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Impact of the Transboundary Transport of Air Pollutants on Air Quality in Spain

Journal of Environmental Protection 2012年第9期3卷 1167-1175页

作者： Marta G. Vivanco inmaculada Palomino Juan Luis Garrido Ma ángeles González Gonzalo Alonso Fernando Martín Centro de Investigaciones Energéticas Medioambientales y Teconológicas (CIEMAT) Air Pollution Unit Madrid Spain

Although compliance with the European limit values for air pollutants has been achieved over large parts in Spain, some challenges remain for O3 on the maximum daily 8-hour mean and information limit values, for particulate matter on the PM10 annual and daily limit values and for NO2 on annual and hourly limit values. Transboundary transport of air pollutants has started to be recognized as a mechanism affecting air quality. Nevertheless, as a consequence of the complexity of atmospheric chemistry it is not easy to determine the importance of this effect. Photochemical models constitute an adequate tool to address this challenge, allowing the identification of pollutant pathways and the quantifi- cation of the influence of long-range transport of air pollutants. In this paper we evaluate the influence of out-of-Spain emissions on this non-compliance picture by using the CHIMERE photochemical model. For this purpose the model was run at a 0.2?-horizontal resolution for a European domain. Although at this resolution not all the local effects can be captured, transboundary transport of air pollutants can be examined. Several simulations were performed considering different emission scenarios. To see all out-of-Spain emissions influence, all the emissions were set to zero, excepting those in Spain. This includes examining European and ships effects on air quality in Spain. A second simulation was performed setting to zero just European-countries emissions, to see the effect of Europe. The third and fourth simulations were carried out by setting to zero France and Portugal emissions respectively. Ozone has been found to be the pollutant more affected by this transboundary transport, in particular in the summer period. The model indicates that the incoming air masses contributed in 2009 to the non-compliance with the European normative regulating the maximum daily 8-hour mean.

关键词： Transboundary Transport Air Pollution

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综述非洲猪瘟病毒

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猪业科学 2019年第9期36卷 18-20页

作者：刘颖昳(编译) inmaculada Galindo Covadonga Alonso 中国动物疫病预防控制中心北京102600 不详

非洲猪瘟(African swine fever,ASF)是一种具有高度传染性的猪病毒病。在家猪中可导致接近100%的高死亡率。ASF是由ASF病毒(ASF Virus,ASFV)引起,ASFV是一种较大的双链DNA病毒,主要在巨噬细胞的细胞质中复制,ASFV是Asfarviridae科Asfivi... 详细信息

非洲猪瘟(African swine fever,ASF)是一种具有高度传染性的猪病毒病。在家猪中可导致接近100%的高死亡率。ASF是由ASF病毒(ASF Virus,ASFV)引起,ASFV是一种较大的双链DNA病毒,主要在巨噬细胞的细胞质中复制,ASFV是Asfarviridae科Asfivirus属唯一的成员。ASFV的天然宿主包括野猪和Ornithodoros属的节肢动物媒介。ASFV在其储存宿主的感染通常是无症状的,并且发展为持续感染。相反,ASFV对家猪的感染可导致致命的出血热,目前且无有效疫苗。确定ASFV毒力相关基因,以及探索病毒逃避宿主免疫应答的机制,公认为是影响疫苗开发的关键步骤。此外,病毒产物与宿主的相互作用与病毒复制紧密相关,为寻找防治该疾病的潜在靶标提供有效信息。

关键词：非洲猪瘟病毒基因表达 DNA复制 A179L

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New antimyeloma drugs in spinal cord infiltration for multiple myeloma. Determination of lenalidomide in cerebrospinal fluid with ultrasensitive high-performance liquid chromatography

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Modern Chemotherapy 2012年第2期1卷 11-13页

作者： inmaculada Rapado Juan José Lahuerta Laura Montejano María ángeles Montalbán Laura Pares Joaquín Martínez- López Servicio de Bioquímica Hospital Universitario 12 de Octubre Madrid Spain Servicio de Hematología Hospital Universitario 12 de Octubre Madrid Spain

