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Liver structural transformation after partial hepatectomy and repeated partial hepatectomy in rats: A renewed view on liver regeneration

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World Journal of Gastroenterology 2020年第27期26卷 3899-3916页

作者： Keti Tsomaia Leila Patarashvili Nino Karumidze irakli bebiashvili Elza Azmaipharashvili Irina Modebadze Diana Dzidziguri Marom Sareli Sergey Gusev Dimitri Kordzaia Faculty of Medicine Ivane Javakhishvili Tbilisi State UniversityTbilisi 0159Georgia Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State UniversityTbilisi 0179Georgia Department of Surgical Oncology(Surgery C) Chaim Sheba Medical Center at HaShomerTel Aviv 52621Israel Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency Moscow 119435Russia Clinical Anatomy and Operative Surgery Ivane Javakhishvili Tbilisi State UniversityTbilisi 0159Georgia

BACKGROUND The phenomenon of liver regeneration after partial hepatectomy(PH)is still a subject of considerable interest due to the increasing frequency of half liver transplantation on the one hand,and on the other hand,new surgical approaches which allow removal of massive space-occupying hepatic tumors,which earlier was considered as ***,the mechanisms of liver regeneration are extensively studied after PH but less attention is paid to the architectonics of the regenerated *** of this,the question“How does the structure of regenerated liver differ from normal,regular liver?”has not been fully answered ***,almost without any attention is left the liver's structural transformation after repeated hepatectomy(of the re-regenereted liver).ATM To compare the architectonics of the lobules and circulatory bed of normal,regenerated and re-regenerated *** The livers of 40 adult,male,albino Wistar rats were studied.14 rats were subjected to PH-the 1st study group(SG1);10 rats underwent repeated PH–the 2nd study group(SG2);16 rats were subjected to sham operation-control group(CG);The livers were studied after 9 months from PH,and after 6 months from repeated ***(Schiff reaction for the determination of DNA concentration),histological(H&E,Masson trichrome,CK8 Immunohistochemical marker,transparent slides after Indian Ink injection,),morphometrical(hepatocytes areas,perimeters and ploidy)and Electron Microscopical(Scanning Electron Microscopy of corrosion casts)methods were *** In the SG1 and SG2,the area of hepatocytes and their perimeter are increased compared to the CG(P<0.05).However,the areas and perimeters of the hepatocytes of the SG1 and SG2 groups reveal a lesser *** regenerated(SG1)and re-regenerated(SG2)livers,the hepatocytes form the remodeled lobules,which size(300-1200μm)exceeds the sizes of the lobules from CG(300-600μm).The remodeled lobules(especially the“mega-lobules”with the

关键词： Partial hepatectomy Repeated hepatectomy Liver regeneration Liver reregeneration Hepatocytes hypertrophy Remodeling Ploidy Corrosion casts

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