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Identification and Characterization of a Rat Novel Gene RSEP4 Expressed Specifically in Central Nervous System

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 501-507页

作者： Xi-Dao WANG1,2, Ling-Wei KONG1, Zhi-Qin XIE1, Yu-Qiu ZHANG3, Zhi-Xin LIN2, Zhi-Qi ZHAO3,Lei YU4, and Nai-He JING1* 1 Laboratory of Molecular Cell Biology, Laboratory of Stem Cell Biology, institute of Biochemistry and Cell Biology, shanghai institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, shanghai 200031, china School of Life Science and Biotechnology, 2 shanghai Jiaotong university, shanghai 200030, china institute of neurobiology, fudan university, shanghai 200433, china 3 4 Department of Cell Biology, neurobiology and Anatomy, College of Medicine, university of Cincinnati, Cincinnati, Ohio, USA Laboratory of Molecular Cell Biology and Stem Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China

The low-abundantly expressed genes composed the majorities of the mRNAs expressed in the central nervous system (CNS), and were thought to be important for the normal brain functions. Through differential screening a low-abundance cDNA sublibrary with mRNA from neuropathic pain of chronic constriction injury (CCI) model, we have identified a novel rat gene, rat spinal-cord expression protein 4 gene (RSEP4). The total length of RSEP4 cDNA is 2006 bp, with a 501 nucleotide open reading frame (ORF) that encodes a 167 amino acid polypeptide. Northern blot revealed that RSEP4 was expressed specifically in the CNS. In situ hybridization showed that the mRNA of RSEP4 was strongly expressed in the CA1, CA2, CA3 and DG regions of hippocampus, the Purkinje cells of cerebellum, and the small sensory neurons of dorsal horn and large motor neurons of ventral horn of spinal cord. Over-expression of RSEP4-EGFP fusion protein in the human embryonic kidney 293T cells showed that RSEP4 protein was mainly localized in the cell cytoplasm. These results suggest that RSEP4 may play some roles in the CNS.

关键词： central nervous system (CNS) rat Northern blot in situ hybridization

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甘氨酸受体的研究进展

生物化学与生物物理进展 2001年第5期28卷 609-614页

作者：李萍徐祥敏杨雄里中国科学院上海生理研究所上海200031 复旦大学神经生物学研究所上海200433

甘氨酸受体 (GlyR)是中枢神经系统中一种重要的抑制性受体 .GlyR是氯离子 (Cl-)选择性通道蛋白 ,属于配体门控离子通道超家族的一员 .天然GlyR是由α和β亚基组装而成的五聚体 .介绍了近年来有关GlyR的结构、功能、药理特性研究的重要进... 详细信息

甘氨酸受体 (GlyR)是中枢神经系统中一种重要的抑制性受体 .GlyR是氯离子 (Cl-)选择性通道蛋白 ,属于配体门控离子通道超家族的一员 .天然GlyR是由α和β亚基组装而成的五聚体 .介绍了近年来有关GlyR的结构、功能、药理特性研究的重要进展 ,并结合本实验室工作。

关键词：甘氨酸甘氨酸受体配体门控离子通道抑制性神经递质视网膜

Involvement of GABA and opioid peptide receptors in sevoflurane-induced antinociception in rat spinal cord

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Acta Pharmacologica Sinica 2005年第9期26卷 1045-1048页

作者： Ying-wei WANG~1 Xiao-ming DENG~2 Xin-min YOU~1 Shu-xiao LIU~2 Zhi-qi ZHAO~31 Department of Anesthesiology,Xinhua Hospital,shanghai Second Medical university,shanghai 200092,china 2 Department of Anesthesiology,Changhai Hospital,Second Military Medical university shanghai 200433,china 3 institute of neurobiology,fudan university,shanghai 200433,china DepartmentofAnesthesiology XinhuaHospitalShanghaiSecondMedicalUniversityShanghai200092China

