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International Journal of Digital Earth 2019年第8期12卷 948-961页

作者： Alexander V.Evseev Tatiana M.Krasovskaya Vladimir S.Tikunov irina N.Tikunova Geographical Faculty Lomonosov Moscow State UniversityMoscowRussia

Territories of traditional nature use(TTNU)of indigenous population in the Arctic zone presents a historical model of sustainable development whose main principles are valuable for modern practice of economic activities in this region as *** peoples traditional nature management practice in the Russian Arctic nowadays exists only within tribal community lands,though their virtual limits may be larger and known to indigenous population,helping to preserve regional *** of TTNU in the course of modern economic development,including the Northern Silk Road coastal infrastructure,is important for regional ecological and social *** may be regarded as ecological buffer zones,restoring ecosystem functions important for regional sustainable development,though modern market economy treats them mainly as economic units less valuable for incomes than industrial.A new look at TTNU may be supported by their ecologicaleconomic assessment.A case study in the coastal Nenets TTNU belonging to family-clan community‘Ya’Erv’demonstrates its possible input to local sustainable development.

关键词： Indigenous peoples Russian Arctic traditional nature management ecosystem services value sustainable development Ice Silk Road

Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?

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World Journal of Gastroenterology 2011年第20期17卷 2465-2472页

作者： Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili irina Kirpich Craig J McClain Shirish Barve University of Louisville Alcohol Research Center Department of Pharmacology and Toxicology University of Louisville Department of Internal Medicine Division of GastroenterologyHepatology and NutritionUniversity of Louisville Robley Rex Veterans Affairs Medical Center

Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and *** is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and *** can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease ***,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene *** review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to *** review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD.

关键词： Alcohol Liver disease Nutrients Metabolism Histone Epigenetic modifications S-adenosylmethionine Acetate Zinc NAD

Latitudinal gradients in body size and sexual size dimorphism in fleas:males drive Bergmann’s pattern

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Integrative Zoology 2023年第3期18卷 414-426页

作者： Boris R.KRASNOV Elena N.SURKOVA Georgy I.SHENBROT irina S.KHOKHLOVA Mitrani Department of Desert Ecology Swiss Institute for Environmental and Energy ResearchJacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevMidreshet Ben-GurionIsrael French Associates Institute for Agriculture and Biotechnology of Drylands Jacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevMidreshet Ben-GurionIsrael

We tested for the effects of latitude and geographic range size(GRS)on body size,leg length,and sexual size dimorphism(SSD)across 103 species ofﬂeas,taking into account phylogenetic between-species *** the data on body size were combined for males and females,the positive correlation between body size and latitude,but not GRS,was *** the analysis was restricted to one sex only,the effect of latitude appeared to be non-signiﬁcant for females,whereas male body size increased with an increase in ***ﬁc body size variation was not associated with either the latitude or the latitudinal span of the geographic range,independently of which data subset was *** evidence of association between size-independent tibia length and latitude was found for either females,males,or both sexes *** degree of SSD decreased with a decrease in latitude but was not affected by *** conclude that macroecological patterns might be manifested differently in males and *** should be kept in mind while searching for these patterns.

关键词： Bergmann’s rule ﬂeas geographic range latitude sexual dimorphism

Moscow and Moscow Region： Ecological Focus for Sustainable Development

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Sociology Study 2012年第7期2卷 540-550页

作者： irina Ivashkina Moscow State University Named After M V LomonosovRussia

This paper presents some results of sustainable urban-planning development in Moscow Capital Region. Moscow City and Moscow Region （Moscow Oblast） are the parts of the Moscow Capital Region. According to the Constitution of Russia, adopted in December 1993, Moscow Region and Moscow City are two independent federal subjects of Russian Federation. The sustainable development of Moscow City and Moscow Region as an integrated regional economic and natural complex which plays the most important part in Russia＇s economy must be based on the integrated solution to the problems of environmental protection, social equity, and economic feasibility. The latest initiative of Russian Government concerns the creation of the Greater Moscow within the new borders of Moscow. Making the decision on the extension of the city limits and stimulation of the Moscow Agglomeration development provides the real way of resolution of the accumulated problems and provides enormous impetus to the sustainable development. The key task of the environmentally sound development of the Greater Moscow is to relieve the historical center of Moscow City; maintain the rational balance of built-up areas, natural and rural landscapes; ensure joint control of the urban development and economic activity; and create the favorable environment for the population.

