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Brain protective effect of dexmedetomidine vs propofol for sedation during prolonged mechanical ventilation in non-brain injured patients

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World Journal of Psychiatry 2024年第3期14卷 370-379页

作者： Hong-Xun Yuan Li-na Zhang Gang Li Li Qiao Intensive Care Unit Peking University International HospitalBeijing 102206China Central Operating Room The Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing 100020China

BACKGROUND Dexmedetomidine and propofol are two sedatives used for long-term *** remains unclear whether dexmedetomidine provides superior cerebral protection for patients undergoing long-term mechanical *** To compare the neuroprotective effects of dexmedetomidine and propofol for sedation during prolonged mechanical ventilation in patients without brain *** Patients who underwent mechanical ventilation for>72 h were randomly assigned to receive sedation with dexmedetomidine or *** Richmond Agitation and Sedation Scale(RASS)was used to evaluate sedation effects,with a target range of-3 to *** primary outcomes were serum levels of S100-βand neuron-specific enolase(NSE)every 24 *** secondary outcomes were remifentanil dosage,the proportion of patients requiring rescue sedation,and the time and frequency of RASS scores within the target *** A total of 52 and 63 patients were allocated to the dexmedetomidine group and propofol group,*** data were comparable between *** significant differences were identified between groups within the median duration of study drug infusion[52.0(IQR:36.0-73.5)h vs 53.0(IQR:37.0-72.0)h,P=0.958],the median dose of remifentanil[4.5(IQR:4.0-5.0)μg/kg/h vs 4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the median percentage of time in the target RASS range without rescue sedation[85.6%(IQR:65.8%-96.6%)vs 86.7%(IQR:72.3%-95.3),P=0.592],and the median frequency within the target RASS range without rescue sedation[72.2%(60.8%-91.7%)vs 73.3%(60.0%-100.0%),P=0.880].The proportion of patients in the dexmedetomidine group who required rescue sedation was higher than in the propofol group with statistical significance(69.2%vs 50.8%,P=0.045).Serum S100-βand NSE levels in the propofol group were higher than in the dexmedetomidine group with statistical significance during the first six and five days of mechanical ventilation,respectively(all P<0.05).CONCLUSION Dexmedetomidine demonstrated

关键词： Dexmedetomidine Propofol Sedation Prolonged mechanical ventilation Brain protective

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Optimal Operation Strategy of Electricity-Hydrogen Regional Energy System under Carbon-Electricity Market Trading

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Energy Engineering 2024年第3期121卷 619-641页

作者： Jingyu Li Mushui Wang Zhaoyuan Wu Guizhen Tian na Zhang Guangchen Liu Inner Mongolia Key Laboratory of Electrical Energy Conversion Transmission and Control Inner Mongolia University of TechnologyHohhot010080China School of Electric Power Inner Mongolia University of TechnologyHohhot010080China School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing102206China

Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction ***,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-Hydrogen(P2H)technology,focusing on participating in combined carbon-electricity market *** study introduces an innovative Electro-Hydrogen Regional Energy System(EHRES)in this *** system integrates renewable energy sources,a P2H system,cogeneration units,and energy storage *** core purpose of this integration is to optimize renewable energy utilization and minimize carbon *** study aims to formulate an optimal operational strategy for EHRES,enabling its dynamic engagement in carbon-electricity market *** initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with ***,an analysis is conducted to examine the operational mode of EHRES as it participates in carbon-electricity market ***,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the Hydrogen Fuel Cell(HFC).This facilitates the establishment of an optimal operational model for EHRES,aiming to minimize the overall operating *** simulation example illustrates that the coordinated operation of EHRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system *** result carries significant implications for attaining advantages in both low-carbon and economic aspects.

关键词： Regional energy system electro-hydrogen coupling carbon-electricity market step carbon trading coordination and optimization

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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

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Current Medical Science 2024年第1期44卷 223-231页

作者： Hong-li ZHAng na LI Lin DOng Hong-xia MA Mo-chi YAng Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRna and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDna-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDna-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance

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Analysis of sensitivity to hydrate blockage risk in natural gas gathering pipeline

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Petroleum Science 2024年第4期21卷 2723-2733页

作者： Ao-Yang Zhang Meng Cai na Wei Hai-Tao Li Chao Zhang Jun Pei Xin-Wei Wang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Research institute of Production Engineering Daqing Oilfield Co.Ltd.

