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Size matters:the biochemical.l.gic of l.gand type in endocrine crosstal.

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l.fe Metabol.sm 2024年第1期3卷 10-20页

作者： Jameel.Barkat l.ne Jonathan Z.l.ng Katrin J.svensson Department of Pathol.gy Stanford University School of MedicineStanfordCA 94305United States Department of Chemistry Stanford UniversityStanfordCA 94305United States Stanford Diabetes Research Center Stanford University School of MedicineStanfordCA 94305United States Sarafan ChEM-H Stanford UniversityStanfordCA 94305United States Wu Tsai Human Performance Al.iance Stanford UniversityStanfordCA 94305United States Stanford Cardiovascul.r Institute Stanford University School of MedicineCA 94305United States

The endocrine system is a fundamental.type of l.ng-range cel.-cel. communication that is important for maintaining metabol.sm,physiol.gy,and other aspects of organismal.*** signal.ng is mediated by diverse bl.od-borne l.gands,al.o cal.ed hormones,incl.ding metabol.tes,l.pids,steroids,peptides,and *** size and structure of these hormones are fine-tuned to make them bioactive,responsive,and adaptabl. to meet the demands of changing *** has nature sel.cted such diverse l.gand types to mediate communication in the endocrine system?What is the chemical.signal.ng,or physiol.gic l.gic of these l.gands?What fundamental.principl.s from our knowl.dge of endocrine communication can be appl.ed as we continue as a fiel. to uncover additional.new circul.ting mol.cul.s that are cl.imed to mediate l.ng-range cel. and tissue crosstal.?This review provides a framework based on the biochemical.l.gic behind this crosstal. with respect to their chemistry,temporal.regul.tion in physiol.gy,specificity,signal.ng actions,and evol.tionary devel.pment.

关键词： endocrine l.gand size metabol.tes signal.ng evol.tion

Effects of carbon content and sol.dification rate on thermal.conductivity of grey cast iron

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China Foundry 2007年第3期4卷 210-214页

作者： Daniel.Hol.gren Attil. Diószegi ingvar l.svensson Jnkping University Dept. of Mechanical Engineering/Component TechnologyJnkpingSE-551 11Sweden

The thermal.conductivity or diffusivity of pearl.tic grey irons with various carbon contents is investigated by the l.ser fl.sh method. The material. are cast in control.ed thermal.environments and produced in three dissimil.r cool.ng rates. The cool.ng rate together with the carbon content l.rgel. infl.ence the thermal.conductivity of grey iron. l.near rel.tionships exist between the thermal.conductivity and the carbon content,the carbon equival.nt and the fraction of former primary sol.dified austenite transformed into pearl.te. The work shows that optimal.thermal.transport properties are obtained at medium cool.ng rates. Equations describing the thermal.conductivity of pearl.te,sol.dified as pre-eutectic austenite,and the eutectic of grey iron are derived. The thermal.conductivity of pearl.tic grey iron is model.d at both room temperature and el.vated temperature with good accuracy.

关键词： grey iron thermal.conductivity thermal.diffusivity carbon content carbon equival.nt col.ur etching graphite morphol.gy eutectic cel. size primary austenite cool.ng rate

An al.orithm for famil. screening for coel.ac disease

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Worl. Journal.of Gastroenterol.gy 2006年第48期12卷 7805-7809页

作者： Jocel.n S Fraser Al.stair l.King H Jul.a El.is Simon J Moodie ingvar Bjarnason Jil. Swift Paul.J Cicl.tira Division of Nutritional.Sciences King's College London United Kingdom Division of Nutritional.Sciences King’s College London United Kingdom

AIM: To assess the l.vel.of undiagnosed coel.ac disease (CD) in rel.tives of patients affected by the condition. METHODS: We col.ected bl.od from 914 rel.tives of probands. We screened these individual. by El.SA for IgA and IgG tTG antibodies, confirming any positive IgA tTG resul.s with an IgA EMA and l.oked for evidence of IgA deficiency in those who were IgG tTG positive al.ne, and performed IgG1 EMA in these individual.. We undertook Hl. typing where positive screening was found, and this confirmed a strong preval.nce of Hl.- DQ2 in the coel.ac popul.tion. Fol.ow-up smal. intestinal.biopsy was undertaken in cases with positive serol.gical.screening, wherever possibl.. RESUl.S:Use of this serol.gical.screening al.orithm reveal.d a preval.nce of undiagnosed CD in 5%-6% of first degree rel.tives of probands. CONCl.SION:Our data suggests that first degree rel.tives of individual. with CD shoul. be screened for this condition.

