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Engineering 2023年第7期26卷 54-62,I0003页

作者： Marina Kljakovic-Gašpic Batinjan Tea Petrovic Frano Vuckovic Irzal Hadz ibegovic Barbara radovani Ivana Jurin LovorkaÐerek Eva Huljev Alemka Markotic Ivica Lukšic irena Trbojevic´-Akmacic Gordan Lauc Ivan Gudelj rok Civljak University Hospital Centre Zagreb Zagreb 10000Croatia Genos Glycoscience research Laboratory Zagreb 10000Croatia Department of Cardiology University Hospital DubravaZagreb 10000Croatia Faculty of Dental Medicine and Health Josip Juraj Strossmayer UniversityOsijek 31000Croatia Department of Biotechnology University of RijekaRijeka 51000Croatia Department for Laboratory Diagnostics University Hospital DubravaZagreb 10000Croatia Department for Acute respiratory Infections University Hospital for Infectious Diseases“Dr.Fran Mihaljevic”Zagreb 10000Croatia Department for Urogenital Infections University Hospital for Infectious Diseases“Dr.Fran Mihaljevic”Zagreb 10000Croatia Department for Infectious Diseases School of MedicineCatholic University of Croatia10000 ZagrebCroatia Postdoctoral Study Faculty of MedicineUniversity of RijekaRijeka 51000Croatia Department of Maxillofacial Surgery University of Zagreb School of MedicineDubrava University HospitalZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia Department of Infectious Diseases University of Zagreb School of MedicineZagreb 10000Croatia

The essential role of immunoglobulin G(IgG)in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystallizable(Fc)domain that occur under such *** glycans impact the antibody stability,half-life,secretion,immunogenicity,and effector ***,in this study,we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits(sialylation,galactosylation,fucosylation,and bisecting Nacetylglucosamine(GlcNAc))—of 64 patients with influenza,77 patients with coronavirus disease 2019(COVID-19),and 56 healthy *** study revealed a significant decrease in IgG galactosylation,sialylation,and bisecting GlcNAc(where the latter shows the most significant decrease)in deceased COVID19 patients,whereas IgG fucosylation was *** the other hand,IgG galactosylation remained stable in influenza patients and COVID-19 *** glycosylation in influenza patients was more time-dependent:In the first seven days of the disease,sialylation increased and fucosylation and bisecting GlcNAc decreased;in the next 21 days,sialylation decreased and fucosylation increased(while bisecting GlcNAc remained stable).The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses,while the observed changes in deceased COVID-19 patients may indicate its deviation.

关键词： Influenza COVID-19 Viral infection Glycosylation Immunoglobulin G Pneumonia

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Exposure of Fluoride in Coal Basin

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International Journal of Clean Coal and Energy 2016年第1期5卷 1-12页

作者： Khageshwar Singh Patel Ankit Yadav Keshaw Prakash rajhans Shobhana ramteke reetu Sharma irena Wysocka irena Jaron School of Studies in Chemistry/Environmental Science Pt. Ravishankar Shukla University Raipur India Polish Geological Institute Rakowiecka Warsaw Poland

Coal is a dirty fuel contaminated with F- and other elements. Several million tons of coal are burnt in Korba basin, central India to generate electricity with pouring fluorine and other elements into the environment. The water is contaminated with F- and other chemicals beyond the permissible limits. The contaminated water is consumed by the human and animals by excreting the balanced toxicants through the stool and urine. Several folds higher concentration of F- in urine (44 mg/L) and stool (266 mg/kg) samples of the cattle are observed. The prevalence of fluorosis diseases in cattle of the Korba basin is reported.

关键词： Coal Fluoride Contamination Toxicity

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Analysis of Sheep Lymphocyte Chromosomal Aberrations after Exposition to Chlortetracycline

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Journal of Environmental Protection 2013年第6期4卷 38-42页

作者： irena Sutiakova Vaclav Sutiak Maria Tulenkova Department of Biology Faculty of Humanities and Natural SciencesUniversity of PresovPresovSlovak Republic St.Elizabeth University College of Health and Social Work BratislavaSlovak Republic

