检索结果-南通市图书馆

Dexmedetomidine Causes Increased Hypotension in Older Adults When Used for Cataract Surgery Compared to Propofol

Open Journal of Anesthesiology 2013年第4期3卷 237-242页

作者： irwin gratz Smith Jean Edward Deal Erin Pukenas Elaine Allen Marc C. Torjman Department of Anesthesiology Cooper Medical School at Rowan University Cooper University Hospital Camden USA Department of Anesthesiology Cooper Medical School at Rowan University Cooper University Hospital Camden USA Department of Epidemiology & Biostatistics University of California at San Francisco San Francisco USA.

Purpose: This study evaluated the hemodynamic effects, suitability and safety of dexmedetomidine (DEX) compared with propofol (PRO) in older adults having outpatient cataract surgery under monitored anesthesia care. The patients, surgeon and the anesthesia staff evaluated satisfaction for both ***: This prospective, single blind, randomized study was conducted using forty-seven patients ≥55 years old undergoing cataract surgery. The two patient groups received either i.v. dexmedetomidine 1 μg/kg over 10 min;followed by maintenance i.v. infusion at 0.2 -0.7 μg/kg/hr (DEX group, N = 24), or propofol infused between 25 -120 μg/kg/min (PRO group, N = 23). Both agents were titrated to patient comfort. Results: Patients’ mean arterial pressures (SEM) at baseline were 104.7 (2.6) and 107.5 (2.7) mmHg for the DEX and PRO groups, respectively (p = 0.45). At discharge the pressures were 78.1 (2.5) and 98.1 (2.6) mmHg in DEX and PRO groups, respectively (p 0.05). Patients’ heart rates (SEM) at baseline were 74.8 (3.0) for the DEX group and 73.2 (2.8) bpm for the PRO groups (p = 0.71). At the time of discharge following surgery, the mean heart rate for the DEX group was 61.5 (2.2) bpm vs. 69.1 (2.3) bpm (p 0.05) for the PRO group. Three patients in the DEX group developed complications precluding discharge or requiring readmission while none of the patience in the PRO group had complications (p = 0.08). Patient and surgeon satisfaction scores were similar between the groups. Conclusion: Dexmedetomidine is a less suitable sedative compared with propofol use in older patients undergoing cataract surgery due to the decrease in hemodynamic parameters and noted increases in complication rates.

关键词： Cataract Surgery Dexmedetomidine Monitored Anesthesia Care Propofol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

学术英语解述中的学科身份构建——语言宗源关系视角

引用

外语研究 2024年第4期41卷 31-35,49页

作者：刘宁 Derek irwin 北京理工大学(珠海)中美国际学院广东珠海519000 宁波诺丁汉大学人文与社会科学学院浙江宁波315000

本文以学术英语教材中的解述为例,运用系统功能语言学宗源性理论及分析方法,从学科身份构建维度对其进行重新解读。研究发现解述语言在小句层内存在编码和解码两种过程,在不同级阶间存在组合和拆解两种实现方式。基于这一发现,本文提出... 详细信息

本文以学术英语教材中的解述为例,运用系统功能语言学宗源性理论及分析方法,从学科身份构建维度对其进行重新解读。研究发现解述语言在小句层内存在编码和解码两种过程,在不同级阶间存在组合和拆解两种实现方式。基于这一发现,本文提出解述具有双重特点,一方面将源引文献中的部分信息进行一般化,另一方面将其中部分信息进行专业化。这一转化的目的是为了适应不同学术共同体的学科身份期待。上述发现表明,学术英语解述具有学科身份构建的资源潜力,并可为学术英语教学提供参考。

关键词：学术英语学科身份解述语言宗源关系理论

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Duplication and diversification of insulin genes in ray-finned fish

引用

Zoological Research 2019年第3期40卷 185-197页

作者： David M.irwin Department of Laboratory Medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in *** is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store *** also has additional functions in regulating *** work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these *** of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish *** two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in ***,a duplicate copy of the insa gene,which I named insab,is found in many *** coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide ***,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin Teleost fish Gene duplicati on Adaptive evolution Gene loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Basic Engineering Circuit Analysis J. David irwin, Chwan-Hua Wu 6th ed.

Basic Engineering Circuit Analysis J. David Irwin, Chwan-Hua...

引用

1999年

作者： J. David irwin Chwan-Hua Wu

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Penile revascularization--contemporary update

引用

Asian Journal of Andrology 2013年第1期15卷 5-9页

作者： Brian Dicks Martin Bastuba irwin Goldstein rwin Goldstein 1San Diego Sexual Medicine San Diego CA 92120 USA Male Fertility Sexual Medicine Specialists San Diego CA 92120 USA

Contemporary therapies for erectile dysfunction are generally targeted towards older men and universally engage pharmacological and/ or device related treatment options. Penile revascularization, using microvascular arterial bypass surgical techniques, is a non-pharmacological, non-device-related, and reconstructive surgical strategy for men with erectile dysfunction that was first described by Dr Vaclav Michal in 1973.

