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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： irene Navarro-Lobato mariam masmudi-martín manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinforiano Posadas maría E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORm),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORm in young animals and prevent ORm deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORm *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa maria Jose Curras-Tuala Sara Pischedda miriam Cebey-Lopez Jose Gomez-Rial irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian montoto-Louzao Alba Camino-mera Isabel Ferreiros-Vidal maximo Fraga Jose RAntunez Rodolfo Gomez Federico martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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A Knowledge Graph-Based Deep Learning Framework for Efficient Content Similarity Search of Sustainable Development Goals Data

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Data Intelligence 2023年第3期5卷 663-684页

作者： irene Kilanioti George A.Papadopoulos School of Electrical and Computer Engineering National Technical University of Athens9 Heroon Polytechneiou St.Zografou Campus Athens15780Greece Department of Computer Science University of Cyprus1 University AvenueAglantziaCY-2109NicosiaCyprus

Sustainable development denotes the enhancement ofliving standards in the present without compromising future generations'*** Development Goals(SDGs)quantify the accomplishment of sustainable development and pave the way for a world worth living in for future *** can contribute to the achievement of the SDGs by guiding the actions of practitioners based on the analysis of SDG data,as intended by this *** propose a framework of algorithms based on dimensionality reduction methods with the use of Hilbert Space Filling Curves(HSFCs)in order to semantically cluster new uncategorised SDG data and novel indicators,and efficiently place them in the environment of a distributed knowledge graph ***,a framework of algorithms for insertion of new indicators and projection on the HSFC curve based on their transformer-based similarity assessment,for retrieval of indicators and loadbalancing along with an approach for data classification of entrant-indicators is ***,a thorough case study in a distributed knowledge graph environment experimentally evaluates our *** results are presented and discussed in light of theory along with the actual impact that can have for practitioners analysing SDG data,including intergovernmental organizations,government agencies and social welfare *** approach empowers SDG knowledge graphs for causal analysis,inference,and manifold interpretations of the societal implications of SDG-related actions,as data are accessed in reduced retrieval *** facilitates quicker measurement of influence of users and communities on specific goals and serves for faster distributed knowledge matching,as semantic cohesion of data is preserved.

关键词： Content similarity Distributed knowledge graphs Sustainable Development Goals Hilbert space filling curves Deep learning

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Immediate and long-term effects of invasive plant species on soil characteristics

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Soil Ecology Letters 2022年第3期4卷 276-288页

作者： irene m.Unger Robert J.Kremer Kristen S.Veum Keith W.Goyne Department of Biology and Chemistry Baker UniversityP.O.Box 65Baldwin CityKS 66006USA School of Natural Resources University of missouri 302 ABNR Bldg.ColumbiaMO 65211USA USDA-ARS Cropping Systems and Water Quality UnitUniversity of Missouri302 ABNR Bldg.ColumbiaMO 65211USA Department of Forest Resources and Environmental Conservation Virginia Tech324 Cheatham HallBlacksburgVA 24061USA

Invasive plant species may alter soil characteristics or interact with the soil microbial community resulting in a competitive *** objectives were to determine:i)if invasive plant species alter soil properties;and ii)the long-term effects of invasive plant species on soil properties and subsequent implications on ecological restoration *** focused on Lespedeza cuneata,a plant that may be *** samples were collected from four locations in Central missouri,USA:an old-field with abundant ***,two reconstructed sites,and a remnant prairie that has never been *** health indictors were used to characterize soil properties at these *** every soil property differed significantly between the unplowed prairie reference site and the other three *** reconstructed sites,however,generally did not differ from the invaded *** results indicate that the reconstructed prairies are not fully *** above-ground traits,such as the plant community structure,appear similar to the prairie,the soil microbial community structure still resembles that of an invaded old-field *** results indicate that more time may be needed before soil microbial populations fully recover after invasive plant removal.