Tetracyclines are broad spectrum antibiotics and one type of various their compounds—chlortetracycline has been successfully used for our cytogenetic studies. We have selected for these studies the chromosomal assay because it is wellknown cytogenetic biomarker, which has been used to assess DNA damage at the chromosomal level. We analyzed the chromosomal aberrations and mitotic index in peripheral lymphocytes of sheep exposed by chlortetracycline chloride in pure tap water. To the food of the experimental group of animals (à n = 6) were added also 0.35 gof preparation Aureovit12 C80 plv. a. u. v. per kg b. w. and day (i.e. 168 mg of chlortetracycline hydrochloride/kg b. w.) daily in food. The frequencies of aberrant cells (ABC) in the experimental and control groups of sheep were stated to differ significantly (P = 0.001). In experimental group, chromatid breaks were the dominant type of chromosomal aberrations. No statistical differences in mitotic index values were found in the both groups (P > 0.05). Increased frequencies of chromosome aberrations in peripheral lymphocytes of sheep exposed by chlortetracycline in food, suggested a potential hazard which needs the attention from the viewpoint of human and animal health. This knowledge is useful for all, for the human and veterinary medicine, as well as for the aquaculture. Many of these chlortetracycline substances for their environmental persistence and chemical unstability are present in the environment for various periods, and as a result, they are responsible for several effects on human and animal health through food chain.

关键词： Antibiotics Ovine Lymphocytes Chromosomal Assay Genotoxicity Cytotoxicity Health Environment

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Clash

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语言教育 1992年第11期 36-41页

作者： irena Ioannidou Adamdou 李敏王明华

Oh, you are back.' 'As you can see…' 'The food is ready.' 'I’m not hungry.' 'Have you eaten?' 'No.' 'Are you ill?' 'No.' 'What’s the matter, then?' 'I’m just not hungry. Hasn’t it ever happened toyou?' 'All right... 详细信息

关键词： afternoon eaten night helping think trouble nothing Clash talking tomorrow

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Characteristics of the Sertoli Cells of Salmonidae from Ohrid Lake during Spermatogenesis-Ultrastructural Analysis

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 566-573页

作者： irena Tavchiovska-Vasileva Katerina rebok Maja Jordanova Faculty of Natural Sciences and Mathematics Institute of Biology Skopje 1000 Republic of Macedonia

Ultrastructual characteristics of Sertoli cells of Salmonidae from Ohrid Lake during the spermatogenetic cycle have been analysed. Sertoli cells being an integral part of the seminiferous lobules underwent considerable changes, which influenced their cytomorphological features. The degenerative changes of Sertoli cells were manifested by an extreme vacuolisation, mitochondria in degeneration with widened crysts and thickened matrix, desorganised Er, autophagosomes, "myeline-like" structures and lysed cytoplasmic regions. The above mentioned changes were followed by karyopycnisis, comlete degeneration and delamination of cells from the wall of the seminiferous lobules, lysis and detritus formations (Sertoli necrotic material) in the lumen of the lobules. The aim of this paper is special research of the ultrastructural characteristics, i. e. the changes on a level with testes which happen in the postspawning period in the two species of Teleostei of Ohrid Lake, Ohrid trout (Salmo letnica Kar.) and Ohrid belvica (Acantholingua ochridana Steind.). The postspawning period is emphasized in Teleostei in this relatively short period, when one reproductive cycle finishes and the following has to start, on a level of testicular parenhyma very important histological changes are going on which give special histological identification, i. e. in the postspawning period there is a complete reorganization of the testes.

关键词：睾丸细胞微结构分析形态学特征 Sertoli细胞鲑鱼精子超微结构繁殖周期

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波中/中波词典的新型编纂方法研究

波中/中波词典的新型编纂方法研究

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作者： Marlena irena Achinger 北京外国语大学

学位级别：硕士

"波中/中波词典的新型编纂方法研究"这个题目是伴随计算机技术的发展而产生的。计算机技术能够加快词典的编纂速度,优化词典的编纂流程,甚至彻底改变词典的编纂模式。这种情况的出现至今还不超过30年。30年以前,计算机技术的发展水平还... 详细信息

