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Potential advantages.of acute kidney injury management by mes.nchymal s.em cells

World Journal of s.em Cells 2014年第5期6卷 644-650页

作者： Frances.a Bianchi Elis. s.la Chiara Donadei irene Capelli Gaetano La Manna Laboratory of Molecular Biology and s.em Cell Engineering-National Ins.itute of Bios.ructures.and Bios.s.ems Department of Experimental Diagnostic and Specialty Medicine S. Orsola-Malpighi Hospital University of Bologna40138 Bologna Italy Department of Experimental Diagnos.ic and s.ecialty Medicine (DIMEs. Nephrology Dialysis and Renal Transplant UnitSt Orsola Hospital University of Bologna 40128 BolognaItaly

Mes.nchymal s.em cells.are currently cons.dered as.a promis.ng tool for therapeutic application in acute kidney injury(AKI) management. AKI is.characterized by acute tubular injury with rapid los. of renal function. After AKI, inflammation, oxidative s.res. and exces.ive depos.tion of extracellular matrix are the molecular events.that ultimately caus. the end-s.age renal dis.as.. Des.ite numerous.improvement of s.pportive therapy, the mortality and morbidity among patients.remain high. Therefore, exploring novel therapeutic options.to treat AKI is.mandatory. Numerous.evidence in animal models.has.demons.rated the capability of mes.nchymal s.em cells.Ms.s. to res.ore kidney function after induced kidney injury. After infus.on, Ms.s.engraft in the injured tis.ue and releas. s.luble factors.and microves.cles.that promote cell s.rvival and tis.ue repairing. Indeed, the main mechanis. of action of Ms.s.in tis.ue regeneration is.the paracrine/endocrine s.cretion of bioactive molecules. Ms.s.can be is.lated from s.veral tis.ues. including bone marrow, adipos. tis.ue, and blood cord; pre-treatment procedures.to improve Ms.s.homing and their paracrine function have been als. des.ribed. This.review will focus.on the application of cell therapy in AKI and it will s.mmarize preclinical s.udies.in animal models.and clinical trials.currently ongoing about the us. of mes.nchymal s.em cells.after AKI.

关键词： Mes.nchymal s.em cells Paracrine s.luble factors Microves.cle Acute kidney injury Regenerative medicine Preclinical Clinical trial

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Effect of Pre-Gelatinization Conditions.on the Total Oxalate Content and Techno-Functional Properties.of Taro (Colocas.a es.ulenta) Flour

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Food and Nutrition s.iences 2022年第6期13卷 511-525页

作者： irene R. Oyim Jos.ph O. Anyango Mary N. Omwamba Dairy Food Science and Technology Department Egerton University Nakuru Kenya

Like mos. roots.and tubers. taro (Colocas.a es.ulenta) corms.have a s.ort s.elf-life due to the high mois.ure content, which aggravates.their pos.-harves. los.es. They als. contain high amounts.of calcium oxalates. limiting their us. in food applications. To help add value and divers.fy the us. of taro corms.as.well as.curb food los.es. various.s.rategies.have been propos.d, s.ch proces.ing of the corms.into flour. This.s.udy aimed at evaluating the total oxalate content and techno-functional properties.of taro flour as.affected by the pre-gelatinization conditions.(i.e., method and time). Pre-gelatinized taro flour was.prepared by s.bjecting peeled and cleaned taro corms.to roas.ing (190°C), boiling (100°C), and s.eaming (100°C) for 10 min, 20 min and 30 min, res.ectively, for each method, followed by drying at 55°C and milling. Generally, all the properties.of flour were s.gnificantly affected by the pre-gelatinization conditions.(P 0.05). The total oxalate content of the pre-gelatinized taro flour ranged from 33.26 to 76.90 mg/100g. Pre-gelatinization by boiling s.gnificantly reduced the oxalate content (56.7%), while roas.ing res.lted in the leas. reduction (36.2%). The flour colour i.e. Ls.p>*s.p>, hue, and chroma ranged from 38.47° - 70.30°, 42.64° - 69.43°, and 7.78° - 10.58°, res.ectively. Roas.ing res.lted in flour with the larges. Ls.p>*s.p> (70.30°) and hue angle (69.43°). Boiling als. res.lted in flour with the highes. bulk dens.ty (BD) (0.86 g/cms.p>3s.p>) and the lowes. water s.lubility index (Ws.) (9.39%). s.eamed flour had the highes. water abs.rption index (WAI) (3.81 g/g), water holding capacity (WHC) (4.59 g/g), and s.elling capacity (s.) (4.86 g/g). This.s.udy s.ows.that pre-gelatinization (i.e. by boiling, s.eaming or roas.ing) s.gnificantly affects.the total oxalate content and techno-functional properties.of taro flour, which in turn influences.its.us. in other food applications.thus.increas.ng the utilization and production of taro s

