检索结果-南通市图书馆

Translational research and innovation in modern transplant practice:Paradigms from Greece and around the world

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2023年第2期13卷 25-27页

作者： Georgios Tsoulfas ioannis Boletis Vassilios Papalois Department of Transplantation Surgery Aristotle University School of MedicineThessaloniki 54124Greece Department of Nephrology EKPA UniversityAthens 11527Greece Department of Transplant Surgery Imperial College Renal and Transplant CentreLondon W120HSUnited Kingdom

The continuous clinical and technological advances,together with the social,health and economic challenges that the global population faces,have created an environment where the evolution of the field of transplantation is essentially *** goal of this special issue is to provide a picture of the current status of transplantation in Greece as well as in many other countries in Europe and around the *** from Greece and several other countries provide us with valuable insight into their respective areas of transplant expertise,with a main focus on the field of translational research and *** papers that are part of this Special Issue“Translational Research and Innovation and the current status of Transplantation in Greece”have presented innovative and meaningful approaches in modern transplant research and *** provide us with a clear overview of the current landscape in transplantation,including liver transplantation in the context of a major pandemic,the evolution of living donor kidney transplantation or the evolution of the effect of hepatitis C virus infection in transplantation,while at the same time explore more recent challenges,such as the issue of frailty in the transplant candidate and the changes brought by newer treatments,such as immunotherapy,in transplant ***,they offer us a glimpse of the effect that technological innovations,such as virtual reality,can have on transplantation,both in terms of clinical and educational *** as critical is the fact that this Special Issue emphasizes the multidisciplinary,collaborative efforts currently taking place that link transplant research and innovation with other cutting-edge disciplines such as bioengineering,advanced information technology and artificial *** this Special Issue,in addition to the clinical and research evolution of the field of transplantation,we are witnessing the importance of interdisciplinary collaboration in medicine

关键词： Translational research Non-alcoholic fatty liver disease Immunotherapy Pandemic Liver transplantation Bioengineering Artificial intelligence Immunosuppression Transplant oncology Living donor kidney transplantation

COVID-19 and the cardiovascular system-current knowledge and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第27期10卷 9602-9610页

作者： Dimitrios G Chatzis Kalliopi Magounaki ioannis Pantazopoulos Sonu Menachem Maimonides Bhaskar Medical School European University CyprusNicosia 2404Cyprus Department of Internal Medicine KAT General HospitalAthens 14561Greece Department of Emergency Medicine Faculty of MedicineUniversity of ThessalyLarissa 41500Greece NSW Brain Clot Bank NSW Health PathologySydneyNSW 2170Australia Department of Neurology and Neurophysiology Liverpool Hospital and South Western Sydney Local Health DistrictSydneyNSW 2170Australia

The current coronavirus disease 2019(COVID-19) pandemic has had devastating impact on populations around the *** high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),its causative viral agent,on several physiological systems in human body,including the respiratory,cardiovascular,and neurological *** is emerging evidence on propensity of this virus to attack cardiovascular ***,various pathophysiological mechanisms by which SARS-CoV-2 interacts with cardiovascular system and leads to high morbidity and mortality,including cardiovascular complications,are poorly *** mini review aims to provide an update on the current knowledge and perspectives on areas of future research.

关键词： COVID-19 Angiotensin-converting enzyme 2 receptors Cardiovascular manifestations Therapies

Global dissemination of minimally invasive living donor hepatectomy: What are the barriers?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2023年第5期15卷 776-787页

作者： Christos Dimitrios Kakos Angelos Papanikolaou ioannis A Ziogas Georgios Tsoulfas Surgery Working Group Society of Junior DoctorsAthens 15123Greece Department of Transplant Surgery Aristotle University of ThessalonikiSchool of MedicineThessaloniki 54622Greece Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of Surgery University of Colorado Anschutz Medical CampusAuroraCO 80045United States

