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Unilateral rNurr1-V5 transgene.expression in nigral dopamine.gic ne.rons mitigates bilateral ne.ropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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ne.ral Regene.ation Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon irma alicia martíne.-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Mine.va Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar daniel martine.-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogéne.is Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red MEdICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene.via ne.rotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral ne.ropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the ne.ative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine.hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine.hydroxylase-positive ramifications in the *** addition,tyrosine.hydroxylase-positive cells displayed less sene.cence markerβ-galactosidase and more ne.ron-cytoskeleton markerβIII-tubulin and brain-derived ne.rotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and ne.rotoxic astrocytes(positive to glial fibrillary acidic protein and complement compone.t 3)and increased ne.rotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene.expression in nigral dopamine.gic ne.rons mitigates bilateral ne.rodegene.ation(sene.cence and loss of ne.ron-cytoskeleton and tyrosine.hydroxylase-positive cells),ne.roinflammation(activated microglia,ne.rotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** ne.rotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene.therapy microglia motor deficits nanoparticles ne.rodegene.ation ne.roinflammation sene.cence α-synuclein aggregates

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Oxidative stress,the blood-brain barrier and ne.rodegene.ative diseases:The critical bene.icial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo irma Ares marta martíne. Bernardo Lopez-Torres María-Rosa martíne.-Larran aga Xu Wang Arturo Anadon María-Aranzazu martíne. National Reference Laboratory of Veterinary drug Residues(HZAU)and MAO Key Laboratory for detection of Veterinary drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awarene.s of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with ne.rodegene.ative diseases(Nds).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awarene.s of their potential for preventive and protective agents against Nds,as well as their abundant natural sources,gene.ally non-toxic nature,and ease of long-term *** review article examine. the role of oxidative stress in the development of Nds,explores the‘two-sidedne.s’of the blood-brain barrier(BBB)as a protective barrier to the ne.vous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of Nds using dietary antioxidants are discussed,and useful information on the prevention and treatment of Nds is provided.

关键词： dietary antioxidant supplements Oxidative stress Blood-brain barrier ne.rodegene.ative diseases Vitamins Carotenoids Flavonoids Polyphenols

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Lactase non-persistence and milk consumption in Estonia

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World Journal of Gastroenterology 2006年第45期12卷 7329-7331页

作者： Margus Lember Suvi Torniaine. mart Kull Riina Kallikorm Peeter Saadla Tarvo Rajasalu Hanna Komu irma Jrvel department of Internal Medicine University of Tartu Tartu Estonia department ofMedical Gene.ics University of Helsinki Helsinki Finland department of Medical Gene.ics University of Helsinki Helsinki Finland Laboratory of Molecular gene.ics Helsinki University Central Hospital Helsinki Finland

AIM： To define.the frequency of the cfr-13910 variant associated with lactase persistence/non-persistence trait and to analyze the milk consumption of lactase non- persistent subjects in Estonia. METHOdS： We genotyped 355 Estonians by polymerase chain reaction and direct sequencing, Milk consumption was analyzed by a questionnaire, specially developed to analyze milk consumption and abdominal complaints. RESULTS： The frequency of the genotype of the C/ C-13910 （lactase non-persistence） was found to be 24.8% in native Estonians. No other single nucleotide polymorphisms covering the region of 400 bp adjacent to the C/T-13910 variant were found. Lactase non- persistence subjects were found to consume less milk than lactase persistence subjects. CONCLUSION： The frequency of lactase non- persistence define. by the C/C-13910 genotype confirms the results of the previous studies based on indirect methods of determining hypolactasia, Milk consumption of lactase non-persistence subjects is consistent with previously reported figures of adult-type hypolactasia in Estonia, However, lactase non-persistence does not prevent the intake of milk in many adults.

关键词： Lactase persistence Milk Estonia

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Cerebral dopamine.ne.rotrophic factor transfection in dopamine.ne.rons using ne.rotensin-polyplex nanoparticles reverses 6-hydroxydopamine.induced nigrostriatal ne.rodegene.ation

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ne.ral Regene.ation Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla david Reyes-Corona Yazmin M.Flores-martine. Rasajna Nadella Michael J.Bannon Lourdes Escobedo Mine.va Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez irma A.martíne.-dávila Porfirio Nava daniel martine.-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia department of Pharmacology Wayne State University School of MedicineDetroitMIUSA departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de ne.ropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of ne.rotrophic factors in nigral dopamine.ne.rons is a promising approach to reverse ne.rodegene.ation of the nigrostriatal dopamine.system,a hallmark in Parkinson's *** human cerebral dopamine.ne.rotrophic factor(h CdNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CdNF expression in dopamine.ne.rons using the ne.rotensinpolyplex nanoparticle system reverses 6-hydroxydopamine.induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the ne.rotensin-polyplex nanoparticles containing the h CdNF gene.ranging in size from 20 to 150 nm,enabled the expression of a secretable h CdNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine.lesion resulted in detectable h CdNF in dopamine.ne.rons,whose levels remaine. constant throughout the study in the substantia nigra compacta and *** with the lesione. group,tyrosine.hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CdNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine.and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontane.us motor and non-motor behavior were ***-derived ne.rotrophic factor recovery in dopamine.ne.rons that also occurred suggests its participation in the ne.rotrophic *** findings support the potential of nanoparticle-mediated h CdNF gene.delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June.9,2019.