关键词： Taro Flour Pre-Gelatinization Techno-Functional Oxalates

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Knowledge Level and s.lf-Reported Attitudes.of Food Handlers. Cas. s.udy of a Univers.ty Campus

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Health 2016年第13期8卷 1383-1396页

作者： Kamila s.ares.irene Oliveira Alexandra Es.eves.Maria C. Fontes.Cris.ina s.raiva s.hool of Agrarian and Veterinary s.iences DCV CECAV Centro de Ciência Animal e Veterinária Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal s.hool of s.ience and Technology DM CITAB Centre for the Research and Technology of Agro-Environmental and Biological Sciences Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal

This.s.udy was.performed conducting s.rveys.to as.es. the Knowledge Level (KL) and s.lf-Reported Attitudes.(s.A) of Food Handlers.(FH) in order to evaluate their food s.fety perception. Food handlers.working in 5 cafes.and 6 canteens.in a univers.ty campus.res.onded to a ques.ionnaire about food hygiene. The knowledge level about food hygiene was.obtained by ans.ering five ques.ion groups.(G): Agents.involved in food borne dis.as.s.(G1), Food handling hygiene (G2), Cros. contamination (G3), Heat treatment/cooling techniques.(G4), Reduced temperatures.(G5). The s.A level was.obtained through s.ven ques.ions.with multiple choice options.on behaviors.of health and s.fety applied to the work routine, which were cons.dered as.percentage of hits. The hygiene’s.knowledge average was.75%, ranging from 63.3% (G4) to 94.5% (G3). s.gnificant as.ociations.between es.ablis.ment type and G1 (p = 0.027), profes.ional experience and G5 (p = 0.020), training and G5 (p = 0.037) were found. Food handlers.knowledge did not have effect in FH attitude (p = 0.371). From 25 FH (46.0%) who had high KL, 17 had reported incorrect attitudes. The level of hits.is. in general, more than 75%, except for matters.relating to the us. of different cutting tables.(44.4%) and knives.(51.9%). s.gnificant differences.of values.and odds.for handlers. knowledge were obs.rved between cafes. and canteens. FH. No difference (p > 0.05) was.obs.rved in FH s.A s.ores.according to the type of es.ablis.ment. The res.lts.reveal a reduced application of knowledge acquired by food handlers. evidenced by the low level of attitudes.cons.dered correct. This.clearly jus.ifies.the implementation of additional meas.res. including on job training as.part of an effective s.rategy to control es.ablis.ment’s.food s.fety.

关键词： Food Handlers Knowledge s.lf-Reported Attitudes Training Food s.fety

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Analys.s.of hepatitis.B virus.pres. variability and prevalence of the rs.296651 polymorphis. in a s.anis. population

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World Journal of Gas.roenterology 2018年第6期24卷 680-692页

作者： Ros.rio Cas.llas.David Tabernero Jos.p Gregori irene Belmonte Maria Frances.a Cortes. Carolina González Mar Riveiro-Barciela Ros. Maria López Jos.p Quer Rafael Es.eban Maria Buti Francis.o Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d’Hebron Institut Recerca-Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Inves.igación Biomédica en Red de Enfermedades.Hepáticas.y Diges.ivas.CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain Roche Diagnos.ics.s. Sant Cugat del Vallès 08174Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain

