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Translation and validation of the Greek chronic liver disease questionnaire

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World Journal of Gastroenterology 2010年第46期16卷 5838-5844页

作者： Zoi Kollia Evridiki Patelarou Victoria Vivilaki Eleni Kollia Florentia Kefou ioannis elefsiniotis Spyros P Dourakis Hero Brokalaki Department of Internal Medicine Faculty of NursingUniversity of Athens Department of Nursing University Hospital of Heraklion Department of Midwifery SEYPTEI of Athens Department of Nursing Hippokration General Hospital of Athens Department of Nursing Naval Hospital of Athens 2nd Department of Internal Medicine Medical SchoolUniversity of Athens

AIM:To translate into Greek and validate the chronic liver disease questionnaire (CLDQ).METHODS:Two hundred and six consecutive adult patients with the diagnosis of a chronic liver disease from 2 general hospitals in Athens were enrolled in the study from May to September *** order to assess their quality of life (QOL) the CLDQ was *** instrument was translated from English,back translated and reviewed in focus groups within the framework of a large multicenter *** measurements that were performed included:2 independent sample t tests,oneway analysis of variance,reliability coefficients,explanatory factor analysis using a varimax rotation and the principal components ***:One hundred and twenty five (61%) patients were men,half were aged 40-59 years and > 33% were > 60 years *** the patients,48 (23%) were hospitalized and 97 (47%) were cirrhotic according to the Child-Pugh *** internal consistency of the Greek CLDQ version using Cronbach's alpha coefficient was found to be *** factor analysis identified 7 domains accounting for 65% of the variance of CLDQ items and only partially overlapping with those found in the original *** area under the receiver operating characteristics curve was calculated at 0.813 and the logistic estimate for the threshold score of 167.50 provided a sensitivity of 74.3% and a specificity of 71.6% for the ***:Our data confirmed the validity of the Greek version of the CLDQ in identifying the QOL among patients with chronic liver disease.

关键词： Chronic disease Questionnaires Validation Quality of life Liver cirrhosis

Epinephrine also acts on beta cells and insulin secretion

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World Journal of Clinical Cases 2024年第9期12卷 1712-1713页

作者： Lina Zabuliene ioannis Ilias Faculty of Medicine Vilnius UniversityVilnius LT-03101Lithuania Department of Endocrinology “Hippokration”General HospitalAthens GR-11527Greece

In a recent review examining neurotransmitter modulation of insulin secretion,the significant impact of epinephrine was not *** primary action involves inhibiting insulin release via alpha-adrenergic receptors,thereby reducing the response to insulin secretion stimulators,through the activation of K+channels and resulting in membrane hyperpolarization in beta cells.

关键词： Epinephrine Insulin Islets Glucose Human

Testing the value of simple arterial blood pressure measurements in a Greek children’s hospital

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Open Journal of Pediatrics 2013年第2期3卷 108-115页

作者： Konstantinos Tsoumakas Konstantina Giamaiou Chara Tzavara Vasiliki Matziou ioannis elefsiniotis Evangelia Lagona Centre for Health Services Research Department of Hygiene Epidemiology and Medical Statistics Athens University Medical School Athens Greece Faculty of Nursing National and Kapodistrian University of Athens Athens Greece First University Department of Paediatrics “Aghia Sophia” Children’s Hospital Athens Greece

Arterial hypertension begins in childhood and may continue, without intervention, throughout adulthood with severe health *** base of timely diagnosis is the systematic blood pressure (BP) measurement. Background: The study aims at revealing the level of parental and community awareness and testing the value of a simple measurement in uncovering children who need further assessment when performing an in-hospital BP screening. Methods: BP was measured in 600 children (0 - 17 yr, mean age 5.1 ± 4.3 yr) at a Children’s hospital. Parents were asked to fill in a specially structured questionnaire. Results: In 47.2% of the subjects (40.1% of them were Greeks and 60.6% foreigners), BP had never been checked before (p arterial BP had never been checked before. Surprisingly, a health certificate was issued for school purposes for 81.2% of the schoolchildren of this study, and 75.3% of the enrolled children were allowed to participate in sports clubs without first checking BP. Moreover, parents demonstrated a low level of alertness with respect to paediatric hypertension. Conclusions: Simple arterial BP measurements can ensure early detection and thus early referral to specialists.

