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Open-Label Real-World Pharmacy Purchaser Study of Two Fixed-Dose Combination OTC Cold Treatments;Wick MediNait, Wick DayMed Capsules or a Combination of Both

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Open Journal of Respiratory Diseases 2018年第3期8卷 43-62页

作者： Gillian Phillipson David Ramsey Sue Aspley ingo Fietze Procter&Gamble International Operations Geneva Business CenterGenevaSwitzerland Procter&Gamble Health Care MasonOHUSA Procter&Gamble Technical Centres Ltd. SurreyUK Center of Sleep Medicine Charité—Universitatsmedizin BerlinBerlinGermany

Acute upper respiratory tract infections, i.e. common colds cause multiple symptoms and affect adults on average 2 - 4 times a year and children 6 - 8 times per year. Thousands of non-prescription, over-the-counter products are used by sufferers, aimed at relieving the various both er some symptoms such as cough, nasal congestion, sore throat, etc. This study evaluated real-world effectiveness of Wick MediNait or Wick DayMed medicines alone and together in a combination as a day and night treatment regimen. Adult cold sufferers were recruited in pharmacy by pharmacy staff following self-purchase of either Wick MediNait, Wick DayMed capsules, or the combination of DayMed and MediNait. Participants completed online questionnaires before and after product use (evening of the first day for DayMed and the morning after using MediNait at bedtime). For the primary endpoint “Wick MediNait was effective at relieving my symptoms”, there was a statistically significant difference (p < 0.0001) in the users who Strongly Agreed or Agreed vs. Neither Agreed or Disagreed, Disagreed or Strongly Disagreed. Further, all symptoms evaluated (cough, runny nose, nasal congestion, fever, headache, sore throat, muscle aches and pains, sneezing) were statistically improved after MediNait and DayMed alone and when both were used, and users were satisfied with both treatments. All treatments were well tolerated with minimal adverse event reporting. The diurnal use of DayMed capsules combined with the nocturnal use of MediNait allows cold sufferers to efficiently self-manage their symptom relief throughout the day and night.

关键词： Wick MediNait Real-World Use User Satisfaction Observational Cold Symptom Relief Sleep Quality

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新疆罗布泊东部发现球粒陨石雨

科学通报 2017年第21期62卷 2407-2415页

作者：李世杰王世杰 LEYA ingo SMITH Thomas 唐俊林王鹏曾小家李阳中国科学院地球化学研究所月球与行星科学研究中心贵阳550081 中国科学院地球化学研究所环境地球化学国家重点实验室贵阳550081 Physical Institute University of Bern Sidlerstrasse 5 新疆地质矿产勘查开发局第六地质大队哈密839000 中国科学院大学北京100049

新疆罗布泊以东65 km处的三峰山区域发现了陨石(Tuya 002~007)散落区,呈3 km×11 km的椭圆状.散落区内收集到130余块普通球粒陨石,总重超过160 kg,最大的陨石重30 kg,最小的陨石重约15 g.散落区为一南东-北西向分布且陨石样品逐渐增大... 详细信息

新疆罗布泊以东65 km处的三峰山区域发现了陨石(Tuya 002~007)散落区,呈3 km×11 km的椭圆状.散落区内收集到130余块普通球粒陨石,总重超过160 kg,最大的陨石重30 kg,最小的陨石重约15 g.散落区为一南东-北西向分布且陨石样品逐渐增大的椭圆形区域,这意味着陨石从南东向以较低的角度进入地球大气层.除Tuya002(760 g)外,散落区内的陨石可能来自同一次陨石雨,陨石类型为L5,冲击程度为S2,风化程度为*** 003的宇宙射线暴露年龄为45.6±4.4 Ma,因此三峰山陨石雨的流星体可能形成于约40 Ma时普通球粒陨石L群母体的破裂事件中.Tuya 002具有和其他三峰山陨石显著不同的外表特征,表面熔壳全部脱落,球粒清晰可见,为L4型普通球粒陨石,样品中有大量的硫酸钙.其宇宙射线暴露年龄为17.0±4.1 Ma,也证明了其不是三峰山陨石雨的产物.三峰山区域陨石的研究表明三峰山区域不是陨石富集区,而是L5普通球粒陨石散落区.因此,需要对其他一些区域的陨石样品进行矿物岩石学、风化特征、宇宙射线暴露年龄和居地年龄的研究,从而确定出新疆及其周边沙漠区域的陨石富集区.

