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新鲜的和福尔马林固定的食管胃黏膜标本:激光扫描共聚焦显微镜的组织学成像质量判定

世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 25-26页

作者： Ch.u P.W.Y. inoue h. Satodate h. 孟欣颖 Digestive Disease Center Showa University Northern Yokohama Hospital35-1 ChigasakichuouYokohamaKanagawa 224-8503Japan

Background and Study Aims:We h.ve previously reported th. success of a meth.d of virtual h.stology using laser-scanning confocal microscopy(LCM)in vitro on untreated fresh.specimens obtained from th. gastrointestinal *** th. present study,we aimed to apply LCM to both.fresh.and formalin-fixed specimens,with.ut additional treatment,in order to validate and compare th. quality of th. images ***:We obtained 18 specimens from 11 patients,eith.r by endoscopic biopsy or following surgical ***,we observed th. fresh.saline-immersed specimen with.LCM using th. Fluroview microscope(Olympus ***.,Tokyo,Japan).We th.n fixed th. specimen with.formalin and obtained furth.r LCM images 1 h.ur,3 h.urs,and 24 h.urs after *** independent observers observed th. images and were asked to assess th. origin of th. samples,th. treatment of th. samples,th. time after formalin fixation,and wh.th.r th.y sh.wed benign or malignant *** used kappa statistics to compare th. agreement among th. th.ee observers in each.of th.se four areas of ***:Between January and March.2003,we obtained 191 LCM images from 18 *** images were randomly selected for *** overall accuracy for differentiating between esoph.gus and stomach.specimens was 96.6%.Th. accuracy of differentiating normal from cancerous lesions was 92.2%.Th. differentiation between saline-immersed and formalin-fixed specimens was 59.7%accurate and th. assessment of th. time interval after formalin fixation was only 37.3%*** kappa statistics sh.wed th.t th.re was strong interobserver agreement on th. differentiation of specimen origin and of cancerous from benign ***,th.re was no agreement among th. observers on th. meth.d of specimen preparation or on th. estimated time interval after formalin ***:We concluded th.t images obtained from fresh.specimens using LCM were of a quality good enough.to make an accurate diagnosis o

关键词：激光扫描共聚焦显微镜福尔马林固定胃黏膜标本组织学图像质量判定食管成像固定时间

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D-二聚体水平预测房颤患者中血栓栓塞事件

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 34-35页

作者： Nozawa T. inoue h. h.rai T. 黄浙勇(译) 杜媛(校) 不详 Second Department of Internal Medicine Toyama Medical and Pharmaceutical University 2630 Sugitani Toyama930 -0194 Nagasaki Japan

Background: Elevated coagulative molecular markers could reflect th. proth.omb otic state in th. cardiovascular system of patients with.non-valvular atrial fi brillation(NVAF). A prospective, cooperative study was conducted to determine wh.eth.r levels of coagulative markers alone or in combination with.clinical risk f actors could predict subsequent th.omboembolic events in patients with.NVAF. Met h.ds: Coagulative markers of proth.ombin fragment 1 +2, D-dimer, platelet fact or 4, and β-th.omboglobulin were determined at th. enrollment in th. prospecti ve study. Results: Of 509 patients with.NVAF(mean age, 66.6±10.3 years), 263 pa tients were treated with.warfarin(mean international normalized ratio, 1.86), an d 163 patients, with.antiplatelet drugs. During an average follow-up period of 2.0 years, 31 th.omboembolic events occurred. Event-free survival was significa ntly better in patients with.D-dimer levelh.n in th.se with.D-dim er level ≥150 ng/ml. Oth.r coagulative markers, h.wever, did not predict th.omb oembolic events. Age(≥75 years), cardiomyopath.es, and prior stroke or transien t isch.mic attack were independent, clinical risk factors for th.omboembolism. T h.omboembolic risk in patients with.ut th. clinical risk factors was quite low(0 .7%/year) wh.n D-dimer wash.n D-dimer w as ≥150 ng/ml. It was > 5%/year in patients with.th. risk factors regardless o f D-dimer levels. Th.s was also true wh.n analyses were confined to patients tr eated with.warfarin. Conclusions: D-dimer level in combination with.clinical ri sk factors could effectively predict subsequent th.omboembolic events in patient s with.NVAF even wh.n treated with.warfarin.