关键词： Children Hypertension Blood Pressure Screening Community Awareness

The Transmission,Establishment and Cross-cultural Integration of Chinese Medicine in the Mainstream Healthcare,through the Eyes of a Generation of Visionaries and Pioneers

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Chinese Medicine and Culture 2024年第1期7卷 1-4页

作者： ioannis Solos Charles Buck Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom

It has historically been very difficult to trace the history of the westward transmission of Chinese medicine through the accounts of its protagonists. Many of the early scholars such as Jack Worsley, Dick Van Buren, and Joe Goodman were reluctant to divulge information about the source of their knowledge, or their professional qualifications. Others, such as John Shen and Hong Yuan-bain were early 20th century immigrants who transmitted highly personalized versions of acupuncture and Chinese medicine to select disciples. Eventually, a new class of scholars appeared, including names such as Ted Kaptchuk, Peter Deadman, Nigel Wiseman, William Morris, Peter Eckman, John Mc Donald, Charles Buck, and the late Giovanni Maciocia who looked for answers back in China, developed translation methodologies and terminology, compiled the main textbooks currently in use at TCM colleges, overcame enormous scholastic adversity, developed courses and pursued the regulation and accreditation of TCM in various countries. This special issue synopsizes the path towards the global acculturation of TCM over the last 50 years, the main protagonists, the enormous accomplishments they have achieved for the profession, their philosophy, their clinical perspectives and visions for the future.

关键词： Chinese medicine Cross-cultural integration Westward transmission James Reston Acupuncture History

Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine

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World Journal of Gastroenterology 2005年第13期11卷 1922-1928页

作者： ioannis S.elefsiniotis Antonios Moulakakis Konstantinos D.Pantazis Irene Glynou ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos Department of Internal Medicine Department of Microbiology Department of Hepatogastroenterology

AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and ***: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB.

关键词： b2-微球蛋白血清 HBeAg 慢性乙型肝炎拉米夫定药物治疗

Retinal capillary plexus in Parkinson’s disease using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 131-136页

作者： ioannis Giachos Spyridon Doumazos Anastasia Tsiogka Konstantina Manoli George Tagaris Tryfon Rotsos Vassilios Kozobolis ioannis Iliopoulos Marilita Moschos First Department of Ophthalmology National and Kapodistrian University of Athens Medical SchoolAthens 11527Greece Department of Neurology General Hospital of Athens“Georgios Gennimatas”Athens 11527Greece Department of Ophthalmology Faculty of MedicineSchool of Health SciencesUniversity of PatrasPatras 26504Greece Neurology Department Democritus University of ThraceAlexandroupolis 68100Greece

AIM:To evaluate the alterations of the retinal microvasculature and foveal avascular zone in patients with Parkinson’s disease(PD)using optical coherence tomography angiography(OCT-A).METHODS:A retrospective study of PD patients examined in the Ophthalmology Department of the General Hospital of Athens,“Georgios Gennimatas”from March 2021 to March 2022 was *** 44 patients with PD were included and 18 healthy controls were examined,hence a total of 124 eyes were enrolled in the *** foveal and parafoveal superficial and deep capillary plexus vascular density(fSCP-VD,fDCP-VD,pSCP-VD,pDCP-CD)and foveal avascular zone(FAZ)were quantified with *** coherence tomography(OCT)was used to measure macular *** statistical analysis was conducted by using a mixed effect linear regression ***:After adjustment for age and gender,the mean parafoveal superficial capillary plexus vascular density(pSCP-VD)and mean parafoveal deep capillary plexus vascular density(pDCP-VD)were significantly decreased in individuals with PD(P<0.001 in both)by-2.35(95%CI-3.3,-1.45)and-7.5(95%CI-10.4,-4.6)***-VD and fDCP-VD didn’t approach statistical *** FAZ area and perimeter were significantly decreased(P<0.001 in both)by-0.1 mm^(2)(95%CI-0.13,-0.07)and-0.49 mm^(2)(95%CI-0.66,-0.32)*** didn’t approach statistical *** retinal thickness(CRT)was significantly decreased in individuals with PD(P<0.001)by-23.1μm(95%CI-30.2,-16)and temporal retinal thickness(TRT)was decreased(P=0.025)by-11μm(95%CI-22,-1.5)while nasal retinal thickness(NRT)only approached statistical significance(P=0.066).CONCLUSION:The mean pSCP-VD,pDCP-VD,CRT and TRT are significantly decreased and FAZ is altered in individuals with *** findings can be potentially used as biomarkers for the diagnosis and evaluation of early PD.