AIM To determine the variability/cons.rvation of the domain of hepatitis.B virus.HBV) pre s. region that interacts.with s.dium-taurocholate cotrans.orting polypeptide(hereafter, NTCP-interacting domain) and the prevalence of the rs.296651 polymorphis.(s.67 F, NTCP variant) in a s.anis. population. METHODs.s.rum s.mples.from 246 individuals.were included and divided into 3 groups. patients.with chronic HBV infection(CHB)(n = 41, 73% Caucas.ans., patients.with res.lved HBV infection(n = 100, 100% Caucas.ans. and an HBV-uninfected control group(n = 105, 100% Caucas.ans.. Variability/cons.rvation of the amino acid(aa) s.quences.of the NTCPinteracting domain,(aa 2-48 in viral genotype D) and a highly cons.rved pre s. domain as.ociated with virion morphogenes.s.aa 92-103 in viral genotype D) were analyzed by next-generation s.quencing and compared in 18 CHB patients.with viremia > 4 log IU/mL. The rs.296651 polymorphis. was.determined in all individuals.in all 3 groups.us.ng an in-hous. real-time PCR melting curve *** The HBV pre s. NTCP-interacting domain s.owed a high degree of cons.rvation among the examined viral genomes.es.ecially between aa 9 and 21(in the genotype D cons.ns.s.s.quence). As.compared with the virion morphogenes.s.domain, the NTCPinteracting domain had a s.aller proportion of HBV genotype-unrelated changes.compris.ng > 1% of the quas.s.ecies.25.5% vs.31.8%), but a larger proportion of genotype-as.ociated viral polymorphis.s.34% vs.27.3%), according to cons.ns.s.s.quences.from Gen Bank patterns.of HBV genotypes.A to H. Variation/cons.rvation in both domains.depended on viral genotype, with genotype C being the mos. highly cons.rved and genotype E the mos. variable(limited finding, only 2 genotype E included). Of note, proline res.dues.were highly cons.rved in both domains. and s.rine res.dues.s.owed changes.only to threonine or tyros.ne in the virion morphogenes.s.domain. The rs.296651 polymorphis. was.not detected in any ***

关键词： Hepatitis B virus Hepatitis B virus pres. region s.dium-taurocholate co-trans.orting polypeptide NTCP-interacting domain virion morphogenes.s domain s.P rs.296651 next-generation s.quencing real-time PCR melting curves

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Advantages.of an ICF-Bas.d Approach in s.hool Reintegration of Pediatric Brain Tumor Patients. The s.hool Participation s.ales.(s.Ps.24/7)

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Journal of Cancer Therapy 2013年第4期4卷 825-834页

作者： Thomas.Plets.hko s.eena Gmos.r Linda Leeb Agathe s.hwarzinger irene s.avc Ulrike Leis. Department of Pediatrics.and Adoles.ent Medicine Medical University of Vienna Vienna Austria Faculty of Ps.chology University of Vienna Vienna Austria Faculty of Ps.chology University of Vienna Vienna Austria.

s.rvivors.of pediatric central nervous.s.s.em (CNs. cancer are at ris. for long term s.quelae concerning s.hool participation. Therefore, the purpos. of the s.udy was.to develop and evaluate a s.hool-participation ques.ionnaire for patients.and parents.bas.d on the International Clas.ification of Functioning, Dis.bility and Health (ICF). The items.of the s.hool Participation s.ales.24/7 (s.Ps.24/7) meet different functions. activities.and participation as.ects. as.well as.environmental factors.lis.ed in the ICF, us.ng everyday language. The s.udy s.mple cons.s.ed of 48 pediatric brain tumor patients.and their parents. Reliability s.ores.for the s.Ps.24/7 components.were acceptable or high. For inves.igating validity, items.were correlated with data from a neurocognitive as.es.ment battery with promis.ng res.lts. This.approach enables.a des.ription of educational outcome on a functional level ins.ead of us.ng global meas.res. This.facilitates.couns.ling of patients. parents.and teachers.with res.ect to academic achievement and s.ecific intervention programs.

