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Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis

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World Journal of Gastroenterology 2022年第10期28卷 1067-1077页

作者： Roman Maslennikov vladimir Ivashkin irina Efremova Elena Poluektova Anna Kudryavtseva George Krasnov Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Scientific Community for Human Microbiome Research Moscow 119435Russia Department of Internal Medicine 1 Сonsultative and Diagnostic Center 2 of the Moscow City Health DepartmentMoscow 107564Russia Laboratory of Postgenomic Research Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND Gut dysbiosis and small intestinal bacterial overgrowth(SIBO)are commonly observed in patients with *** the substantial number of articles describing the relations between disorders of gut microbiota and various manifestations of cirrhosis,dysbiosis and SIBO were always studied *** To study the relationship of gut dysbiosis and SIBO in *** This observational study included 47 in-patients with *** microbiome was assessed using 16 S r RNA gene *** was assessed using the lactulose hydrogen breath *** SIBO was found in 24/47(51.1%)*** with SIBO had a higher abundance of Firmicutes(P=0.017)and Fusobacteria(P=0.011),and a lower abundance of Bacteroidetes(P=0.013)than patients without *** increase in the abundance of Firmicutes occurred mainly due to an increase in the abundance of bacteria from the genus Blautia(P=0.020)of the Lachnospiraceae family(P=0.047),while the abundance of other major families of this phylum[Ruminococcaceae(P=0.856),Peptostreptococcaceae(P=0.066),Clostridiaceae(P=0.463),Eubacteriaceae(P=0.463),Lactobacillaceae(P=0.413),and veillonellaceae(P=0.632)]did not differ significantly between the patients with and without *** level of Bacteroidetes in samples from patients with SIBO was a result of the decrease in bacterial numbers from all the major families of this phylum[Bacteroidaceae(P=0.014),Porphyromonadaceae(P=0.002),and Rikenellaceae(P=0.047)],with the exception of Prevotellaceae(P=0.941).There were no significant differences in the abundance of taxa that were the main biomarkers of cirrhosis-associated gut dysbiosis[Proteobacteria(P=0.790),Bacilli(P=0.573),Enterobacteriaceae(P=0.632),Streptococcaceae(P=0.170),Staphylococcaceae(P=0.450),and Enterococcaceae(P=0.873)]between patients with and without *** Despite the differences observed in the gut microbiome between patients with and without SIBO,gut dysbiosis and SIBO are most

关键词： Dysbiosis Gut-liver axis Microbiome Small intestinal bacterial overgrowth Cirrhosis Microbiota

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NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety

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World Journal of Hepatology 2014年第5期6卷 326-339页

作者： Igor Bakulin victor Pasechnikov Anna varlamicheva irina Sannikova Central Scientific Research Institute of Gastroenterology of Moscow Clinical Scientific Center 111123 Moscow Russia Stavropol State Medical University 355020 Stavropol Russia

A new treatment paradigm for hepatitis C is that the treatment must include an existing direct-acting antiviral agent, namely, a protease inhibitor(PI) combined with PEGylated interferon-a and ribavirin. The currently mar-keted PIs and PIs in clinical trials have different mecha-nisms of action. The development of new PIs aims for an improved safety profile and higher effectiveness. This article reviews NS3/4A protease inhibitors, focusing on major criteria such as their effectiveness and safety. Specific attention is paid to dosing regimens and adverse event profiles of PIs administered in clinical settings.

关键词： Protease inhibitor PEGylated interferon-α Ribavirin Antiviral treatment Adverse event Response-guided therapy Hepatitis C virus

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CvD生长多壁碳纳米管的拉曼光谱径向呼吸振动模式观察(英文)

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新型炭材料 2015年第5期30卷 385-390页

作者： valeriy v.Bolotov vasiliy E.Kan Egor v.Knyazev Peter M.Korusenko Sergey N.Nesov Yuriy A.Sten`kin viktor A.Sachkov irina v.Ponomareva Omsk Scientific Center of Siberian Branch Russian Academy of Sciences

采用拉曼光谱仪、透射电镜、俄歇能谱仪、X射线光电子能谱仪等研究在Si O2/Si基底上化学沉积的多壁碳纳米管(MWCNTs)经390℃的空气中热处理120 min前后与HCl溶液化学处理前后的结构变化情况。拉曼光谱集中测试低频(250-300 cm-1)带。结... 详细信息

采用拉曼光谱仪、透射电镜、俄歇能谱仪、X射线光电子能谱仪等研究在Si O2/Si基底上化学沉积的多壁碳纳米管(MWCNTs)经390℃的空气中热处理120 min前后与HCl溶液化学处理前后的结构变化情况。拉曼光谱集中测试低频(250-300 cm-1)带。结果表明,经热处理和化学处理后,在250-300 cm-1形成的拉曼带在峰位和半宽几乎没变。由透射电镜可知,小直径碳纳米管的内径值与拉曼光谱测试结果一致。这些结果表明,低频带产生于小直径碳纳米管的内壁中碳原子的径向呼吸振动。

关键词：碳纳米管径向振动模式拉曼化学气相沉积显微镜

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Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus

