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Serum neopterin levels in children with hepatitis-B-related chronic liver disease and its relationship to disease severity

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World Journal of Gastroenterology 2008年第44期14卷 6840-6843页

作者： Enver Mahir Gulcan ipek tirit Ayse Anil Erdal Adal Gulsen Ozbay Department of Pediatric Gastroenterology Istanbul Bakirkoy Maternity and Children Training and Research HospitalIstanbulTurkey Department of Pediatrics Istanbul Bakirkoy Maternity and Children Training ad Research HospitalIstanbulTurkey Department of Pathology Cerrahpasa Medical SchoolIstanbulTurkey

AIM:To evaluate serum neopterin levels and their correlations with liver function tests and histological grade in children with hepatitis-B-related chronic liver disease. METHODS:The study population comprised 48 patients with chronic active hepatitis B,32 patients with hepatitis-B-related active liver cirrhosis and 40 normal controls. Serum neopterin was measured using an enzyme-linked immunosorbent assay. RESULTS:The mean ± SD serum neopterin levels were 14.2 ± 5.6 nmol/L in patients with chronic hepatitis,20.3 ± 7.9 nmol/L in patients with liver cirrhosis and 5.2 ± 1.4 nmol/L in control group. Serum neopterin levels were signif icantly higher in patients with chronic hepatitis (P = 0.005) and cirrhosis patients (P = 0.008),than in control subjects. Cirrhotic patients had signif icantly higher serum neopterin levels than patients with chronic hepatitis (P = 0.004). There was a positive correlation between serum neopterin levels and alanine aminotransferase levels in patients with chronic hepatitis (r = 0.41,P = 0.004) and cirrhotic patients (r = 0.39,P = 0.005). Positive correlations were detected between serum neopterin levels and inflammatory score in patients with chronic hepatitis (r = 0.51,P = 0.003) and cirrhotic patients (r = 0.49,P = 0.001). CONCLUSION:Our results suggest that serum neopterin levels can be considered as a marker of inflammatory activity and severity of disease in children with hepatitis-B-related chronic liver disease.

关键词： Hepatitis B Chronic liver disease Serumneopterin Histological grade Children

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