Aim:The spinal cord is pivotal in immobility induced by volatile anestheticsbecause the anesthetics depress the activity of motor neurons in the spinal *** aim of this study was to observe the effects of sevoflurane on pain process-ing at the spinal ***:The firing of the gastrocnemius muscle wasevoked by electrical stimulation to the ipsilateral hindpaw in *** nociceptiveC response of electromyography（EMG）was selected to *** GABAAreceptor antagonist bicuculline（0.1 mg/kg）and opioid receptor antagonist nalo-xone（0.4 mg/kg）were administered intravenously,either in the presence or in theabsence of 1.0% ***:In rats with transected spinal cord,sevoflurane produced a profound reduction in the C response in a dose-and time-dependent *** the presence of 1.0% sevoflurane,the C responses wereincreased after injections of bicuculline and ***:Sevofluraneis a volatile anesthetic that acts directly on the spinal cord to suppress the nocice-ptive *** sevoflurane-induced suppression of the C response is antago-nized by either bicuculline or *** results suggest that spinal GABAAreceptors and opioid peptide receptors are involved in the sevoflurane-inducedsuppression of spinal nociception.

关键词： sevoflurane spinal cord pain measurement GABA receptors opioid receptors

Neonatal exposure to fluoxetine and fluvoxamine altered spine density

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Neonatal exposure to fluoxetine and fluvoxamine altered spin...

Requirement for activation of glycine site of NMDA receptors in the rostral anterior cingulate cortex in cat pain-related negative affect

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ting-Jia LU~(1,2),Ya-Jie SUN~(1,3),Xue-Han ZHANG~4,Bao-Ming LI~4,Xiao-Hua CAO~5,Zhi-Qi XIONG~(1,2) 1 institute of Neuroscience and Key Laboratory of neurobiology,shanghai institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 200031,china 2 Graduate School of the Chinese Academy of Sciences,shanghai 200031,china 3 Hangzhou Normal university,Hangzhou 310036,china 4 Laboratory of Higher Brain Functions, institute of neurobiology,fudan university,shanghai 200433,china 5Laboratorory of Synaptic Plasticity and Learning Behavior,shanghai institute of Brain Functional Genomics,East china Normal university,shanghai 200062,china

＜正＞Early-life exposure to SSRI antidepressants increases the chances of developing mood disorders later in life. However,the biological basis in term of neuronal morphology for these behavioral changes is ***,we have employed animal models,mimicking maternal use of SSRIs in clinical,to study neonatal exposure to SSRIs on neuronal *** used confocal microscopy to investigate the acute and long-lasting effects of SSRI administration during early life on dendritic spine density in hippocampal CA1 pyramidal *** observed an acute decrease,and a delayed increase,in dendritic spine density of CA1 pyramidal *** detrimental changes in neuronal morphology were associated with decreased locomotor ***,our findings demonstrate that neonatal exposure to SSRIs is capable of influencing the morphological plasticity of excitatory synapses and raise the caution of clinical medication with SSRIs especially in pregnant women.

关键词： early life SSRI dendritic spine

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Requirement for activation of glycine site of NMDA receptors...

Modulation of dopamine release by stimulus pattern in striatum in vivo

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Ren Wen-hua, Guo Ji-dong, Cao Hong, Ru-Rong ji, Zhao Zhi-qi, Zhang Yu-qiu institute of neurobiology, fudan university, shanghai 200433, china shanghai institutes for Biological Sciences, Chinese Academy of Sciences, shanghai 200031, china: Pain Research Center, Dept. of Anesthesiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02115, USA

＜正＞Emotional distress is the most disruptive and undesirable feature of painful experiences. More and more clinical observations indicate the patients with chronic pain suffer from as much emotional disturbance as pain sensation per se. Physiological arousal and hypersensitivity to pain cause varying severities and qualities of negative affect, such as fear, anxiety, anger, aversion, and depression, even tendency of suicide, and these negative affective states in turn enhance pain perception. Previous study suggests that the activation of NMDA receptors in the rostrol cingulated cortex （rACC） may involve in pain related aversive emotion acquisition. Combination of a rat formalin-induced conditioned place

关键词： pain-related negative emotion conditioned place avoidance (CPA) glycine site of NMDA receptors whole-cell recording rostral anterior cingulate cortex (ACC) rat

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Modulation of dopamine release by stimulus pattern in striat...