"波中/中波词典的新型编纂方法研究"这个题目是伴随计算机技术的发展而产生的。计算机技术能够加快词典的编纂速度,优化词典的编纂流程,甚至彻底改变词典的编纂模式。这种情况的出现至今还不超过30年。30年以前,计算机技术的发展水平还不足以支持现代词典编纂方式的存在。关于使用现代方法编纂词典已经被很多国际专家研究和讨论过。在中国也有一些相关的研究成果。例如广东外语外贸大学的章宜华教授就曾在2013年出版《计算词典学与新型词典》,系统讨论计算机对各种词典的支持以及各种电子词典的特点。然而,无论是在中国、波兰,还是在世界其他地方,都还没有人就波中和中波词典编纂中的现代方法进行研究。本论文作者长期参与中波/波中网络词典的构建工作,并曾在网络词典的基础上,于2015年正式出版了《波汉-汉波商务词典》(波汉出版社)。在此过程中,本人对如何利用互联网,提高波中/中波词典编纂效率,有着大量第一手的、直观的经验和体会。本论文的正文分为六部分,分别是:前言、词典学理论概述(第一章)、波中/中波词典编纂历史与现状(第二章)、波中/中波词典编纂中的现代方法运用(第三章)和波中/中波词典编纂传统与现代方法述评(第四章)、结论。在前言部分,本人主要对论文的选题背景、选题意义,目前在世界范围内此课题的研究情况等问题进行了探讨。在第一章中,本人对词典学的一些基本理论、词典的分类、词典的传统编纂方法以及当代最新词典编纂方法进行了简要的概述。在第二章中,本人对中波语言交流史,中波/波中词典编纂历史与现状以及当前中波/波中词典编纂需求等问题进行了系统的考察。在第三章中,本人对目前存在的几种比较成功的中波/波中网络词典进行了研究,分析了它们各自的特点和问题。在第四章中,本人基于前面的介绍,分析了新型词典编纂方式的优缺点。在结论部分,对文章的整体进行回顾和总结,提出自己关于中波/波中新型词典编纂方式的具体建议。

关键词：词典词典学中波波中现代方法

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Progressive familial intrahepatic cholestasis—farnesoid X receptor deficiency due to Nr1H4 mutation:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3631-3636页

作者： Piotr Czubkowski richard J Thompson irena Jankowska A S Knisely Milton Finegold Pamela Parsons Joanna Cielecka-Kuszyk Sandra Strautnieks Joanna Pawłowska Laura N Bull Department of Gastroenterology HepatologyNutritional Disorders and PediatricsThe Children’s Memorial Health InstituteWarsaw 04-730Poland Institute of Liver Studies King's College London HospitalLondon SE59RSUnited Kingdom Institut für Pathologie Medizinische Universität GrazGraz 8010Austria Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030United States Texas Children’s Hospital HoustonTX 77030United States Department of Pathology The Children’s Memorial Health InstituteWarsaw 04-730Poland Department of Medicine and Institute for Human Genetics UCSF Liver Center LaboratoryUniversity of California San FranciscoSan FranciscoCA 94143United States

BACKGrOUND Functioning farnesoid X receptor(FXr;encoded by Nr1H4)is key to normal bile acid *** mutations in Nr1H4 are reported in a few children with intrahepatic *** describe a boy with progressive familial intrahepatic cholestasis and homozygous mutation in *** SUMMArY A boy had severe neonatal cholestasis with moderate hypercholanemia and persistently elevated *** medical treatment,coagulopathy was uncontrollable,prompting liver transplantation at age 8 mo with incidental *** patient experienced catch-up growth with good liver function and did not develop allograft ***,1 year after transplant,he died from an acute infection,considered secondary to immunosuppression and asplenia.A homozygous protein-truncating mutation,c.547C>T,p.(Arg183Ter),was subsequently identified in Nr1H4,and both parents were shown to be heterozygous *** of FXr and of bile salt export pump expression was confirmed by immunostaining of explanted *** Severe cholestasis with persistently high alpha-fetoprotein and modest elevation of serum bile acid levels may suggest FXr *** patients with FXr deficiency may not develop allograft steatosis and may respond well to liver transplantation.

关键词： Neonatal cholestasis Progressive familial intrahepatic cholestasis Bile salt export pump Liver transplantation Alpha-fetoprotein Case report

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“AniFair”:A GUI Based Software Tool for Multi-Criteria Decision Analysis--An Example of Assessing Animal Welfare

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Agricultural Sciences 2020年第3期11卷 278-331页

作者： Jennifer Salau Lena Friedrich irena Czycholl Joachim Krieter Institute of Animal Breeding and Husbandry Christian-Albrechts-University KielKielGermany

