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Cognitive disorder and dementia in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第4期13卷 319-337页

作者： Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih irma E Velázquez-Brizuela Department of Philosophical and Methodological Disciplines University Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Neurology Movement Disorders ClinicSub-Specialty Medical UnitNational Western Medical CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico University Biomedical Research Center University of ColimaColima 28040Mexico Department of Medical and Life Sciences University Center of‘La Ciénega’University of GuadalajaraOcotlán 47810JaliscoMexico Department of Chemistry University Center of Exact Sciences and EngineeringUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico Gerontology Postgraduate Program Public Health DepartmentUniversity Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico

Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and *** the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative *** the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are *** and animal model studies suggest that memory improvements are due to changes in insulin ***,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis ***, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, a

关键词： Alzheimer´s disease Diabetes mellitus Insulin Vascular dementia Cognitive decline

Knowledge of coronavirus disease 2019(COVID-19) among healthcare providers: A cross-sectional study in Indonesia

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Asian Pacific Journal of Tropical Medicine 2020年第9期13卷 402-408页

作者： Kurnia Fitri Jamil Wira Winardi Amanda Yufika Samsul Anwar Nurfanida Librianty Nyoman Ananda Putri Prashanti Tri Novita Wulan Sari Prattama Santoso Utomo Theresia Dwiamelia Putu Pangestu Cendra Natha Salwiyadi Salwiyadi Febrivan Wahyu Asrizal Ikram Ikram irma Wulandari Sotianingsih Haryanto Nice Fenobileri Abram L.Wagner Mudatsir Mudatsir Harapan Harapan Department of Internal Medicine School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia Medical Research Unit School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia Tropical Disease Centre School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia Department of Pulmonology and Respiratory Medicine School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia Department of Family Medicine School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia Department of Statistics Faculty of Mathematics and Natural SciencesUniversitas Syiah KualaBanda AcehAcehIndonesia Department of Environmental Health Faculty of Public HealthUniversitas IndonesiaDepokWest JavaIndonesia Bangli Hospital BangliBaliIndonesia Sungai Dareh Hospital DharmasrayaWest SumatraIndonesia Department of Medical Education and Bioethics Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Panti Rahayu Hospital KarangmojoYogyakartaIndonesia Department of Internal Medicine Faculty of MedicineUniversitas UdayanaDenpasarBaliIndonesia Department of Internal Medicine Sanglah HospitalDenpasarBaliIndonesia Department of Internal Medicine Dr.Zainoel Abidin HospitalBanda AcehAcehIndonesia M Natsir Hospital SolokWest SumatraIndonesia Dr H Yuliddin Away Hospital TapaktuanAcehIndonesia M.Hatta Brain Hospital BukittinggiWest SumatraIndonesia Raden Mattaher Hospital JambiJambiIndonesia Faculty of Medicine and Medical Sciences Jambi UniversityJambiJambiIndonesia Pariaman Hostiptal PariamanWest SumatraIndonesia Department of Epidemiology University of MichiganAnn ArborMichiganUSA Department of Microbiology School of MedicineUniversitas Syiah KualaBanda AcehAcehIndonesia

Objective:To assess healthcare workers’knowledge of novel coronavirus disease 2019(COVID-19)in the early phase of the outbreak in ***:A cross-sectional survey was conducted in 12 hospitals in Indonesia from March 6 to March 25,*** workers’knowledge on COVID-19 was assessed,and demographic data,workplace characteristics,and medical professional characteristics as well as the current local situation of COVID-19 were *** characterize determinants associated with knowledge,a logistic regression analysis was ***:Out of 288 healthcare workers who completed the interview-assisted questionnaire,149(51.7%)respondents had a good *** and other types of healthcare workers had lower odds of having good knowledge compared to doctors:adjusted odds ratio(aO R):0.38;95%CI:0.20-0.72 and aO R:0.31;95%CI:0.13-0.73,*** to healthcare workers who had medical practice experience less than 5 years,those who had worked for more than 10 years had lower knowledge(a OR:0.43;95%CI:0.20-0.90).Healthcare workers who worked in the infection department had higher knowledge compared to those in the emergency room(aO R:14.33;95%CI:3.67-55.88).Conclusions:The knowledge of COVID-19 among surveyed healthcare workers was relatively *** COVID-19 response in Indonesia will require further education and enhancement of the capacity of healthcare workers in the emergency room where COVID-19 patients may be treated the earliest.

