检索结果-南通市图书馆

Immunization with rPb27 Protects Mice from the Disruption of VEGF Signaling in Paracoccidioides brasiliensis Infection

引用

Journal of Life Sciences 2013年第9期7卷 913-927页

作者： Elis Araujo Morais Estefania Mara do Nascimento Martins Viviane Cristina Femandes iria gabriela dias dos santos Gerluza Aparecida Borges Silva Dawidson Assis Gomes Alfredo Miranda de Goes Department of Biochemistry and Immunology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte 31270-901 Brazil Albert Einstein College of Medicine Yeshiva University New York NY 10033 USA Department of Morphology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte 31270-901Brazil

VEGF （Vascular endothelial growth factor） signaling is critical for endothelial cell survival and maintenance of the vasculature. Deregulation of VEGF signaling contributes to the physiopathology of many diseases. However, the ways in which infection with Paracoccidioides brasiliensis affects VEGF signaling and the influence of immunization with rPb27 （recombinant protein Pb27） on VEGF signaling have not yet been studied. Animals were immunized with rPb27 and subsequently infected with a virulent strain of P. brasiliensis. The fungal load was evaluated by measuring CFU （colony-forming unit） and histology was performed to evaluate the inflammatory reaction. At the two time points analyzed, the PC （positive control） and TREAT （treated） animals had decreased levels of pulmonary VEGF compared to basal levels. However, in the immunized （Pb27） and treated mice （Pb27 ＋ TREAT）, VEGF expression remained unchanged after infection. In the case of VEGFR-2, the Pb27 and Pb27 ＋ TREAT groups showed increased levels of expression. Regarding the levels of the eNOS enzyme, only the Pb27 group did not reduce the expression levels relative to baseline. The immunization with rPb27 kept VEGF signaling, NO production and increased VEGFR-2 expression, after infection with P. brasiliensis. Thus, the authors infer that immunization with rPb27 protects mice from the disruption of VEGF signaling in Paracoccidioides brasiliensis infection.

关键词： rPb27 VEGF VEGFR eNOS Paracoccidioides brasiliensis paracoccidioidomycosis inflammatory infiltrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drug-induced liver injury and COVID-19:Use of artificial intelligence and the updated Roussel Uclaf Causality Assessment Method in clinical practice

引用

Artificial Intelligence in Gastroenterology 2023年第2期4卷 36-47页

作者： gabriela Xavier Ortiz Ana Helena dias Pereira dos santos Ulbrich Gabriele Lenhart Henrique dias Pereirados santos Karin Hepp Schwambach Matheus William Becker Carine Raquel Blatt Graduate Program in Medicine–Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Institute of Artificial Intelligence in Healthcare Porto Alegre 90.620-200Brazil Multiprofessional Residency Integrated in Health Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Department of Pharmacoscience Graduate Program in Medicine–HepatologyFederal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil

BACKGROUND Liver injury is a relevant condition in coronavirus disease 2019(COVID-19)*** varies from direct infection by virus,systemic inflammation or drug-induced adverse reaction(DILI).DILI detection and monitoring is clinically relevant,as it may contribute to poor prognosis,prolonged hospitalization and increase indirect healthcare *** Intelligence(AI)applied in data mining of electronic medical records combining abnormal liver tests,keyword searching tools,and risk factors analysis is a relevant opportunity for early DILI detection by automated *** To describe DILI cases in COVID-19 inpatients detected from data mining in electronic medical records(EMR)using AI and the updated Roussel Uclaf Causality Assessment Method(RUCAM).METHODS The study was conducted in March 2021 in a hospital in southern *** NoHarm©system uses AI to support decision making in clinical *** admissions were 100523 during this period,of which 478 met the inclusion *** these,290 inpatients were excluded due to alternative causes of liver injury and/or due to not having *** manually reviewed the EMR of 188 patients for DILI *** of clinical information excluded most eligible *** DILI assessment causality was possible via the updated RUCAM in 17 *** Mean patient age was 53 years(SD±18.37;range 22-83),most were male(70%),and admitted to the non-intensive care unit sector(65%).Liver injury pattern was mainly mixed,mean time to normalization of liver markers was 10 d,and mean length of hospitalization was 20.5 d(SD±16;range 7-70).Almost all patients recovered from DILI and one patient died of multiple organ *** were 31 suspected drugs with the following RUCAM score:Possible(n=24),probable(n=5),and unlikely(n=2).DILI agents in our study were ivermectin,bicalutamide,linezolid,azithromycin,ceftriaxone,amoxicillin-clavulanate,tocilizumab,piperacillin-tazobactam,and a

关键词： Chemical and drug induced liver injury RUCAM Artificial intelligence COVID-19 Liver injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：