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Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

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Traditional Medicine Research 2025年第2期10卷 30-36页

作者： Abdur Rauf Zuneera Akram Naveed Muhammad Najla AlMasoud Taghrid Saad Alomar Saima naz Abdul Wadood Chandni Hayat Marcello Iriti Department of Chemistry University of SwabiAmbar 23561Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesBaqai Medical UniversityKarachi 74600Pakistan Department of Pharmacy Abdul Wali Khan University MardanMardan 23200Pakistan Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Biotechnology BKUC-Bacha Khan University CharsaddaCharsadda 24620Pakistan Department of Biochemistry Abdul Wali Khan University MardanMardan 23200Pakistan Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20129Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) Firenze 50121Italy

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and *** study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia ***:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were *** docking studies were conducted using a molecular operating ***:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µ*** antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%*** docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/***:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

关键词： Pistacia chinensis Bunge antioxidant DPPH assay antilipoxygenase docking analysis

Developing strategy for rural transformation to alleviate poverty in Pakistan:Stylized facts from panel analysis

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Journal of Integrative Agriculture 2023年第12期22卷 3610-3623页

作者： ABEDULLAH Shujaat FAROOQ Farah naz Pakistan Institute of Development Economics(PIDE) Islamabad 44000Pakistan

Sustainable income growth and poverty reduction remain critical challenges at the forefront of research in Pakistan,particularly in rural *** overcome these challenges,the role of rural transformation(RT)has emerged and gained importance in recent *** present study is based on district-level data and covers the period from 1981 to *** study attempts to quantify the role of rural transformation in boosting rural per capita income and alleviating rural poverty in the *** study also aims to explore the impact of stages of rural transformation on rural per capita income and rural poverty *** empirical findings reveal that rural transformation(RT_(1)and RT_(2))is essential in enhancing rural per capita income and alleviating rural *** role of the share of high-value crops(RT_(1))is more pronounced than the share of non-farm employment(RT_(2))in boosting rural per capita income and poverty *** trend of larger contribution of RT_(1)to enhance rural per capita income also continued at 2nd stage of rural *** the case of poverty reduction,at 3rd stage of rural transformation,the role of RT_(2)is *** results indicate that districts at higher stages of rural transformation(both RT_(1)and RT_(2))tend to correlate positively with increased rural per capita income and reduced poverty rates,suggesting that progress in rural transformation is associated with improved economic ***,it is important to note that this correlation does not necessarily imply a direct causal relationship between rural transformation and these economic outcomes;other factors may have influenced this *** addition,the welfare impacts are more noticeable among the districts where a simultaneous shift from grain crops to cash crops and from farm employment to non-farm employment is *** study provides baseline information to learn experiences from fast-growing districts and to replicate the strategie

关键词： rural transformation rural income rural poverty agriculture panel analysis

Removal of lead and cadmium ions by single and binary systems using phytogenic magnetic nanoparticles functionalized by 3-marcaptopropanic acid

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Chinese Journal of Chemical Engineering 2019年第4期27卷 949-964页

作者： Imran Ali Changsheng Peng Iffat naz College of Environmental Science and Engineering Ocean University of China Qingdao 266100 China The Key Lab of Marine Environmental Science and Ecology Ministry of Education Ocean University of China Qingdao 266100 China School of Environmental and Chemical Engineering Zhaoqing University Zhaoqing 526061 China Department of Biology. Qassim University Buraidah 51452 Kingdom of Saudi Arabia (KSA)

The present research study is focused on green fabrication of superparamagnetic Phytogenic Magnetic Nanoparticles(PMNPs), and then its surface functionalization with 3-Mercaptopropionic acid(3-MPA). The resulting material(i.e. 3-MPA@PMNPs) characterized by FTIR, powder XRD, SEM, TEM, EDX, VSM, BET and TGA techniques and then further employed for the investigation of the adsorptive removal of lead(Pb^2+) and cadmium(Cd^2+) ions from aqueous solutions in single and binary systems. The material showed fastest adsorptive rate(98.23%) for Pb^2+ and(96.5%) Cd2+within the contact time of 60 min at pH 6.5 in the single system. The experimental data were fitted well to Langmuir isotherm, indicated monolayer adsorption of both metal ions onto 3-MPA@PMNPs and an estimated comparable adsorptive capacity of 68.41 mg·g^-1(Pb2+) and 79.8 mg·g^-1(Cd2+) at p H 6.5. However, kinetic data agreed well with pseudo-second-order model, and indicated that the removal mainly supported chemisorption and/or ion-exchange mechanism. Thermodynamic parameters such asΔGo,ΔHo, and ΔSo, were-3259.20, 119.35 and 20.73 for Pb^2+, and-1491.10, 45.441 and 7.87 for Cd^2+ at temperature 298.15 K, confirmed that adsorption was endothermic, spontaneous and favorable. The material demonstrated higher selectivity of Pb2+ and its removal efficiency was(98.20 ± 0.3)% in binary system experiments. The material persisted performance up-to seven(07) consecutive treatment cycles without losing their stability and offered comparable fastest magnetic separation(35 s) from aqueous solutions. Therefore, it is recommended that the prepared material can be employed to remove toxic heavy metal ions from water/wastewaters and this "green" method can easily be implemented at large scale in low economy countries.

