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COVID-19 and hyperglycemia/diabetes

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World Journal of Diabetes 2021年第5期12卷 642-650页

作者： Konstantinos Michalakis ioannis Ilias Private Practice Athens GR-11521Greece Department of Endocrinology Diabetes and MetabolismElena Venizelou HospitalAthens GR-11521Greece

In early studies regarding coronavirus disease 2019(COVID-19),type 2 diabetes mellitus was considered to contribute substantially to the disease’s inflammatory ***,even hyperglycemia,regardless of insulin resistance or diabetes mellitus,was found to be additionally *** studies have shown inflammation of the pancreaticβcells in COVID-19,even leading to new onset diabetes *** hereby summarize core literature on glycemia and COVID-19,and present implicated pathways and mechanisms.

关键词： COVID-19 Humans sARs-CoV-2 Risk factors Glucose Inflammation Diabetes

Thrombosis and inflammatory bowel disease-the role of genetic risk factors

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World Journal of Gastroenterology 2008年第28期14卷 4440-4444页

作者： Georgia Tsiolakidou ioannis E Koutroubakis Department of Gastroenterology University Hospital Heraklion CreteHeraklion 71110Greece

Thromboembolism is a significant cause of morbidity and mortality in patients with inflammatory bowel disease （IBD）. Recent data suggest thromboembolism as a disease-specific extraintestinal manifestation of IBD, which is developed as the result of multiple interactions between acquired and genetic risk factors. There is evidence indicating an imbalance of procoagulant, anticoagulant and fibrinolitic factors predisposing in thrombosis in patients with IBD. The genetic factors that have been suggested to interfere in the thrombotic manifestations of IBD include factor V Leiden, factor Ⅱ （prothrombin, G20210A）, methylenetetrahydrofolate reductase gene mutation （MTHFR, 6777T, plasminogen activator inhibitor type 1 （PAI-1） gene mutation and factor X Ⅲ （val34leu）. In this article we review the current data and future prospects on the role of genetic risk factors in the development of thromboembolism in TBD.

关键词： Crohn's disease Factor Ⅴ Leiden Genetics Thrombosis Ulcerative colitis

Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine

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Cell Research 2004年第5期14卷 415-422页

作者： Evangelos KONTARGIRIs,Evangelos KOLETTAs,Athina VADALOUCA,ioannis P. TROUGAKOs,Efstathios s. GONOs,Vasiliki KALFAKAKOU Laboratory of Experimental Physiology University of Ioannina Medical school 45110 Ioannina Greece Laboratory of Experimental Physiology University of Ioannina Medical school 45110 Ioannina Greece Department of Anesthesia Pain Relief and Palliative Care University Clinic Areteion Hospital Athens Greece Laboratory of Molecular and Cellular Aging Institute of Biological Research and Biotechnology National Hellenic Research Foundation 11635 Athens Greece Laboratory of Molecular and Cellular Aging Institute of Biological Research and Biotechnology National Hellenic Research Foundation 11635 Athens Greece Laboratory of Experimental Physiology University of Ioannina Medical school 45110 Ioannina Greece

Local anesthetics inhibit cell proliferation and induce apoptosis in various cell types. Ropivacaine, a unique, novel tertiary amine-type anesthetic, was shown to inhibit the proliferation of several cell types including keratinocytes. We found that Ropivacaine could inhibit the proliferation and induce apoptosis in an immortalized human keratinocyte line, HaCaT, in a dose- and time-dependent manner and with the deprivation of serum. The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate — poly (ADP-ribose) polymerase (PARP). In addition, ropivacaine downregulated the expression of clusterin/ apoliporotein J, a protein with anti-apoptotic properties, in a dose-dependent manner, which well correlated with the induction of apoptosis of HaCaT cells. To investigate the role of clusterin/apoliporotein J in ropivacaine-induced apoptosis, HaCaT cells overexpressing clusterin/apoliporotein J were generated and compared to cells expressing the well estab- lished anti-apoptotic Bcl-2 protein. Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression. Furthermore, the downregulation of endogenous clusterin/apolipoprotein J levels by ropivacaine suggested that this might be one mechanism by which ropivacaine induced cell death in HaCaT cells. In conclusion, the ability of ropivacaine to induce antiproliferative responses and to suppress the expression of the anti-apoptotic protein clusterin/apolipoprotein J, combined with previ- ously reported anti-inflammatory activity and analgesic property of the drug, suggests that ropivacaine may have poten- tial utility in the local treatment of tumors.

