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Nano Research 2016年第4期9卷 1022-1031页

作者： sheng Liang yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo yuan irvin s.y. chen Wei chen Hui Wang Linqi shi Xinyuan Zhu yunfeng Lu Department of Nuclear Medicine Xinhua HospitalAffiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University Shanghai 200092 China Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles CA 90095 USA Collaborative Innovation Center of Chemical science and Engineering (Tianjin) Key Laboratory of Functional Polymer Materials of Ministry of Education and State Key Laboratory of Medicinal Chemical Biology Institute of Polymer Chemistry Nankai University Tianjin 30007 I China school of Chemistry and Chemical Engineering ShanghaiJiao Tong University Shanghai 200240 China school of Materials science and Engineering Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China Beiiina Institute ofBiatechnoloav. Beiiina 100071. China

Protein therap34 wherein therapeutic proteins are delivered to treat disorders, is considered the safest and most direct approach for treating diseases. However, its applications are highly limited by the paucity of efficient strategies for delivering proteins and the rapid clearance of therapeutic proteins in vivo after their administration. Here, we demonstrate a novel strategy that can significantly prolong the circulation time of therapeutic proteins as well as minimize their immunogenicity. This is achieved by encapsulating individual protein molecules with a thin layer of crosslinked phosphorylcholine polymer that resists protein adsorption. Through extensive cellular studies, we demonstrate that the crosslinked phosphorylcholine polymer shell effectively prevents the encapsulated protein from being phagocytosed by macrophages, which play an essential role in the clearance of nanoparfides in vivo. Moreover, the polymer shell prevents the encapsulated protein from being identified by immune cells. As a result, immune responses against the therapeutic protein are effectively suppressed. This work describes a feasible method to prolong the circulation time and reduce the immunogenicity of therapeutic proteins, which may promote the development and application of novel protein therapies in the treatment of diverse diseases.

关键词： protein nanocapsule,protein delivery,protein therapy long-circulation,stealth therapeutic

Over 100-THz bandwidth selective difference frequency generation at LaAlO_(3)/srTiO_(3) nanojunctions

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Light(science & Applications) 2019年第1期8卷 968-974页

作者： Lu chen Erin sutton Hyungwoo Lee Jung-Woo Lee Jianan Li Chang-Beom Eom Patrick irvin Jeremy Levy Department of Physics and Astronomy University of PittsburghPittsburghPA 15260USA Pittsburgh Quantum Institute PittsburghPA 15260USA Department of Materials science and Engineering University of Wisconsin-MadisonMadisonWA 53706USA

The ability to combine continuously tunable narrow-band terahertz(THz)generation that can access both the farinfrared and mid-infrared regimes with nanometer-scale spatial resolution is highly promising for identifying underlying light-matter interactions and realizing selective control of rotational or vibrational resonances in nanoparticles or ***,we report selective difference frequency generation with over 100 THz bandwidth via femtosecond optical pulse *** THz emission is generated at nanoscale junctions at the interface of LaAlO_(3)/srTiO_(3)(LAO/sTO)that is defined by conductive atomic force microscope lithography,with the potential to perform THz spectroscopy on individual nanoparticles or *** simulation of the time-domain signal facilitates the identification of components that contribute to the THz *** ultra-wide-bandwidth tunable nanoscale coherent THz source transforms the LAO/sTO interface into a promising platform for integrated lab-on-chip optoelectronic devices with various functionalities.

关键词： tunable lithography selective

Comparison of hepatitis C virus testing recommendations in high-income countries

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World Journal of Hepatology 2018年第10期10卷 743-751页

作者： Risha irvin Kathleen Ward Tracy Agee Noele P Nelson Claudia Vellozzi David L Thomas Alexander J Millman Division of Infectious Diseases Johns Hopkins University School of Medicine Division of Viral Hepatitis Centers for Disease Control and Prevention

AIM To investigate hepatitis C virus(HCV) testing recommendations from the United states and other high-income *** A comprehensive search for current HCV testing recommendations from the top quartile of United Nations Human Development Index(HDI) countries(very high HDI) was performed using Google and reviewed from May 1-October 30, 2014 and re-reviewed April 1-October 2, 2017. REsULTs Of the 51 countries identified, 16 had HCV testing recom-mendations from a government body or recommendations issued collaboratively between a government and a medical organization. Of these 16 countries, 15 had HCV testing recommendations that were primarily risk-based and highlight behaviors, exposures, and conditions that are associated with HCV transmission in that region. In addition to risk-based testing, the HCV Guidance Panel(United states) incorporates recommendations for aone-time test for individuals born during 1945-1965(the birth cohort) without prior ascertainment of risk into their guidance. In addition to the United states, six other countries either have an age-based testing recommendation or recommend one-time testing for all adults independent of risk factors typical of the region. CONCLUsION This review affirmed the similarities of the HCV Guidance Panel's guidance with those of recommendations from very high HDI countries.