关键词： COVID-19 Knowledge Healthcare provider Indonesia

Phenotypical Aspects of a Familial Syndromic Retinitis Pigmentosa

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Sensory denervation with capsaicin reduces ovarian follicular development and delays the onset of puberty in guinea pigs

Open Journal of Ophthalmology（眼科学期刊） 2024年第2期 168页

作者： irma Eneida Dos Santos Joseph Matar Mass Ndiaye Mariama Diambone Badji Alioune Abdoulaye Ndongo Gerauld Akpo Jean Pierre Diagne Gabriel Karold Mendy Mouhamed Attye Aboubacry Sadikh Sow Elhadji Amadou Ba Paule Aida Ndoye Roth

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Advances in Reproductive Sciences 2013年第3期1卷 29-37页

作者： Victorino Alatriste irma Herrera-Camacho María I. Martínez Ilhicamina D. Limón Oscar González-Flores Félix Luna Centro de Investigación en Reproducción Animal UAT-CINVESTAV Tlaxcala México Centro de Química ICUAP Puebla México Departamento de Farmacia FCQ-BUAP Puebla México

Introduction: It has been documented that mammalian ovaries receive sympathetic, parasympathetic and sensory nerve fibers. The aim of this work was to investigate the effects of sensory denervation with capsaicin at the first vaginal opening (FVO) on follicular development and the expression of TRPV1 receptors in ovary cells as well as in the dorsal root ganglia (DRGs) and lumbar dorsal spinal cord neurons of guinea pigs. The DRGs and lumbar dorsal spinal cord neurons serve as a nerve connection from the ovaries to the CNS. Materials and Methods: Female guinea pigs received a subcutaneous injection of capsaicin (30 mM) at 10 days of age (P10), while control animals were injected with vehicle. Using light microscopy, we counted healthy preantral follicles (HPF), healthy antral follicles (HAF), atretic preantral follicles (APF), and atretic antral follicles (AAF) in the ovaries at the FVO, and the numbers of TRPV1-positive cells were counted in the ovarian follicles, DRGs, and lumbar dorsal spinal cord (L2-L4) neurons by immunohistochemistry. Results: Guinea pigs treated with capsaicin showed a significant delay of FVO in comparison with the control animals (36 vs. 44 days). In the ovaries, the number of preantral and antral follicles decreased significantly. Additionally, the number of TRPV1-positive thecainterstitial cells of the antral follicles was reduced significantly, and the number of TRPV1-positive neurons in the DRGs and lumbar dorsal spinal cord (L2-L4) decreased. Thus, we showed that TRPV1 receptors throughout the sensory fibers modulate ovarian follicular development and the onset of puberty in guinea pigs. Conclusion: Sensory denervation decreases ovarian follicular development and delays the onset of puberty of guinea pigs. Our data support the idea that through TRPV1 receptors, ovarian afferent fibers sense local stimuli that are sent to the CNS.

关键词： TRPV1 Receptors Capsaicin DRG Spinal Cord Ovary Guinea Pigs

Fatal Leptospirosis Case in Pediatric Patient: Clinical Case

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Open Journal of Medical Microbiology 2013年第1期3卷 12-17页

作者： Laura I. Santiago García Citlalli Martínez Cruz irma Zamudio Lugo Beatriz Rivas Sánchez Oscar Velasco Castrejón Joel Navarrete Espinosa Clinic of Tropical Medicine Unit of Experimental Medicine School of Medicine UNAM Mexico Coordination of Epidemiologic Surveillance Unit of Public Health IMSS Mexico City Mexico Division of Hospital Epidemiologic Children’s Hospital CMN Century XXI IMSS Mexico City Mexico

Introduction: Leptospirosis is a worldwide zoonosis. It is transmitted through the urine of infected animals. Currently, there is an increase of reports in many countries. In humans, it presents an ample clinical spectrum, which goes from an asymptomatic infection up to Weil syndrome, which is generally fatal. Clinical Case: A male, 6 years of age, who started with onset fever and jaundice, handled in private means, diagnosed as viral hepatitis “A” and was referred to an institutional hospital where hepatomegaly and splenomegaly were detected. His evolution was towards graveness and, therefore, he was referred to a third level hospital with reactive Hepatitis diagnosis and to rule out lymphoma. On admission, he presented liver and kidney failure, as well as metabolic acidosis and pulmonary haemorrhage that led to death 6 hours later. Confirmatory tests for hepatitis were negative;biopsies were taken post-mortem for Leptospira diagnosis, which were positive in liver and kidney. Conclusions: Leptospirosis is a disease that may be manifested in multiple ways. It is important the understanding of this disease by the physician to improve the diagnosis and, for general population, to avoid exposure. The examination of the epidemiological history of the patient is essential.