关键词： axonal growth brain-derived ne.rotrophic factor gene.delivery nanoparticles ne.ritogene.is ne.ronal cytoskeleton ne.roregene.ation ne.rorestoration ne.rotrophic therapy Parkinson's disease reinne.vation substantia nigra

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Sensory dene.vation with capsaicin reduces ovarian follicular development and delays the onset of puberty in guine. pigs

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Advances in Reproductive Sciences 2013年第3期1卷 29-37页

作者： Victorino Alatriste irma Herrera-Camacho María I. martíne. Ilhicamina d. Limón Oscar González-Flores Félix Luna Centro de Investigación en Reproducción Animal UAT-CINVESTAV Tlaxcala México Centro de Química ICUAP Puebla México departamento de Farmacia FCQ-BUAP Puebla México

Introduction: It has been documented that mammalian ovaries receive sympathetic, parasympathetic and sensory ne.ve fibers. The aim of this work was to investigate the effects of sensory dene.vation with capsaicin at the first vaginal opening (FVO) on follicular development and the expression of TRPV1 receptors in ovary cells as well as in the dorsal root ganglia (dRGs) and lumbar dorsal spinal cord ne.rons of guine. pigs. The dRGs and lumbar dorsal spinal cord ne.rons serve as a ne.ve conne.tion from the ovaries to the CNS. Materials and Methods: Female guine. pigs received a subcutane.us injection of capsaicin (30 mM) at 10 days of age (P10), while control animals were injected with vehicle. Using light microscopy, we counted healthy preantral follicles (HPF), healthy antral follicles (HAF), atretic preantral follicles (APF), and atretic antral follicles (AAF) in the ovaries at the FVO, and the numbers of TRPV1-positive cells were counted in the ovarian follicles, dRGs, and lumbar dorsal spinal cord (L2-L4) ne.rons by immunohistochemistry. Results: Guine. pigs treated with capsaicin showed a significant delay of FVO in comparison with the control animals (36 vs. 44 days). In the ovaries, the number of preantral and antral follicles decreased significantly. Additionally, the number of TRPV1-positive thecainterstitial cells of the antral follicles was reduced significantly, and the number of TRPV1-positive ne.rons in the dRGs and lumbar dorsal spinal cord (L2-L4) decreased. Thus, we showed that TRPV1 receptors throughout the sensory fibers modulate ovarian follicular development and the onset of puberty in guine. pigs. Conclusion: Sensory dene.vation decreases ovarian follicular development and delays the onset of puberty of guine. pigs. Our data support the idea that through TRPV1 receptors, ovarian afferent fibers sense local stimuli that are sent to the CNS.

关键词： TRPV1 Receptors Capsaicin dRG Spinal Cord Ovary Guine. Pigs

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Multinational Measles Outbreak in Post-Elimination Era,Involves Three Countries of North America and a European Country in a Short Transmission Chain

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World Journal of Vaccine. 2015年第2期5卷 79-87页

作者： Cuitláhuac Ruiz-Matus Lorena Suárez-Idueta Ilse Herbas-Rocha Jose Luis diaz-Ortega Edith Cruz-Ramírez Abraham Ramírez-Jurado irma Lopez-martíne. Jose Cruz Rodríguez-martíne. Jose Alberto díaz-Quinone. Gene.al directorate of Epidemiology Ministry of HealthMexico CityMexico National Center for Health of Children and Adolescents Ministry of HealthMexico CityMexico National Institute of Public Health Mexico CityMexico Institute for Epidemiological diagnosis and Reference Ministry of Health MexicoMexico CityMexico State Health Services Quintana RooMexico

Background: Four measles cases in Canada and one.in the United States are linked to international importation of measles in Playa del Carmen, Quintana Roo, Mexico. Objective: To describe characteristics of transmission and not spillover to local population in Mexico. Material and Methods: The outbreak investigation was based on active search of cases and in the rapid monitoring of vaccination coverage in children aged 1 - 7 years old. Laboratory confirmation by Enzyme-Linked Immunosorbent Assay (ELISA) and molecular detection by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) assay in throat swab and urine.were done. Results: One.transmission chain with three gene.ations of cases was identified. The primary case was a 9-year-old boy who was infected in Wales, UK. His sisters aged 7 and 15 years old respectively, were the first gene.ation of cases in Mexico. The second gene.ation was related to the imported cases, and affected two Canadian tourists and an American woman aged 39 years old. A third gene.ation occurred in Canada and affected an infant of 15 months of age and his sister aged 4 years old. The genotype d8 which was circulating in UK was identified in these patients. One.probable case was detected in Quintana Roo, but was discarded by laboratory testing. The coverage with at least one.dose of Measles-Mumps-Rubella (MMR) vaccine.ranged from 95% to 99.5%. Conclusion: International travelers with no history of vaccination are at risk of acquiring measles even in countries that have interrupted endemic transmission. The high immunization coverage of measles containing vaccine.could explain the absence of cases in Mexican population. Highlights: Multinational measles outbreak in a country without endemic transmission. The findings exhibit the importance of immunization in international travelers in the post-elimination era.