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World Journal of Diabetes 2018年第9期9卷 149-156页

作者： vladislav A Zykov Taisiia P Tuchina Denis A Lebedev irina B Krylova Alina Y Babenko Elvira v Kuleshova Elena N Grineva Alekber A Bayramov Michael M Galagudza Almazov National Medical Research Centre St-Petersburg 197341Russia Institute of Experimental Medicine St-Petersburg 197376Russia

AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic *** Type 2 diabetes mellitus(T2 DM) was induced in maleWistar rats with streptozotocin(65 mg/kg) and verified using an oral glucose tolerance test. After anesthesia, the left coronary artery was occluded for 40 min followed by 80 min reperfusion. Blood glucose level was measured during surgery. Rats were randomized into six groups as follows:(1) control rats;(2) insulin(0.1 U/kg) treated rats prior to ischemia;(3) insulin(0.1 U/kg) treated rats at reperfusion;(4) GLP-1 a(140 mg/kg) treated rats prior to ischemia;(5) GLP-1 a(140 mg/kg) treated rats at reperfusion; and(6) rats treated with GLP-1 a(140 mg/kg) prior to ischemia plus insulin(0.1 U/kg) at reperfusion. Myocardial area at risk and infarct size was measured planimetrically using Evans blue and triphenyltetrazolium chloride staining, *** There was no significant difference in the myocardial area at risk among groups. Insulin treatment before ischemia resulted in a significant increase in infarct size(34.7% ± 3.4% vs 18.6% ± 3.1% in the control rats, P ver, pre-ischemic administration of GLP-1 a reduced infarct size to 12% ± 2.2%(P ved in the group treated with GLP-1 a prior to ischemia and insulin at reperfusion(8% ± 1.6%, P vs the control and GLP-1 a alone treated groups).CONCLUSION GLP-1 a pre-administration results in myocardial infarct size reduction in rats with T2 DM. These effects are maximal in rats treated with GLP-1 a pre-ischemia plus insulin at reperfusion.

关键词： Glucagon-like peptide-1 analog Insulin Myocardial ischemia-reperfusion injury Infarct size Type 2 diabetes mellitus Rats Experimental research

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Optimizing Fluid Flow Cooling in Gas Transmission Systems

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Fluid Dynamics & Materials Processing 2022年第4期18卷 1099-1109页

作者： Gunawan Widjaja Mohaimen Al-Thamir Farshid Mehran Lis M.Yapanto irina N.Fardeeva Alim Al Ayub Ahmed Supat Chupradit v.A.Kukushkina Oleg R.Kuzichkin Universitas Krisnadwipayana Senior Lecturer Faculty of Public Health Universitas IndonesiaFaculty of Law Universitas KrisnadwipayanaJawa Barat13077Indonesia Scientific Research Center Al-Ayen UniversityThi-Qar64001Iraq Islamic Azad University Jolfa International BranchJolfa***Iran Departement of Aquatic Management Faculty of Fisheries and Marine ScienceUniversitas Negeri GorontaloGorontalo96128Indonesia Kazan Federal University Kazan420008Russia School of Accounting Jiujiang UniversityJiujiang33200China Department of Occupational Therapy Faculty of Associated Medical SciencesChiang Mai UniversityChiang Mai50200Thailand Lipetsk State Technical University Lipetsk398600Russia Department of Information and Robototechnic Systems Belgorod State UniversityBelgorod308015Russia

In this study,structural theory was used to examine the geometric configuration of channels embedded inside an object in the presence of internal heat generation for cooling by a heat transfer *** growth and development of gas transmission lines and the lack of up-to-date integrated information systems have made the design and maintenance of pipelines,as well as the handling of problems caused by various accidents in the pipeline,very complex in many *** accurate descriptive and spatial information in tolls on gas transmission line maps such as pipes,booster stations,valves,and forks in a spatial reference database can engage planners,operators,and paramedics in a variety of *** are used to help in the direction of optimal and purposeful ***,in this paper,by considering appropriate laboratory conditions and numerical experiments and calculations,it is possible to determine the optimal attraction of duct holes for cooling components of the gas transmission system,so that the industry can produce and developed gas transmission without *** this study,in addition to studying the geometric characteristics of channel spacing and their length,the dimensions of a specific channel for reducing the maximum produced temperature are also discussed.

关键词： Cooling component duct hole gas transmission line pipeline cooling system

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Combined Action of Lysozymes of Fresh-Water Bivalve Mollusks and Antibacterial Preparations against Some Clinical Strains of Microorganisms

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Journal of Pharmacy and Pharmacology 2014年第2期2卷 123-128页

作者： victoria v. Minakova Alexey v. Pryakhin Galina N. Solovykh irina v. Karnauldaova Department of Chemistry Department of Biomedical Sciences University of Dodoma Dodoma Tanzania Department of Chemistry Orenburg State Pedagogical University Orenburg 460000 Russia Department of Biology Orenburg State Medical Academy Orenburg 460000 Russia

The aim of the present study was to determine the MICs using broth microdilution method and their combination effect by （minimum inhibitory concentrations） of selected antibiotic agents determination of FICindex （fractional inhibitory concentrations）. Lysozyme Anodonta cygnea was more active than Lysozyme Uniopictorum, especially against Gram-negative bacterias. Combination of Macropen and Lysozyme Unio pictorum has a synergistic effect, while a separation of these antibacterial agents was not active against some of the strains of microorganisms.