关键词： Leptospirosis Fatal Pediatric México

Temperature Effect on the Viscosity of Commercial Carrot Puree

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Journal of Food Science and Engineering 2017年第10期7卷 505-513页

作者： Vimes-Delgadillo Jorge-Octavio, Dominguez-Rendón Ana-Cristina López-del-Castillo-Lozano Micloth Dominguez-Cafiedo irma-Liliana Galán-Méndez Frixia Facultad de Ciencias Quimicas Universidad Veracruzana Lomas del Estadio S/N Xalapa Veracruz 91000 México

Temperature effect was evaluated over the viscosity of commercial carrot puree in the range 30 to 60 ℃, using aBrookfield viscometer, model 4535, Lab-Line instruments. In order to perform the viscosity tests, 28 specimens of carrot puree froma local market were used. Totally, 72 tests （each one with a couple replicas） were performed during five minutes, using fourtemperatures （30, 40, 50 and 60 ℃）, six shear rates （0.26, 0.52, 1.05, 2.09, 5.24 and 10.47 s1） and three spindles （4, 5 and 6）.Statistical analysis was performed using LSD and Duncan tests with a confidence interval of 95% （p value of 0.05）. In the currentstudy, it was observed that an increase in the temperature triggers a reduction in the viscosity of the carrot specimens analyzed,although the samples tested at 60℃ were deviated from this trend, which may be due to denaturation of the starch containing carrotsamples at such temperature. Multiple biochemical and micro-structural changes inside the food specimens may begin to occur belowand over the physiological range （20-45 ℃）. Experimental data were analyzed with Power Law model in order to obtain the bestfitted parameters as a function of shear rate： It was observed that the consistent index （k） decreased with an increment in thetemperature; while all the values of parameter ＂n＂ lesser than one, which means that the puree samples behaved as a pseudo-plasticfluid. Besides that, an Arrhenius model was used to fit the parameters as a function of temperature： Parameter A was lower usingtheexperimental data at shear rates of 10.47 s-1. The modeling performed may be helpful for the appropriate selection of some processvariables, as the shear rate and operation temperature, used for the production of carrot puree; all this is in order to obtain the finishedproduct with the desired consistency.

关键词： Food rheology, viscosity, temperature, carrot puree.

Evaluation of the Opuntia dillenii as Natural Coagulant in Water Clarification:Case of Treatment of Highly Turbid Surface Water

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Journal of Water Resource and Protection 2013年第12期5卷 1242-1246页

作者： Yewegnon Alima Esther irma Nougbode Cokou Pascal Agbangnan Alain Yaya Koudoro Comlan Achille Dedjiho Martin Pepin Aina Daouda Mama Dominique Codjo Koko Sohounhloue Laboratoire d’Hydrologie Appliquée(LHA) Facultédes Sciences et TechniquesUniversite d’Abomey-CalaviCotonouRépublique du Bénin Laboratoire d’Etude et de Recherche en Chimie Appliquée(LERCA) Ecole Polytechnique d’Abomey Calavi(EPAC)Universite d’Abomey-CalaviCotonouRépublique du Bénin

This study was performed in laboratory scale and consisted of the using of aqueous Opuntia dillenii solution for the clarification of very turbid surface water (Turbidities varying between 186 NTU and 418 NTU). This plant from Cactaceae family was used as a natural coagulant for the different clarification tests. The preliminary phytochemical Screening of the powder of this plant showed that it contains tanins, saponins and mucilages. Flocculation and coagulation tests showed that Opuntia dillenii can be used in highly turbid water treatment. The removal efficiency varied from 89% to 93% for the turbidity and suspended solids, and from 4% to 15% for the obvious color in water when we used the optimum values of this natural coagulant (1 mL to 10 mL). The successive addition of this natural coagulant and the lime, gave a better elimination of turbidity and suspended solids, and a good reduction for the color. The removal efficiency of the turbidity and suspended solids became more than 95% and the one of the color between 67% and 94%.

