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Assessment of phytochemicals, antioxidant, anti-hemolytic, anti-inflammatory and anti-cancer potential of flowers, leaves and stem extracts of Rosa arvensis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 804-812页

作者： Zubaria Tul Ain iram fatima Sana Naseer Sobia Kanwal Tariq Mahmood Department of Plant Sciences Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biology Allama Iqbal Open UniversityIslamabad 04403Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Pakistan Academy of Sciences Islamabad 04403Pakistan

OBJECTIVE:To evaluate phytochemicals and in vitro biological potential of flowers,leaves and stem extracts of Rosa ***:Presence of twenty secondary metabolites was confirmed and then phenolic and flavonoid contents were quantified *** Transform Infrared spectroscopy was conducted to ascertain functional groups and antioxidant potential was examined using 2,2-diphenyl-1-picrylhydrazyl scavenging activity,total antioxidant capacity and total reducing power *** erythrocytes were used to assess anti-hemolytic activity and five bacterial strains were examined to determine antibacterial potential of plant *** seeds were used to perform phytotoxic activity and cytotoxic potential was evaluated via brine shrimps and PC3 cell ***:Highest phenolic contents were detected in the methanolic extract of Rosa arvensis flower(RAFM)[(151.635±0.005)gallic acid equivalent mg/g]and highest flavonoid contents in the chloroform leaf extract(RALC)[(108.228±0.004)quercetin equivalent mg/g].Fourier-transform infrared spectroscopy analysis showed the presence of wide range of functional *** antioxidant assays indicated highest DPPH scavenging activity[IC50(23.5±0.6)μg/mL]in the methanolic stem extract(RASM),highest total antioxidant capacity[(265.1±0.9)μg/mL]in RAFM and highest reducing potential[(209.9±0.6)μg/mL]in leaf extract(RALM).Highest antihemolytic activity[(90.0±0.5)μg/mL]was recorded in RAFM and brine shrimp cytotoxicity potential[(52.3±0.3)μg/mL]in *** antimicrobial activity was detected highest[(21.1±0.5)mm inhibition zones]in RALM against Streptococcus *** the end,antiinflammatory and anti-cancer activity results depicted less than 50%inhibition in the methanolic ***:Our findings will be helpful in designing pharmaceutical regimens and therefore,more studies can be recommended to isolate and characterize compounds associated with the biological activities of Rosa arvensis.

关键词： anti-inflammatory agents spectroscopy,fourier transform infrared hemolysis oxidative stress PC-3 cells

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Microbiostatic, antioxidative and cytotoxic potentiation of some grasses of Bahawalpur, Pakistan

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Journal of Traditional Chinese Medicine 2019年第4期39卷 482-491页

作者： iram fatima Sobia Kanwal Tariq Mahmood Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad 45320Pakistan Department of Zoology University of GujratSub-campus Rawalpindi46000Pakistan.

OBJECTIVE: To evaluate biological potential of methanol and n-hexane extracts of aerial parts in seven species of family ***: Qualitative phytochemical tests were done by using standard protocols. In vitro antioxidant activity was performed via different assays and antimicrobial potential was observed via disc diffusion method. Cytotoxic activity was carried out using brine shrimps’ ***: Phytochemical studies revealed the presence of alkaloids, flavonoids, glycosides, phenols,steroids, saponins, tannins, anthocyanins and coumarins in most of the plant extracts. Maximum antioxidant and antimicrobial potential were observed in Cymbopogon citratus methanol extract and Cymbopogon citratus n-hexane extract along with significant number of total flavonoids and phenols contents. However, Polypogon monspeliensis methanol extract and Polypogon monspeliensis n-hexane extract showed minimum antioxidant as well as antimicrobial potential. Moreover, methanol extracts showed a cytotoxic effect with their effectiveness ranked Polypogon monspeliensis methanol extract > Cymbopogon citratus methanol extract > Phalaris minor n-hexane extract > Aristida funiculata methanol extract > Stipagrostis plumosa methanol extract > Cenchrus ciliaris methanol extract > Panicum antidotale methanol extract. Similarly, n-hexane plant extracts revealed cytotoxic activity in decreasing order Cenchrus ciliaris n-hexane extract > Stipagrostis plumosa n-hexane extract > Phalaris minor n-hexane extract > Aristida funiculata n-hexane extract > Polypogon monspeliensis n-hexane extract > Panicum antidotale n-hexane extract > Cymbopogon citratus n-hexane extract ***: Methanol extracts exhibit significant antioxidant and antimicrobial potential which can be correlated to their medicinal values. The observed brine shrimp’s lethality of the plant extracts revealed the presence of potent cytotoxic components in these plants.