关键词： Green recipe Phytogenic magnetic nanoparticles Physical characterization of nanoparticles Lead and cadmium ions removal

Toxicity Evaluation of Green Synthesized Iron Oxide Nanoparticles in Sprague-Dawley Rats:Biochemical and Histological Assessment

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Biomedical and Environmental Sciences 2020年第11期33卷 882-886页

作者： Sania naz Muhammad Majid Muhammad Zia Department of Biotechnology Quaid-i-Azam University Islamabad Pakistan 45320 Department of Pharmacy Quaid-i-Azam University Islamabad Pakistan 45320

The exploitation of nanotechnology has increased in all ramifications due to the spectacular potential of nano-products(NPs).Among the nanoproducts,iron oxide(Fe2 O3)NPs has attracted more scientific attentions due it... 详细信息

关键词： characteristics. Iron Oxide

Laser-assisted ablation and plasma formation of titanium explored by LIBS,QCM, optical microscopy and SEM analyses along with mechanical modifications under different pressures of Ar and Ne

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Plasma Science and Technology 2023年第3期25卷 181-192页

作者： Maryam RIAZ Shazia BASHIR Asma HAYAT Zarish naz Centre for Advanced Studies in Physics GC University Lahore

This study deals with the investigation of Nd:YAG laser-assisted ablation and plasma formation of Ti at irradiance of 0.85 GW cm-2 under Ar and Ne environment at various pressures ranging from 10-120 ***-induced breakdown spectroscopy is used to evaluate plasma parameters,whereas quartz crystal microbalance is used for ablation yield *** crater depth is evaluated by optical *** surface features are explored by scanning electron microscope(SEM) analysis and the micro-hardness is measured by a Vickers hardness *** is observed that the plasma parameters are higher in Ar than in Ne,and are strongly correlated with the ablation yield,ablation depth,surface features and hardness of laser-ablated *** parameters increase with increasing the pressure of environmental gases,attain their maxima at 40 Torr for Ar and at 60 Torr for ***,they show a decreasing trend up till a maximum pressure of 120 *** maximum value of the electron temperature(Te) is5480 K,number density(ne) is 1.46 × 1018 cm-3,ablation depth is 184 μm,ablation yield is3.9 × 1015 atoms/pulse and hardness is 300 HV in the case of Ar *** analysis reveals the growth of surface features,such as cones,ridges and pores,whose appearance is more distinct in Ar than Ne and is attributed to temperature,pressure and density gradients along with recoil pressure of the Ti plasma.

关键词： ablation plasma electron temperature electron density laser-induced breakdown spectroscopy surface structures

Nanocellulose isolation characterization and applications:a journey from non-remedial to biomedical claims

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Bio-Design and Manufacturing 2019年第3期2卷 187-212页

作者： Sania naz Joham S.Ali Muhammad Zia Department of Biotechnology Quaid-i-Azam University IslamabadIslamabadPakistan

Cellulose is a renewable,biodegradable,ecofriendly and sustainable *** market of nanocellulose is comprehensively very high due to its *** of nanocellulose from bacteria and plant results in different morphology and size of ***,mechanical strength,biofabrication,crystallinity,high surface area per unit mass,hydrophilicity,porosity,transparency and non-toxicity of bacterial cellulose make it more *** extravagant nanoscaled three-dimensional network of cellulosic structures possess extraordinary properties for biomedical application,evidencing its usage in skin therapy,cardiovascular implants,cartilage meniscus implants,tissue engineering,bone tissue and neural implants,wound care products,drug delivery agents,tablet modification,tissue engineered urinary conduits,and synthesis of artificial *** due to potential benefits associated with nanocellulose effective and efficient techniques are required for the isolation of nanocellulose that should be economical,ecofriendly and non-toxic.