关键词： erectile dysfunction microvascular arterial bypass surgery penile revascularization traumatic arterial occlusive disease vascular reconstructive surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats

引用

Acta Pharmacologica Sinica 2005年第05期26卷 546-550页

作者： Michael G irwin Tak-ming WONG Department of Anesthesiology Department of Physiology the University of Hong Kong Hong Kong China

Aim:To examine whether the protective effect of remifentanil preconditioning（RPC）on postischemic hearts is mediated by protein kinase（PKC）activation incomparison with ischemic preconditioning（IPC）.Methods:Male Sprague-Dawleyrats were anesthetized and their chests were *** experiment was per-formed with chelerythrine（CHE,2mg/kg）,GF109203X（0.05 mg/kg）protein kinaseC（PKC）inhibitors administered before RPC(remifentanil 6μ***-1·min-1×3 cycle)orIPC,*** size（IS）,as a percentage of the area at risk（AAR）,wasdetermined by triphenyltetrazolium ***:In groups subjected to IPCand RPC the IS/AAR were significantly reduced（IS/AAR from 52.7%±5.5% to12.9%±3.4%,P0.05 vs CON）or IPC（CHE+IPC 53.7%±4.3%,GF+IPC54.1%±6.2%,P>0.05 vs CON）.The difference was not significant in any of thehemodynamic parameters between control and treatment groups during ischemiaand ***:Remifentanil confers myocardial protection againstischemic injury through a mechanism that is similar to IPC and involves PKCactivation.

关键词： remifentanil myocardial ischemia preconditioning myocardial reperfusion injury protein kinase C chelerythrine GF109203X

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Genomic organization and evolution of ruminant lysozyme c genes

引用

Zoological Research 2015年第1期36卷 1-17页

作者： David M.irwin Department of Laboratory Medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Ruminant stomach lysozyme is a long established model of adaptive gene evolution. Evolution of stomach lysozyme function required changes in the site of expression of the lysozyme c gene and changes in the enzymatic properties of the enzyme. In ruminant mammals, these changes were associated with a change in the size of the lysozyme c gene family. The recent release of near complete genome sequences from several ruminant species allows a more complete examination of the evolution and diversification of the lysozyme c gene family. Here we characterize the size of the lysozyme c gene family in extant ruminants and demonstrate that their pecoran ruminant ancestor had a family of at least 10 lysozyme c genes, which included at least two pseudogenes. Evolutionary analysis of the ruminant lysozyme c gene sequences demonstrate that each of the four exons of the lysozyme c gene has a unique evolutionary history, indicating that they participated independently in concerted evolution. These analyses also show that episodic changes in the evolutionary constraints on the protein sequences occurred, with lysozyme c genes expressed in the abomasum of the stomach of extant ruminant species showing the greatest levels of selective constraints.

关键词： lysozyme ruminant evolutionary Genomic extant stomach genomic constraints Ailuropoda duplication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene duplication plays a major role in gene co-option: Studies into the evolution of the motilin/ghrelin family and their receptors

引用

Chinese Science Bulletin 2011年第25期56卷 2690-2697页

作者： HE Jing irwin M. DAVID ZHANG YaPing State Key Laboratory of Genetic Resource and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Department of Laboratory Medicine and Pathobiology and Banting and Best Diabetes Centre University of Toronto Toronto M5S1A1 Canada Laboratory for Conservation and Utilization ofBioresource Yunnan University Kunming 650091 China

Extant genes can be modified, or 'tinkered with', to provide new roles or new characteristics of these genes. At the genetic level, this often involves gene duplication and specialization of the resulting genes into particular functions. We investigate how ligand-receptor partnerships evolve after gene duplication. While significant work has been conducted in this area, the examination of additional models should help us better understand the proposed models and potentially reveal novel evolutionary patterns and dynamics. We use bioinformatics, comparative genomics and phylogenetic analyses to show that preproghrelin and prepromotilin descended from a common ancestor and that a gene duplication generated these two genes shortly after the divergence of amphibians and amniotes. The evolutionary history of the receptor family differs from that of their cognate ligands. GPR39 diverges first, and an ancestral receptor gives rise to receptors classified as fish-specific clade A, GHSR and MLNR by successive gene duplications occurring before the divergence of tetrapods and ray-finned fish. The ghrelin/GHSR system is maintained and functionally conserved from fish to mammals. Motilin-MLNR specificity must have arisen by ligand-receptor coevolution after the MLN hormone gene diverged from the GHRL gene in the amniote lineage. Conserved molecular machinery can give rise to new neuroendocrine response mechanisms by the co-option of duplicated genes. Gene duplication is both parsimonious and creative in producing elements for evolutionary tinkering and plays a major role in gene co-option, thus aiding the evolution of greater biological complexity.

关键词：基因重复生长素胃动素受体选项演变家庭进化模式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alzheimer's disease: the silver tsunami of the 21^(st) century

引用

Neural Regeneration Research 2016年第5期11卷 693-697页

作者： Ankita Sarkar Madison irwin Aditi Singh Matthew Riccetti Amit Singh Department of Biology University of Dayton Department of Biological Science University of Pittsburgh Premedical Program University of Dayton Center for Tissue Regeneration and Engineering at Dayton (TREND) University of Dayton

Alzheimer＇s disease（AD）, a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42（Aβ42） plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to（i） study etiology of disease,（ii） look for genetic modifiers, and（iii） identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer＇s disease.

关键词： Alzheimer's disease neurodegeneration amyloid plaques amyloid hypothesis animal models drosophila melanogaster drosophila eye

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adiponectin:mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning

引用

Frontiers of Medicine 2013年第3期7卷 301-305页

作者： Tingting Wang Shanglong Yao Zhengyuan Xia Michael G.irwin Department of Anesthesiology and Critical Care Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Anesthesiology The University of Hong KongHong Kong SARChina

Systemic inflammatory response following myocardial ischemia-reperfusion injury(IRI)to a specific organ may cause *** post-conditioning(IPostC)has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical *** of endogenous nitric oxide(NO)is one of the major mechanisms by which IPostC confers ***,the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is ***(APN)is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory *** levels of APN are decreased in obese subjects and in patients with type 2 *** supplementation has been shown to increase NO production and attenuate myocardial IRI in normal(non-diabetic)***,the effect of APN on myocardial injury in diabetic subjects,especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been *** the current paper,we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in *** review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.

关键词： adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：