关键词： Poaceae Methanol n-Hexane Anti-infective agents Antioxidants Cytotoxins

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A rare complication of measles infection presented with subacute sclerosing panencephalitis: Report of two cases in India

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 184-187页

作者： Razeen fatima Amir Husain iram Tabish Department of Medicine JN Medical CollegeAMUAligarhIndia

Rationale:Subacute sclerosing panencephalitis(SSPE)is a progressive neurological disorder caused by persistent measles virus *** predominantly affects children and *** symptoms usually develop 6-15 years after measles infection and ultimately leading to death in many *** concerns:Patient 1 presented with cognitive decline and myoclonus and the Patient 2 presented with diminution of vision with myoclonic ***:Based on the clinical features with a characteristic electroencephalogram pattern and the presence of a high titer of anti-measles IgG in serum and cerebrospinal fluid,these patients were diagnosed as ***:Antiepileptics were started for controlling myoclonus along with supportive ***:Both patients were discharged on antiepileptics and supportive ***:Whenever there are unusual clinical manifestations with unknown vaccination status,SSPE can be suspected and the cerebrospinal fluid should be examined for anti-measles *** case study also highlights the importance of universal coverage of measles *** reduce the incidence of measles and associated deaths,it is important to maintain a high level of immunization coverage for the measles vaccine and to strengthen all the integral components of the national immunization program.

关键词： Subacute sclerosing panencephalitis Measles Myoclonus Electroencephalogram Cerebrospinal fluid

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Volatility and Dynamic Herding in Energy Sector of Developed Markets During COVID-19:A Markov Regime-Switching Approach

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Fudan Journal of the Humanities and Social Sciences 2024年第1期17卷 115-138页

作者： Zuee Javaira Najam Us Sahar Syed Danial Hashmi iram Naz Federal Urdu University of Arts Science and Technology FUUASTIslamabadPakistan AFIPGM National University of Medical SciencesRawalpindiPakistan Faculty of Management Sciences Riphah International UniversityIslamabadPakistan College of Signals National University of Science and TechnologyIslamabadPakistan

This study examines a novel relationship between volatility and dynamic herding behavior during COVID-19 by examining the relationship of oil market volatility,Global volatility and Infectious disease equity market volatility with time-varying herding behavior in energy stock of Developed *** country level data,this study observes that market switch between anti-herding to herding state during pandemic and all three volatility measures have significant impact on dynamic herding state under high dispersion ***,in low dispersion regime only global volatility has significant impact on time-varying herding *** study suggests that the level of speculation in energy sector affect investor behavior;therefore,policy makers should monitor and model possible signals related to health crisis that can be transformed in to financial market crisis.

关键词： Herding Energy sector COVID-19 Volatility Markov regime approach

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不同营养组成食物对花鼠肠道菌群的影响

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野生动物学报 2024年第3期45卷 521-530页

作者：朱紫薇魏爽 iram Maqsood 司雨蕙钟涵戎可东北林业大学野生动物与自然保护地学院哈尔滨150040 国家林业和草原局野生动物保护生物学重点实验室哈尔滨150040 黑龙江省林业科学院齐齐哈尔分院齐齐哈尔161005 沙希德·贝娜齐尔·布托女子大学野生动物系白沙瓦25000

