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In‑depth proteome characterization of endometrium and extraembryonic membranes during implantation in pig

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1027-1055页

作者： Maria A.Gil Josep M.Cambra Heriberto Rodriguez‑Martinez Cristina Cuello inmaculada Parrilla Emilio A.Martinez Department of Medicine and Animal Surgery International Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of MurciaMurciaSpain Institute for Biomedical Research of Murcia(IMIB-Pascual Parrilla) MurciaSpain Technical University of Munich MunichGermany Department of Biomedical&Clinical Sciences(BKV) BKH/Obstetrics&GynaecologyLinkoping UniversityLinkopingSweden

Background Proteome characterization of the porcine endometrium and extraembryonic membranes is important to understand mother-embryo *** this study,the proteome of the endometrium and cho-rioallantoic membrane was characterized in pregnant sows(PS)during early gestation(d 18 and 24 of gestation)and in the endometrium of non-pregnant sows(NPS)during the same days using LC-MS/MS *** UniProtKB database and ClueGO were used to obtain functional Gene Ontology annotations and biological and functional networks,*** Our analysis yielded 3,254 and 3,457 proteins identified in the endometrium of PS and NPS,respectively;of these,1,753 being common while 1,501 and 1,704 were exclusive to PS and NPS,*** addition,we iden-tified 3,968 proteins in the extraembryonic membranes of *** analyses of function revealed some proteins had relevance for the immune system process and biological adhesion in endometrium while the embryonic chorion displayed abundance of proteins related to cell adhesion and cytoskeletal organization,suggesting they dominated the moment of endometrial remodeling,implantation and adhesion of the lining *** are available via Pro-teomeXchange with identifier *** This is the first in-depth proteomic characterization of the endometrium and extraembryonic mem-branes during weeks 3 to 4 of gestation;data that contribute to the molecular understanding of the dynamic environ-ment during this critical period,associated with the majority of pregnancy losses.

关键词： Endometrium Extraembryonic membranes Implantation Pig Proteome

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan Jose Urquijo-Ponce Carlos Alventosa-Mateu Mercedes Latorre-Sánchez inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant Systemic therapy

Shop&Go:TSP heuristics for an optimal shopping with smartphones

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Science China(Information Sciences) 2013年第11期56卷 45-56页

作者： inmaculada PARDINES Victoria LOPEZ Department of Computer Architecture Faculty of Computer Science Universidad ComplutenseMadrid 28040 Spain

Mobile technology has been under constant growth in last *** emergence of smartphones has encouraged the development of a wide variety of mobile *** of them are related to daily *** this regard,we propose the Shop&Go mobile application which allows a supermarket customer to do the shopping covering the shortest distance1).An analysis of the routing problem applied to an efcient way of doing the shopping is made.A map with items distribution and distances between products is provided by the *** on these information two heuristics have been proposed to do the shopping following the optimum *** heuristics have been compared,proving that neither of them can be defned as the best one in all *** products in the shopping list determine which is the best solution for each ***,both algorithms have been included in our application,letting the user decide which route he/she wants to ***&Go has also other functionalities which are extensively described in the *** over an HTC Desire mobile are shown to demonstrate the proper tool ***,a study of consumer acceptance has been made to know its possibilities of success in the mobile technology market.

关键词： mobile applications routing problems Android operating system shopping list optimum path

Recovery of carbon monoxide from flue gases by reactive absorption in ionic liquid imidazolium chlorocuprate(I): Mass transfer coefficients

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Chinese Journal of Chemical Engineering 2015年第5期23卷 769-774页

作者： Gabriel Zarca inmaculada Ortiz Ane Urtiaga Department of Chemical and Biomolecular Engineering Universidad de Cantabria Av. Los Castros s/n.