A 64-year-old woman with IgA kappa multiple myeloma was treated with thalidomide-dexa- methasone. Due to progression of the disease, bortezomib, doxorubicin and dexamethasone were administered, followed by autologous stem cell transplantation. Although near-complete remission was achieved, 5 months later, neuro- logical symptoms appeared and the patient was diagnosed with multiple myeloma with cells in- filtrating the spinal cord. Bis-chloronitrosourea, bortezomib and lenalidomide were then admin- istered and although the patient remained neu- rologically asymptomatic, she died 3 months later becausee of disease progression. Lena- lidomide entered into the cerebrospinal fluid (confirmed by ultrasensitive high-performance liquid chromatography), although did not im- prove the poor prognosis of multiple myeloma involving the central nervous system.

关键词： Lenalidomide Multiple Myeloma Spinal Cord Infiltration High-Performance Liquid Chromatography

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Effects on physiologic measures of appetite from intragastric balloon and endoscopic sleeve gastroplasty: results of a prospective study

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Chinese Medical Journal 2022年第10期135卷 1234-1241页

作者： Babusai Rapaka Daniel B.Maselli Gontrand Lopez-Nava inmaculada Bautista-Castano Reem Matar Veeravich Jaruvongvanich Eric J.Vargas Andrew C.Storm Andres Acosta Barham K.Abu Dayyeh Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA Madrid Sanchinarro University Hospital MadridSpain

Background: Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored ***: We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) (n = 18) placed between October 2016 and June 2017 or underwent endoscopic sleeve gastroplasty (ESG) (n = 23) from March 2018 to June 2018. Patients underwent physiologic appraisal at 3 months with13C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (%TBWL) at 3 and 6 months using best-fit linear ***: The change in T50 at 3 months correlated with %TBWL at 3 months for IGB (P = 0.01) and ESG (P = 0.01) but with greater impact on %TBWL in IGB compared to ESG (R2 = 0.42vs. 0.26). Change in T50 at 3 months was predictive of weight loss at 6 months for IGB (P = 0.01) but not ESG (P = 0.11). ESG was associated with greater decrease in MTV compared to IGB (340.25 ± 297.97 mLvs. 183.00 ± 217.13 mL,P = 0.08), indicting an enhanced effect on satiation through decreased gastric accommodation. Changes in MTV at 3 months did not correlate with %TBWL for either IGB (P = 0.26) or ESG (P = 0.49) but trended toward significance for predicting %TBWL at 6 months for ESG (P = 0.06) but not IGB (P = 0.19).Conclusion: IGB and ESG both induce weight loss but likely through distinct gastric motor function phenotypes, and gastric emptying may predict future weight loss in patients with IGB.

关键词： Intragastric balloon Endoscopic sleeve gastroplasty Gastric emptying Gastric accommodation Obesity

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Clinical Parameters in the First 5 Minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants

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Maternal-Fetal Medicine 2023年第4期5卷 244-247页

作者： Laura Torrejón-Rodríguez Álvaro Solaz-García inmaculada Lara-Cantón Alejandro Pinilla-González Marta Aguar Máximo Vento Division of Neonatology University and Polytechnic Hospital La Fe(HULAFE)Valencia 46026Spain Neonatal Research Group Instituto de Investigación Sanitaria La Fe(IISLAFE)Valencia 46026Spain

Extreme preterm infants(60%)and lower(<30%)initial FiO_(2).Recent evidence and meta-analyses have underscored the predictive value for survival and/or relevant clinical outcomes of the Apgar score and the achievement of arterial oxygen saturation measured by pulse oximetry≥85%at 5 minutes after *** clinical trials comparing higher versus lower initial FiO_(2)have been launched aiming to optimize postnatal stabilization of extreme preterm while avoiding adverse effects of hypoxemia or hyperoxemia.