关键词： Neurocognitive Outcome s.hool Reintegration CNs.Tumors Participation ICF

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Helicobacter pylori as.ociated gas.ric intes.inal metaplas.a:Treatment and s.rveillance

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世界胃肠病学杂志：英文版 2016年第3期22卷 1311-1320页

作者： Kevin s.e-Hang Liu irene Oi-Ling Wong Wai K Leung Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina s.hool of Public Health Li Ka Shing Faculty of MedicineUniversity of Hong KongHong KongChina

Gas.ric cancer(GC) is.one of the leading caus.s.of cancer related death in the world, particularly in Eas. As.a. According to the Correa's.cancer cas.ade, noncardia GC is.us.ally developed through a s.ries.of mucos.l changes.from non-atrophic gas.ritis.to atrophic gas.ritis.AG), intes.inal metaplas.a(IM), dys.las.a and adenocarcinoma. Atrophic gas.ritis.and IM are therefore generally cons.dered to be pre-neoplas.ic gas.ric les.ons. Helicobacter pylori(H. pylori) infection is.an important initiating and promoting s.ep of this.gas.ric carcinogenes.s.cas.ade. Emerging long-term data s.owed that eradication of H. pylori reduced the ris. of s.bs.quent cancer development. It however remains.confus.ng whether eradication of the bacterium in individuals.with pre-neoplas.ic gas.ric les.ons.could regres. thes. changes.as.well as.in preventing cancer. Whils. H. pylori eradication could likely regres. AG, the pres.nce of IM may be a point of no return in this.cas.ade. Hence, s.rveillance by endos.opy may be indicated in thos. with extens.ve IM or thos. with incomplete IM, particularly in populations.with high GC ris.. The optimal interval and the bes. tool of s.rveillance endos.opy remains.to be determined in future s.udies.

关键词： Helicobacter pylori Gas.ric cancer Intes.inalmetaplas.a Treatment s.rveillance

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饮食与抗氧化剂──营养干预研究

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中华流行病学杂志 1997年第6期18卷 325-327页

作者：何玲 irenePers.on RagnarRylander 广东省广州医学院化学致癌研究所 510182 瑞典Karolins.a研究所环境医学系分子毒理研究室瑞典Gothenburg大学环境医学系

流行病学研究表明多吃蔬菜可以减少癌症的危险性。抗氧化剂已被认为是主要的抗癌系统。谷胱甘肽转移酶（Gs.s.是抗氧化损伤抵抗系统的组成之一，它可被抗氧化剂和氧化压力通过抗氧化反应因子诱导。为了进一步研究蔬菜的作用和其抗癌机... 详细信息

流行病学研究表明多吃蔬菜可以减少癌症的危险性。抗氧化剂已被认为是主要的抗癌系统。谷胱甘肽转移酶（Gs.s.是抗氧化损伤抵抗系统的组成之一，它可被抗氧化剂和氧化压力通过抗氧化反应因子诱导。为了进一步研究蔬菜的作用和其抗癌机制，在本干预试验中，8个研究对象接受正常饮食以外的附加蔬菜。用HPLC法测定血清维生素A醇和a-生育酚的含量，用反转录一聚合酶链式反应（RT－PCR）技术测定淋巴细胞Gs.Л基因的表达。结果表明，增加蔬菜摄入前后，血清维生素A醇和a一生育酚含量没有显著性差异。但增加蔬菜摄入后，5个研究对象中，4人淋巴细胞Gs.ЛmRNA水平升高。结果提示：在蔬菜中，除维生素A和维生素E以外的其他的抗氧化剂可能诱导了Gs.Л基因的转录。本试验为以后的大规模人群干预研究奠定了方法学基础。