Multi-criteria decision analysis deals with decision problems in which multiple criteria need to be considered. The criteria might be measured on different scales so that comparability is difficult. One approach to help the user to organize the problem and to reflect on his or her assessment on the decision is Measuring Attractiveness by a Categorical Based Evaluation TecHnique (MACBETH). Here the user needs to provide qualitative judgment about differences of attractiveness regarding pairs of options. MACBETH was implemented in the M-MACBETH software using the additive aggregation model. The present article introduces the software tool “AniFair” which combines the MACBETH approach with the Choquet integral as an aggregation function, because the Choquet integral enables the modeling of interaction between criteria. With the Choquet integral, the user can define constraints on the relative importance of criteria (Shapley value) and the interaction between criteria. In contrast to M-MACBETH, with every instance of “AniFair” the user is made available at least two aggregation level. “AniFair” provides Graphical User Interfaces for the entering of information. The software tool is introduced via an example from the Welfare Quality Assessment protocol for pigs. With this, “AniFair” is applied to real data that were collected from thirteen farms in Northern Germany by an animal welfare expert. The “AniFair” results enabled a division of the farms into five groups of comparable performance concerning the welfare principle “Good feeding”. Hereby, the results differed in how much the interaction between criteria contributed to the Choquet integral values. The shares varied from 5% to 55%. With this, the vulnerability of aggregation results towards relative importance of and interaction between criteria was stressed, as changes in the ranking due to the definition of constraints could be shown. All results were exported to human readable txt or csv files for further analyses

关键词： Multi-Criteria Decision Analysis MACBETH Choquet Integral GUI Software Tool Welfare Quality?Assessment Protocol for Pigs

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Impact of the residues of detergents and disinfectants used in dairy farms on the results of inhibitor tests for raw milk

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Advances in Bioscience and Biotechnology 2013年第2期4卷 266-272页

作者： Joana Salomskiene irena Macioniene renata Zvirdauskiene Dovile Jonkuviene Kaunas University of Technology Food instituteKaunasLithuania

The aim of the study was to determine the impact of residues of detergents and disinfectants on the results of most commonly used inhibitor tests for raw milk. Microbiological test (Delvotest SP-NT) and three rapid tests (Charm 3 MrL BL/TET2, Charm rOSA MrL BL/TET and Penzym) were used in the study. Three concentrations (recommended by the manufacturer, 10 times lower and twice higher) of 36 detergents and disinfectants in raw milk were investigated. All methods did not detect concentrations of detergents and disinfectants of alkaline and acid origin 10 times lower than recommended by the manufacturer. 39% of the investigated substances of alkaline origin were detected by Delvotest SP-NT and Penzym;Charm tests showed non-typical results only. Delvotest SP-NT did not detect substances of acid origin;Penzym detected 50% of these substances, Charm tests showed only non-typical results. Delvotest SP-NT and Penzym appeared to be more sensitive to the substances used for teat hygiene and disinfection. The scope of rapid tests (receptor or enzymatic) does not cover the detection of detergent and disinfectant re- sidues in milk. However, according to the non-typical results of the test, it is possible to suspect the presence of these substances in milk. McNemar’s and Cochran’s Q tests were used for statistical analysis of the data.

关键词： Detergents Disinfectants residues Sensitivity Inhibitor Tests raw Milk

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The Elderly Health Office- Public Health respond to the Ageing Challenge

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Journal of Pharmacy and Pharmacology 2018年第2期6卷 161-169页

作者： irena Dzeletovic Milosevic Dusanka Matijevic Svetlana Mladenovic Jankovic Public Health Institute of City of Belgrade Belgrade 11000 Serbia

Introduction: Demographic structure in Belgrade is regressive biological type with 16.4% of the Elderly in whole population. Addressing this fact Public Health Institute of City of Belgrade in 2008 established the EHO (Elderly Health Office). Aim: This paper emphasizes the importance of Public Health response to ageing population challenges. Method: This public health study is retrospective review based on work of EHO from 2008 to 2017 year. results: Numerous health promotion activities were performed by EHO: development guidelines for elderly care services coordination as well as for effective communication within health care system; development of age-friendly web portal; cooperation with the mass media; building partnership with representatives of the state- and private-owned facilities and NGOs (non-governmental organizations); support to strengthening inter-generation cooperation; promotion of elderly age-friendly phone line; organizing and participation in public health events, meetings and conferences. EHO participated in evaluation capacities of healthcare in Belgrade, regarding human resources, equipment and facilities, and monitoring elderly health status. Conclusions: The role of the EHO of IPHB is: (1) support to active, healthy, productive ageing of the citizens of Belgrade; (2) strategic planning of the Elderly health care; (3) strengthening of intersectional cooperation. Measures suggested: Public Health approach of EHO is response to challenges of ageing population and potential model for age oriented program management.

关键词： The elderly public health health promotion

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