关键词： Parkinson’s disease optical coherence tomography angiography retinal vascular density foveal avascular zone

Extending the decision-making process during yellow phase from human drivers to autonomous vehicles:A microsimulation study with safety considerations

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 362-379页

作者： Efthymis Papadopoulos Anastasia Nikolaidou Emmanouil Lilis ioannis Politis Panagiotis Papaioannou Transport Engineering Laboratory School of Civil EngineeringFaculty of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece

One of the main factors affecting the safety of signalised intersections is the stop/go behaviour during the yellow *** previous research has exhaustively examined drivers’stop/go decision-making,the expected autonomous vehicles’(AVs’)stop/go behaviour has not yet been thoroughly *** a series of simulation experiments developed for conventional and autonomous vehicles using different carfollowing,lane-changing,lateral placement and stop/go model parameter values,we examine here whether the default VISSIM stop/go parameter values can adequately replicate the observed drivers’behaviour at the considered intersection and assess the suitability of using the currently available options,albeit referring to human drivers,to simulate the expected stop/go behaviour of *** also propose a policy framework for determining the desired behaviour of AVs in yellow interval,which is integrated into an AVs logic and achieved in the last simulation to explore the effect of automation on the stop/go outcome and,hence,on the safety level of signalised *** data analysis and modeling techniques were used for the formulation of certain scenarios,including binary choice *** default stop/go parameter values were found unfit to replicate the observed stop/go behaviour and subjected to *** to the currently available options,the proposed AVs logic proved to produce the most accurate results,in terms of the stop/go simulation *** the impact of automation on the stop/go outcome,the simulation experiments showed that AVs preferred a more conservative behaviour in favor of road safety,as indicated by the significant reduction(≈15%)in the number of vehicles crossing the stop line during the yellow light and zero instances of red light ***,compared to the conservative drivers represented by the default stop/go parameter values,AVs preferred a more rational behaviour in favor of intersection capacit

关键词： Driver behaviour AVs behaviour Signalised intersection Choice model Micro-simulation Policy framework

William Morris,Establishing the Foundation for the Advancement of TCM in the US

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Chinese Medicine and Culture 2024年第1期7卷 29-40页

作者： ioannis Solos Charles Buck William Morris Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom AOMA Graduate School of Integrative Medicine Austin 78745the United States of America

The interview was conducted on March 2nd, 2023 by ioannis Solos and Charles Buck. William Morris has sustained practice since 1980. He has served on the California, Texas and Massachusetts Professional Associations, as well as the National Association. He has tendered 20 years of service to the field through academic medicine, earning a master’s degree in medical education to assist in developing Chinese medical doctoral programs and institutional review boards. He earned an OM.D. in 1988, a DAOM in 2002, and a Ph.D. focused on pulse diagnosis as clinical epistemology in 2009. He has published five books, including TCM Case Studies Dermatology, Li Shi-zhen Pulse Studies: An Illustrated Guide, Neoclassical Pulse Diagnosis, Cycles in Medical Astrology, and Transformation: Treating Trauma with Acupuncture and Herbs.

关键词： Acupuncture sustained diagnosis

First case of fungal keratitis secondary to Yamadazyma mexicana

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1164-1167页

作者： ioannis Giachos Aristea Velegraki Sotiria Palioura First Department of Ophthalmology National and Kapodistrian University of Athens Medical SchoolAthens 11527Greece Mycology Research Laboratory Microbiology DepartmentMedical SchoolNational and Kapodistrian University of AthensAthen 11527Greece BIOIATRIKI S.A Healthcare Group Athens 11526Greece Department of Ophthalmology University of Cyprus Medical SchoolNicosia 2109Cyprus

Dear Editor,Fungal keratitis is a serious and potentially sightthreatening infection that poses a global health concern,with higher incidence rates reported in low-income countries and regions with tropical climates[1-3].Risk factors for fungal keratitis include trauma with vegetative matter,contact lens wear,history of ocular surgery,chronic topical steroid use,low socioeconomic status and tropical climate[1-2].Fungi have the propensity to penetrate deep into the corneal stroma,making the infection difficult to treat with topical antifungal agents *** such as corneal perforation and endophthalmitis can arise in severe cases,making early identification of the causative fungal pathogen of utmost importance[4-5].Moreover,obtaining susceptibilities to the available antifungal agents can be sight and eye saving[5].

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