THE MODULI SPACE OF COMPLEX LAGRANGIAN SUBMANIFOLDS IN THE HYPER-KAEHLER MANIFOLD

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Shi-Rong WANG~1,Wei YAO~1,Hong-Ping HUANG~1,Jing-Zhi ZHENG~1,Panli ZUO~1,Claire Xi ZHANG~1,Bao-Ming LI~2, Zhuan ZHOU~1 1 institute of Molecular Medicine,Peking university,Beijing 100871 2 institute of neurobiology,fudan university,shanghai 200433,china

＜正＞A long-standing question in how the nervous system processes information is whether patterns of action potentials（APs）,in addition to their mean frequency,have specific effects on neurotransmitter *** previous studies on different AP patterns showed that the number of AP bursts effectively modulate cell secretion in cultured adrenal chromaffin ***,it is not clear how such patterns modulate transmitter release in the central nervous system in *** answer this question,amperometry was used to measure dopamine release in the rat striatum,in response to electrical stimulation of the medial forebrain *** stimulus pattern was defined by the four parameters, number（"N"） and frequency（"f’） of stimuli pulses,number of bursts（"m"）,and inter-burst interval（"d"）.We found that for a given "N",in addition to "f’,"m" effectively modulated dopamine ***,this "burst effect" was modulated by stimulus numbers,frequency and inter-burst *** dopamine signals were measured also in mice. Cocaine and nomifensine,inhibitors of dopamine transporter,enhanced the burst *** proposed that the secretion efficiency modulated by stimuli code may play an important role in information transfer in neural networks in vivo.

关键词： Dopamine release striatum in vivo action potential pattern

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Chinese Annals of Mathematics,Series B 1999年第4期20卷 393-400页

作者： FU JIXIANG(institute of Mathematics, fudan university, shanghai 200433, china) fudan Univ Inst Math Shanghai 200433 Peoples R China

The deformation of a compact complex Lagrangian submanifold in a hyper-Kaehler manifold and the moduli space are studied. It is proved that the moduli space Mc1 is a special Kaehler manifold, where special means that there is a real flat torsionfree symplectic connection satisfying dI = 0 (I is a complex structure of Mcl). Thus, following [4], one knows thatT*Mcl is a hyper-Kaehler manifold and then that Mcl is a complex Lagrangian submanifold in T* Mcl.

关键词： Moduli space Complex Lagrangian submanifold Hyper-Kaehler manifold Special Lagrangian submanifold Special Kaehler manifold Deformation

THE OCCUPATION DENSITY FIELD FOR THE CATALYTIC SUPER-BROWNIAN MOTION

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Chinese Annals of Mathematics,Series B 1999年第4期20卷 447-454页

作者： HONG WENMING(institute of Mathematics, fudan university shanghai 200433, china) fudan Univ Inst Math Shanghai 200433 Peoples R China

It is proved that the occupation time of the catalytic super-Brownian motion is absolutely continuous for d = 1, and the occupation density field is jointly continuous and jointly Holder continuous.

关键词： Branching rate functional Brownian collision local time Catalytic super-Brownian motion Occupation time Occupation density field

GLOBAL CLASSICAL SOLUTIONS WITH SMALL INITIAL TOTAL VARIATION FOR QUASILINEAR HYPERBOLIC SYSTEMS

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Chinese Annals of Mathematics,Series B 2002年第3期23卷 335-348页

作者： YAN PING institute of Mathematics, fudan university, shanghai 200433, china institute of Mathematics Fudan University Shanghai 200433 China

By means of the continuous Glimm functional, a proof is given on the global existence of classical solutions to Cauchy problem for general first order quasilinear hyperbolic systems with small initial total variation.

关键词： Weak linear degeneracy Continuous Glimm functional Total variation Global classical solution Quasilinear hyperbolic system