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The movement dynamics of autotomized lizards and their tails reveal functional costs of caudal autotomy

Integrative Zoology 2020年第6期15卷 511-521页

作者： irene fernández-rodríguez Florentino BRAÑA Department of Organisms and Systems Biology(Zoology) University of OviedoOviedoSpain Research Unit of Biodiversity(UMIB UO/CSIC/PA)University of OviedoMieresSpain

Autotomy has evolved independently several times in different animal *** frequently involves immediate functional costs,so regeneration evolved in many instances to restore the functionality of that body *** autotomy is a widespread antipredator strategy in lizards,although it may affect energy storage,locomotion dynamics,or survival in future encounters with ***,we assessed the effect of tail loss on the locomotor performance of wall lizards(Podarcis muralis),as well as the recovery of locomotor functionality of lizards with regenerated tails,and the movement dynamics of shed tails that were either intact or having regenerated *** loss had no effect on locomotion over unhindered spaces,possibly due to compensation between a negative effect on the stride of front limbs,and a positive effect of losing mass and friction *** found a clear negative impact of tail loss on locomotion in spaces with interspersed obstacles,in which tailed lizards jumped larger distances when leaving the ***,lizards that used the tail to push off the ground were able to approach the obstacles from further,so that the tail seemed to be useful when used during *** fully restores lizard’s locomotor capacities,but tail antipredator value,as indicated by the intensity of post-autotomic movements,is only partially *** these results,we propose that,together with the recovery of post-autotomy antipredator capacities,the restoration of the organismal locomotor performance may have been an important,yet frequently neglected factor in the evolution of lizard’s regeneration ability.

关键词： autotomy locomotor performance regeneration tail wall lizard

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A role for lipids as agents to alleviate stroke damage： the neuroprotective effect of 2-hydroxy arachidonic acid

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Neural Regeneration Research 2017年第8期12卷 1273-1275页

作者： irene F.Ugidos Diego Pérez-rodríguez Arsenio fernández-López Area de Biologia Celular Instituto de Biomedicina Universidad deLeon Leon Spain

Cerebrovascular accident（CVA）or stroke is one of the world＇s leading causes of death and permanent *** high social and medical costs associated with this pathology mean there is an urgent need to find effective ***... 详细信息

关键词： the neuroprotective effect of 2-hydroxy arachidonic acid FFA OAA A role for lipids as agents to alleviate stroke damage MCAO

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Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments

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Neural Regeneration Research 2023年第9期18卷 1961-1967页

作者： irene fernández Ugidos Paloma González-rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-rodríguez JoséManuel Gonzalo-Orden Arsenio fernández-López Área de Biología Celular Instituto de BiomedicinaCampus de Vegazana s/nUniversidad de LeónLeónSpain Neural Therapies SL.Edif.Institutos de Investigación.Planta baja.Local B43.Campus de Vegazana s/n.León.Spain Department of Medicina Cirugía y Anatomía VeterinariaUniversity of LeónLeónSpain Department of Pharmacology Tulane University School of MedicineNew OrleansLAUSA Department of Neurology David Geffen School of Medicine at University of California(UCLA)Los AngelesCAUSA Department of Life Sciences Imperial College London(ICL)LondonUK Department of Clinical and Movement Neurosciences UCL Queen Square Institute of NeurologyLondonUK

The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic *** use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental *** this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic *** study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged *** show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ***,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal ***,this treatment decreased the formation of neuronal progenitor *** study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.

关键词： anti-inflammatories astrocyte axonal sprouting cylinder test doublecortin focal brain ischemia glial scar inflammation neuroprotection new neuron generation transient stroke

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study

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Journal of Sport and Health Science 2022年第5期11卷 578-585页

作者： Asier Manas Borja del Pozo Cruz Ulf Ekelund JoséLosa Reyna irene rodríguez Gómez JoséAntonio Carnicero Carreno Leocadio rodríguez Manas Francisco J.García García Ignacio Ara GENUD Toledo Research Group University of Castilla-La ManchaToledo 45071Spain CIBER of Frailty and Healthy Aging(CIBERFES) Madrid 28029Spain Motivation and Behaviour Research Program Institute for Positive Psychology and EducationFaculty of Health SciencesAustralian Catholic UniversitySydneyNSW 2060Australia Department of Sports Medicine Norwegian School of Sport SciencesOslo 0806Norway Department of Chronic Diseases and Ageing Norwegian Institute of Public HealthOslo 0473Norway Geriatric Department Hospital Virgen del ValleToledo 45071Spain Geriatric Department Hospital Universitario de GetafeGetafe 28905Spain