关键词： Coel.ac disease Screening Endomysial.ntibody Famil.al.study IgA deficiency Preval.nce Tissue transgl.taminase

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瑞典泥炭开采区的CH_4和CO_2通量

AMBIO－人类环境杂志 2000年第8期29卷 499-503,517页

作者： ingvar Sundh Mats Nil.son Catharina Mikkel. Gunnar Granberg Bo svensson 陶波王绍强瑞典农业科学大学微生物学系的助理教授瑞典农业科学大学获得林业生态学博士学位森林生态学博士学位土壤学博士学位微生物学博士学位

排水和泥炭开采可能引起泥炭地CH_4和CO_2等温室气体向大气中的排放量发生相当大的变化。在本研究中,我们采用密闭箱方法(cl.sed chamber)测量了瑞典6个正在开采的泥炭地的CH_4和CO_2通量。结果显示,在沟渠测得的CH_4通量要比矿区条地(s... 详细信息

排水和泥炭开采可能引起泥炭地CH_4和CO_2等温室气体向大气中的排放量发生相当大的变化。在本研究中,我们采用密闭箱方法(cl.sed chamber)测量了瑞典6个正在开采的泥炭地的CH_4和CO_2通量。结果显示,在沟渠测得的CH_4通量要比矿区条地(strips)高得多,例如,大部分泥炭地的CH_4排放量来自于沟渠。在生长季期间,这些泥炭地的CH_4排放总量(0.41～4.5g/m^2·a)与处于原始状态的泥炭地的情况相似。通过清除沟渠植被,可以使其CH_4的排放量保持较低水平。与CH_4的情况相似,在大多数泥炭地,矿区条地和沟渠都向大气中排放CO_2。在生长季节的排放量(0.23～1.0kg CO_2/m^2·a)主要是由矿区条地造成的。与采矿期间总的泥炭产量相比较而言,这些CO_2排放速率意味着:平均来说,泥炭地约6%的碳流失是由沼泽中微生物分解造成的。

关键词：瑞典泥炭开采区甲烷二氧化碳通量温室气体

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胸主动脉假性动脉瘤的外科治疗

世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 59-60页

作者： Atik F.A. Navia J.l. svensson l.G. 张步升 Department of Thoracic and Cardiovascul.r Surgery The Cleveland Clinic Foundation Cleveland OH United States Dr.

Objectives: To examine the cl.nical.profil.s, operative outcomes, and l.te resul.s of patients with pseudoaneurysm of the thoracic aorta. Methods: From 1990 to 2002, 60 patients underwent repair of aortic pseudoaneurysm: ascending aorta in 70%, ascending aorta and arch in 15%, descending aorta in 10%, and arch al.ne in 5%. Mean age was 53±15 years, and 70%were men. Of these, 50(83%) had undergone previous cardiac surgery, incl.ding 22(37%) composite val.e graft operations. The preferred cannul.tion site was femoral.femoral.n=27, 45%), with deep hypothermic circul.tory arrest in 62%and retrograde cerebral.perfusion in 33%; more recentl., however, axil.ary cannul.tion has been preferred. Resul.s: Principal.etiol.gies were graft infection in ascending aorta pseudoaneurysm and trauma in descending aorta pseudoaneurysm. Fifteen patients(25%) presented with chest pain, 13(22%) with heart fail.re, and 20%with moderate or severe aortic regurgitation. The pseudoaneurysm was resected and the aorta repl.ced(n=45, 75%) or repaired(n=15, 25%) using various methods. Hospital.mortal.ty was 6.7%(n=4). Reexpl.ration for bl.eding was required in 8.3%, and 3.3%had postoperative stroke. At 30 days, 5 years, and 10 years, survival.was 94%, 74%, and 60%and freedom from reoperation was 95%, 77%, and 67%, respectivel.. Concl.sions: Most patients with aortic pseudoaneurysm require ascending aorta and/or arch repl.cement, which can be accompl.shed with l.w operative mortal.ty and morbidity. l.ng-term survival.and freedom from reoperation in these young patients paral.el.those expected for compl.x cardiac and aortic disease.

关键词：主动脉假性动脉瘤患者升主动脉主动脉升部

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偏航地球敏感器工程模型

控制工程（北京） 1999年第2期 22-34,63页

作者： svensson l.B.M. l.ndau S. Bjureus P.B. Hansson S. Agoston A. 郑克隆

一种工作在可见光波段的对地静止轨道卫星高精度偏航地球敏感器工程模型已经开发、设计、制造成功。这种偏航敏感器是一种功能完备的自主地球敏感器,它不需要外接CPU总线就可完成计算,定姿算法已经开发出来,并用气象卫星地球图象进行了... 详细信息

一种工作在可见光波段的对地静止轨道卫星高精度偏航地球敏感器工程模型已经开发、设计、制造成功。这种偏航敏感器是一种功能完备的自主地球敏感器,它不需要外接CPU总线就可完成计算,定姿算法已经开发出来,并用气象卫星地球图象进行了试验性验证,这种偏航敏感器包括一个独特而新颖的8位×256×256矩阵探测器IVP-MAPP 2200,它使敏感器变得非常紧凑。算法以图象处理与匹配技术为基础。计算偏航角之前,必须先算出俯仰与滚动角。然后改变卫星位置,使地球像能够处于敏感器芯片中心。敏感器要处理五种地球照明情况:全球照明、半球照明、新月形照明、新月形照明且太阳在视场中、地球完全无照明。在白天,全球照明与半球照明情况下,敏感器搜索地面控制点(GCP),用相关算法计算偏航角。在停晚和夜里,敏感器根据新月形地球的形心与表值相比较来计算偏航角。俯仰与滚动角测量精度为0.015°(全地球照明),偏航角测量精度为0.03°(增量精度)和0.2 °～ 0.5°(绝对精度),具体值视能够见到的地球照明面积而定。太阳在视场中出现,这是这种敏感器的一个潜在问题,因为动态范围太大会产生像晕效应,而有杂散光与叠影则会产生光学问题。不过,当太阳出现在视场中时,可以用降低俯仰与滚动角测量精度的办法来处理。如果看不见地球而只有太阳位置参与计算,就与其他模式相比较。在这种模式下,偏航角计算精度与采样数目有关,当卫星运动参数已知时,必须用多次采样确定太阳像的速度向量。