关键词： Sericea lespedeza Legacy effects Soil microorganisms

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Local hardening and asymmetric twin growth by twin-twin interactions in a mg alloy

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Journal of magnesium and Alloys 2023年第1期11卷 176-191页

作者： Krishna Yaddanapudi mariyappan Arul Kumar Jiaxiang Wang Xin Wang Timothy J.Rupert Enrique J.Lavernia Julie m.Schoenung irene J.Beyerlein Subhash mahajan Department of materials Science and Engineering University of CaliforniaDavisCA 95616USA materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA Department of mechanical Engineering Materials DepartmentUniversity of CaliforniaSanta BarbaraCA 93106USA Department of materials Science and Engineering University of CaliforniaIrvineUSA materials Department University of CaliforniaSanta BarbaraCA 93106USA

In this study,the role of twin-twin interactions on the distributions of local defects(e.g.,dislocations)and stress fields in a magnesium alloy is investigated.A co-zone(1012)-(1012)tensile twin junction in a deformed mg-3wt.%Y alloy is analyzed using transmission electron microscopy(TEm).The results show that the morphology of the impinging(1012)twin is asymmetric,and the non-interacting boundary of the recipient(1012)twin is *** analysis of TEm images reveals that type-II pyramidal[1213](1212)dislocations concentrate in the vicinity of the twin-twin junction *** samedislocations are also observed inside the interacting twin domains along with a few ***dislocations emanating from the impinging(1012)twin boundary have edge character and are extended with faults parallel to the basal *** contrast,thedislocations connected to the recipient(1012)twin are predominantly screw orientation and ***-viscoplastic fast Fourier transform based crystal plasticity calculations are performed to rationalize the observed twin morphology and local dislocation *** model calculations suggest that the local stress fields generated at the junction site where the two twins meet are responsible for the experimentally observed concentration of*** calculated stress fields are asymmetric with respect to the junction site,explaining the observed asymmetric morphology of the impinging ***,these findings show strong effects of twin-twin interactions on the distribution of dislocations as well as the evolution of the twinned microstructure and as such,can help advance understanding of twinning in mg alloys and their effect on mechanical behavior.

关键词： Tensile twins Twin-twin intersections mg alloys Crystal plasticity TEm

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A Complete Diophantine Characterization of the Rational Torsion of an Elliptic Curve

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Acta mathematica Sinica,English Series 2012年第1期28卷 83-96页

作者： irene GARCíA-SELFA Jos m.TORNERO Departamento de matemáticas Universidad de HuelvaFacultad de Ciencias ExperimentalesCampus de El CarmenAvenida de las Fuerzas Armadass/n21071 HuelvaSpain Departamento de ' Algebra Universidad de SevillaP.O.116041080 SevillaSpain

We give a complete characterization for the rational torsion of an elliptic curve in terms of the （non-）existence of integral solutions of a system of diophantine equations.

关键词： Elliptic curves diophantine equations

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SHOCK AND BOUNDARY STRUCTURE FORmATION BY SPECTRAL-LAGRAngIAN mETHODS FOR THE INHOmOGENEOUS BOLTZmANN TRANSPORT EQUATION

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Journal of Computational mathematics 2010年第4期28卷 430-460页

作者： irene m.Gamba Sri Harsha Tharkabhushanam Department of mathematics & Institute of Computational Engineering and Sciences University of Texas Austin Institute of Computational Engineering and Sciences University of Texas Austin

The numerical approximation of the Spectral-Lagrangian scheme developed by the authors in [30] for a wide range of homogeneous non-linear Boltzmann type equations is extended to the space inhomogeneous case and several shock problems are benchmark. Recognizing that the Boltzmann equation is an important tool in the analysis of formation of shock and boundary layer structures, we present the computational algorithm in Section 3.3 and perform a numerical study case in shock tube geometries well modeled in for ID in x times 3D in v in Section 4. The classic Riemann problem is numerically analyzed for Knudsen numbers close to continuum. The shock tube problem of Aoki et al [2], where the wall temperature is suddenly increased or decreased, is also studied. We consider the problem of heat transfer between two parallel plates with diffusive boundary conditions for a range of Knudsen numbers from close to continuum to a highly rarefied state. Finally, the classical infinite shock tube problem that generates a non-moving shock wave is studied. The point worth noting in this example is that the flow in the final case turns from a supersonic flow to a subsonic flow across the shock.

关键词： Spectral Numerical methods Lagrangian optimization FFT Boltzmann Trans- port Equation Conservative and non-conservative rarefied gas flows.

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Immunosuppressive regimens and outcomes of inflammatory bowel disease patients requiring kidney transplantation

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World Journal of Transplantation 2022年第2期12卷 21-23页

作者： Urvashi Singh Baljit Singh maria irene Bellini Department of Surgery Wythenshawe HospitalManchester University Hospitals NHS Foundation TrustManchester M239LTUnited Kingdom Department of Colorectal Surgery University Hospitals LeicesterLeicester LE15WWUnited Kingdom Department of Surgical Sciences Sapienza UniversityRoma 00161Italy

Patients with inflammatory bowel disease(IBD)can develop extra-renal complications and as a result,suffer from end stage renal failure requiring kidney transplantation(KT).A brief review of available literature revealed that IBD patients undergoing KT have shorter overall survival rates compared to their *** reporting steroid regimens and survival outcomes specific to IBD and post kidney transplant are scarce and these studies have small sample sizes thus making it difficult to draw accurate *** research is required in the form of a randomized controlled study to clarify the effect and mechanism of steroid immunosuppression on the prognosis of renal transplant recipients and explore new treatment schemes.

