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Neuroimmunology and Neuroinflammation 2014年第1期1卷 82-88页

作者： iris Bertha Hovens Csaba Nyakas Regien Geertruida Schoemaker Department of Molecular Neurobiology University of Groningen9747 AGGroningenThe Netherlands Department of Brain Physiology Research Unit Semmelweis UniversityH-1085BudapestHungary Department of Cardiology University of Groningen9747 AGGroningenThe Netherlands

Aim:The aim was to validate a newly developed methodology of semi-automatic image analysis to analyze microglial morphology as marker for microglial activation in ionized calcium-binding adaptor protein-1(IBA-1)stained brain ***:The novel method was compared to currently used analysis methods,visual characterization of activation stage and optical density measurement,in brain sections of young and aged rats that had undergone surgery or remained naï***:The cell body to cell size ratio of microglia was strongly correlated to the visual characterization activation *** addition,we observed specific surgery and age-related changes in cell body size,size of the dendritic processes and cell body to cell size ***:The novel analysis method provides a sensitive marker for microglial activation in the rat brain,which is quick and easy to perform and provides additional information about microglial morphology.

关键词： Image analysis immunohistochemistry ionized calcium-binding adaptor protein-1 microglia neuroinflammation

Boosting Collaborative Project Alignment

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Journal of Mechanics Engineering and Automation 2012年第4期2卷 243-250页

作者： Kim Jansson iris Karvonen Martin Ollus Mikko Uoti VTT Technical Research Centre of Finland Espoo 02044 Finland

Managing a large-scale distributed engineering project needs skilled, motivated and committed personnel. Unified and aligned working methods are needed. Project alignment is the process of ensuring that key stakeholders share a common understanding of the project mission, goals, objectives, tactics, work processes and plans and have the required competences and skills. Based on current advances in the area of collaborative networked organizations, project management and Internet web 2.0 technologies, the authors have identified further needs and opportunities for development in the area of Collaborative Project Management. The Project Alignment Booster is a set of software services used to promote collaborative project management. The tool has been developed to suit industrial requirements in the area of large and complicated engineering project management, The paper reports the results of developing a toolkit to support collaborative project alignment.

关键词： Collaborative project management networked organizations software as a service intemet web 2.0.

Determining Sufficient Number of Imputations Using Variance of Imputation Variances: Data from 2012 NAMCS Physician Workflow Mail Survey

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Applied Mathematics 2014年第21期5卷 3421-3430页

作者： Qiyuan Pan Rong Wei iris Shimizu Eric Jamoom National Center for Health Statistics Centers for Disease Control and Prevention Hyattsville MD USA

How many imputations are sufficient in multiple imputations? The answer given by different researchers varies from as few as 2 - 3 to as many as hundreds. Perhaps no single number of imputations would fit all situations. In this study, η, the minimally sufficient number of imputations, was determined based on the relationship between m, the number of imputations, and ω, the standard error of imputation variances using the 2012 National Ambulatory Medical Care Survey (NAMCS) Physician Workflow mail survey. Five variables of various value ranges, variances, and missing data percentages were tested. For all variables tested, ω decreased as m increased. The m value above which the cost of further increase in m would outweigh the benefit of reducing ω was recognized as the η. This method has a potential to be used by anyone to determine η that fits his or her own data situation.

关键词： Multiple Imputation Sufficient Number of Imputations Hot-Deck Imputation

Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology

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World Journal of Gastroenterology 2020年第39期26卷 6037-6046页

作者： Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen iris D Nagtegaal Camiel Rosman Rachel S van der Post Department of Surgery Radboud Institute for Health SciencesRadboud University Medical CenterRadboud University Medical CenterNijmegen 6525 GANetherlands Department of Pathology Radboud Institute for Molecular Life SciencesRadboud University Medical CenterRadboud University Medical CenterNijmegen 6525 GANetherlands Department of Gastroenterology Oncology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands

BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is *** recognition of metastases is important to avoid futile locoregional ***,knowledge on metastatic patterns is necessary for further development of personalized treatment *** To gain insight into the metastatic pattern of gastroesophageal *** A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was *** patient with metastases were included for *** metastatic pattern was analyzed according to the primary tumor location and histological *** Metastatic disease was found in 268 esophageal and 331 gastric cancer *** esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal *** gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric *** This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype.