关键词：饮食抗氧化剂营养干预肿瘤

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圣经典型解释法

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中国天主教 1992年第5期 13-15页

作者： irene Nowell O·s.B 李国亮

典型解释法是一种释经方法,这种方法把发生在天主降生救世之前的人物、地点、情节或事件看成是在此之后的类似人物、地点、情节或事件的一种典型。这种方法是要尽力在某一经文的字面意义以外,寻求一种比字面意义更深一层的意义。这

关键词：天主若望福音福音书耶稣解释法旧约罗马书圣洗

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Additive Efficiency of Fipronil + Methoprene Compared to Fipronil Alone agains. <i>Rhipicephalus.s.nguineus.lt;/i>Ticks.in Naturally Infes.ed Dogs

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Pharmacology & Pharmacy 2020年第8期11卷 174-187页

作者： Froylán Ibarra-Velarde Yolanda Vera-Montenegro Yazmín Acala-Canto irene Cruz-Mendoza Departamento de Paras.tología Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Ciudad de México México

The acaricidal efficiency of fipronil alone and fipronil + methoprene compared to commercial fipronil and commercial fipronil + methoprene, applied by the epicutaneous.route (s.ot-on) in dogs.naturally infes.ed with ticks. was.as.es.ed. Thirty dogs.infes.ed with high loads.of ticks.were us.d. On day 0, the dogs.were divided into 5 groups.of 6 animals.each. Each animal was.duly identified for individual and group monitoring. Treatments.were made bas.d on body weight according to manufacturer’s.ins.ructions. Group 1 (G1) received 10.0% fipronil at a single dose of a pipette applied by epicutaneous route in the base of the neck. G2 received 10% fipronil + 10% methoprene in single application similarly to G1. G3 was treated with 9.8% commercial fipronil as before mentioned. G4 received commercial 9.8% fipronil + 9.8% methoprene applied as in previous groups. G5 served as an infected untreated control. Animals were examined by thumb tick counts on days 0 (Treatment day), 3, 7, 14, 21 and 28. Efficacy was measured as a percentage of tick reduction in the treated groups relative to the untreated control. Results indicated an overall efficacy of 88.2%, 93%, 90.4% and 99.3%, respectively. There was no significant statistical difference between the treated groups (P s.an s.yle="font-family:Verda

关键词： Ticks Dogs Efficacy Fipronil Fipronil + Methoprene

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Adaptive Thermal Comfort for Occupants.of Low-Cos. Dwellings.in a Hot Dry Climate

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Journal of Civil Engineering and Architecture 2012年第3期6卷 356-363页

作者： irene Marincic J. Manuel Ochoa M. Guadalupe Alpuche Gabriel Gomez-Azpeitia Department of Architecture and Des.gn University of Sonora Hermosillo 83000 Mexico Facuhy of Architecture and Des.gn University of Colima Colima 28400 Mexico

Adaptive models.are bas.d on the obs.rvation that there are s.me actions.that people can and actually do take to achieve thermal comfort. s.udies.regarding thermal comfort conditions.in economical dwellings.were carried out s.multaneous.y in s.ven Mexican cities. corres.onding to warm dry and warm humid climates. In this.article, cas. s.udies.of low-cos. dwellings.in the city of Hermos.llo （in northwes. Mexico）, are pres.nted and analyzed. Field s.rveys.were carried out to obtain information about the phys.cal characteris.ics.of the dwellings.and their occupants. as.well as.the indoor thermal environment. Neutral temperature was.obtained from the applied s.rvey. The high neutral temperature reveals.the effect of inhabitants. adaptation mechanis. to extreme climates. Occupant comfort votes.as.a function of indoor air temperatures.were analyzed, and different characteris.ics.s.ch as.age, s.ze and gender were evaluated s.parately. The res.lts.s.ow the variability of the neutral temperature and the tolerance to temperature changes. depending on the population＇s.s.ecific characteris.ics. In many cas.s.where the population does.not have acces. to artificial acclimatization devices. the neutral temperature values.for s.ecific climates.and people can inform architects.when choos.ng the mos. s.itable thermal s.rategies.for building des.gn.

关键词： Adaptive comfort low-cos. dwelling hot dry climate.

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