Minimally invasive donor hepatectomy(MIDH)is a relatively novel procedure that can potentially increase donor safety and contribute to faster rehabilitation of *** an initial period in which donor safety was not effectively validated,MIDH currently seems to provide improved results,provided that it is conducted by experienced *** selection criteria are crucial to achieve better outcomes in terms of complications,blood loss,operative time,and hospital *** a pure laparoscopic technique,various approaches have been recommended such as hand-assisted,laparoscopic-assisted,and robotic *** latter has shown equal outcomes compared to open and laparoscopic approaches.A steep learning curve seems to exist in MIDH,mainly due to the fragility of the liver parenchyma and the experience needed for adequate control of *** review investigated the challenges and the opportunities of MIDH and the barriers to its global *** need expertise in liver transplantation,hepatobiliary surgery,and minimally invasive techniques to perform *** can be categorized into surgeon-related,institutionalrelated,and *** robust data and the creation of international registries are needed for further evaluation of the technique and the acceptance from more centers worldwide.

关键词： Minimally invasive donor hepatectomy Liver transplantation Living donation Laparoscopic donor hepatectomy Global surgery

Radiation protection measures during endourological therapies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2023年第3期10卷 215-225页

作者： Lazaros Tzelves Patrick Juliebø-Jones ioannis Manolitsis Themistoklis Bellos ioannis Mykoniatis Marinos Berdempes Titos Markopoulosa Michael Lardas Belthangady M.Zeeshan Hameed Panagiotis Angelopoulos Amelia Pietropaolo Bhaskar Somani ioannis Varkarakis Andreas Skolarikos nd Department of Urology National and Kapodistrian University of AthensSismanogleion HospitalAthensGreece Young Academic Urologists(YAU) Urolithiasis&Endourology Working Party6846 Arnhemthe Netherlands Department of Urology Haukeland University HospitalN-5021 BergenNorway Department of Urology Faculty of Health SciencesSchool of MedicineAristotle University of Thessaloniki54124 ThessalonikiGreece Department of Urology Kasturba Medical College ManipalManipal Academy of Higher EducationManipal 576104India Department of Urology University Hospital Southampton NHS TrustSouthamptonUK

Objective The objective of this narrative review was to search the existing literature for studies reporting measures to minimize radiation use during endoscopic management of stone disease and present ways of reducing the exposure of both patients and operating room *** A literature review in PubMed was performed to identify studies describing protocols or measures to reduce radiation received during endourological procedures from January 1970 to August *** studies were those that reported outcomes for ureteroscopy or percutaneous nephrolithotripsy regarding measures to minimize radiation doses used intraoperatively,performed either in real-life theatres or using *** comparative and non-comparative studies were deemed *** Protection can be achieved initially at the level of diagnosis and follow-up of patients,which should be done following an algorithm and choice of more conservative imaging *** protocols,which follow principles for minimized fluoroscopy use should be implemented and urologists as well as operating room staff should be continuously trained regarding radiation damage and protection *** protective lead equipment remains a cornerstone for personnel protection,while configuration of the operating room and adjusting X-ray machine settings can also significantly reduce radiation *** There are specific measures,which can be implemented to reduce radiation *** include avoiding excessive use of computed tomography scans and X-rays during diagnosis and follow-up of urolithiasis *** protocols with minimal fluoroscopy use can be *** training regarding dangers of radiation plays also a major *** and maintenance of protective equipment and setting up the operating room properly also serve towards this *** settings can be customized appropriately and finally continuously monitoring of exposure with dosimeters can be adopted.