关键词： Esophageal cancer Gastric cancer Metastases Histology Gastroesophageal junction Adenocarcinoma Carcinoma Squamous cell

德语中国指南中的陌生特征——对其深层假设的分析与批判审视

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德语中国指南中的陌生特征——对其深层假设的分析与批判审视

作者： iris Barbara Maria Wachendorf 北京外国语大学

学位级别：硕士

本文通过深入剖析马小娟所著和Florian Becker所著的Business-Kultur in ***-Expertise in Werten,Kultur und Kommunikation(《企业文化在中国:价值、文化与交流中国通》)以及张或所著的 Die *** Networking im Reich der Mitte(《中国策略:在中国构建成功的人脉网》)中构建中国文化特征的相关段落,对其陌生特征以及深层假设进行分析。本文的目标首先是发现中国指南一类文本可能存在的理念上的优、缺点;其次是揭示一些方法,以实现指南文学对异文化更具甄别性的介绍。本文的理论基础之一是陌生特征。陌生特征具有虚拟而非真实的结构。当事物的某些特点被解读为“陌生”的时候,这些特点便构成“陌生特征”。在陌生特征的构建过程中,观察异文化陌生特征的视角起到重要作用。对自身出发点以及局限性的知觉是在构建过程中加深认知的重要一环。在理解过程中,对自我视角的反思能深化认识。对陌异性的研究认为,刻板印象影响陌生特征的构建。刻板印象描述的并非个人,而是某特定群体成员的行为模式。但通过与更多的人或人群交流及反思可使他者形象的形式更具甄别性。指南文学在对异文化不同点的描述中主要存在两个问题,其一是以文化对比的方式进行解释;其二是在描述异文化的过程中忽略对自身视角的审视。在进行文化对比时,指南倾向于使用文化解释方式,高估了文化作为行为动因的作用,忽视了其它非文化动因,如环境及个性等。此外,一些根植于文化对比的科研成果,如文化特点归类,被看作是绝对真理并不加反思地挪用。文化在此中被看作是静止的,其特征是不变的,同时文化的复杂性也被低估。亚文化及个体特征在同一文化同质性的前提下被忽视。这一点可引发对文化概念的进一步思考。文化概念有各种不同的变体,规制了文化间相互作用的可能性。在本文分析的指南文本中,作者提及了价值观的变化,体现了作者并未忽视文化间相互影响的可能性。但这种影响局限于单向,是中国向西方文化的靠近,因此缺乏对交流过程以及相互性的关注。指南文本一方面体现了文化对比研究,另一方面也体现了跨文化研究的成果。指南中一方面运用文化对比研究的成果,指出不同文化系统的特点;另一方面,在对行为进行分析及做出建议时,指南提到了文化间的互动,也指出了互动过程中出现的问题。需指出的是,在跨文化互动过程中会产生新的行为策略。这些行为策略并不一定是针对某个问题,也并非直接产生于某种文化。分析还发现,指南作者并未提及在互动过程中可能产生的协同效应。针对指南文本中中国特征构建的分析显示,指南文本构筑了传统的、与所属文化密切相关的中国人行为图景。这使得原有的中国文化特征被进一步固化和印证。研究结果表明,指南文本在写作方法上可采用更准确的语言描述。同时还应吸纳相关领域更前沿的科研成果。基于指南作者的学术背景,这一点应该是可以实现的。此外,指南行文中还应明确指出,并不是每个行为动因都是由文化决定的,并藉此引发对文化预设的反思。对指南文本的审视具有重要意义,因为此类文本是在华工作的专业人士及领导层重要的信息来源。他们依赖指南文本提供的对对象国有甄别性及有理论依托的介绍。

关键词：陌生特征文化对比文化概念指南文学文化研究

Community Rehabilitation for Diabetes Patient

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Community Rehabilitation for Diabetes Patient

美国威斯康星大学密尔沃基分校的信息构建实验教学

中华护理学会健康教育研讨会

作者： LAW Sau kuen iris Community Nursing Service Alice Ho Miu Ling Nethersole Hospital Hong Kong

Diabetes patients are gradually increasing in Hong Kong and some of them are even yrnptonless. As diabetes is a chronic and lifelonging disease, without proper treatment will bring forth health related diseases and even affect the quality of life of patient as well as their families. The Community Nursing Service (CNS) and DM Specialty of Medical Department of

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图书馆学研究 2014年第20期 28-30,43页

作者：陆泉王宝陈静 iris Xie 武汉大学信息管理学院华中师范大学信息管理学院不详

信息构建实验教学既与多门前期课程紧密相关,又有其独特的用户信息行为实验内容与方法,国外相关经验有助于提高国内的信息构建实验教学水平。文章介绍美国威斯康星大学密尔沃基分校信息构建实验教学相关的课程体系、信息智能与信息构建... 详细信息

信息构建实验教学既与多门前期课程紧密相关,又有其独特的用户信息行为实验内容与方法,国外相关经验有助于提高国内的信息构建实验教学水平。文章介绍美国威斯康星大学密尔沃基分校信息构建实验教学相关的课程体系、信息智能与信息构建实验室、常用的三种用户信息行为分析方法和三种实验模式。

关键词：信息构建实验教学分析方法实验模式

Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

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World Journal of Gastroenterology 2010年第1期16卷 83-88页