为探究食物主要营养成分对花鼠(Tamias sibiricus)肠道菌群结构的影响,以人工饲料饲喂花鼠,以野外自由取食为对照,通过粪便采样,以16S rRNA高通量测序分析花鼠肠道菌群组成。依据食物来源和饲料中脂肪、淀粉含量的不同,将被饲喂的花鼠... 详细信息

为探究食物主要营养成分对花鼠(Tamias sibiricus)肠道菌群结构的影响,以人工饲料饲喂花鼠,以野外自由取食为对照,通过粪便采样,以16S rRNA高通量测序分析花鼠肠道菌群组成。依据食物来源和饲料中脂肪、淀粉含量的不同,将被饲喂的花鼠分为野外组、脂肪组、淀粉组和饲料组。结果显示:不同饲喂条件下,花鼠肠道菌群的优势菌门均为厚壁菌门(Firmicutes)、拟杆菌门(Bacteroidetes)和变形菌门(Proteobacteria),优势菌属为Muribaculaceae_norank和联合乳杆菌属(Ligilactobacillus)。多样性分析显示,野外组肠道菌群物种丰度和多样性较高,但野外组与淀粉组菌群组成相似度较高。相关性分析表明,厚壁菌门与粗蛋白含量呈显著正相关,拟杆菌门与淀粉和粗纤维含量呈显著正相关、与粗脂肪含量呈显著负相关,放线菌门(Actinobacteria)与粗蛋白含量呈显著正相关。研究表明食物成分变化影响了花鼠肠道菌群的组成、结构和丰富度;食物主要营养成分与特定菌群存在显著相关性。

关键词：花鼠肠道菌群营养成分高通量测序

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GRAFTING OF POLY(SODIUM STYRENESULFONATE) ONTO GOLD SURFACE FROM NaNO_3 SOLUTION

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Chinese Journal of Polymer Science 2011年第5期29卷 575-579页

作者： iram Bibi Mohammad Siddiq Department of Chemistry Quaid-i-Azam University Islamabad 45320Pakistan

The chemical grafting of thiol terminated poly（sodium styrenesulfonate）（HS-PSSS） chains from sodium nitrate （NaNO3） salt solution to a gold surface was investigated with a quartz crystal microbalance with dissipation monitoring （QCM-D） in different salt concentrations, It was found that at low salt concentration grafting density of HS-PSSS was low and the grafted chains adopted a mushroom conformation. With the increase of salt concentration polyelectrolyte chains underwent a transition toward coiled state due to reduction of electrostatic repulsion and as a result more chains were grafted on the surface, When the grafting density reached a certain limit after which further grafting caused repulsion between already grafted HS-PSSS chains and as a result grafted chains adopted a brush conformation.

关键词： Poly(sodium styrenesulfonate) Quartz crystal microbalance Kinetics of grafting.

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Screening-Assisted Dynamic Multiple Testing with False Discovery Rate Control

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Journal of Systems Science & Complexity 2023年第2期36卷 716-754页

作者： MUSHTAQ iram ZHOU Qin ZI Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300350China

In the era of big data,high-dimensional data always arrive in streams,making timely and accurate decision *** has become particularly important to rapidly and sequentially identify individuals whose behavior deviates from the *** at identifying as many irregular behavioral patterns as possible,the authors develop a large-scale dynamic testing system in the framework of false discovery rate(FDR)*** fully exploiting the sequential feature of datastreams,the authors propose a screening-assisted procedure that filters streams and then only tests streams that pass the filter at each time point.A data-driven optimal screening threshold is derived,giving the new method an edge over existing *** some mild conditions on the dependence structure of datastreams,the FDR is shown to be strongly controlled and the suggested approach for determining screening thresholds is asymptotically *** studies show that the proposed method is both accurate and powerful,and a real-data example is used for illustrative purpose.