关键词： Hepatitis C Testing Recommendations Mass screening Guidelines

Robotic pendant drop:containerless liquid for μs-resolved,AI-executable XPCs

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Light(science & Applications) 2023年第9期12卷 1857-1866页

作者： Doga yamac Ozgulbas Don Jensen Jr. Rory Butler Rafael Vescovi Ian T.Foster Michael irvin yasukazu Nakaye Miaoqi Chu Eric M.Dufresne soenke seifert Gyorgy Babnigg Arvind Ramanathan Qingteng Zhang Data science and Learning Division Argonne National LaboratoryLemontIL 60439USA X-ray science Division Argonne National LaboratoryLemontIL 60439USA Departement of Computer science University of Chicago5801 S Ellis AveChicagoIL 60637USA XRD Design and Engineering Department Rigaku Corporation 3-9-12 Matsubara-choAkishima-shiTokyo 196-8666Japan Bioscience Division Argonne National LaboratoryLemontIL 60439USA

The dynamics and structure of mixed phases in a complex fluid can significantly impact its material properties,such as ***-angle X-ray Photon Correlation spectroscopy(sA-XPCs)can probe the spontaneous spatial fluctuations of the mixed phases under various in situ environments over wide spatiotemporal ranges(10−6–103 s/10−10–10−6 m).Tailored material design,however,requires searching through a massive number of sample compositions and experimental parameters,which is beyond the bandwidth of the current coherent X-ray *** 3.7-μs-resolved XPCs synchronized with the clock frequency at the Advanced Photon source,we demonstrated the consistency between the Brownian dynamics of~100 nm diameter colloidal silica nanoparticles measured from an enclosed pendant drop and a sealed *** electronic pipette can also be mounted on a robotic arm to access different stock solutions and create complex fluids with highly-repeatable and precisely controlled composition *** closed-loop,AI-executable protocol is applicable to light scattering techniques regardless of the light wavelength and optical coherence,and is a first step towards high-throughput,autonomous material discovery.

关键词： resolved sealed mounted

神经内分泌肿瘤68Ga-DOTATATE显像新观点:图像解读、体内分布、辐射内照射剂量及分子机制

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中华核医学与分子影像杂志 2019年第8期39卷 504-512页

作者：胡桂兰庞芮(译) 霍力(审校) Lisa Bodei Valentina Ambrosini Ken Herrmann irvin Modlin 首都医科大学附属北京世纪坛医院核医学科 100038 中国医学科学院、北京协和医学院北京协和医院核医学科、核医学分子靶向诊疗北京市重点实验室 100730 Molecular Imaging and Therapy service Department of RadiologyMemorial Sloan Kettering Cancer CenterNew YorkNew York Nuclear Medicine Department of Experimental Diagnostic and Specialized MedicineUniversity of Bologna and S.Orsola-Malpighi HospitalBolognaItaly Department of Molecular and Medical Pharmacology David Geffen School of Medicine at UCLALos AngelesCalifornia Klinik für Nuklearmedizin Universitatsklinikum EssenEssenGermany yale University school of Medicine Department of SurgeryNew HavenConnecticut

利用68Ga-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)PET/CT显像对表达生长抑素受体(ssTR)的肿瘤进行定位,就必须将图像信息有效地与患者诊疗过程相结合,包括临床病史、组织病理学、生物... 详细信息

利用68Ga-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)PET/CT显像对表达生长抑素受体(ssTR)的肿瘤进行定位,就必须将图像信息有效地与患者诊疗过程相结合,包括临床病史、组织病理学、生物标志物、肿瘤分期和分级以及已知的影像学检查结果,另外还要考虑到患者已完成的治疗及检查对68Ga-DOTATATE图像的影响(如影响正常生理性分布并导致假阳性结果)。该文针对68Ga-DOTATATE PET/CT显像在图像采集、分析、神经内分泌肿瘤诊断方案及治疗中的价值提供指导意见。

关键词：内分泌神经内分泌肿瘤学肽 68Ga-DOTATATE 生物分布

HPV DNA检测在细胞学AGC处理中的有效性

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 16-17页

作者： irvin W. Evans s.R. Andersen W. 朱晓明 Division of Gynecologic Oncology Box 800712 University of Virginia Health System Charlottesville VA 22908 United States Dr.