Recovery of carbon monoxide from flue gases by selective absorption of carbon monoxide in an imidazolium chlorocuprate(I) ionic liquid is considered in this work as an alternative to the use of molecular volatile solvents such as aromatic hydrocarbons. The present work evaluates the CO mass transfer rates from the gas phase to the ionic liquid solutions in the absence of chemical reaction. To that end, carbon dioxide was employed as an inert model gas and absorption experiments were performed to assess the influence of different process variables in a batch reactor with flat gas–liquid interface. The experimental mass transfer coefficients showed significant variation with temperature,(3.4–10.9) × 10-7m·s-1between 293 and 313 K; stirring speed,(10.2–33.1) × 10-7m·s-1between 100 and 300 r·min-1; and concentration of copper(I),(6.6–10.2) × 10-7m·s-1between 0.25 and 2 mol·L-1. In addition, the mass transfer coefficients were eventually found to follow a potential proportionality of the type kL∝μ-0.5and the dimensionless correlation that makes the estimation of the mass transfer coefficients possible in the studied range of process variables was obtained: Sh = 10-2.64· Re1.07·*** results constitute the first step in the kinetic analysis of the reaction between CO and imidazolium chlorocuprate(I) ionic liquid that determines the design of the separation units.

关键词：选择性吸收传质系数离子液体一氧化碳化学反应咪唑回收烟气

Three-dimensional trees for virtual globes

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International Journal of Digital Earth 2014年第10期7卷 789-810页

作者： Cristina Rebollo inmaculada Remolar Jesus Gumbau Miguel Chover Institute of New Imaging Technologies Universitat Jaume ICastellonSpain

One of the problems in virtual globes technologies is the real-time representation of vegetal *** forest or garden representations,the low detailed plants produce a lack of *** techniques are required to achieve accurate interactive visualisation due to the great number of polygons the vegetal species *** article presents a multi-resolution model based on a geometric representation of vegetal species that allows the application to perform the progressive transmission of the model,that is,the transmission of a simple representation followed by successive refinements of *** has a hardware-oriented design in order to obtain interactive frame *** geometric data of the objects are stored in the graphics processing unit and,moreover,the change from one approximation to another is obtained by performing mathematical calcula-tions in this graphics *** multi-resolution model presented here enables instancing:as many vegetal species as desired can be rendered with different levels of detail,while all of them are accessing the same geometric *** model has been used to build a real-time representation of a not imaginary scenario.

关键词： virtual globes real-time rendering vegetal species level of detail graphics hardware progressive transmission

Identification of the Breach of Short-Term Rental Regulations in Irish Rent Pressure Zones

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Journal of Computer and Communications 2023年第2期11卷 8-19页

作者： Guowen Liu inmaculada Arnedillo-Sánchez Zhenshuo Chen Trinity College Dublin Dublin Ireland Dublin City University Dublin Ireland

The housing crisis in Ireland has rapidly grown in recent years. To make a more significant profit, many landlords are no longer renting out their houses under long-term tenancies but under short-term tenancies. Regulating rentals in Rent Pressure Zones with the highest and rising rents is becoming a tricky issue. In this paper, we develop a breach identifier to check short-term rentals located in Rent Pressure Zones with potential breaches only using publicly available data from Airbnb (an online marketplace focused on short-term home-stays) and Irish government websites. First, we use a Residual Neural Network to filter out outdoor landscape photos that negatively impact identifying whether an owner has multiple rentals in a Rent Pressure Zone. Second, a Siamese Neural Network is used to compare the similarity of indoor photos to determine if multiple rental posts correspond to the same residence. Next, we use the Haversine algorithm to locate short-term rentals within a circle centered on the coordinate of a permit. Short-term rentals with a permit will not be restricted. Finally, we improve the occupancy estimation model combined with sentiment analysis, which may provide higher accuracy.

关键词： Housing Crisis Short-Term Rental Irish Rent Pressure Zone Image Recognition Breach Identification

Effects on physiologic measures of appetite from intragastric balloon and endoscopic sleeve gastroplasty: results of a prospective study

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Chinese Medical Journal 2022年第10期135卷 1234-1241页

作者： Babusai Rapaka Daniel B.Maselli Gontrand Lopez-Nava inmaculada Bautista-Castano Reem Matar Veeravich Jaruvongvanich Eric J.Vargas Andrew C.Storm Andres Acosta Barham K.Abu Dayyeh Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905USA Madrid Sanchinarro University Hospital MadridSpain