关键词： Change-point false discovery rate high-dimensional datastreams large-scale inference sequential analysis weak dependence structure

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MICELLAR PARAMETERS OF DIBLOCK COPOLYMERS AND THEIR INTERACTIONS WITH IONIC SURFACTANTS

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Chinese Journal of Polymer Science 2012年第2期30卷 217-226页

作者： Noor Rehman Abbas Khan iram Bibi Mohammad Siddiq Department of Chemistry Quaid-I-Azam UniversityIslamabad 45320Pakistan Instituto de Quimica Universidade Federal do Rio Grande do SulUFRGS PO Box 15010CEP 91501-930Porto Alegre/RS/Brazil Department of Chemistry Abdul Wali Khan UniversityMardan K-PukhtoonkhwaPakistan

The interactions of non-ionic amphiphilic diblock copolymer poly（oxyethylene/oxybutylene）（E39B18） with anionic surfactant sodium dodecyl sulphate （SDS） and cationic surfactant hexadecyltrimethylammonium bromide （CTAB） were studied by using various techniques such as surface tension, conductivity, steady-state fluorescence and dynamic light scattering. Surface tension measurements were used to determine the critical micelle concentration （CMC） and thereby the free energy of micellization （AGmic）, free energy of adsorption （AG^ds）, surface excess concentration （F） and minimum area per molecule （A）. Conductivity measurements were used to determine the critical micelle concentration （CMC）, critical aggregation concentration （CAC）, polymer saturation point （PSP）, degree of ionization （tr） and counter ion binding （l]）. Dynamic light scattering experiments were performed to check the changes in physiochemical properties of the block copolymer micelles taken place due to the interactions of diblock copolymers with ionic surfactants. The ratio of the first and third vibronic peaks （11/Is） indicated the polarity of the pyrene micro environment and was used for the detection of micelle as well as polymer-surfactant interactions. Aggregation number （N）, number of binding sites （n） and free energy of binding （AGb） for pure surfactants as well as for polymer-surfactant mixed micellar systems were determined by the fluorescence quenching method.

关键词： Surface tension Conductivity Dynamic light scattering steady-state fluorescence Micellization.

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Big Data Testing Techniques:Taxonomy,Challenges and Future Trends

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Computers, Materials & Continua 2023年第2期74卷 2739-2770页

作者： iram Arshad Saeed Hamood Alsamhi Wasif Afzal SRI TUSAthloneIreland Mälardalen University VästeråsSweden

Big Data is reforming many industrial domains by providing decision support through analyzing large data *** Data testing aims to ensure that Big Data systems run smoothly and error-free while maintaining the performance and quality of ***,because of the diversity and complexity of data,testing Big Data is *** numerous research efforts deal with Big Data testing,a comprehensive review to address testing techniques and challenges of BigData is not available as ***,we have systematically reviewed the Big Data testing techniques’evidence occurring in the period 2010–*** paper discusses testing data processing by highlighting the techniques used in every processing ***,we discuss the challenges and future *** findings show that diverse functional,non-functional and combined(functional and non-functional)testing techniques have been used to solve specific problems related to Big *** the same time,most of the testing challenges have been faced during the MapReduce validation *** addition,the combinatorial testing technique is one of the most applied techniques in combination with other techniques(i.e.,random testing,mutation testing,input space partitioning and equivalence testing)to find various functional faults through Big Data testing.

关键词： Big data testing techniques testing process

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Mass dependence of pion-induced fission cross sections on the level density parameter

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Chinese Physics C 2012年第9期36卷 831-835页

作者： Zafar Yasin Warda iram M.Ikram Shahzad Physics Division PINSTECHP.O.NiloreIslamabadPakistan Physics Department Islamia UniversityBahawalpurPakistan

Fission probabilities and fission cross sections strongly depend on the mass number of the target and energy of the projectile. In this research work, a cascade-exciton model （using CEM95 computer code） has been implemented to observe the dependence of pion-induced fission cross sections and fission probabilities on the target mass and ratio of the level density parameter in fission to neutron emission. The analysis has been performed for both the positive and negative pions as the projectile at 80, 100 and 150 MeV energies. The computed cross sections satisfactorily reproduced the experimental findings when compared with the available experimental data in the literature. We observed a smooth dependence at 150 MeV, and a sharper dependence at 80 and 100 MeV pion energy, in the fissility region above 29.44.

关键词： CEM95 fission cross section level density parameter

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