Objective: Given the demonstrated utility of human papilloma virus DNA triage in the management of atypical squamous cells of undetermined significance, this study sought to evaluate the potential role of human papilloma virus DNA testing in the evaluation and management of cytological atypical glandular cells. study design: Following institutional review board approval, 28 women presenting with cytological atypical glandular cells underwent repeat thin-prep cytology, Hybrid Capture 2 human papilloma virus DNA testing, colposcopic evaluation, Fisher electrosurgical conization, and endometrial sampling. Human papilloma virus test results in each patient were then correlated with histologic lesions, if present. Results: sixteen of the 28 study patients had pathologic lesions (11/28 high-grade squamous intraepithelial lesion, 3/28 low-grade squamous intraepithelial lesion, 1/28 adenocarcinoma in situ, 1/28 simple endometrial hyperplasia). Human papilloma virus DNA testing was available in 24 of 28 subjects (86% ). The sensitivity of human papilloma virus positivity to predict the presence of cervical intraepithelial neoplasia was 100% (confidence interval 77% to 100% ), specificity 64% (confidence interval 35% to 85% ), positive predictive value 76% , and negative predictive value 100% . Women who tested human papilloma virus positive were 12 times more likely to have cervical intraepithelial neoplasia than women who were human papilloma virus negative (Fisher Ps positivity was not predictive of endometrial pathology; women who were human papilloma virus positive were less likely to have endometrial pathology than were women who were human papilloma virus negative (risk ratio 1.6, 95% confidence interval 0.01- 1.7). Conclusion: Atypical glandular cells can represent a variety of lesions. The majority of the lesions will be squamous intraepithelial lesions of the cervix (50% ), with high-grade squamous intraepithelial lesion present in 40% of

关键词：细胞学诊断 HPV DNA检测 AGC DNA 鳞状上皮内病变宫颈锥切子宫内膜人乳头瘤病毒原位腺癌阴道镜检

A comparative, randomized study of levonorgestrel Intrauterine system (LNG-IUs) vs Copper T 380 A intrauterine device applied during cesarean section

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 151-155页

作者： José A. López-Farfan Alicia Hernandez-Gonzalez irvin J. Vélez-Machorro Leopoldo A. Vázquez-Estrada Department of Obstetrics and Gynecology Regional Hospital of Puebla Mexican Institute of Social Security Puebla City Mexico Hospital Angeles Lindavista Mexico City Mexico

Objective: To assess levonorgestrel-releasing intrauterine system LNG-IUs (Mirena?) application at caesarean section (Cs). Design: Randomized, comparative study. setting: Department of obstetrics and gynecology in a primary reference hospital at Puebla City, Mexico. sample: 396 women requiring Cs signed informed consent and were randomly allocated to the post-placental application of LNG-IUs (198) or Copper T 380 A (198). Methods: Follow up visits at 6 weeks, and 6 and 12 months were performed. Main Outcomes Measures: IUDs expulsion, maternal and babies’ health conditions, breastfeeding and menstrual patterns, adverse effects and pregnancies. Differences between groups were analyzed by Fisher and X2 tests, Odds ratios, relative risk and 95% confidence limits, as appropriate. Results: After one year of follow up, no pregnancies were reported. The IUD expulsion rate was 4.5% in each group. LNG-IUs users had a higher incidence of amenorrhea (OR 2.5 95% CI 2.2 - 3) and menstrual patterns significantly brief and lighter than Copper T 380 A (p ysmenorrhea (OR 0.1 95% CI 0.04 - 0.2). No detrimental effects of LNG-IUs on breastfeeding was observed and interestingly babies weights of LNG-IUs users was slightly above the average for age compared with Copper T 380 A users. This was probably related with a major proportion of women with normal ferritin serum levels (94% vs 68%) leading to better mother’s general condition. Conclusions: LNG-IUs inserted during Cs provides high efficacy contraception with additional benefits, mainly reducing menstrual bleeding and doing so, faster recovery of ferrous homeostasis after Cs.

