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Alien plant species coexist over time with native ones in Chilean Mediterranean grasslands

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Journal of Plant Ecology 2016年第6期9卷 682-691页

作者： irene martín-forés Isabel Castro Belén Acosta-Gallo Alejandro del Pozo Laura sánchez-Jardón JoséM.de Miguel Carlos Ovalle Miguel A.Casado Department of Ecology Complutense University of MadridMadridSpain Department of Ecology Autónoma University of MadridMadridSpain Faculty of Agricultural sciences University of TalcaTalcaChile Agricultural Research Institute InIA-La Cruz La CruzChile

Aims Alien species are commonly considered as harmful weeds capa-ble of decreasing native biodiversity and threatening *** this assumption,little is known about the long-term patterns of the native-alien relationships associated with human disturbed managed *** study aims to elucidate the commu-nity dynamics associated with a successional gradient in chilean Mediterranean grasslands,considering both native and alien *** species richness(natives and aliens separately)and life-form(annu-als and perennials)were recorded in four chilean post-agricultural grazed grasslands each covering a broad successional gradient(from 1 to 40 years since crop abandonment).A detrended correspondence analysis(DcA),mixed model effects analyses and cor-relation tests were conducted to assess how this temporal gradient influenced natives and aliens through community *** Findings Our results show different life-form patterns between natives and aliens over *** were mainly represented by annuals(especially ruderals and weeds),which were established at the beginning of *** aliens also predominated at mid-successional stages,but in old grasslands native species were slightly more representative than alien ones within the *** the late successional states,positive or no correlations at all between alien and native species richness suggested the absence of competition between both species groups,as a result of differ-ent strategies in occupation of the *** dynamics over time constitute a net gain in biodiversity,increasing natives and maintaining a general alien pool,allowing the coexistence of *** interactions including facilitation and/or tolerance processes might be occurring in chilean post-agricultural grasslands,a fact that contradicts the accepted idea of the alien species as contenders.

关键词： community dynamics land abandonment gradient life-form livestock grazing successional gradient

Fungal infections in immunocompromised critically ill patients

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Journal of Intensive Medicine 2024年第3期4卷 299-306页

作者： JoséGarnacho-Montero irene Barrero-García Cristina León-Moya Unidad Clínica de Cuidados Intensivos Hospital Universitario Virgen MacarenaSevillaSpain

Diverse pathogenic fungi can produce severe infections in immunocompromised patients, thereby justifying intensive care unit (ICU) admissions. In some cases, the infections can develop in immunocompromised patients who were previously admitted to the ICU. Aspergillus spp., Pneumocystis jirovecii, Candida spp., and Mucorales are the fungi that are most frequently involved in these infections. Diagnosis continues to be challenging because symptoms and signs are unspecific. Herein, we provide an in-depth review about the diagnosis, with emphasis on recent advances, and treatment of these invasive fungal infections in the ICU setting.

关键词： Invasive aspergillosis Immunocompromised patient Critically ill patient Antifungal Invasive candidiasis Pneumocystis jirovecii

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： irene navarro-Lobato Mariam Masmudi-martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades neurodegenerativas(CIBERnED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGs14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGs14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDnF).A knockdown of BDnF gene in RGs14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDnF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGs14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGs14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Analytic Regularity for a singularly Perturbed Reaction-Convection-Diffusion Boundary Value Problem with Two small Parameters

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Communications in Mathematical Research 2024年第2期40卷 125-153页

作者： irene sykopetritou Christos Xenophontos Department of Mathematics and statistics University of CyprusPo Box 20537Nicosia 1678Cyprus.

We consider a second order,two-point,singularly perturbed boundary value problem,of reaction-convection-diffusion type with two small parameters,and we obtain analytic regularity results for its solution,under the assumption of analytic input ***,we establish classical differentiability bounds that are explicit in the order of differentiation and the singular perturbation ***,for small values of these parameters we show that the solution can be decomposed into a smooth part,boundary layers at the two endpoints,and a negligible *** estimates are obtained for each component of the solution,which again are explicit in the differentiation order and the singular perturbation parameters.