关键词： Nanocellulose Plant and bacterial source Extraction Applications

Aqueous solution of basic fuchsin as food irradiation dosimeter

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Nuclear Science and Techniques 2007年第3期18卷 141-144页

作者： Hasan M.KHAN Shagufta naz Radiation Chemistry Laboratory National Centre of Excellence in Physical ChemistryUniversity of PeshawarPeshawar 25120 Pakistan

Dosimetric characterization of aqueous solution of basic fuchsin was studied spectrophotometrically for possible application in the low-dose food irradiation dosimetry. Absorption spectra of unirradiated and irradiated solu- tions were determined and the decrease in absorbance with the dose was noted down. Radiation-induced bleaching of the dye was measured at wavelengths of maximum absorption λmax (540nm) as well as 510nm and 460 nm. At all these wavelengths, the decrease in absorbance of the dosimeter was linear with respect to the absorbed dose from 50 Gy to 600 Gy. The stability of dosimetric solution during post-irradiation storage in the dark at room temperature showed that after initial bleaching during first ten to twenty days, the response was almost stable for about 34 days. The study on the effect of different light and temperature conditions also showed that the response gradually decreased during the storage period of 34 days, which shows that basic fuchsin dye is photosensitive as well as thermally sensitive.

关键词：水溶液食物辐射计量品红

Heterogeneous Expansion of End-moraine Dammed Lakes in the Hindukush-Karakoram-Himalaya Ranges of Pakistan during 2001-2013

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Journal of Mountain Science 2015年第5期12卷 1113-1124页

作者： Arshad ASHRAF Rozina naz Muhammad Bilal IQBAL Climate Change Alternate Energy and Water Resources Institute (CAEWRI) National Agricultural Research Center

Global climate change during the twentieth century had a significant impact on the glaciers that resulted in creation of new lakes and expansion of existing ones, and ultimately an increase in the number of glacial lake outburst floods(GLOFs) in the Himalayan region. This study reports variation of the end-moraine dammed lakes in the high altitude Hindukush-Karakoram-Himalaya(HKH) region of Pakistan to evaluate future floods hazard under changing climate in this region. An integrated temporal remote sensing and Geographic information system(GIS) based approach using satellite images of Landsat-7 and 8 was adopted to detect 482 endmoraine dammed lakes out of which 339 lakes(>0.02 km2) were selected for temporal change analysis during the 2001-2013 period. The findings of the study revealed a net expansion in the end-moraine dammed lakes area in the Karakoram(about 7.7%) and in the Himalayas(4.6%), while there was a net shrinkage of about 1.5% in the lakes area in the Hindukush range during this period. The percentage increase in the lakes' area was highest above 4500 m asl in the Hindukush, within 3500-4000 m asl in the Himalayas and below 3500 m asl in the Karakoram range. The overall positive change in the lakes' area appears to prevail in various altitudinal ranges of the region. The heterogeneous areal changes in the endmoraine dammed lakes might be attributed to different climate regimes and glacial hydrodynamics in the three HKH ranges. A periodic monitoring of the glacial lakes and their associated glaciers is essential for developing effective hazard assessment and risk reduction strategies for this high altitude Himalayan region.

关键词： End-moraine glacial lakes GLOF Karakoram Himalayan region

Study of Fractional Order Dynamical System of Viral Infection Disease under Piecewise Derivative

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 921-941页

作者： Kamal Shah Hafsa naz Thabet Abdeljawad Bahaaeldin Abdalla Department of Mathematics and Sciences Prince Sultan UniversityP.O.Box 66833Riyadh11586Saudi Arabia Department of Mathematics University of MalakandChakdara Dir(L)Khyber Pakhtunkhwa18000Pakistan Department of Medical Research China Medical UniversityTaichung40402Taiwan

This research aims to understand the fractional order dynamics of the deadly Nipah virus(NiV)*** focus on using piecewise derivatives in the context of classical and singular kernels of power operators in the Caputo sense to investigate the crossover behavior of the considered dynamical *** establish some qualitative results about the existence and uniqueness of the solution to the proposed *** utilizing the Newtonian polynomials interpolation technique,we recall a powerful algorithm to interpret the numerical findings for the aforesaid ***,we remark that the said viral infection is caused by an RNA type virus which can transmit from animals and also from an infected person to *** bats which are also known as flying foxes are one of the sources of transmission of NiV *** in this work,we investigate its transmission mechanism through some new concepts of fractional calculus for further analysis and *** present the approximate results for different compartments using different fractional *** using the piecewise derivative concept,we detect the crossover ormulti-steps behavior in the transmission dynamics of the mentioned ***,the considered form of the derivative is used to deal with problems exhibiting crossover behaviors.

关键词： NiV disease fractional calculus piecewise derivative qualitative results newton polynomial RNA virus