关键词： Extreme preterm Postnatal stabilization Oxygen saturation Heart rate Inspired fraction of oxygen Apgar score

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西班牙的比较教育

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全球教育展望 2006年第8期35卷 3-5,18页

作者：黄志成伊玛古拉达华东师范大学国际与比较教育研究所西班牙马德里自治大学教育理论与教学系

20世纪80年代,西班牙走向了改革开放、民主发展的道路。西班牙的比较教育正处于一个重要的发展时期。了解和研究中等发达国家的发展经验,对我国具有很现实的意义。西班牙比较教育研究领域主要集中在欧洲和拉丁美洲,既取得了很大成绩,产... 详细信息

20世纪80年代,西班牙走向了改革开放、民主发展的道路。西班牙的比较教育正处于一个重要的发展时期。了解和研究中等发达国家的发展经验,对我国具有很现实的意义。西班牙比较教育研究领域主要集中在欧洲和拉丁美洲,既取得了很大成绩,产生了许多著名学者,同时也存在一些有待解决的问题。

关键词：西班牙比较教育教育研究研究领域欧洲拉丁美洲著名学者

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Gender Sensitive and Socially Responsible Philosophy of Science

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Journal of Philosophy Study 2019年第8期9卷 484-490页

作者： inmaculada Perdomo Reyes University of La Laguna San Cristobal de La LagunaSpain

The aim of this paper is to defend a view of the philosophy of science as a practice that should reflect not only about the disciplinary classical topics: science methodology, the practice of model construction, explanation or relations with technology. Philosophy of science should reflect also on the directions science might take and the goals sought, and ponder;as well, must include questions concerning who should make these decisions and in accordance with what procedures to promote a more inclusive and democratic science. It’s an agenda that includes gender and ethical topics and a commitment with responsible research and innovation in the context of our democratic societies.

关键词： philosophy of science responsible research gender democratic science women and ICT

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Effective prophylaxis with rFVIIa in young haemophiliacs with inhibitors using a schedule similar to FVIII prophylaxis in non-inhibitor patients

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Health 2013年第7期5卷 1151-1157页

作者： Maria Fernanda Lopez-Fernandez Carmen Altisent Victor Jimenez-Yuste Faustino Garcia-Candel Carmen Sedano Ana Cid Eva Mingot Ramiro Nunez Maria Jose Paloma inmaculada Soto Manuel Prieto Haematology Complejo Hospitalario Universitario A CorunaA CorunaSpain Haemophilia Unit Hospital Universitario Vall d’HebronBarcelonaSpain Haemophilia Unit Hospital UniversitarioMadridSpain Haemophilia Unit Hospital Universitario Virgen de la ArreixacaMurciaSpain Haematology Complejo Hospitalario Universitario Marques de ValdecillaSantanderSpain Congenital Coagulophaties Unit Hospital Universitario La FeValenciaSpain Haematology Hospital Universitario Carlos HayaMalagaSpain Haematology Hospital Universitario Virgen del RocíoSevillaSpain Haematology Hospital Virgen del CaminoPamplonaSpain Haematology Hospital General de AsturiasOviedoSpain Haematology Hospital General YagüeBurgosSpain

Objective: To assess the role of early prophylaxis with recombinant activated factor VII (rFVIIa) in young haemophiliacs with inhibitors and to determine whether it can reduce bleeding episodes and prevent joint damage. Patients and Methods: Ten severe haemophiliacs, less of three years old, with up to four joint bleeds and inhibitors to FVIII who started early prophylaxis with rFVIIa, were included. A number of haemorrhages/year/patient and haemarthroses/ year/patient were compared before the start of prophylaxis, which include both the time before (initial period) and after inhibitor diagnosis (inhibitor period), with those during prophylaxis (prophylaxis period). Results: The mean time of inhibitor diagnosis was 15.6 months (range: 2.3-34.1). The mean time between inhibitor diagnosis and the start of prophylaxis was 7.1 months (range: 0-23.2), shorter than the time of rFVIIa prophylaxis (mean: 10.3 months;range: 4.1-32.0). Bleeding episodes for the three time periods were 45, 36 and 17, respectively, or 0.29 and 0.51 haemorrhages/year/patient in the two periods prior to prophylaxis compared to 0.17 during prophylaxis. Total haemarthroses for the three-time periods were 7, 5 and 5, respectively. The haemarthroses/year/patient in the pre-prophylaxis period were 0.032 and 0.070, compared to0.049 inthe prophylaxis period. rFVIIa schedules were either 90 μg/kg three times weekly or 90 μg/kg daily. Conclusions: Early prophylaxis with rFVIIa may be efficacious in young haemophiliacs with inhibitors, reducing joint bleeds. After the risky period of inhibitor presence, they are able to continue rFVIII prophylaxis with success assured to prevent arthropathy.

