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Evaluation of inpatients clostridium difficile prevalence and risk factors in cameroon

Infectious Diseases of Poverty 2020年第4期9卷 172-172页

作者： ingrid cécile Djuikoue Ernest Tambo Gildas Tazemda Omer Njajou Denise Makoudjou Vanessa Sokeng Morelle Wandji charlène Tomi Aubain Nanfack Audrey Dayomo Suzie Lacmago Falubert Tassadjo Raissa Talla Sipowo caroline Kakam Aicha Bibiane Djoko clement Nguedia Assob Antoine Andremont Frédéric Barbut Département de Microbiologie de la Facultédes Sciences de la Santéde l’Universitédes Montagnes BangangteCameroon Prevention and control Foundation BangangteCameroon Medical Diagnostic centerto Yaounde YaoundeCameroon Laboratoire de Bactériologie du centre Pasteur du cameroun YaoundeCameroon Faculty of Health Sciences University of BueaPO Box 63BueaSW RegionCameroon Faculty of Medicine Xavier-Bichat CampusUniversity of Paris VII–Denis DiderotParisFrance Faculty of Pharmacy Paris–University of Paris DescartesParisFrance

Background clostridium difficile,rarely found in hospitals,is a bacterium responsible for post-antibiotic diarrhea and Pseudomembranous colitis(cPM).*** selective pressure represents potential public health problem due to the production of toxins A and B serious pathologies effects/consequences.A transversal and analytic study was to assess the risk factors of *** infection and to determine the prevalence of *** in patients received in randomly selected five hospitals in Yaoundé,*** A total of 300 stool samples were collected from consented patients using a transversal and analytic study conducted from 10th July to 10th November 2018 in five hospitals in *** detection or diagnostic kit was cerTest *** Glutamate Dehydrogenase+Toxin A+Toxin B based on immuno-chromatographic assay.A univariate and multivariate analysis allowed us to highlight the associated *** The results showed a prevalence of *** of 27.33%(82/300 stool patients’samples taken).Of these 27.33%,the production of Toxin A and Toxin B were 37.80 and 7.31%*** univariate analysis,hospitalization was a significant(P=0.01)risk factor favoring *** *** multivariate analysis,corticosteroids and quinolones use/administration were significantly(adjusted Odd Ratio,aOR=14.09,95%cI:1.62–122.54,P=0.02 and aOR=3.39,95%cI:1.00–11.34,P=0.05 respectively)risk factor for this *** The prevalence of *** infections(cDI)remain high in these settings and may be related not only to permanent steroids and *** education to both medical staff and patients on the prevalence and public health impact of *** can be core inimproving rationale prescription of steroids and antibiotics to patients and promote human health and exponential growth in cameroon.

关键词： clostridium difficile Prevalence Diarrhea Risk factors Quinolone cephalosporin cameroon

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ELF磁场对3T3细胞生长的影响及其机理的探讨

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生物物理学报 1993年第3期9卷 488-492页

作者：陈树德 ingrid S Palcic B. 华东师范大学物理系上海200062 加拿大Bc省癌研究中心

用细胞分析成像光盘记录系统测量了3T3细胞在某些ELF磁场和温度条件下生长周期的变化.实验结果表明,只有某些频率的ELF磁场才对细胞生长产生影响,磁场对细胞生长的影响还与培养细胞的生化环境有关.温度和ELF磁场都能影响细胞的生长.但... 详细信息

用细胞分析成像光盘记录系统测量了3T3细胞在某些ELF磁场和温度条件下生长周期的变化.实验结果表明,只有某些频率的ELF磁场才对细胞生长产生影响,磁场对细胞生长的影响还与培养细胞的生化环境有关.温度和ELF磁场都能影响细胞的生长.但二者的机理是不一样的,当撤除ELF磁场后,细胞在短时间内(2天以上)继续保持着ELF场对其生长的影响.而细胞生长周期能在短时间内(2天以内)随着温度的变化而变化.温度引起的细胞生长的变化可能与细胞内的各种生长因子、生物离子的活性有关.ELF磁场引起的细胞生长的变化可能与ELF磁场对细胞膜的影响有关,与细胞内细胞生长必不可少的生物离子(如ca^(2+))的浓度有关.

关键词：极低频率磁场磁场细胞

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脂肪细胞力学感知受体的发现

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医用生物力学 2021年第S1期36卷 77-77页

作者： WANG Shengpeng WANG Lei SHI Yue ingrid Flemming Nina Wettschureck Eric Honoré YUAN Zuyi Stefan Offermanns cardiovascular Research center Xi’an Jiaotong UniversityChina Max Planck Institute for Heart and Lung Research Germany centre for Molecular Medicine University of FrankfurtGermany Universitécte d’Azur Centre National de la Recherche ScientifiqueFrance 不详

肥胖已经成为世界性的公共卫生问题。申请人团队围绕代谢疾病的力学调控,取得以下发现:(1)发现Piezo1通道是肥胖中脂肪细胞体积膨胀的力学感知受体,提出机械应力-脂肪生成偶联的新概念,开创性地揭示了肥胖发生的力学调控规律。本文发掘... 详细信息

