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Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality

Asian Journal of Andrology 2018年第5期20卷 498-504页

作者： Marta Gianzo Itziar Urizar-Arenaza iraia munoa-hoyos Zaloa Larreategui Nicolas Garrido Luis Casis Jon Irazusta Nerea Subiran Department of Physiology Faculty of Medicine and Nursery University of the Basque Country (UPV/EHU) Leioa Biscay 48940 Spain In Vitro Fertilization Laboratory IVI Bilbao Landabarri Promenade 1 Leioa Biscay 48940 Spain IVI Foundation IVI Valencia Local Police Square 3 Valencia 46015 Spain

Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed. Semen parameters, embryos quality, and blastocyst development were examined according to the World Health Organization standards and the Spanish Association of Reproduction Biology Studies criteria. The percentage of testicular angiotensin-converting enzyme-positive spermatozoa and the number of molecules per spermatozoon were analyzed by flow cytometry. Both parameters were inversely correlated with human sperm motility. Higher percentages of testicular angiotensin-converting enzyme-positive spermatozoa together with fewer enzyme molecules per spermatozoon were positively correlated with better embryo quality and development. Our results suggest that embryos with a higher implantation potential come from semen samples with higher percentages of testicular angiotensin-converting enzyme-positive cells and fewer enzyme molecules per spermatozoon. Based on these findings, we propose that testicular angiotensin-converting enzyme could be used to aid embryologists in selecting better semen samples for obtaining high-quality blastocysts during in vitro fertilization procedures.

关键词： angiotensin-converting enzyme ART embryonic development human sperm male fertility

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