Purpose:This study aimed to examine the associations of accelerometer-derived steps volume and intensity with hospitalizations and all-cause mortality in older ***:This prospective cohort study involved 768 community-dwelling Spanish older adults(78.8±4.9 years,mean±SD;53.9% females)from the Toledo Study for Healthy Aging(2012-2017).The number of steps per day and step cadence(steps/min) were derived from a hip-mounted accelerometer worn for at least 4 days at *** were followed-up over a mean period of 3.1 years for hospitalization and 5.7 years for all-cause *** proportional hazards regression models were used to estimate the individual and joint associations between daily steps and stepping intensity with hospitalizations and all-cause ***:Included participants walked 5835± 3445 steps/day with an intensity of 7.3± 4.1 steps/*** adjusting for age,sex,body mass index(BMI),education,income,marital status and comorbidities,higher step count(hazard ratio(HR)=0.95,95% confidence interval(95%CI:0.90-1.00,and HR=0.87,95%CI:0.81-0.95 per additional 1000 steps) and higher step intensity(HR=0.95,95%CI:0.91-0.99,and HR=0.89,95%CI:0.84-0.95 per each additional step/min) were associated with fewer hospitalizations and all-cause mortality risk,*** to the group having low step volume and intensity,individuals in the group having high step volume and intensity had a lower risk of hospitalization(HR=0.72,95%CI:0.52-0.98) and all-cause mortality(HR=0.60,95%CI:0.37-0.98).Conclusion:Among older adults,both high step volume and step intensity were significantly associated with lower hospitalization and all-cause mortality *** step volume and intensity may benefit older people.

关键词： Aging Follow-up Objective Physical activity Walking

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Early-onset colorectal cancer:A separate subset of colorectal cancer

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World Journal of Gastroenterology 2014年第46期20卷 17288-17296页

作者： irene Osorio Silla Daniel Rueda Yolanda rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea Department of Surgery 12 de Octubre University HospitalMadrid 28041Spain Molecular Biology Laboratory 12 de Octubre University HospitalMadrid 28041Spain Department of Pathology 12 de Octubre University HospitalMadrid 28041Spain Centre for Cancer Research Medical University of SalamancaSalamanca 37008Spain

Colorectal cancer(CRC)has a great impact on the world *** increasing frequency,CRC is described according to the presenting phenotype,based on its molecular *** of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized ***-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of *** molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial ***,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular *** purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular ***,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC.

关键词： Chromosomal instability CpG island methylator phenotype Early-onset colorectal cancer Lynch syndrome Microsatellite instability

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Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress

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Neural Regeneration Research 2019年第1期14卷 65-66页

作者： Elisa Landucci irene L.Llorente Berta Anuncibay-Soto Domenico E.Pellegrini-Giampietro Arsenio fernández-López Sezione di Farmacologia Clinica e Oncologia Dipartimento di Scienze della SaluteUniversità di Firenze Department of Neurology David Geffen School of Medicine University of California área de Biología Celular Instituto de BiomedicinaUniversidad de León Neural Therapies SL Edificio Institutos de Investigación

This perspective aims to put into context the recent article by Landucci et al.(2018)on mechanisms involved in the neuroprotective effects of meloxicam on an organotypic hippocampal slice cultures(OHSCs)*** vitro cell cultures are the main method for studying large quantities of homogeneous cells in an isolated ***,the use of primary dissociated neuron,astrocyte,oligodendrocyte,microglia,or endothelial cell cultures has become a standard

关键词： gamma 文化海马机制应力蜂窝环境学习胃

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Response to McAvoy and Tudor-Locke on their commentary on our manuscript:“Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study”

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Journal of Sport and Health Science 2022年第6期11卷 639-640页