关键词： Levonorgestrel-Releasing Intrauterine system Medicated IUD Copper T IUD Cesarean section Postpartum Contraception Ferritin Levels

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森林郑州中心

Diet-Induced Alteration of the Murine Intestinal Microbiome Following Antibiotic Ablation

城市环境设计 2023年第2期 206-209页

作者：张堇盈王典唐晓棠宋和贞 Andrew irvin 贾城杨秉鑫杨佩琛 Malgorzata Mutkowska Bernardo Taliani 李秋橙 Larade Pedro 陈相宇马瑞君陈洋扬苏禹竹张妍顾嘉诚 Erin chen Lisa chen 杨新越谢博宇周原仰郑丽丽辛海鸥洪明月

中原地区是华夏文明的摇篮。6世纪末,位于此地的郑州古城逐渐成为重要城市之一。如今的郑州快速崛起,成为河南省的政治与经济中心,不懈地试图在未来图景中重塑昔日形象。由如恩设计的郑州中心大楼位于城市一处待开发区域。在这座城市中...

中原地区是华夏文明的摇篮。6世纪末,位于此地的郑州古城逐渐成为重要城市之一。如今的郑州快速崛起,成为河南省的政治与经济中心,不懈地试图在未来图景中重塑昔日形象。由如恩设计的郑州中心大楼位于城市一处待开发区域。在这座城市中,文化遗产与现代化发展之间充斥着各样的矛盾。郑州的历史古迹,如城墙和要塞塔楼,其建造形式和材料与这片土地密切相关。而如今的郑州规划了新的城市中心,并用大片的玻璃塔楼群向天空示意,

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Advances in Microbiology 2017年第7期7卷 545-564页

作者： Adam irvin Andrew Cockburn Donald A. Primerano Jim Denvir Goran Boskovic Aniello M. Infante Gary D. Wu Christopher F. Cuff Department of Microbiology Immunology and Cell Biology Robert C. Byrd Health Sciences Center West Virginia University Morgantown WV USA Department of Biomedical sciences Robert C. Byrd Biotechnology Science Center Joan C. Edwards School of Medicine Marshall University Huntington WV USA Department of Biostatistics Robert C. Byrd Health Sciences Center West Virginia University Morgantown WV USA Division of Gastroenterology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

Mouse models of antibiotic-induced ablation of the intestinal microbiome have been used to study the microbiome in health and disease. The fecal microbiomes of mice treated with broad-spectrum antibiotics while being fed different laboratory chows were analyzed by Gram stain, quantitative flow cytometry, bacterial cell culture, next generation sequencing of the V3 regions of the 16s ribosomal RNA (rRNA) gene, microscopy, and sequence analysis of the tuf gene. Noncultivatable gram-positive cocci and cultivatable yeast were the microorganisms most readily detected in feces of antibiotic-treated mice fed a defined diet that utilizes casein as a protein source, maltodextrin 10 and sucrose as sources of carbohydrates, and lard as the major source of fat. High-throughput sequencing of the variable regions of the 16s rRNA gene and tuf gene sequencing identified the major bacterial phylotype as Lactococcus. The mouse chow was heavily laden with noncultivatable Lactococcus, which dominated the intestinal flora after consumption. The microbiome of antibiotic-treated mice fed a grain-based diet (mainly wheat, corn and alfalfa) consisted predominantly of a member of the Enterobacteriaceae identified as Escherichia coli, and yeast was not detected by culture or Gram stain. Appearance of intestinal yeast by culture and Gram stain was dependent on the specific chow, although yeast was not detected by culture or Gram stain in the chow. We conclude that bacteria found in food sources can influence qualitative and quantitative assessments of the fecal microbiome, at least in the context of antibiotic therapy, and potentially confound molecular studies that assess the effects of diet on the intestinal ecology. Not surprisingly, different food sources can influence the microbiome, particularly in the context of antibiotic-mediated ablation of the intestinal microbiome. Whether and how the food-derived dead bacteria alter intestinal physiology needs to be determined.

关键词： Mouse Intestinal Microbiome Antibiotics Diet Lactococcus