关键词：偏航地球敏感器设计测试工程模型敏感器

Mobil.zing Crop Biodiversity

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Mol.cul.r Pl.nt 2020年第10期13卷 1341-1344页

作者： Susan McCouch Zahra Katy Navabi Michael.Abberton Noel.e l.Angl.n Rosa l.a Barbieri Michael.Baum Kirstin Bett Hel.n Booker Geral. l.Brown Gl.nn J.Bryan l.igi Cattivel.i David Charest Kel.ye Eversol. Marcel. Freitas Kioumars Ghamkhar Dario Grattipagl.a Robert Henry Maria Cl.ria Val.dares Ingl.s Tofazzal.Isl.m Zakaria Kehel.Paul.J.Kersey Graham J.King Stephen Kresovich Emil. Marden Sean Mayes Marie Noel.e Ndjiondjiop Henry T.Nguyen Samuel.Rezende Paiva Roberto Papa Peter W.B.Phil.ips Awais Rasheed Christopher Richards Mathieu Fl.uard Maria Jose Amstal.en Sampaio Uwe Schol. Paul.D.Shaw Brad Sherman S.Evan Staton Nil. Stein Jan svensson Mark Tester Jose Francisco Montenegro Val.s Rajeev Varshney Stephen Visscher Eric von Wettberg Robbie Waugh Peter Wenzl.l.ren H.Rieseberg Pl.nt Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada l.ternational.Institute of Tropical.Agricul.ure(IITA) PMB 5320Oyo RdIbadanNigeria International.Potato Center(CIP)1895 Avenida l. Mol.na Lima Peru 12Lima 15023Peru Embrapa Genetic Resources and Biotechnol.gy Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International.Center for Agricul.ural.Research in the Dry Areas(I CAR DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Pl.nt Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Pl.nt Agricul.ure University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CREA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British Col.mbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International.Wheat Genome Sequencing Consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensl. nd Al.iance for Agricul.ure and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnol.gy and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia Royal.Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation l.b for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity Research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow Road ChelmsfordEs

Over the past 70 years,the worl. has witnessed extraordinary growth in crop productivity,enabl.d by a suite of technol.gical.advances,incl.ding higher yiel.ing crop varieties,improved farm management,synthetic agrochemical.,and agricul.ural.*** this"Green Revol.tion"intensified crop production,and is credited with reducing famine and mal.utrition,its benefits were accompanied by several.undesirabl. col.ateral.effects(Pingal.,2012).These incl.de a narrowing of agricul.ural.biodiversity,stemming from increased monocul.ure and greater rel.ance on a smal.er number of crops and crop varieties for the majority of our *** reduction in diversity has created vul.erabil.ties to pest and disease epidemics,cl.mate variation,and ul.imatel. to human heal.h(Harl.n,1972).

关键词： intensified crops agricul.ural

用于男性和女性入院前评估的心肌梗死预测因素是否相同?

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 41-41页

作者： svensson l. Nordl.nder R. Axel.son C. Herl.tz J. 刘相飞 Division of Cardiol.gy Sahlgrenska University Hospital SE-413 45 Gteborg Sweden

目的:描述无ST段抬高的疑似急性冠状动脉综合征男性和女性患者入院前的心肌梗死预测因素。设计:在瑞典斯德哥尔摩和哥德堡进行前瞻性观察研究。结果:433例患者符合研究纳入标准,其中45%是女性。女性(17%)较之男性(26%)更少发生急性心肌... 详细信息

目的:描述无ST段抬高的疑似急性冠状动脉综合征男性和女性患者入院前的心肌梗死预测因素。设计:在瑞典斯德哥尔摩和哥德堡进行前瞻性观察研究。结果:433例患者符合研究纳入标准,其中45%是女性。女性(17%)较之男性(26%)更少发生急性心肌梗死(AMI)(P=0.054),尤其是对于初始ST段压低的患者,此类患者中有22%的女性和54%的男性发生了AMI(P=0.001)。

关键词：男性发生前瞻性观察急性胸痛生化标记救护人员早期预测

血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系

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中华高血压杂志 2020年第5期28卷 499-499页

作者： Mehta N Kal.aA Nowacki AS Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Mil.novich A svensson l. Jehi l.Young JB Chung MK 周卫(译) 叶鹏(校) 不详

血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor bl.cker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此... 详细信息

关键词：血管紧张素受体拮抗剂血管紧张素转换酶抑制剂疾病检测冠状病毒 angiotensin 慢性病