During the operational process of natural gas gathering and transmission pipelines, the formation of hydrates is highly probable, leading to uncontrolled movement and aggregation of hydrates. The continuous migration and accumulation of hydrates further contribute to the obstruction of natural gas pipelines, resulting in production reduction, shutdowns, and pressure build-ups. Consequently, a cascade of risks is prone to occur. To address this issue, this study focuses on the operational process of natural gas gathering and transmission pipelines, where a comprehensive framework is established. This framework includes theoretical models for pipeline temperature distribution, pipeline pressure distribution, multiphase flow within the pipeline, hydrate blockage, and numerical solution methods. By analyzing the influence of inlet temperature, inlet pressure, and terminal pressure on hydrate formation within the pipeline, the sensitivity patterns of hydrate blockage risks are derived. The research indicates that reducing inlet pressure and terminal pressure could lead to a decreased maximum hydrate formation rate, potentially mitigating pipeline blockage during natural gas transportation. Furthermore, an increase in inlet temperature and terminal pressure, and a decrease in inlet pressure, results in a displacement of the most probable location for hydrate blockage towards the terminal station. However,it is crucial to note that operating under low-pressure conditions significantly elevates energy consumption within the gathering system, contradicting the operational goal of energy efficiency and reduction of energy consumption. Consequently, for high-pressure gathering pipelines, measures such as raising the inlet temperature or employing inhibitors, electrical heat tracing, and thermal insulation should be adopted to prevent hydrate formation during natural gas transportation. Moreover, considering abnormal conditions such as gas well production and pipeline network s

关键词： natural gas hydrates Gathering pipeline Temperature variation Hydrate formation rate Sensitivity analysis

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Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes

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Science China Chemistry 2024年第6期67卷 2029-2038页

作者： Yan Zhao Qi-Chao Shan Hong Xin Pin Gao Xu Yang Xin-Hua Duan Li-na Guo Department of Chemistry School of ChemistryXi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy StorageMaterials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China

An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is *** tuning the electronic and steric effects of alkyl radicals,both electronrich and electron-deficient 1,3-enynes were compatible with this *** protocol features mild conditions,broad substrate scope,excellent functional group compatibility and facile gram-scale synthesis,providing a practical approach to the quaternary carbon center-containing allenyl *** study revealed that the acyl-NiIIspecies plays an important role in both the coupling and the alkyl radical generation processes.

关键词： Ni catalysis four-component 1 4-carbocarbonylation 1 3-enynes

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Advanced oxidation via the synergy of C-defective/C-O band modified ultrathin porous g-C_(3)N_(4)and PMS for efficient photothermal degradation of bisphenol pollutants and lignin derivatives

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Green Energy & Environment 2024年第7期9卷 1159-1170页

作者： Liquan Jing Meng Xie Yuanguo Xu Chun Tong Xia Du Heng Zhao na Zhong Huaming Li Jinguang Hu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang212013China Department of Chemical and Petroleum Engineering University of Calgary2500 University DriveNWCalgaryAlbertaT2N1N4Canada School of Pharmacy Jiangsu UniversityZhenjiang212013China School of Material Science&Chemical Engineering Harbin University of Science and TechnologyHarbin150080China institute for Energy Research Jiangsu UniversityZhenjiang212013China

This work uses thermal polymerization of urea nitrate,oxyacetic acid and urea as the raw material to prepare ultra-thin porous carbon nitride with carbon defects and C-O band(OA-UN-CN).Density functional theory(DFT)calculations showed OA-UN-CN had narrower band gap,faster electron transport and a new internal construction electric ***,the prepared OA-UN-CN significantly enhanced photocatalytic activation of peroxymonosulfate(PMS)due to enhanced light absorption performance and faster electron *** the result,the OA-UN-CN/PMS could entirely degrade bisphenol A(BPA)within 30 min,where the photodegradation rate was 81.8 and 7.9 times higher than that of g-C_(3)N_(4)and OA-UN-CN,***,the OA-UN-CN/PMS could likewise degrade other bisphenol pollutants and sodium lignosulfonate *** suggested possible photocatalytic degradation pathways accordingly and explored the toxicity of its degradation *** work provides a new idea on the development of advanced photocatalytic oxidation processes for the treatment of bisphenol pollutants and lignin derivatives,via a metal-free photothermal-catalyst.

关键词： Photothermal-catalytic G-C_(3)N_(4) Peroxymonosulfate Bisphenol Sodium lignosulfonate

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Diphylleia Grayi-inspired Intelligent Temperature-Responsive Transparent nanofiber Membranes

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nano-Micro Letters 2024年第4期16卷 67-78页

作者： Cengceng Zhao Gaohui Liu Yanyan Lin Xueqin Li na Meng Xianfeng Wang Shaoju Fu Jianyong Yu Bin Ding Shanghai Frontier Science Research Center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620People’s Republic of China

nanofiber membranes(NFMs) have become attractive candidates for next-generation flexible transparent materials due to their exceptional flexibility and breathability. However, improving the transmittance of NFMs is a great challenge due to the enormous reflection and incredibly poor transmission generated by the nanofiber-air interface. In this research, we report a general strategy for the preparation of flexible temperature-responsive transparent(TRT) membranes,which achieves a rapid transformation of NFMs from opaque to highly transparent under a narrow temperature window. In this process, the phase change material eicosane is coated on the surface of the polyurethane nanofibers by electrospray technology. When the temperature rises to 37 ℃, eicosane rapidly completes the phase transition and establishes the light transmission path between the nanofibers, preventing light loss from reflection at the nanofiber-air interface. The resulting TRT membrane exhibits high transmittance(> 90%), and fast response(5 s). This study achieves the first TRT transition of NFMs, offering a general strategy for building highly transparent nanofiber materials, shaping the future of next-generation intelligent temperature monitoring, anti-counterfeiting measures, and other high-performance devices.