关键词： Macrolide antibiotics lysozyme of bivalve fresh-water mollusks minimum inhibitory concentration synergy fractional inhibitory concentration.

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Experience of Using the Recombinant Human Superoxide Dismutase Drug in Neurological and Ophthalmological Practice

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Open Journal of Medicinal Chemistry 2014年第2期4卷 70-78页

作者： Elena E. Dubinina irina v. Churilova Liudmila v. Lipatova Liudmila v. Zhuravleva St. Petersburg v. M. Bekhterev Psychoneurological Research Institute St. Petersburg Russian Federation State Research Institute of Highly Pure Biopreparations St. Petersburg Russian Federation

Recsod? has been used for treating epilepsy and ophthalmological disease. Oxidative stress has been demonstrated to be a pathogenic chain of these diseases. Parameters of pro- and antioxidant systems were studied in all the patients treated. Recsod? drug was shown to produce positive effect in all the patients. Improvement of patients’ clinical condition correlated with an increase in antioxidant activities. Antioxidants, in particular, the recombinant human SOD drug, proved to be effective in treatment of some neurological and ophthalmological diseases.

关键词： Superoxide Dismutase Oxidative Stress Reactive Oxygen Species Epilepsy Age-Related Macular Degeneration

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Pb-Ca-Sn-Ba Grid Alloys for valve-Regulated Lead Acid Batteries

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Engineering（科研） 2013年第10期5卷 9-15页

作者： Marina M. Burashnikova irina v. Zotova Ivan A. Kazarinov Department of Physical Chemistry Saratov State University Named after N. G. Chernyshevsky Saratov Russia

The effect of barium additives on the process of anodic corrosion of lead-tin-calcium alloys in a 4.8 М sulfuric acid solution was studied. Cyclic voltammetry, impedance spectroscopy, weight loss measurements and scanning electronic microscope analysis have allowed exploring the oxidation process and characterizing the formed corrosion layer. According to our results, barium introduction into lead-tin-calcium alloys increases their hardness, reduces their electrochemical activity, and improves their corrosion stability. Reduction of the calcium content in the alloy can be compensated by adding barium. Barium dopation at lead-tin-calcium alloys decreases the resistance of the oxide layer formed on the grid surface, in a deeply discharged state, and raises its resistance during floating conditions and at a charged state of the positive electrode.

关键词： Lead-Acid Battery Lead Alloys Barium Corrosion Layer

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The Usefulness of Zhukovsky Double Balloon in Obstetric Hemorrhage

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Maternal-Fetal Medicine 2019年第1期1卷 10-17页

作者： Sergey v.Barinov irina v.Medyannikova Anna v.Borisova Yulia I.Tyrskaya irina v.Savelieva Inna v.Shamina Oksana v.Lazareva Tatyana v.Kadtsyna The Second Department of Obstetrics and Gynaecology Federal State Budget Institution of HigherProfessional EducationOmsk State Medical Universitythe Russian Ministry of HealthcareOmsk644043Russia Department of Obstetrics and Gynaecology Federal State Budget Institution ofHigher EducationPeoples'Friendship Universitythe Russian Ministry of HealthcareMoscow117198Russia

Objective:To evaluate the effectiveness of the use of a modified Zhukovsky double(vaginal and uterine)balloon to improve the results of treatment in women with obstetric ***:We conducted an observational controlled study including 701 puerperas,which were divided into two groups:The main group consisted of 508 women,who underwent a combined management,that is,traditional(transfusion of fresh frozen plasma,erythrocyte mass,uterotonics,hemostatic agents),surgical hemostasis in cases of caesarean section,and insertion of a double Zhukovsky balloon;while the comparison group included 193 patients,who were managed *** main group and the comparison group were divided into subgroups according to the main etiology of obstetric hemorrhage:ⅠA andⅠB-postpartum;ⅡA andⅡB-placenta accreta;ⅢA andⅢB-postpartum ***:The most frequent causes of massive obstetric hemorrhage were atony of the uterus(39.2%),placenta previa(29.1%),and placental abruption(11.5%).Of the 508 balloon insertions,345(70.7%)were inserted for hemorrhage during cesarean section and 148(29.3%)for obstetric hemorrhage after spontaneous *** the obstetric hemorrhage at caesarean section,lower segment bleeding prevailed(78.1%),caused mainly by placenta previa,placenta accreta,placental abruption,polyhydramnios,and uterine scar *** management,including surgical hemostasis and insertion of vaginal and uterine balloon of Zhukovsky,reduced blood loss by 1.5 times and the number of hysterectomies by 6.72 times compared to ***:The use of a modified Zhukovsky double balloon in the management of obstetric hemorrhage may reduce the number of hysterectomies and the amount of blood loss.

关键词： Obstetric hemorrhage Placenta previa Accrete vaginal wall rupture Uterine ligation Hypotonic hemorrhage

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