肥胖已经成为世界性的公共卫生问题。申请人团队围绕代谢疾病的力学调控,取得以下发现:(1)发现Piezo1通道是肥胖中脂肪细胞体积膨胀的力学感知受体,提出机械应力-脂肪生成偶联的新概念,开创性地揭示了肥胖发生的力学调控规律。本文发掘了脂肪细胞响应机械应力的确切上游感受器Piezo1,首次提出肥胖力学调控的新理论:脂肪生成受脂肪细胞体积膨胀产生的机械应力反馈调控。

关键词：脂肪生成机械应力代谢疾病反馈调控脂肪细胞力学调控肥胖感受器

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Podiatric Risk Assessment in Diabetic Patients at University Hospital center of Point G

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Open Journal of Endocrine and Metabolic Diseases 2019年第8期9卷 85-94页

作者： Sy Djibril Traoré Abdel Kader Soukho Assétou Kaya Traoré Djenebou Thomas ingrid Gladys Keita Zakaria Dembelé Ibrahima Amadou cissoko Mamadou Sangaré Barry Boubacar Togo Mamadou Keita Kaly Keita Adramé Tolo Nagou camara Boua Daoud Dao Karim Doumbia Alassane Alfousseni Saliou Mahamadou Fofana Youssouf Mallé Mamadou Traoré Abdramane Sangaré Drissa cissé Sékou Mamadou Berthé Brehima Boly Sanogo Abasse Sy Seydou Dembélé Mamadou Traoré Hamar Alassane Department of Internal Medicine of University Hospital center of Point G Bamako Mali Association “Rabies in West Africa—Mali” Bamako Mali Internal Medicine Service Kati Hospital Koulikoro Mali Department of Internal Medicine Nianankoro Fomba Hospital Segou Mali Department of Medicine Regional Hospital Gao Mali Department of Medicine Regional Hospital Sikasso Mali Department of Medicine University Hospital Center Gabriel Toure Bamako Mali Department of Internal Medicine Hospital Center Mother-Child Luxemburg Bamako Mali Department of Medicine Fousseyni Daou Hospital Kayes Mali Department of Nephrology University Hospital Center of Point G Bamako Mali

Introduction: Diabetes, a chronic pathology, is the source of many acute and chronic complications whose treatment requires many daily constraints that can have a serious impact on the quality of life of the patient and his family. The diabetic foot is a real public health problem which is still dominated by a very high lower limb amputation rate even in countries with high socioeconomic status. The diabetic foot classically results from the association of three entangled mechanisms which are neuropathy, arteriopathy and infection. Objectives: To determine the frequency of arterial disease, neuropathy, and other aggravating factors that influence the podiatry risk, and to proceed with the gradation of the podiatry risk. Methodology: This was a cross-sectional study concerning the period from July 1 to October 31, 2017, covering all diabetic patients received in consultation and hospitalization in the Internal Medicine Department of the G-University Hospital center. Results: Our study included 50 patients (35 women for 15 men) out of 95 diabetic patients receiving a frequency of 52.6%, with a sex ratio of 0.42. The average age of our patients was 54.38 ± 13.98 years. Overweight/obesity found in 44% of patients. The average Body Mass Index (BMI) of our patients was 27.16 kg/m2. Patients with diabetes less than 5 years old represented 56% with an average duration of 5.39 ± 5.34 years. The mode of discovery of diabetes was polyuria-polydipsia syndrome in 56% of cases. Type 2 diabetes represented 74% of patients. Among the patients who had performed the HbA1c test, 80.77% were not well balanced. The antecedent of macrosomia in women accounted for 77.1%. Patients who did not know foot hygiene recommendations accounted for 82%. Among the identified podiatry risk factors, diabetic neuropathy accounted for 73.8%, and arterial disease was 32.3%. Grade 1 patients in our study accounted for 52% (gradation of foot risk). conclusion: The diabetic foot is a major public health pro

关键词： Monitoring Diabetes Foot Risk Mali

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Intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly cEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRccS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

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小胶质细胞控制成年小鼠海马中的谷氨酸能突触

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神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano Maria T Golia Alfonso Grimaldi Maria Rosito Valentina Ferretti ingrid Reverte caterina Sanchini Maria c Marrone Maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo Marie-Kim St-Pierre Micael carrier Massimiliano Renzi Francesca Pagani Brijesh Modi Marcello Raspa Ferdinando Scavizzi cornelius T Gross Silvia Marinelli Marie-Ève Tremblay Daniele caprioli Laura Maggi cristina Limatola Silvia Di Angelantonio Davide Ragozzino Department of Physiology and Pharmacology Sapienza University of RomeRomeItaly. Neurophysiology and Neuropharmacology Inflammaging Unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. center for Life Nano-and Neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartimento di Biologia e Biotecnologie“charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(IRccS Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-Montalcini’ RomeItaly. crestOptics S.p.A RomeItaly. centre de Recherche du cHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Département de Médecine Moléculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and Neurobiology Unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of Medical Sciences University of VictoriaVictoriaCanada.1 Department of Physiology and Pharmacology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马cA3-cA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马cA3-cA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明cX3cL1/cX3cR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触

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