关键词： rFVIIa Haemarthroses Haemophilia Inhibitors Prophylaxis

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Ileocolic Intussusception Prolapsing from the Rectum in von Recklinghausen's Disease

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Surgical Science 2012年第8期3卷 421-423页

作者： Marlén Alvite Canosa Leticia Alonso Fernández Lucía Dorado Castro Rocío González López Ana álvarez Gutiérrez inmaculada Monjero Ares José Conde Vales Félix Arija Val General surgery department of Hospital Universitario Lucus Augusti Lugo Spain

Intussusception is a paediatric condition that rarely presents in adults. We report an exceptional case of ileocolic intussusception prolapsing from the rectum in an adult with Von Recklinghausen′s disease. A 31-year-old man with von Recklinghausen′s disease presented to emergency department with a history of severe abdominal pain, vomits and rectal bleeding. Abdominal computed tomography showed intestinal obstruction probably due to a sigmoidorectal intussusception. Ileum, appendix, cecum and ascending colon were found to be intussuscepting through transverse, descending and sigmoid colon and prolapsing from the rectum during an emergent laparotomy. A right hemicolectomy was performed. An anatomical pathology examination revealed a neurofibroma of the appendix as lead point for intussusception. Intussusception in adults requires early surgical resection regardless of the nature of the initial case. Neurofibroma of the appendix is very rare;although it is benign, prompt resection is recommended because of a high risk of appendicitis and malignant transformation.

关键词： Adult Intussusceptions Neurofibromatosis Von Recklinghausen′s Disease Appendiceal Neurofibroma

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Single doses of p38 MAP kinase inhibitors or prednisolone affect CRP and IL-6 in patients with active Rheumatoid Arthritis (RA)

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Open Journal of Immunology 2012年第3期2卷 85-97页

作者： Pauline T. Lukey Hayley C. Perry Shuying Yang Simon Parry Marion C. Dickson Virginia H. Norris Paul G. Russell Marie Watissée inmaculada Rioja Keith P. Ray Scott Crowe Michael Binks GlaxoSmithKline R&D Medicines Research Centre Stevenage UK

Purpose: To investigate the effects of single doses of losmapimod, dilmapimod (inhibitors of p38 MAPK) and prednisolone on biomarkers of systemic inflammation (serum C-reactive protein (CRP) and interleukin (IL)-6) in subjects with active rheumatoid arthritis (RA). Methods: Two randomized, double blind, placebo controlled, parallel group, single dose studies investigated the CRP and IL-6 dose-response relationships for losmapimod (study A) and dilmapimod and prednisolone (study B) in patients with active RA on stable weekly doses of methotrexate. CRP, IL-6 and other exploratory biomarkers were measured in blood at baseline and up to 72 hours post-dosing. Results: In study A, 51 subjects were randomized to receive losmapimod (7.5, 20 and 60 mg) or placebo and in study B, 77 subjects were randomized to receive dilmapimod (7.5, 15 and 25 mg) or prednisolone (10, 20 and 50 mg) or placebo. Single doses of prednisolone caused a decrease in circulating IL-6 detectable at 3 and 24 hours post-dose as well as a CRP single-dose relationship at 48 hours post-dose in patients with active RA. All doses of losmapimod produced a statistically significant reduction in serum IL-6, 3 hours post-dose but had no effect on CRP. Dilmapimod had no effect on IL-6 or CRP at any dose or time. Conclusion: This single-dose response clinical study design could be useful in the early clinical development of anti-inflammatory agents for the treatment of rheumatoid arthritis. Inhibition of both circulating IL-6 and CRP would increase confidence that a new chemical entity may have the potential to deliver clinical benefit in RA. Trial registration: [***: NCT00256919 and NCT00134693].

关键词： p38 MAPK Prednisolone RA Biomarkers Proof of Mechanism Randomised Controlled Trial

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