作者： Asier Mañas Borja del Pozo Cruz Ulf Ekelund JoséLosa Reyna irene rodríguez Gómez JoséAntonio Carnicero Carreño Leocadio rodríguez Mañas Francisco J.García García Ignacio Ara GENUD Toledo Research Group University of Castilla-La ManchaToledo 45071Spain CIBER of Frailty and Healthy Aging(CIBERFES) Instituto de Salud Carlos IIIMadrid 28029Spain Center UCM-ISCIII for Human Evolution and Behavior Madrid 28029Spain Faculty of Education Complutense University of MadridMadrid 28040Spain Biomedical Research and Innovation Institute of Cadiz(INiBICA)Research Unit Puerto Real University HospitalUniversity of CadizCadiz 11009Spain Department of Physical Education Faculty of Education SciencesUniversity of CadizCadiz 11009Spain Department of Sports Medicine Norwegian School of Sport SciencesOslo 0806Norway Department of Chronic Diseases and Ageing Norwegian Institute of Public HealthOslo 0473Norway Geriatric Department Hospital Universitario de GetafeGetafe 28905Spain Geriatric Department Hospital Virgen del ValleToledo 45071Spain

Dear Editor,We have read with interest the commentary by McAvoy and Tudor-Locke on our article entitled "Association of accelerometer-derived step volume and intensity with ho spitalizations and mortality in older adults:A prospective cohort study". The authors expressed some concerns about our methodology used to define accelerometer-derived step intensity and the analytical approach applied in our study.

关键词： accelerometer prospective mortality

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Thermal analysis of olive tree pruning and the by-products obtained by its gasification and pyrolysis: The effect of some heavy metals on their devolatilization behavior

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Journal of Energy Chemistry 2019年第5期28卷 105-117页

作者： irene lanez-rodriguez Maria Angeles Martin-Lara Gabriel Blazquez Oscar Osegueda Monica Calero Department of Chemical Engineering Faculty of SciencesUniversity of GranadaAvda.Fuentenuevas/n 18071 GranadaSpain Department of Process Engineering and Environmental Sciences Jose Simeon Canas Central American UniversityBulevar Los ProceresSan SalvadorEl Salvador

In this work, the effect of the presence of nickel and lead in thermal decomposition of olive tree pruning (OTP), OTP-char and OTP-ashes was studied by thermogravimetry. Experiments were conducted in two kinds of atmosphere (nitrogen atmosphere and oxidizing atmosphere with 20% of O2) at a heating rate of 10 ℃/min. This investigation describes the chemical, physical and fuel properties of the OTP, which shows a similar composition to other lignocellulosic materials such as hazelnut husk and wood sawdust. In addition, SEM analysis indicated that OTP-char surface is higher than OTP surface with plenty of holes and channels. It makes the char an ideal support for metal retention specially for Pb metal (OTP retained 8.55 mg/g whereas OTP char retained 11.57 mg/g). On the other hand, metal retention occurred by adsorption or ion exchange, according to the IR spectrum of the samples. The results of thermogravimetric tests proved that the presence of lead did not have a strong effect on the decomposition of the samples, since TG and DTG curves were very similar. However, nickel increased the mass loss rate, accelerating the decomposition process, showing higher peaks in DTG curves. Additionally, for temperatures higher than 360 ℃, the volatilization of the samples was improved in the nickel-polluted sample, achieving a higher mass loss, getting more energy from the biomass and reducing the quantity of residues left after the process.

关键词： Biosorption Lead Metal-polluted biomass Nickel Thermal decomposition Thermogravimetric analysis

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A New Proof of the Existence of Suitable Weak Solutions and Other Remarks for the Navier-Stokes Equations

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Applied Mathematics 2018年第4期9卷 383-402页

作者： Enrique fernández-Cara irene Marín-Gayte Departamento EDAN and IMUS Universidad de Sevilla Campus Reina Mercedes Sevilla Spain Departamento EDAN Universidad de Sevilla Campus Reina Mercedes Sevilla Spain

We prove that the limits of the semi-discrete and the discrete semi-implicit Euler schemes for the 3D Navier-Stokes equations supplemented with Dirichlet boundary conditions are suitable in the sense of Scheffer [1]. This provides a new proof of the existence of suitable weak solutions, first established by Caffarelli, Kohn and Nirenberg [2]. Our results are similar to the main result in [3]. We also present some additional remarks and open questions on suitable solutions.

关键词： Navier-Stokes Equations Regularity Caffarelli-Kohn-Nirenberg Estimates Semi-Implicit Euler Approximation Schemes

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