关键词： Endourology Radiation Fluoroless ureteroscopy Percutaneous nephrolithotripsy As low as reasonably achievable

Pediatric transplantation during the COVID-19 pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2022年第5期12卷 88-99页

作者： Christos Dimitrios Kakos ioannis A Ziogas Georgios Tsoulfas Surgery Working Group Society of Junior DoctorsAthens 15123Greece Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States Department of Transplantation Surgery Aristotle University School of MedicineThessaloniki 54622Greece

Children infected by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)seem to have a better prognosis than ***,pediatric solid organ transplantation(SOT)has been significantly affected by the unprecedented coronavirus disease 2019(COVID-19)pandemic during the pre-,peri-,and posttransplant ***,immunosuppression constitutes a real challenge for transplant clinicians as increased immunosuppression may prolong disease recovery,while its decrease can contribute to more severe *** date,most pediatric SOT recipients infected by SARS-CoV-2 experience mild disease with only scarce reports of life-threatening *** a consequence,after an initial drop during the early phase of the pandemic,pediatric SOTs are now performed with the same frequency as during the pre-pandemic *** review summarizes the currently available evidence regarding pediatric SOT during the COVID-19 pandemic.

关键词： Pediatric Transplantation SARS-CoV-2 COVID-19 Immunosuppression

On-chain analytics for sentiment-driven statistical causality in cryptocurrencies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain(Research and Applications) 2022年第2期3卷 39-63页

作者： ioannis Chalkiadakis Anna Zaremba Gareth W.Peters Michael J.Chantler School of Mathematical and Computer Sciences Heriot-Watt UniversityScotlandEH144ASUK Department of Computer Science University CollegeLondonWC1E 7HUUK Janet and Ian Duncan Endowed Chair of Actuarial Science Department of Statistics and Applied ProbabilityUniversity of CaliforniaSanta BarbaraCA93106USA

This paper establishes a new framework for assessing multimodal statistical causality between cryptocurrency market(cryptomarket)sentiment and cryptocurrency price *** order to achieve this,we present an efficient algorithm for multimodal statistical causality analysis based on Multiple-Output Gaussian *** from different information sources(modalities)are jointly modelled as a Multiple-Output Gaussian Process,and then using a novel approach to statistical causality based on Gaussian Processes(GPs),we study linear and non-linear causal effects between the different *** demonstrate the effectiveness of our approach in a machine learning application by studying the relationship between cryptocurrency spot price dynamics and sentiment time-series data specific to the crypto sector,which we conjecture influences retail investor *** investor sentiment is extracted from cryptomarket news data via methods developed in the area of statistical machine learning known as Natural Language Processing(NLP).To capture sentiment,we present a novel framework for text to time-series embedding,which we then use to construct a sentiment index from publicly available news *** conduct a statistical analysis of our sentiment statistical index model and compare it to alternative state-of-the-art sentiment models popular in the NLP *** regard to the multimodal causality,the investor sentiment is our primary modality of exploration,in addition to price and a blockchain technologyrelated indicator(hash rate).Analysis shows that our approach is effective in modelling causal structures of variable degree of complexity between heterogeneous data sources and illustrates the impact that certain modelling choices for the different modalities can have on detecting causality.A solid understanding of these factors is necessary to gauge cryptocurrency adoption by retail investors and provide sentiment-and technologybased insights about the cry

关键词： Cryptocurrencies Statistical causality Blockchain regression Multiple-output Gaussian process Natural language processing Cryptonews sentiment

Fabrication of 3D-printed molds for polydimethylsiloxane-based microfluidic devices using a liquid crystal display-based vat photopolymerization process:printing quality,drug response and 3D invasion cell culture assays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第6期9卷 205-219页

作者： Matthew D.Poskus Tuo Wang Yuxuan Deng Sydney Borcherding Jake Atkinson ioannis K.Zervantonakis Department of Bioengineering UPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPAUSA McGowan Institute of Regenerative Medicine PittsburghPAUSA