关键词： Biomimetic Transparent nanofibrous membrane Temperature response Phase change materials

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High efficiency removal of NO using waste calcium carbide slag by facile KOH modification

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Journal of Environmental Sciences 2024年第5期139卷 182-192页

作者： Fang Wang Hui Li Jiyun Gao na Geng Enzhu Jiang Futing Xia Mingwu Xiang Lijuan Jia Ping Ning School of Chemistry and Environment Yunnan Minzu UniversityKunming 650504China Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500China

Waste calcium carbide slags(CS),which are widely applied to desulfurisation,are not typically used in ***,to well achieve waste control by waste,a facile and highefficiency denitration strategy is developed using KOH to modify the calcium carbide slags(KCS).Various KCS samples were investigated using a series of physical and chemical *** performance test results showed that the KOH concentration and reaction temperature are the main factors affecting the denitration efficiency of KCS,and CS modified with 1.5 mol/L KOH(KCS-1.5)can achieve 100% denitration efficiency at 300℃.Such excellent removal efficiency is due to the catalytic oxidation of the oxygen-containing functional groups derived from the *** studies showed that KOH treatment significantly increased the concentration of oxygen vacancies,nitro compounds,and basic sites of *** study provides a novel strategy for the resource utilisation of waste CS in the future.

关键词： Waste Carbide slag KOH Effective denitration

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Bio-inspired Attachment Mechanism of Dynastes Hercules:Vertical Climbing for On-Orbit Assembly Legged Robots

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Journal of Bionic Engineering 2024年第1期21卷 137-148页

作者： Yuetian Shi Xuyan Hou Zhonglai na Jie Zhou nan Yu Song Liu Linbo Xin Guowei Gao Yuhui Liu School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

With the increasing size of space facilities,on-orbit assembly requires robots to move on different heights of *** paper proposes a bio-inspired attachment mechanism for robot feet to enable climbing on different heights of *** by the attachment and grasping abilities of Dynastes Hercules,we utilize its foot microstructures,such as microhooks and setae,to achieve efficient contact and firm grip with the *** morphology and arrangement of these structures can inspire the design of robot feet to improve their grasping and stability *** study the biological structure of Dynastes Hercules,design and optimize the bio-inspired structure,analyze the influence of various factors from theoretical and experimental perspectives,and verify the feasibility of the scheme through *** propose an ideal climbing strategy that provides useful reference for robot applications in ***,the influence laws of various factors in this paper can be applied to robot foot design to improve their operation ability and stability performance in the space *** bio-inspired mechanism can improve robot working range and efficiency,which is critical for on-orbit assemblyin space.

关键词： Space assembly robot Truss climbing Bionic structure Dynastes Hercules tarsus

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Structure characterization of the oxide film on FGH96 superalloy powders with various oxidation degrees

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2037-2047页

作者： Yang Liu Yufeng Liu Sha Zhang Lin Zhang Peng Zhang Shaorong Zhang na Liu Zhou Li Xuanhui Qu Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Science and Technology on Advanced High Temperature Structural Materials Laboratory AECC Beijing Institute of Aeronautical MaterialsBeijing 100095China

The structure of the oxide film on FGH96 alloy powders significantly influences the mechanical properties of *** this study,FGH96 alloy powders with various oxygen contents were investigated using high-resolution transmission electron microscopy and atomic probe technology to elucidate the structure evolution of the oxide *** dispersive spectrometer analysis revealed the presence of two distinct components in the oxide film of the alloy powders:amorphous oxide layer covering the γ matrix and amorphous oxide particles above the *** alloying elements within the oxide layer showed a laminated distribution,with Ni,Co,Cr,and Al/Ti,which was attributed to the decreasing oxygen equilibrium pressure as oxygen diffused from the surface into the γ *** the other hand,Ti enrichment was observed in the oxide particles caused by the oxidation and decomposition of the carbide *** analysis of the oxide film with oxygen contents of 140,280,and 340 ppm showed similar element distributions,while the thickness of the oxide film varies approximately at 9,14,and 30 nm,*** findings provide valuable insights into the structural analysis of the oxide film on FGH96 alloy powders.

关键词： Ni-based superalloys surface structure oxide layer thickness oxidation behavior element distribution

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