Background: Endoscopic bariatric therapies can help address widening management gaps in obesity. Their ability to facilitate weight loss is largely tied to influences on appetite through perturbations of gastric emptying and accommodation. As these tools gain traction in obesity therapy, their physiologic underpinnings require exploration, which may enhance efficacy, tolerance, and patient-tailored ***: We prospectively assessed consecutive subjects with fluid-filled intragastric balloons (IGBs) (n = 18) placed between October 2016 and June 2017 or underwent endoscopic sleeve gastroplasty (ESG) (n = 23) from March 2018 to June 2018. Patients underwent physiologic appraisal at 3 months with13C-spirulina-based gastric emptying breath test to determine time to half emptying (T50), as well as maximum tolerated volume (MTV) of a standard nutrient drink test. Changes in T50 and MTV at 3 months were compared with percent total body weight loss (%TBWL) at 3 and 6 months using best-fit linear ***: The change in T50 at 3 months correlated with %TBWL at 3 months for IGB (P = 0.01) and ESG (P = 0.01) but with greater impact on %TBWL in IGB compared to ESG (R2 = 0.42vs. 0.26). Change in T50 at 3 months was predictive of weight loss at 6 months for IGB (P = 0.01) but not ESG (P = 0.11). ESG was associated with greater decrease in MTV compared to IGB (340.25 ± 297.97 mLvs. 183.00 ± 217.13 mL,P = 0.08), indicting an enhanced effect on satiation through decreased gastric accommodation. Changes in MTV at 3 months did not correlate with %TBWL for either IGB (P = 0.26) or ESG (P = 0.49) but trended toward significance for predicting %TBWL at 6 months for ESG (P = 0.06) but not IGB (P = 0.19).Conclusion: IGB and ESG both induce weight loss but likely through distinct gastric motor function phenotypes, and gastric emptying may predict future weight loss in patients with IGB.

关键词： Intragastric balloon Endoscopic sleeve gastroplasty Gastric emptying Gastric accommodation Obesity

Clinical Parameters in the First 5 Minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants

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Maternal-Fetal Medicine 2023年第4期5卷 244-247页

作者： Laura Torrejón-Rodríguez Álvaro Solaz-García inmaculada Lara-Cantón Alejandro Pinilla-González Marta Aguar Máximo Vento Division of Neonatology University and Polytechnic Hospital La Fe(HULAFE)Valencia 46026Spain Neonatal Research Group Instituto de Investigación Sanitaria La Fe(IISLAFE)Valencia 46026Spain

Extreme preterm infants(60%)and lower(<30%)initial FiO_(2).Recent evidence and meta-analyses have underscored the predictive value for survival and/or relevant clinical outcomes of the Apgar score and the achievement of arterial oxygen saturation measured by pulse oximetry≥85%at 5 minutes after *** clinical trials comparing higher versus lower initial FiO_(2)have been launched aiming to optimize postnatal stabilization of extreme preterm while avoiding adverse effects of hypoxemia or hyperoxemia.

关键词： Extreme preterm Postnatal stabilization Oxygen saturation Heart rate Inspired fraction of oxygen Apgar score

Protein Shuttle between Nucleus and Cytoplasm:New Paradigms in the ABI5-dependent ABA Responses

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Molecular Plant 2019年第11期12卷 1425-1427页

作者： inmaculada Sanchez-Vicente Pablo Albertos Oscar Lorenzo Dpto.de Botanica y Fisiologia Vegetal Instituto Hispano-Luso de Investigaciones Agrarias(CIALE)Facultad de BiologiaUniversidad de SalamancaC/Rio Duero 1237185 SalamancaSpain Present address:Biotechnology in Horticultural Crops TU Munchen-WeihenstephanLiesel-Beckmann-Strasse 185354 FreisingGermany

Plant survival depends on seed germination,progression through post-germinative developmental checkpoints,and adaptation to abiotic *** these processes underlie a tightly controlled regulation by the stress hormone abscisic acid(ABA)at different levels,even though the main research focuses on changes in transcript and protein ***,protein fate undergoes complex readjustments that allow signal transduction to be integrated into physiological *** them,protein redox status,stability,capacity of oligomerization,formation of complexes,and subcellular compartmentalization become key points for plant reprogramming against stresses to acquire an optimal *** this Spotlight,we highlight and discuss the latest advances in dissecting the mechanisms driving protein dynamics of nucleocytoplasmic trafficking in the cell and its relevance for regulating the stability of ABI5 and the ABI5-dependent AB A signaling pathway(Figure 1).

关键词： Figure driving programming