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Thermal analysis of olive tree pruning and the by-products obtained by its gasification and pyrolysis: The effect of some heavy metals on their devolatilization behavior

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Journal of Energy Chemistry 2019年第5期28卷 105-117页

作者： irene lanez-Rodriguez Maria Angeles Martin-Lara Gabriel Blazquez Oscar Osegueda Monica Calero Department of Chemical Engineering Faculty of SciencesUniversity of GranadaAvda.Fuentenuevas/n 18071 GranadaSpain Department of Process Engineering and Environmental Sciences Jose Simeon Canas Central American UniversityBulevar Los ProceresSan SalvadorEl Salvador

In this work, the effect of the presence of nickel and lead in thermal decomposition of olive tree pruning (OTP), OTP-char and OTP-ashes was studied by thermogravimetry. Experiments were conducted in two kinds of atmosphere (nitrogen atmosphere and oxidizing atmosphere with 20% of O2) at a heating rate of 10 ℃/min. This investigation describes the chemical, physical and fuel properties of the OTP, which shows a similar composition to other lignocellulosic materials such as hazelnut husk and wood sawdust. In addition, SEM analysis indicated that OTP-char surface is higher than OTP surface with plenty of holes and channels. It makes the char an ideal support for metal retention specially for Pb metal (OTP retained 8.55 mg/g whereas OTP char retained 11.57 mg/g). On the other hand, metal retention occurred by adsorption or ion exchange, according to the IR spectrum of the samples. The results of thermogravimetric tests proved that the presence of lead did not have a strong effect on the decomposition of the samples, since TG and DTG curves were very similar. However, nickel increased the mass loss rate, accelerating the decomposition process, showing higher peaks in DTG curves. Additionally, for temperatures higher than 360 ℃, the volatilization of the samples was improved in the nickel-polluted sample, achieving a higher mass loss, getting more energy from the biomass and reducing the quantity of residues left after the process.

关键词： Biosorption Lead Metal-polluted biomass Nickel Thermal decomposition Thermogravimetric analysis

Evaluation of hot pressing parameters on the electrochemical performance of MEAs based on Aquivion^(■) PFSA membranes

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Journal of Energy Chemistry 2019年第8期28卷 168-173,I0006页

作者： irene Gatto Ada Sacca Vincenzo Baglio Antonino Salvatore Arico Claudio Oldani Luca Merlo Alessandra Carbone CNR-ITAE Institute for Advanced Energy Technologies"N. Giordano" Via S. Lucia Sopra Contesse 5Messina Italy Solvay Specialty Polymers Viale Lombardia 20 20021 Bollate MI Italy

The membrane-electrodes assembly(MEA) is the core of the Polymer Electrolyte Fuel Cell(PEFC). It consists of a membrane, catalytic(CL) and gas diffusion layers(GDL). In order to manufacture MEAs with suitable performance, a hot-pressing procedure is generally used. The relevant parameters are the temperature, pressure and time of hot-pressing. Such variables need to be adjusted as a function of the type of ionomer used in the catalytic layer and membrane. In this study, an evaluation of the temperature of hot-pressing was carried out and its influence on MEA electrochemical performance was assessed. In particular, preparation trials of MEAs were carried out with reinforced experimental membranes based on Aquivion^■ short-side-chain PFSA(by Solvay Specialty Polymers). The membranes were coupled to gas diffusion electrodes, and MEAs were manufactured using different temperatures for the hot-pressing procedure in order to evaluate their influence on the electrochemical performance of PEFCs, in the temperature range of 80–95 °C, with low relative humidity of the reactant gases. The electrochemical performance of the prepared MEAs was tested in a H2/Air 25 cm^2 single cell in terms of polarization curves and accelerated stress test(AST).

关键词： Aquivion^(■) Short-side chain PEFC Hot-pressing parameters Automotive applications

Pancreatic cancer–Pathology

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The Chinese-German Journal of Clinical Oncology 2007年第2期6卷 95-101页

作者： Frank Bergmann irene Esposito Peter Schirmacher Institute of Pathology University of Heidelberg Im Neuenheimer Feld 220 D-69120 Heidelberg Germany

IntroductionsPancreatic ductal adenocarcinoma (frequently simply being referred to as “pancreatic cancer”) represents the most frequent neoplasm of the pancreas, accounting for 85% to 90% of all pancreatic tumors [1, 2]. According to the definition of the World Health Organization [1], it “prob-ably arises from and is phenotypically similar to

关键词：胰腺癌病理学类型发病率组织学免疫组化

The effects of tannins-containing ground pine bark diet upon nutrient digestion,nitrogen balance,and mineral retention in meat goats