关键词： Moscow Capital Region ecological and social issues sustainable development urban planning

Our Future:Children or Old Age?New Goals of Continuing Architectural Education

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Journal of Civil Engineering and Architecture 2020年第12期14卷 685-692页

作者： irina Topchiy Moscow Architecture Institute State AcademyRozhdestvenka Street 11Moscow 107031Russia

The research is aimed at the potential of the professional architectural education and solving one of the important problems of society—creating conditions for maintaining health and social rehabilitation of older *** experience of universities,public organizations,museums in Europe and North America was *** types of strategies of these organizations were *** were differing in the degree of development of social and professional *** most interested in developing supplementary architecture and art education for older people are Colleges of Arts and Art *** the first case,the communication’s basis of the Colleges is there interest in the public appreciation of new art *** the second case,the social missions of the Art *** the final stage,the sociological study of the attitude towards these programs among the participants of the Moscow Mayor’s Project“Moscow Longevity”had been *** showed that the most attractive for 3-d age people was the opportunity to visit the Moscow Architectural Institute-an architectural monument and communicate with professors.

关键词： 3-d age education Moscow Longevity supplementary architecture education

Preventative Strategies in the Management of ROP: A Review of Literature

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Open Journal of Pediatrics 2015年第2期5卷 121-127页

作者： irina Livshitz University Hospitals Case Medical Center Cleveland USA

Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that primarily affects premature infants weighing 1250 grams or less that are born before 31 weeks of gestation. It is one of the most common causes of visual loss in childhood and can lead to lifelong vision impairment and blindness. Certain strategies for prevention have been confirmed by numerous trials, namely the role of oxygen therapy as an independent risk factor for the development of ROP and the benefits of strict control of premature infant oxygen saturations in the NICU. There is valuable data that supports use of other approaches, such as beta adrenergic blockade and IGF-1 supplementation, for which clinical trials are still in the works to establish clear protocols for their clinical use. Supplementation with vitamin A, omega-3 fatty acids, and inositol are all exciting arenas for further trials as preliminary data shows promising results in ROP prevention. It has also been shown that the benefit of vitamin E is not worth the increased incidence of NEC and sepsis as potential side effects. Furthermore, while it was an interesting idea to use the chelator D-penicillamine as a preventative strategy for ROP, the results of multiple trials seemed to be equivocal. This brief review is not all-inclusive, as there are many more modes of prevention currently being studied.

关键词： Retinopathy of Prematurity (ROP) Proliferative Retinopathy Neonatology

望天鹅火山喷发时限的激光 ^(40)Ar/ ^(39)Ar年代学

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岩石学报 2021年第8期37卷 2521-2530,I0001-I0004页

作者：周鑫周晶 ANDREEVA Olga A ANDREEVA irina A 季建清北京大学地球与空间科学学院造山带与地壳演化教育部重点实验室北京100871 俄罗斯科学院矿床岩石矿物与地球化学研究所莫斯科119017

在中国东北地区,望天鹅火山的覆盖范围仅次于长白山,前人测得的K-Ar年龄主要集中在2~3Ma,但其精确的喷发年代一直没有很好的限定。这是因为第四纪以来的火山岩40 Ar/39 Ar定年与较老的地质样品有显著的不同,测试过程中极其微小的偏差会... 详细信息

在中国东北地区,望天鹅火山的覆盖范围仅次于长白山,前人测得的K-Ar年龄主要集中在2~3Ma,但其精确的喷发年代一直没有很好的限定。这是因为第四纪以来的火山岩40 Ar/39 Ar定年与较老的地质样品有显著的不同,测试过程中极其微小的偏差会呈指数方式放大,带来测年结果的极大误差,难以严格限定火山喷发的年代。本文选用的激光40 Ar/39 Ar年代学方法具有样品用量小、精度高、自动化测试稳定等优点。通过增加测试次数,在数据处理中引入高斯混合模型进行统计分析,可以更准确地判别火山喷发期次。在此基础上,提出符合等时线计算要求的同位素体系“同源、同时、封闭”的数学表达是表观年龄的正态分布,对构成同一正态分布的数据计算等时线年龄,能够实现对望天鹅火山喷发时代的精细限定。结果显示,在测试精度尺度内,望天鹅火山可以看作是一期喷发的结果,喷发时限为2.73±0.18Ma。这一时限可以帮助解释北太平洋深海钻探中同一时期火山凝灰质沉积层的出现,并由此可以把2.73Ma前后的北半球大冰期事件与望天鹅火山喷发联系起来,为研究火山喷发与气候变冷效应提供一个新的实证案例。