关键词： Natural Coagulant Opuntia dillenii Lime Phytochemical Screening Turbidity Suspended Solids

Ammonium Thiosulfate Ecological Viable Alternative to Replace Sodium Cyanide in Gold and Silver Dissolution Ores

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Journal of Environmental Science and Engineering(A) 2016年第5期5卷 223-229页

作者： Maria del Carmen Hernandez Maria del Carmen Avitia Heriberto Pena irma Leticia Gonzalez Nancy Veronica Torres Abdiel Rosaldo Felix[ Luis Miguel Rodriguez Laura Bibiana Hernandez Department of Chemical and Biochemical Engineering Technological Institute of Parral Chihuahua 33850 Mexico Department of Economic Administrative Department Technological Institute of Parral Chihuahua 33850 Mexico Department of Industrial Engineering Technological Institute of Parral Chihuahua 33850 Mexico Engineering and Independent Consultant Palma Triangular 108 San Jose de Pozo Bravo Aguascalientes 20126 Mexico

The southern region of the state of Chihuahua is mining by origin, as this has been proved ghost towns of Minas Nuevas, it is also called Villa Escobedo, Emerald and Blue. Minerals are nonrenewable resources. There are only reserves and waste deposited in tailings ponds of low-rade precious metals （gold and silver）. A conventional method for recovering gold and silver ore is low-grade cyanidation and the solvent consider toxic and highly dangerous for the flora, fauna, humans and the environment. The mechanism of cyanide poisoning is inhibition of cytochrome oxidase--an enzyme needed for cell respiration. Without compromising efficiency, sensitivity and cost of the process, the toxic solvent is replaced by a less aggressive one, which helps the environment, public and occupational health. （NH4）2S203 has no appreciable damage to conservative amounts, is a selective aqueous solvent for leaching gold and silver, easy to get and manipulate. This work is done in the Technological Institute of Parral in a low-grade ore from the southern region of the state of Chihuahua. This document has been enriched presented in the IMEC 2014, with the increase of series Ⅴ and Ⅵ.

关键词： Leaching cyanide ammonium thiosulfate.

Comparative Analysis of the Antioxidant and Free-Radical Scavenging Activities of Different Water-Soluble Extracts of Green, Black and Oolong Tea Samples

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Food and Nutrition Sciences 2014年第22期5卷 2157-2166页

作者： Jesús Tejero Sara Gayoso irma Caro Damián Cordoba-Diaz Javier Mateo José E. Basterrechea Tomás Girbés Pilar Jiménez Nutrició n y Bromatologí a Facultad de Medicina and CINAD (Centro de Investigaci&oacute n en Nutrició n Alimentaci&oacute n y Dietética Edificio Lucia-Parque Cientí fico) Universidad de Valladolid Valladolid Spain Farmacia y Tecnologí a Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Higiene de los Alimentos y Tecnologí a Facultad de Veterinaria Universidad de Le&oacute n Le&oacute n Spain

Extracts of 40 green, black or oolong high quality tea samples from China, Japan or India among others, have been prepared according to the manufacturer instructions and assayed for total polyphenols content using the Folin-Ciocalteu phenol reagent. In addition, the antioxidant activity was assessed by the CUPRAC method and the free-radical scavenging activity was determined using the antioxidant-promoting decay of the stable free-radical DPPH. Caffeine and the most important catechins were identified using RP-HPLC previously validated method. Results from this study suggest that teas, even though they content similar amounts of caffeine, differ considerably in polyphenolic content and therefore in antioxidant and free-radical scavenging activities, depending on the part of the plant used and the process applied to the material for the preparation of the final tea presentation. Correlations among Folin-Ciocalteau’s reactivity of tea samples, the neocuproine reactivity, the DPPH decolourization and the HPLC analysis suggest that the antioxidant activity is due essentially to polyphenolic compounds present in teas, mainly EGCG. The best extraction method of tea powder was the one indicated by dealers. In general, the richest samples belong to green teas and the poorest samples belong to the black teas.

关键词： Tea Polyphenols Antioxidants Free-Radical Scavenging