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Journal of Animal Science and Biotechnology 2015年第3期6卷 347-354页

作者： Byeng Ryel Min Sandra Solaiman Thomas Terrill Aina Ramsay irene Mueller-Harvey Department of Agricultural and Environmental Sciences Tuskegee University Agricultural Research Station Fort-Valley State University School of Agriculture Policy and DevelopmentUniversity of Reading

Background： Pine bark is a rich source of phytochemical compounds including tannins, phenolic acids, anthocyanins, and fatty acids. These phytochemicals have potential to significantly impact on animal health and animal production. The goal of this work is to measure the effects of tannins in ground pine bark as a partial feed replacement on feed intake, dietary apparent digestibility, nitrogen balance, and mineral retention in meat goats. Results： Eighteen Kiko cross goats （initial BW = 31.8 ± 1.49 kg） were randomly assigned to three treatment groups （n = 6）. Dietary treatments were tested： control （0 % pine bark powder （PB） and 30 % wheat straw （WS））; ] 5 % PB and 15 % WS, and 30 % PB and 0 % WS. Although dry matter （DM） intake and digestibility were not affected （P〉 0.10） by feeding PB, neutral detergent fiber （linear; P= 0.01）, acid detergent fiber （linear; P= 0.001） and lignin digestibility （linear; P= 0.01） decreased, and crude protein （CP） digestibility tended to decrease （P=0.09） as PB increased in the diet, apparent retention of Ca （P= 0.09）, P （P=0.03）, Mg （P= 0.01）, Mn （P= 0.01）, Zn （P= 0.01） and Fe （P= 0.09） also increased linearly. Nitrogen intake and fecal N excretion were not affected （P〉 0.05） by addition of PB in the diet, but N balance in the body was quadratically increased （P〈 0.01） in the 15 % PB diet compared to other diets. This may be due to more rumen escape protein and less excreted N in the urine with the 15 % PB diet. The study showed that a moderate level of tannin-containing pine bark supplementation could improve gastrointestinal nitrogen balance with the aim of improving animal performance. Conclusion： These results suggest that tannin-containing PB has negative impact on fiber, lignin, and protein digestibility, but positively impacted on N-balance.

关键词： Digestibility Goats Phytochemicals Tannins

Therapeutic approaches for portal biliopathy: A systematic review

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World Journal of Gastroenterology 2016年第45期22卷 9909-9920页

作者： irene Franceschet Alberto Zanetto Alberto Ferrarese Patrizia Burra Marco Senzolo Gastroenterology Unit Department of Surgery Oncology and Gastroenterology University Hospital of Padua Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology University Hospital of Padua

Portal biliopathy(PB) is defined as the presence of biliary abnormalities in patients with non-cirrhotic/nonneoplastic extrahepatic portal vein obstruction(EHPVO) and portal cavernoma(PC). The pathogenesis of PB is due to ab extrinseco compression of bile ducts by PC and/or to ischemic damage secondary to an altered biliary vascularization in EHPVO and PC. Although asymptomatic biliary abnormalities can be frequently seen by magnetic resonance cholangiopancreatography in patients with PC(77%-100%), only a part of these(5%-38%) are symptomatic. Clinical presentation includes jaundice, cholangitis, cholecystitis, abdominal pain, and cholelithiasis. In this subset of patients is required a specific treatment. Different therapeutic approaches aimed to diminish portal hypertension and treat biliary strictures are available. In order to decompress PC, surgical porto-systemic shunt or transjugular intrahepatic porto-systemic shunt can be performed, and treatment on the biliary stenosis includes endoscopic(Endoscopic retrograde cholangiopancreatography with endoscopic sphincterotomy, balloon dilation, stone extraction, stent placement) and surgical(bilioenteric anastomosis, cholecystectomy) approaches. Definitive treatment of PB often requires multiple and combined interventions both on vascular and biliary system. Liver transplantation can be considered in patients with secondary biliary cirrhosis, recurrent cholangitis or unsuccessful control of portal hypertension.