关键词： Inflammatory bowel disease Kidney transplantation Steroids Immunosuppression Kidney failure Ulcerative colitis Crohn’s disease

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From landslide characterization to nature reserve management:The“Scialimata Grande di Torre Alfina”landslide Geosite(Central Apennines,Italy)

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山地科学学报（英文） 2023年第3期20卷 585-606页

作者： Gianluca TRONTI Francesca VERGARI irene maria BOLLATI Filippo BELISARIO maurizio DELmONTE manuela PELFINI Paola FREDI Earth Sciences Department"Ardito Desio" University La StataleMilan 20133(MI)Italy monte Rufeno Nature Reserve Acquapendente 01021(VT)Italy Earth Sciences Department University La SapienzaRome 00185(RM)Italy

Italy is characterized by widespread geomorphological instability,am.ng which landslides leave impressive marks on the ***,landslide bodies may represent key sites for thematic and educational itineraries,especially in protected areas,where their management becomes an important *** study focuses on the"monte Rufeno Nature Reserve"(Central Apennines,Italy),where iconic landslides are ***,the"Scialimata Grande di Torre Alfina"landslide(SGTA)is listed in the regional Geosite *** work aims to propose a multiscale procedure for landslide analysis,in terms of both hazard sources but also educational and geoheritage enhancement opportunities in natural *** perform.ng a Landslide Susceptibility conditional Analysis(LSA)for the reserve territory,attention was focused on the SGTA,to define properly its features and morphodynamics.A multi-disciplinary approach was adopted,by applying both remote sensing(UAV structure from motion,Photointerpretation)and field survey(geomorphological and GPS monitoring).From the LSA,based on drainage density,curvature,and slope triggering factors,the road and trail susceptibility maps were derived,as base tools for future risk assessments and trail paths management within the *** the SGTA scale,the monitoring showed a displacement of up to 23 m during the time interval between 2015 and *** landslide dynamics seem to be driven by alternating dry and extremely wet periods;moreover,leaks from the aqueduct in the detachment area and piping effects through clays may have also decreased the substrate *** SGTA complex influence on the Paglia River valley geometry was also hypothesized,underlining the action of landslide through different spatial scales(on-site and off-site)and on different environment features(sediment connectivity,hydrology).Finally,the SGTA appears highly representative of the geomorphic dynamics within the Nature Reserve(i.e.,scientific value)and it could be

关键词： Landslides Geoheritage Geosites Nature reserves management UAV structure from motion Landslides conditional analyses

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Combining material characterization with single and multi-oxyanion adsorption for mechanistic study of chromate removal by cationic hydrogel

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Journal of Environmental Sciences 2011年第6期23卷 1004-1010页

作者： irene m.C.Lo Samuel C.N.Tang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Cationic hydrogel with magnetic property was synthesized via radical polymerization and its removal capacity of chromate from contaminated water was found to be 200 mg/*** Fourier transform infrared spectroscopy（FT-IR） study,the mechanism of chromate removal by hydrogel was found to be non-specific adsorption,mainly due to ion exchange,as evidenced by the positively charged functional group,trimethyl ammonium-N＋（CH3）3,in the *** were accordingly determined by testing di？erent oxyanion adsorption onto the *** results of the chromate adsorption experiments illustrated that the amount of chromate adsorbed was nearly equal to that of the chloride released from the hydrogel,which is part of the evidence for ion *** and multi-oxyanion adsorption experiments were also performed,and it was demonstrated that ion removal was species independent,but charge dependent,another characteristic of the ion exchange *** was found that the same Langmuir model can be applied to best fit the findings of single and multi-oxyanion adsorption,which further indicates the mechanism of chromate removal is attributed to ion *** view of the above,the background anions compete for adsorption sites with chromate,evidenced by inhibitive chromate removal in the presence of background electrolytes in the batch studies,further echoing the ion exchange mechanism.

关键词： adsorption magnetic hydrogel mechanism ion exchange oxyanion

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