关键词： keratinocytes ropivacaine clusterin/Apolipoprotein J Bcl-2 apoptosis.

The Teacher-Disciple Tradition and secret Teaching in Chinese Medicine

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Chinese Journal of Integrative Medicine 2014年第1期20卷 56-62页

作者： ioannis solos 梁媛岳广欣 Beijing University of Chinese Medicine Institute of Basic Theory in Chinese Medicine China Academy of Chinese Medical Sciences

The ancient teacher-disciple tradition is regarded as one of the most celebrated practices within the Chinese medicine *** traditions of secrecy,private wisdom and honor are deeply rooted in the theories of *** paper only explores the surface of this ancient culture,by investigating relevant popular ancient texts and common Chinese proverbs,as well as utilizing personal experiences,in order to reflect on how the ancient Chinese perceived such practices within their own society and how secret teaching was passed on from teacher to student,including the revelation of secret formulas and their importance and how that tradition differs from our modern-day *** rare manuscripts from the author’s personal library are employed in order to provide relative examples of the importance of secret knowledge,and how these secrets applied in the traditional healing.

关键词： teacher disciple secrecy Chinese medicine Confucianism formulas

A case of primary isolated non-Hodgkin’s lymphoma of the esophagus in an immunocompetent patient

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World Journal of Gastroenterology 2009年第15期15卷 1901-1903页

作者： ioannis V Kalogeropoulos Athanasios N Chalazonitis sofia Tsolaki Fotios Laspas Nikolaos Ptohis ioannis Neofytou Dimitra Rontogianni Department of Radiology "Evagelismos" General Hospital Department of Radiology "Hippocratio" General Hospital

Primary non-Hodgkin’s lymphoma of the esophagus is a rare disease.A case of primary isolated nonHodgkin’s lymphoma of the esophagus in a 77-yearold man without acquired immunodeficiency syndrome is *** describe the clinical features and the imaging findings(barium swallow,endoscopic ultrasonography and CT)of a biopsy proven B-cell lymphoma with diffuse transmural involvement of the esophagus wall,which was discovered *** also briefly review the literature.

关键词： Endoscopic ultrasonography Esophagus Lymphoma Non-Hodgkin's lymphoma

Boym’s "De Indiciis Morborum ex Linguae Coloribus et Affectionibus" : The Earliest Chinese Tongue Diagnosis Manual Published in Europe, Identification of Original Chinese Text, Peculiarities of Printed Edition and Its Impact on European Medicine

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Chinese Journal of Integrative Medicine 2021年第5期27卷 379-383页

作者： solos ioannis Helioti Maria HONG Mei LIANG Yuan Foundation for PIHMA Research and Education Phoenix AZPhoenix AZUSA Phoenix Institute of Herbal Medicine and Acupuncture Phoenix AZPhoenix AZUSA Institute of Chinese Medical History and Literature China Academy of Chinese Medical SciencesBeijing 100700China Institute of Basic Theory in Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Upon his untimely death,Michal Boym(1612–1659)left behind an enormous written legacy;covering a diverse range of interests in fields such as Chinese linguistics,cartography,botany,zoology,philosophy and *** article attempts to examine Boym’s De indiciis morborum ex linguae coloribus&affectionibus(The signs of disease on the tongue,colors and affections),a translation of a previously unidentified Chinese *** text specifically deals with the subject of tongue diagnosis,in relation to contagious diseases that were still raging in the17 th century *** to China at the end of the Ming Dynasty(1368–1644),Boym was able to personally witness the early development of tongue examination as an independent specialty;he recognized its significance and tried to incorporate it into his ultimately unfinished Chinese medical ***’s work eventually facilitated the assimilation of tongue observation in European medicine during the 19 th century.