关键词： Portal biliopathy Portal cavernoma Magnetic resonance cholangiopancreatography Endoscopic retrograde cholangiopancreatography Porto-systemic shunt

Viral integration detection strategies and a technical update on Virus-Clip

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BIOCELL 2021年第6期45卷 1495-1500页

作者： DANIEL WAI-HUNG HO XUEYING LYU irene OI-LIN NG Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Oncovirus infection is crucial in human *** oncoviruses can lead to structural variations in the human genome known as viral genomic integration,which can contribute to *** viral integration detection tools differ in their underlying algorithms pinpointing different aspects or features of viral integration *** discuss about major procedures in performing viral integration *** importantly,we provide a technical update on Virus-Clip to facilitate its usage on the latest human genome builds(hg19 and hg38)and the adoption of multi-thread mode for faster initial read *** comparing the execution of Virus-Clip using single-thread and multi-thread modes of read alignment on targeted-panel sequencing data of HBV-associated hepatocellular carcinoma patients,we demonstrate the marked improvement of multi-thread mode in terms of significantly reduced execution time,while there is negligible difference in memory *** together,with the current update of Virus-Clip,it will continue supporting the in silico detection of oncoviral integration for better understanding of various human malignancies.

关键词： Oncovirus Viral genomic integration In silico detection Tumorigenesis Human malignancies

Proteinase activated-receptors-associated signaling in the control of gastric cancer

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World Journal of Gastroenterology 2014年第34期20卷 11977-11984页

作者： Silvia Sedda irene Marafini Roberta Caruso Francesco Pallone Giovanni Monteleone Dipartimento di Medicina dei Sistemi Università Tor Vergata00133 RomeItaly

Gastric cancer(GC)is the fourth most common cancer in the world and the second cause of cancer-related *** carcinogenesis is a multifactorial process,in which environmental and genetic factors interact to activate multiple intracellular signals thus leading to uncontrolled growth and survival of GC *** such a pathway is regulated by proteinase activated-receptors(PARs),seven transmembrane-spanning domain G protein-coupled receptors,which comprise four receptors(i.e.,PAR-1,PAR-2,PAR-3,and PAR-4)activated by various *** PAR-1 and PAR-2 are over-expressed on GC cells and their activation triggers and/or amplifies intracellular pathways,which sustain gastric *** is also evidence that expression of either PAR-1 or PAR-2 correlates with depth of wall invasion and metastatic dissemination and inversely with the overall survival of ***,data emerging from experimental models of GC suggest that both these receptors can be important targets for therapeutic interventions in GC *** contrast,PAR-4levels are down-regulated in GC and correlate inversely with the aggressiveness of GC,thus suggesting a negative role of this receptor in the control of *** this article we review the available data on the expression and role of PARs in GC and discuss whether manipulation of PAR-driven signals may be useful for interfering with GC cell behavior.

关键词： Proteinase activated-receptors Gastric cancer Helicobacter pylori infection

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma

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Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel Wai-Hung Ho Alan Ka-Lun Kai irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

Soil-transmitted helminths and plasmodium falciparum malaria among individuals living in different agroecosystems in two rural communities in the mount Cameroon area:a cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 573-587页

作者： irene Ule Ngole Sumbele Gladys Belanka Nkemnji Helen Kuokuo Kimbi Department of Zoology and Animal Physiology University of BueaBueaCameroon Department of Medical Laboratory Sciences University of BamendaBamendaCameroon

Background:Soil-transmitted helminths(STHs)and Plasmodium falciparum infections remain public health problems in Cameroon.A cross-sectional study was carried out in the Mount Cameroon area to determine the prevalence and intensity of STHs and *** infections in individuals living in different agroecosystems;to assess the influence of these infections on haematological parameters;and to identify the risk factors associated with STH ***:STH and malaria parasites were detected using the Kato-Katz method and Giemsa staining of blood films,*** blood count values were obtained using an automatic haematology *** samples were analysed using the sucrose floatation sedimentation *** and continuous variables were compared as required and logistic regression models were used to assess the risk factors for STH infections and ***:Of the 450 participants examined,STHs,*** and mixed co-infections were detected in 14.0,33.3 and 5.6%of participants,*** higher prevalences of Ascaris(18.8%)and Trichuris(7.9%)infections were observed in participants from tea plantation areas compared to those from banana and palm plantation areas,with similar trends in egg *** prevalence and parasite density were comparable between the different *** overall prevalence of anaemia was 64.2%.The prevalence of haematological manifestations such as moderate(48.0%)and severe(8.0%)anaemia,leucopenia(26.9%)and microcytosis(30.8%)was significantly higher among Plasmodium-STH co-infected *** samples from plantations showed the highest prevalences of STH eggs compared to soil samples from areas around pit toilets and public water *** in a tea plantation area(OR=3.07),age(AOR=1.49)and lack of access to potable water(OR=2.25)were identified as risk factors for STH infections,while the age groups 15-25 years(OR=2.928)and 26-35 years(OR=2.832),and being fem

关键词： Soil-transmitted helminths Plasmodium falciparum malaria Co-infection Anaemia Agroecosystem Haematological values Environmental contamination Cameroon