关键词： Measles Multinational Outbreak Transmission in Post-Elimination Era Genotype d8

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Fatal Leptospirosis Case in Pediatric Patient: Clinical Case

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Open Journal of Medical Microbiology 2013年第1期3卷 12-17页

作者： Laura I. Santiago García Citlalli martíne. Cruz irma Zamudio Lugo Beatriz Rivas Sánchez Oscar Velasco Castrejón Joel Navarrete Espinosa Clinic of Tropical Medicine Unit of Experimental Medicine School of Medicine UNAM Mexico Coordination of Epidemiologic Surveillance Unit of Public Health IMSS Mexico City Mexico division of Hospital Epidemiologic Children’s Hospital CMN Century XXI IMSS Mexico City Mexico

Introduction: Leptospirosis is a worldwide zoonosis. It is transmitted through the urine.of infected animals. Currently, there is an increase of reports in many countries. In humans, it presents an ample clinical spectrum, which goes from an asymptomatic infection up to Weil syndrome, which is gene.ally fatal. Clinical Case: A male, 6 years of age, who started with onset fever and jaundice, handled in private means, diagnosed as viral hepatitis “A” and was referred to an institutional hospital where hepatomegaly and splenomegaly were detected. His evolution was towards gravene.s and, therefore, he was referred to a third level hospital with reactive Hepatitis diagnosis and to rule out lymphoma. On admission, he presented liver and kidne. failure, as well as metabolic acidosis and pulmonary haemorrhage that led to death 6 hours later. Confirmatory tests for hepatitis were ne.ative;biopsies were taken post-mortem for Leptospira diagnosis, which were positive in liver and kidne.. Conclusions: Leptospirosis is a disease that may be manifested in multiple ways. It is important the understanding of this disease by the physician to improve the diagnosis and, for gene.al population, to avoid exposure. The examination of the epidemiological history of the patient is essential.

关键词： Leptospirosis Fatal Pediatric México

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Soil Carbon Storage in Experimental Forest Plantations with Tropical Species

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Open Journal of Forestry 2022年第1期12卷 1-18页

作者： Celia de La Mora-Orozco José Germán Flores Garnica irma Julieta González Acuña Juan de dios Benavides Solorio César S. Magaña martíne. Laura Izascum Pérez Valencia Instituto Nacional de Investigacione. Forestales Agrícolas y Pecuarias Tepatitlán México Instituto Nacional de Investigacione. Forestales Agrícolas y Pecuarias Guadalajara México Instituto Nacional de Investigacione. Forestales Agrícolas y Pecuarias Santiago Ixcuintla México Instituto Tecnológico José Mario Molina Pasquel y Henríquez Unidad Académica Arandas Arandas México

Forest ecosystems represent a third of the total organic carbon (TOC) stored in the soil. However, studies still ne.d to be carried out to gene.ate reliable information on its soil carbon storage potential in an experimental plantation. Therefore, the objective of this research was to determine.the storage of total organic carbon (TOC) in the soil in two experimental forest plantations with tropical species, located in the state of Nayarit, México. The research was carried out in two experimental plantations with tropical species, located at the Santiago Ixcuintla Experimental Field (CESIX) and at the El Verdine.o Experimental Site (SEEV). The established species are Swietenia macrophylla King (mahogany), Cedrela odorata L. (cedar) and Tabebuia rosea Bertoil (pink trumpet-tree). In addition, data from dasometric variables were used in order to define.if any of these variables had a similar variation to the soil TOC stock by species. The sampling was done.under a randomized block experimental design in each experimental forest plantation (CESIX and SEEV). Nine.composite samples were collected in the soil under the tree species at a depth of 0 - 30 cm, and 1.5 m distance from the tree. To determine.the soil TOC, an elemental analyzer with a thermal conductivity detector Thermo Scientific (Flash 2000) was used. The results showed that TOC presented mean values of 103.60 and 219.98 t·ha-1 at a depth of 0 - 30 cm in CESIX and SEEV respectively. The highest TOC was obtaine. in soil under mahogany;142.95 t·ha-1 in CESIX and 284.41 t·ha-1 in SEEV. The analysis of the differences in TOC between the two plantations was highly significant. In the analysis of the species, it showed a statistically significant difference (p defining that the soil unde

关键词： Carbon Sequestration dasometric Variables Tropical Trees

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