关键词： singularly perturbed problem reaction-convection-diffusion boundary layers analytic regularity.

Quantitative assessment of self-management in patients with nonalcoholic fatty liver disease: An unmet clinical need

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World Journal of Gastroenterology 2024年第25期30卷 3143-3146页

作者： Raffaele Borriello Giorgio Esposto irene Mignini Antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli IRCCSCatholic University of RomeRome 00168Italy

In this editorial we comment on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et al published in a recent issue of the World Journal of ***-alcoholic fatty liver disease(nAFLD)represents one of the current challenges in hepatology and public health,due to its continuous growing prevalence and the rising incidence of nAFLD-related fibrosis,non-alcoholic steatohepatitis and *** only effective therapeutic strategy for this dis-ease is represented by encouraging patients to improve their lifestyle through the modification of dietary intake and increased physical exercise,but the effective application of such modifications is often limited by various factors such as lack of information,psychological barriers or poor social *** poor adherence to a healthy lifestyle can be decisive in determining the clinical outcome,in daily practice there is a lack of quantitative instruments aimed at identifying patients with the lowest adherence to lifestyle changes and higher risk of disease progre-ssion in the course of *** this article,Zeng et al propose a quantitative scale to assess the grade of adherence of patients with nAFLD to hea-lthy lifestyle intervention,called the Exercise and Diet Adherence scale(EDAs).This scale,consisting of 33 items divided into 6 dimensions which relates to six subjective aspects in the self-management of nAFLD,has shown a good correlation with the identification of the sub-cohort of patients with the highest reduction in caloric intake,increase in physical exercise,probability of a reduction in liver stiffness measurement and alanine aminotransferase *** cor-relation among clinical outcomes and specific dimensions of this scale also highlights the pivotal role of a good and confidential doctor-patient relationship and of an effective *** is an urgent need for practical and e

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis Liver cirrhosis Metabolic associated fatty liver disease Metabolic associated steatohepatitis Insulin resistance self-management self-management measurement Patient education

Targeted nGs analysis reveals a complex genetic background of idiopathic erythrocytosis in a large Venetian family

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Genes & Diseases 2024年第2期11卷 561-563页

作者： Bertozzi irene Benetti Andrea Regazzo Daniela Polese Francesca Biagetti Giacomo Ceolotto Giulio Randi Maria Luigia First Medical Clinic University of Padua Department of Medicine – DIMEDVia Giustiniani 2Padova 35123Italy Transfusion Medicine Department Ospedale dell'Angelo - Venezia MestreVia Paccagnella 1Venice 30174Italy Emergency Medicine University of Padua Department of Medicine – DIMEDVia Giustiniani 2Padova 35123Italy

Absolute erythrocytosis,due to an increased production of red blood cells,becomes manifest with hemoglobin(Hb)levels above 165 or 160 g/L or with a hematocrit(HCT)above 51%and 48%in males and females,respectively.1 A minority of patients have polycythemia vera(PV);acquired secondary erythrocytosis frequently occurs due to appropriate or inappropriate erythropoietin(EPO)excess,while congenital secondary erythrocytosis may derive from genetic defects causing tissue *** erythrocytosis occurs in patients with genetic mutations of the oxygen-sensing pathway(VHL,PHD2,_HIF-1-alpha)or the erythropoietin receptor(EPOR)genes.2 Recently,HFE gene variants have been described in sporadic erythrocytoses.3 In a high proportion(about 70%)of patients with erythrocytosis,a specific etiology remains elusive despite extensive testing,and the diagnosis of idiopathic erythrocytosis(IE)is ruled out.