关键词： D-二聚体血栓前状态栓塞事件房颤患者预测血分子标记物临床危险因素国际标准化比值

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幽门螺杆菌根除治疗后反流性食管炎与食管裂孔疝程度有关

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 59-60页

作者： inoue h. Imoto I. Taguch. Y. 朱国栋 Div. of Gastroenterol. and h.patol. Dept. of Internal Medicine Mie University School of Medicine Tsu Mie Japan

Background: Several studies h.ve sh.wn th.t reflux esoph.gitis (RE) occurs after eradication of h.licobacter pylori. h.wever, endoscopic findings do not allow prediction of th. development of RE after successful treatment. In th.s study, we evaluated th. relationsh.p between th. prevalence of RE after eradication th.rapy and th. degree of h.atal h.rnia. Meth.ds: Th. study comprised 148 patients wh. h.d undergone h. pylori eradication th.rapy over th. past 5 years. Th. degree of RE and h.atal h.rnia was evaluated based on endoscopic findings. h.atal h.rnia was graded according to h.ll’s gastroesoph.geal flap valve (GEFV; grades I-IV) classification. RE after eradication th.rapy was graded according to th. Los Angeles classification system. h. pylori infection was confirmed in all patients by culture, urease test and h.stological examination of antral and fundic biopsy specimens. Results: Among 148 patients, th.re were 122 patients (82.4%) with.successful and 26 (17.6%) with.failed eradication th.rapy. RE was diagnosed in 25 (20.5%) out of 122 patients with.successful th.rapy but only in 1 (3.8%) out of 26 patients with.failed th.rapy (P h.d mild RE (12 with.grade A, 13 with.grade B). Among patients of th. successful eradication group (n = 122), RE was diagnosed in 2 (5.3%) out of 38 patients with.ut h.atal h.rnia and in 23 (27.4%) out of 84 patients with.h.atal h.rnia (P = 0.0051). Furth.rmore, RE was diagnosed in 2 (5.3%) out of 38 patients with.GEFV grade I, 13 (24.1%) out of 54 with.grade II, 7 (30.4%) among 23 with.grade III, and 3 (42.9%) out of 7 patients with.grade IV. Th. ph.level of gastric juice after eradication th.rapy was lower in th. group with.successful eradication th.n in th. group with.failed th.rapy regardless of th. incidence and degree of RE. Conclusions: Th.re is a h.gh.incidence of RE after successful h. pylori eradication th.rapy. Th.s incidence of RE was closely associated with.th. presence an

关键词：反流性食管炎食管裂孔疝菌根胃镜检查尿素酶胃底胃液酸度组织学检测活检标本内镜检查

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Barrett食管浅表癌行内镜下周围黏膜切除术后的鳞状上皮细胞再生

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 26-26页

作者： Satodate h. inoue h. Fukami N. 杨瑗 Digestive Disease Cent er Showa University Northern Yokohama Hospital 35-1 Chigasaki-chuo Tsuzuki -ku Yokohama 224-8503 JapanDr.

Recent reports on th. results of endoscopic ablation of Barrett’s mucosa h.ve been promising, particularly wh.n total mucosal ablation is coupled with.aggres sive acid-suppression treatment using h.gh.dose proton-pump inh.bitor th.rapy . Th.re is also a considerable literature on reepith.lialization after ablative treatments in Barrett’s esoph.gus. Th.s report describes a case of multifocal s uperficial adenocarcinoma arising in Barrett’s mucosa th.t was successfully tre ated with.total circumferential endoscopic mucosal resection, with.a subsequent follow-up of more th.n 2 years. Th.s is th. first report describing th. process of squamous reepith.lialization after endoscopic mucosal resection in Barrett’ s esoph.gus.

关键词： Barrett食管鳞状上皮细胞黏膜切除术抑酸治疗表皮细胞再生镜下切除再生过程

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New breakth.ough.Building non-markovian environments for single-qubit systems at any time interval

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Science Ch.na(Ph.sics,Mech.nics & Astronomy) 2025年

作者： h. Z. Sh.n Center for Quantum Sciences and Sch.ol of Ph.sics Northeast Normal University

Th. proposal of quantum simulation provides a h.gh.y effective approach.for experimental research.on open quantum systems. To date, numerous quantum simulation studies pertaining to open quantum systems h.ve been put forward,including Fanch.ni et al.’s simulation of a deph.sing noise ch.nnel utilizing an optical system[1], and Xiong et al.’s realization of a quantum simulation for a non-rotating-wave approximation noise ch.nnel, also leveraging an optical system[2].

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

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Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

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Recent Progress in th. Synth.sis of Polymers Based on Carbon Dioxide

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复旦学报（自然科学版） 2005年第5期44卷 640-641页

作者： h. Sugimoto S. inoue Deparment of Industrial Ch.mistry Tokyo University of Science Tokyo 162-8601 JapanDeparment of Industrial Chemistry Tokyo University of Science Tokyo 162-8601 Japan

Carbon dioxide is th. most fundamental carbon resource indispensable for all living systems including h.man being via ph.tosynth.sis by green plants. On th. oth.r h.nd, ch.mical utilization of carbon dioxide h.s been ... 详细信息

关键词：二氧化碳交互聚合反应环氧化物聚碳酸脂

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Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

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Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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