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Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs

Journal of Animal Science and Biotechnology 2018年第3期9卷 531-547页

作者： Hakhyun Ka Heewon Seo Yohan Choi inkyu yoo Jisoo Han Department of Biological Science and Technology Yonsei University Department of Veterinary Integrated Biosciences Texas A&M University College Station Department of Obstetrics and Gynecology University of Kentucky College of Medicine

The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs.

关键词： Conceptus Endometrium Estrogen Interleukin-1β Pig Uterus

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Transferable,highly crystalline covellite membrane for multifunctional thermoelectric systems

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InfoMat 2024年第11期6卷 66-80页

作者： Myungwoo Choi Geonhee Lee Yea-Lee Lee Hyejeong Lee Jin-Hoon Yang Hanhwi Jang Hyeonseok Han MinSoung Kang Seonggwang yoo A-Rang Jang Yong Suk Oh inkyu Park Min-Wook Oh Hosun Shin Seokwoo Jeon Jeong-O Lee Donghwi Cho Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Thin Film Materials Research Center Korea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Chemical Data-Driven Research Center Korea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Division of Chemical and Material Metrology Korea Research Institute of Standards and ScienceDaejeonRepublic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Therapeutics&Biotechnology Division Drug Discovery Platform Research CenterKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Querry Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIllinoisUSA Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonanRepublic of Korea Department of Mechanical Engineering Changwon National UniversityChangwonRepublic of Korea Department of Materials Science and Engineering Hanbat National UniversityDaejeonRepublic of Korea Advanced Materials and Chemical Engineering University of Science and TechnologyDaejeonRepublic of Korea

Emerging freestanding membrane technologies,especially using inorganic thermoelectric materials,demonstrate the potential for advanced thermoelectric ***,using rare and toxic elements during material processing must be ***,we present a scalable method for synthesizing highly crystalline CuS membranes for thermoelectric *** sulfurizing crystalline Cu,we produce a highly percolated and easily transferable network of submicron CuS *** CuS membrane effectively separates thermal and electrical properties to achieve a power factor of 0.50 mW m^(-1) K^(-2) and thermal conductivity of 0.37 W m^(-1) K^(-1) at 650 K(estimated value).This yields a record-high dimensionless figure-of-merit of 0.91 at 650 K(estimated value)for ***,integrating 12 CuS devices into a module resulted in a power generation of4μW atΔT of 40 K despite using a straightforward configuration with only p-type ***,based on the temperature-dependent electrical characteristics of CuS,we develop a wearable temperature sensor with antibacterial properties.

关键词： copper sulfide flexible thermoelectric generator multifunctional thermoelectric systems sulfurization thermoelectric membrane

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