关键词： Michal Boym tongue diagnosis Chinese medicine Jesuit mission

Multiscale modeling of ultrafast melting phenomena

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npj Computational Materials 2022年第1期8卷 324-333页

作者： Gaetano Calogero Domenica Raciti Pablo Acosta-Alba Fuccio Cristiano ioannis Deretzis Giuseppe Fisicaro Karim Huet sébastien Kerdilès Alberto sciuto Antonino La Magna CNR IMM CataniaItaly UniversitéGrenoble Alpes CEA-LETIGrenobleFrance LAAs CNRSUniversitéde ToulouseToulouseFrance Laser systems&solutions of Europe(LAssE) GennevilliersFrance Dipartimento di Fisica e Astronomia Universitàdi CataniaCataniaItaly

Ultraviolet Nanosecond Laser Annealing(LA)is a powerful tool for both fundamental investigations of ultrafast,nonequilibrium phase-change phenomena and technological applications(e.g.,the processing of 3D sequentially integrated nano-electronic devices)where strongly confined heating and melting is *** the LA process along with the experimental design is challenging,especially when involving complex 3D-nanostructured systems with various shapes and *** this purpose,it is essential to model critical nanoscale physical LA-induced phenomena,such as shape changes or formation and evolution of point and extended *** date,LA simulators are based on continuum models,which cannot fully capture the microscopic kinetics of a solid–liquid *** this work a fully atomistic LA simulation methodology is presented,based on the parallel coupling of a continuum,finite elements,μm-scale electromagnetic-thermal solver with a super-lattice Kinetic Monte Carlo atomistic model for *** against phase-field models and experimental data validate the *** of a si(001)surface is studied varying laser fluence and pulse shape,assuming both homogeneous and inhomogeneous nucleation,revealing how liquid si nuclei generate,deform and coalesce during *** proposed methodology is applicable to any system where the atom kinetics is determined by a strongly space-and time-dependent field,such as temperature or strain.

关键词： kinetics shape melting

A framework for risk analysis of the shellfish aquaculture:The case of the Mediterranean mussel farming in Greece

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Aquaculture and Fisheries 2023年第4期8卷 375-384页

作者： John A.Theodorou ioannis Tzovenis Department of Animal Production Fisheries&AquacultureUniversity of PatrasMesolonghi30200Greece Laboratory of Ecology&systematics Biology Dept.University of AthensPanepistimioupolisZografou15784Greece

Mediterranean mussel farming in Greece developed considerably during the last 40 years reaching a gross commodity product up to the limits of the country’s production capacity(35–40,000 tonnes/year).Despite the achievements in the sector’s growth,little or no effort has been attributed yet to risk assessment and moreover to risk management of the *** present effort aims at developing a working framework for the shellfish aquaculture of Greece to be used as a tool by the sector’s decision makers to advance strategies for risk elimination or *** work was based on a generic risk management standard tool,the Joint Australian and New Zealand Risk Management standard As/NZs IsO 31000:2009 that has been adapted to the specific national characteristics of all levels of the mussel farming business-activities and the industry *** framework supported by data sets regarding development,production,profits and losses,retrieved by surveys through distributed questionnaires or interviews during site-visits,as well as by collecting data from national and international *** input covered technology,farm size,farmer risk-attitude,risk-management strategies,risk-perceptions and socioeconomic *** risks and risk management options were identified providing aid for remediation risk policies to the stakeholders.

关键词： IsO 31000 Risk analysis Mediterranean mussel farming Aquaculture insurance

Multipotent role of platelets in inflammatory bowel diseases:A clinical approach

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World Journal of Gastroenterology 2014年第12期20卷 3180-3190页

作者： Evangelos Voudoukis Konstantinos Karmiris ioannis E Koutroubakis Department of Gastroenterology Venizelion General Hospital Department of Gastroenterology University Hospital Heraklion

There is evidence that inflammatory bowel diseases (IBD) combine both inflammation and coagulation in their pathogenesis and clinical manifestations. Although platelets (PLT) are well known for their role in hemostasis, there are a rising number of studies supporting their considerable role as inflammatory amplifiers in chronic inflammatory conditions. IBD are associated with several alterations of PLT, including number, shape, and function, and these abnormalities are mainly attributed to the highly activated state of circulating PLT in IBD patients. When PLT activate, they increase in size, release a great variety of bio-active inflammatory and procoagulant molecules/particles, and express a variety of inflammatory receptors. These inflammatory products may represent a part of the missing link between coagulation and inflammation, and can be considered as possible IBD pathogenesis instigators. In clinical practice, thrombocytosis is associated both with disease activity and iron deficiency anemia. Controlling inflammation and iron replacement in anemic patients usually leads to a normalization of PLT count. The aim of this review is to update the role of PLT in IBD and present recent data revealing the possible therapeutic implications of anti-PLT agents in future IBD remedies.

关键词： Anemia, Crohn’ s disease, Platelets, Thrombocytosis, Ulcerative colitis