作者： Lea Irene Veijola Aino Mirjam Oksanen Pentti Ilmari Sipponen Hilpi iris Kaarina Rautelin Herttoniemi Hospital City of Helsinki Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki Repolar Oy Box 2602101 EspooFinland HUSLAB Helsinki University Central Hospital Laboratory Department of Medical Sciences University of Uppsala

AIM:To study the association between Helicobacter pylori(***)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present *** *** addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing *** infection,eight showed *** antibodies by *** eight had elevated PCA and 4/8 also had IF *** the six immunoblot-negative patients with severe corpus atrophy,PCA and IF antibodies were detected in *** the patients with low to moderate grade atrophic gastritis(all except one with an ongoing *** infection),serum markers for gastric atrophy and autoimmunity were seldom ***,one *** negative patient with mild atrophic gastritis had PCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of *** infection in autoimmune gastritis,and positive autoimmune serum markers in *** gastritis suggest an etiological role for *** in autoimmune gastritis.

关键词： Helicobacter pylori Autoimmune gastritis Gastric atrophy Vitamin B12 deficiency

Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling

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Molecular Plant 2022年第4期15卷 651-670页

作者： Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie Laboratory Center of Life Sciences College of Life SciencesNanjing Agricultural UniversityNanjing 210095PR China Institute for Biology and Biotechnology of Plants University of Muenster48149 MuensterGermany State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center 17 for Protein SciencesBeijingBeijing Institute of LifeomicsBeijing 102206China Institute of Industrial Crops Jiangsu Academy of Agricultural SciencesNanjing 210014China

Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mechanisms by which plants perceive and transduce redox signals are still underexplored. Here, we report a critical function for the thiol peroxidase GPX1 in osmotic stress response in rice, where it serves as a redox sensor and transducer. GPX1 is quickly oxidized upon exposure to osmotic stress and forms an intramolecular disulfide bond, which is required for the activation of bZIP68, a VRE-like basic leucine zipper (bZIP) transcription factor involved in the ABA-independent osmotic stress response pathway. The disulfide exchange between GPX1 and bZIP68 induces homo-tetramerization of bZIP68 and thus positively regulates osmotic stress response by regulating osmotic-responsive gene expression. Furthermore, we discovered that the nuclear translocation of GPX1 is regulated by its acetylation under osmotic stress. Taken together, our findings not only uncover the redox regulation of the GPX1-bZIP68 module during osmotic stress but also highlight the coordination of protein acetylation and redox signaling in plant osmotic stress responses.

关键词： GPX1 SOH oxidative stress acetylation ZIP68 transactivation

Relaxin prevents the development of severe acute pancreatitis

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World Journal of Gastroenterology 2006年第10期12卷 1558-1568页

作者： Laura iris Cosen-Binker Marcelo Gustavo Binker Rodica Cosen Gustavo Negri Osvaldo Tiscornia RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clinicas Universidad de Buenos AiresArgentina Cátedra de Gastroenterologia y Enzimologia Clinica-Departamento de Bioquimica ClinicaFacultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos AiresArgentina RHC-LICB Medical Research Institute-Buenos Aires Argentina Cátedra de Gastroenterología y Enzimología Clínica-Departamento de Bioquímica Clínica Facultad de Farmacia y Bioquimica Universidad de Buenos AiresArgentina Programa de Estudios Pancreáticos-Hospital de Clínicas Universidad de Buenos Aires Argentina

AIM： TO investigate the severity of acute pancreatitis （AP） is associated to the intensity of leukocyte activation, inflammatory up-regulation and microcirculatory disruption associated to ischernia-reperfusion injury. Hicrovascular integrity and inhibition of pro-inflammatory mediators are key-factors in the evolution of AP. Relaxin is an insulin-like hormone that has been attributed vasorelaxant properties via the nitric oxide pathway while behaving as a glucocorticoid receptor agonist. METHODS： AP was induced by the bilio-pancreatic duct-outlet-exclusion closed-duodenal-loops model. Treatment with relaxin was done at different timepoints. Nitric oxide synthase inhibition by L-NAME and glucocorticoid receptor （GR） blockage by mifepristone was considered. AP severity was assessed by biochemical and histopathological analyses. RESULTS： Treatment with relaxin reduced serum amylase, lipase, C-reactive protein, IL-6, IL-10, hsp72, LDH and 8-isoprostane as well as pancreatic and lung myeloperoxidase. Acinar and fat necrosis, hemorrhage and neutrophil infiltrate were also decreased. ATP depletion and ADP/ATP ratio were reduced while caspases 2-3-8 and 9 activities were increased. L-NAME and mifepristone decreased the efficiency of relaxin. CONCLUSION： Relaxin resulted beneficial in the treatment of AP combining the properties of a GR agonist while preserving the microcirculation and favoring apoptosis over necrosis.

关键词： Acute pancreatitis Relaxin Nitric oxide Glucocorticoid receptor Necrosis Apoptosis