compounds.A continuous strong interface was obtained around Ti-6Al-4V particle with the ***-6Al-4V particles underwent breakage during processing due to severe plastic *** was a remarkable refinement of grains in the composite caused by dynamic recrystallization in addition to the pinning of smaller size broken *** dislocations were observed in the matrix because of plastic deformation and the associated strain ***-6Al-4V particles improved the tensile behavior and assisted to obtain appreciable deformation before *** mode of failure was avoided.

关键词： Magnesium matrix composite Friction stir processing Ti-6Al-4V Microstructure Tensile strength

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Exponential Continuous Non-Parametric Neural Identifier With Predefined Convergence Velocity

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 1049-1060页

作者： Mariana Ballesteros Rita Q.Fuentes-Aguilar isaac Chairez Instituto Politécnico Nacional Centro de Innovación y Desarrollo Tecnológico en Cómputo Unidad Profesional Interdisciplinaria de Biotecnología 07340Mexico CityMexico Tecnológico de Monterrey School of Engineering and SciencesZapopanJalisco 45138Mexico Department of Bioprocesses UPIBIInstituto Politécnico Nacional07340Mexico City

This paper addresses the design of an exponential function-based learning law for artificial neural networks(ANNs)with continuous *** ANN structure is used to obtain a non-parametric model of systems with uncertainties,which are described by a set of nonlinear ordinary differential *** novel adaptive algorithms with predefined exponential convergence rate adjust the weights of the *** first algorithm includes an adaptive gain depending on the identification error which accelerated the convergence of the weights and promotes a faster convergence between the states of the uncertain system and the trajectories of the neural *** second approach uses a time-dependent sigmoidal gain that forces the convergence of the identification error to an invariant set characterized by an *** generalized volume of this ellipsoid depends on the upper bounds of uncertainties,perturbations and modeling *** application of the invariant ellipsoid method yields to obtain an algorithm to reduce the volume of the convergence region for the identification *** adaptive algorithms are derived from the application of a non-standard exponential dependent function and an associated controlled Lyapunov *** examples demonstrate the improvements enforced by the algorithms introduced in this study by comparing the convergence settings concerning classical schemes with non-exponential continuous learning *** proposed identifiers overcome the results of the classical identifier achieving a faster convergence to an invariant set of smaller dimensions.

关键词： Exponential Lyapunov functions learning laws non-parametric identifier predefined convergence rate

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Methodology for the estimation of expansive cement borehole pressure

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International Journal of Mining Science and Technology 2023年第1期33卷 73-81页

作者： Kelly-Meriam Habib isaac Vennes Hani S.Mitri Department of Mining and Materials Engineering McGill UniversityMontreal H3A 0E8Canada

This work is part of a multi-phase project which aims to develop a sound methodology for rock fragmen-tation in underground mines using expansive *** specifically,it is the first phase of the project which focuses on laboratory tests to investigate the mechanical performance of expansive cement,also known as soundless chemical demolition agents(SCDA).This paper reports the results of laboratory tests conducted on instrumented thick-walled cylinders filled with expansive *** pressure evo-lution and temperature variation with time are first examined for different borehole *** clas-sical analytical method for expansive pressure estimation is validated with direct pressure measurement using high-capacity pressure sensor,and an empirical model is obtained.A new methodology based on iterative procedure is developed using axisymmetric finite element modelling and test results to derive the modulus of elasticity of the expansive cement at peak *** results of this study show that the expansive pressure increases with borehole diameter when the rigidity of the steel cylinder is constant reaching 83 MPa for a 38.1 mm *** is also shown that the expansive pressure decreases signif-icantly with increased cylinder rigidity for the same borehole *** newly developed methodol-ogy revealed that the modulus of elasticity of expansive cement at peak pressure is estimated at 8.2 GPa.A discussion on the extension of the findings of this work to hard rock mining applications is presented.

关键词： Rock fragmentation Soundless chemicaldemolitionagents Expansive cement

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