Microfluidic platforms enable more precise control of biological stimuli and environment dimensionality than conventional macroscale cell-based assays;however,long fabrication times and high-cost specialized equipment limit the widespread adoption of microfluidic *** improvements in vat photopolymerization three-dimensional(3D)printing technologies such as liquid crystal display(LCD)printing offer rapid prototyping and a cost-effective solution to microfluidic *** information is available about how 3D printing parameters and resin cytocompatibility impact the performance of 3D-printed molds for the fabrication of polydimethylsiloxane(PDMS)-based microfluidic platforms for cellular *** a low-cost,commercially available LCD-based 3D printer,we assessed the cytocompatibility of several resins,optimized fabrication parameters,and characterized the minimum feature *** evaluated the response to both cytotoxic chemotherapy and targeted kinase therapies in microfluidic devices fabricated using our 3D-printed molds and demonstrated the establishment of flow-based concentration ***,we monitored real-time cancer cell and fibroblast migration in a 3D matrix environment that was dependent on environmental *** results demonstrate how vat photopolymerization LCD-based fabrication can accelerate the prototyping of microfluidic platforms with increased accessibility and resolution for PDMS-based cell culture assays.

关键词： invasion printing culture

A Proposed Methodological Approach for Considering Community Resilience in Technology Development and Disaster Management Pilot Testing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2022年第3期13卷 342-357页

作者： ioannis Benekos Evangelos Bekiaris Katarzyna Wodniak Waleed Serhan Łukasz Sułkowski Hana Gharrad Ansar Yasar Centre for Research&Technology Hellas(CERTH) Hellenic Institute of Transport(HIT)15125MarousiGreece Department of Management University of Social SciencesWarsaw00-842WarsawPoland Transportation Research Institute(IMOB) Hasselt University3590DiepenbeekBelgium

Nowadays,resilience has become an indispensable term in several aspects and areas of research and *** consensus on what actually constitutes"resilience,""community,"and"community resilience"is still a task that guarantees a vivid exchange of opinions,sometimes escalating into debates,both in the scientific community and among *** out how to practically apply resilience principles goes even a step *** study attempts to circumvent the need for a universal agreement on the definition of"community resilience,"which may still be immature,if not impossible,at this *** accomplish this by proposing a practical methodological approach with concrete methods on how to agree and implement commonly accepted community resilience principles in the context of technology development and pilot testing for disaster *** proposed approach was developed,tested,and validated in the context of the Horizon 2020 EU-funded project Search and *** aspects of the approach,along with considerations for further improvement and adaptation in different contexts,are addressed in the article.

关键词： Community resilience Crisis management Disaster preparedness and response Disaster risk management Search and rescue

Role of immunotherapy in downsizing hepatocellular carcinoma prior to liver transplantation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2022年第11期12卷 331-346页

作者： Konstantinos Ouranos Anthi Chatziioannou ioannis Goulis Emmanouil Sinakos 4th Medical Department Hippokratio HospitalAristotle University of ThessalonikiThessaloniki 54642Greece

Hepatocellular carcinoma(HCC)is an aggressive primary liver neoplasm that,according to tumor stage,can be treated with resection,transplantation,locoregional treatment options,or systemic *** interventions only in early-stage disease can offer complete tumor regression,systemic therapy in advanced disease can significantly prolong overall survival,according to published clinical *** emergence of immunotherapy in the field of cancer therapy has had a positive impact on patients with HCC,resulting in atezolizumab–bevacizumab currently being the first-line option for treatment of advanced *** light of this,application of immunotherapy in the preoperative process could increase the number of patients fulfilling the criteria for liver transplantation(LT).Implementation of this approach is faced with challenges regarding the safety of immunotherapy and the possibly increased risk of rejection in the perioperative *** reports and clinical trials assessing the safety profile and effectiveness of neoadjuvant immunotherapy,highlight important aspects regarding this newly evolving approach to HCC *** studies need to be conducted in order to reach a consensus regarding the optimal way to administer immunotherapy prior to *** this review,we summarize the role,safety profile and future considerations regarding the use of neoadjuvant immunotherapy prior to LT in patients with HCC.

关键词： Hepatocellular carcinoma Immunotherapy Tumor downsizing Liver transplantation Neoadjuvant Rejection