关键词： diagnosis patients congenital

Environmental drivers of long-term variations in the abundance of the red hocicudo mouse (Oxymycterus rufus) in Pampas agroecosystems

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Integrative Zoology 2024年第1期19卷 37-51页

作者： Laura Mariel CALFAYAn Regino CAVIA Jimena FRAsCHInA Juan santiago GUIDOBOnO irene Laura GOROsITO María BUsCH Laboratorio de Ecología de Poblaciones Departamento de EcologíaGenética y EvoluciónFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)Buenos AiresArgentina

During the 20th century,there has been an ongoing agricultural expansion and global warming,two of the main determinants influencing biodiversity changes in *** red hocicudo mouse(Oxymycterus rufus)inhabits subtropical grasslands and riparian habitats and has increased its abundance in recent years in central Argentina *** paper describes the long-term temporal changes in *** abundance in Exaltación de la Cruz department,Buenos Aires province,Argentina,in relation to weatherfluctuations and landscape features,as well as analyzes the spatio-temporal structure of captures of *** used generalized liner models,semi-variograms,the Mantel test,and autocorrelation functions for the analysis of rodent data obtained from trappings conducted between 1984 and *** showed an increase in abundance across the years of study,with its distribution depending on landscape features,such as habitat types and the distance *** rates showed a spatio-temporal aggregation,suggesting expansion from previously occupied *** was more abundant at lower minimum temperatures in summer,higher precipitation in spring and summer,and lower precip-itations in *** conditions affected *** abundance,but there was local variation that differed from global patterns of climate change.

关键词： agroecosystems climate change linear habitats Oxymycterus rufus rodent

DER sPATIAL TURn In DEn KLAssIsCHEn ALTERTUMsWIssEnsCHAFTEn(UnD sPEZIELL In DER EPIGRAPHIK)

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Journal of Ancient Civilizations 2024年第1期39卷 99-121,125页

作者： irene Berti Pädagogische Hochschule Heidelberg

since the 1990s the so-called spatial turn has brought back space and topography into the discussion within historical studies,particular ancient *** survey reviews current trends and developments within the field and offers some perspectives on possible future developments related to space,material,objects,their agency,and frames.

关键词： agency frames material objects space spatial turn topography

shear-wave elastography to predict hepatocellular carcinoma after hepatitis C virus eradication:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第10期30卷 1450-1460页

作者： Giorgio Esposto Paolo santini Linda Galasso irene Mignini Maria Elena Ainora Antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione Policlinico Universitario Agostino Gemelli IRCCs Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BACKGROUnD Direct-acting antiviral agents(DAAs)are highly effective treatment for chronic hepatitis C(CHC)with a significant rate of sustained virologic response(sVR).The achievement of sVR is crucial to prevent additional liver damage and slow down fibrosis *** assessment of fibrosis degree can be performed with transient elastography,magnetic resonance elastography or shear-wave elastography(sWE).Liver elastography could function as a predictor for hepato-cellular carcinoma(HCC)in CHC patients treated with *** To explore the predictive value of sWE for HCC development after complete clearance of hepatitis C virus(HCV).METHODs A comprehensive literature search of clinical studies was performed to identify the ability of sWE to predict HCC occurrence after HCV *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** At baseline and after 12 wk of follow-up,a trend was shown towards greater liver stiffness(Ls)in those who go on to develop HCC compared to those who do not[baseline Ls standardized mean difference(sMD):1.15,95%confidence interval(95%CI):020-2.50;Ls sMD after 12 wk:0.83,95%CI:0.33-1.98].The absence of a statistically significant difference between the mean Ls in those who developed HCC or not may be related to the inability to correct for confounding factors and the absence of raw source *** was a statist-ically significant Ls sMD at 24 wk of follow-up between patients who developed HCC vs not(0.64;95%CI:0.04-1.24).COnCLUsIOn sWE could be a promising tool for prediction of HCC occurrence in patients treated with *** studies with larger cohorts and standardized timing of elastographic evaluation are needed to confirm these data.

关键词： shear-wave elastography Hepatocellular carcinoma Hepatitis C virus sustained virologic response