关键词： 40 Ar/39 Ar定年等时线年龄高斯混合模型望天鹅火山

The Road Not Taken by Robert Frost or Empathic Cognition and the Role of Symbols in Comprehension of Poetry

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Sino-US English Teaching 2016年第3期13卷 213-218页

作者： irina Kladenova MBOU of the City of Kurgan "Gymnasium No. 47" Kurgan Russia

The role of empathic cognition is very ＂great for philosophers and philosophy in general and for ordinary people. Empathic cognition gives people a chance ＂to let＂ the emotions of the Other ＂go＂ into their minds. Empathic cognition is based on so-called co-suffering and in-sensation of the feelings of the Other or Others. Clots of energy or certain energy units are formed in consciousness of each person, they are called ＂subjective representants＂. It is possible to understand the Other or Others and to decipher the main idea of the poem （if the task to work on translation is given） and to express it in the native language if to find out not only the meanings of the words but the symbols the author has used in his poem. The reader ＂goes into＂ the world of the author trying to be near the author and trying to grasp what the author felt working on the poem. There is something what gives us a possibility to enter into the world of a creative personality. This ＂something＂ is empathic cognition.

关键词： empathic cognition the Other (the Others) subjective representant symbols poetry

Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms

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World Journal of Clinical Cases 2023年第15期11卷 3408-3417页

作者： Milko Bozhidarov Mirchev irina Boeva Monika Peshevska-Sekulovska Veselin Stoitsov Milena Peruhova Department of Gastroenterology Heart and Brain HospitalBurgas 8000Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria

High rates of extrapancreatic malignancies,in particular colorectal cancer(CRC),have been detected in patients with intraductal papillary mucinous neoplasm(IPMN).So far,there is no distinct explanation in the literature for the development of secondary or synchronous malignancies in patients with *** the past few years,some data related to common genetic alterations in IPMN and other affiliated cancers have been *** review elucidated the association between IPMN and CRC,shedding light on the most relevant genetic alterations that may explain the possible relationship between these *** keeping with our findings,we suggested that once the diagnosis of IPMN is made,special consideration of CRC should be ***,there are no specific guidelines regarding colorectal screening programs for patients with *** recommend that patients with IPMNs are at high-risk for CRC,and a more rigorous colorectal surveillance program should be implemented.

关键词： Colorectal cancer Intraductal papillary mucinous neoplasm Genetic alterations Extrapancreatic malignancies Synchronous neoplasms

Structural Determinants of a Typical Leucine-Rich Repeat Protein

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Communications in Computational Physics 2013年第1期13卷 238-255页

作者： Joao M.Martins Rui M.Ramos irina S.Moreira REQUIMTE/Departamento de Quımica Faculdade de Ciencias da Universidade do PortoRua do Campo Alegre 6874169-007 Porto-Portugal

The structural and functional description of protein-protein complexes and their comprehension is a key concept,not only to increase the scientific knowledge in basic terms but also for the application to the biomedical and pharmaceutical *** binding association between proteins is nowadays attribute to a few key residues at the interface–the *** complex between the RNase inhibitor(RI)and RNaseA protein provides an excellent system to study the role of the functional epitope as it is essential in various molecular recognition processes and constitute one of the tightest complexes *** energetic pattern of the interface is accomplished by computational alanine scanning mutagenesis and a dynamical characterization is accomplished by a detailed study of the molecular dynamical simulations.A special emphasis is given to the role of solvation across the interface and the shielding of warm-and hot-spots from water.

关键词： Structural determinant protein-protein association molecular dynamic simulation mutagenesis protocol