关键词：陨石散落区沙漠陨石三峰山宇宙射线暴露年龄

Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR

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Molecular Plant 2010年第1期3卷 236-245页

作者： Janin Riedelsberger Tripti Sharma Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt ingo Dreyer Universitat Potsdam Institut for Biochemie und Biologie Molekularbiologie Heisenberg-Gruppe Biophysik und Molekulare Pflanzenbiologie BPMPB Karl-Liebknecht-Strasse 24-25 Haus 20 D-14476 Potsdam-Golm Germany Max-Planck Institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany Centro de Bioinformatica y Simulacion Molecular Universidad de Talca Casilla 721 Talca Chile Laboratory of Plant Physiology and Biophysics IBLS Plant Sciences Bower Building University of Glasgow Glasgow G12 8QQ UK Laboratorio de Fisiologia Molecular e Integrativa Institutos de Investigaciones Biologicas Universidad Nacional de Mar del Plata 7600 Mar del Plata Buenos Aires Argentina Universitat Potsdam Institut for Biochemie und Biologie Abteilung Molekularbiologie 14476 Potsdam-Golm Germany

The family of voltage-gated （Shaker-like） potassium channels in plants includes both inward-rectifying （Kin） channels that allow plant cells to accumulate K＋ and outward-rectifying （Kout） channels that mediate K＋ efflux. Despite their dose structural similarities, Kin and Kout channels differ in their gating sensitivity towards voltage and the extracellular K＋ concentration. We have carried out a systematic program of domain swapping between the Kout channel SKOR and the Kin channel KAT1 to examine the impacts on gating of the pore regions, the S4, S5, and the S6 helices. We found that, in particular, the N-terminal part of the S5 played a critical role in KAT1 and SKOR gating. Our findings were supported by molecular dynamics of KAT1 and SKOR homology models. In silico analysis revealed that during channel opening and closing, displacement of certain residues, especially in the S5 and S6 segments, is more pronounced in KAT1 than in SKOR. From our analysis of the S4-S6 region, we conclude that gating （and K＋-sensing in SKOR） depend on a number of structural elements that are dispersed over this -145-residue sequence and that these place additional constraints on configurational rearrangement of the channels during gating.

关键词： Arabidopsis K+ channel outward rectifier inward rectifier channel protein structure channel protein-cation interaction gating, K+-dependent.

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谷物的外源基因转移

世界农业 1991年第1期 26-28页

作者： ingo Potrykus 宋树恢

理论上,改变一个植物基因组只需在该基因组中加入一个特定基因。而从生物学意义上来说,植物基因转移成功必须符合能产生具有完全两性细胞或产生具有单克隆遗传连接的植物。 1984年,世界上首次成功地进行了植物外源基因转移。

关键词：谷物外源基因转移

Modified Vaccinia Virus Ankara Induces Autophagy to Enhance Endogenous MHC ⅡAntigen Processing Pathways in Dendritic Cells

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Modified Vaccinia Virus Ankara Induces Autophagy to Enhance ...

中华医学会2014全国微生物学与免疫学学术年会

作者：张懿 Frank Thiele ingo Drexler 德国慕尼黑工业大学病毒所重庆医科大学感染性疾病分子生物学教育部重点实验室德国杜塞尔多夫大学分子病毒所

Modified vaccinia virus Ankara(MVA)is non-permissive in human cells due to a blockage of viral replication occurs at the late stage of virion *** is considered as a prospective vaccine candidate for immunotherapy because of high safety record and strong ***,an intracellular bulk system,can engulf cytoplasmic pathogens and deliver them to lysosomes for lysis or engergy recycling,so that subsequently facilitates antigen ***

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战略过程研究：我们已经研究的和尚需探索的

管理世界 2012年第2期28卷 148-168,185页

作者： Thomas Hutzschenreuter ingo Kleindienst 韵江马文甲东北财经大学工商管理学院中国社会科学院工业经济研究所

本文试图反映战略过程研究的目前情况及其进展。基于文献综述,我们总结了一个综合框架,它包括关键前因、过程和结果3个因素以及之间的关系。这一综述表明,战略过程的研究在过去已经取得了长足的进展,研究焦点从战略计划向新的领域不断转... 详细信息

本文试图反映战略过程研究的目前情况及其进展。基于文献综述,我们总结了一个综合框架,它包括关键前因、过程和结果3个因素以及之间的关系。这一综述表明,战略过程的研究在过去已经取得了长足的进展,研究焦点从战略计划向新的领域不断转移,由此强调了个人相关因素的重要影响。作者建议学者们对战略过程中以及实际决策制定前后的个人相关因素的影响做更多的探索研究。

关键词：战略过程战略决策制定文献综述

知识网络空间结构演化及对NIS建设的启示——以我国生物技术知识为例

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地理研究 2011年第10期30卷 1861-1872页

作者：汪涛 Stefan HENNEMANN ingo LIEFNER 李丹丹南京师范大学地理科学学院南京210046 吉森大学地理系德国吉森35390

以重庆维普期刊全文数据库中2000～2009年发表于生物技术领域的合著论文作者信息统计数据为数据源,从省级层面运用UCINET和ArcGIS软件分析知识网络的空间结构特征及其演化规律。近十年来生物技术知识网络经历了由萌芽阶段向扩张阶段和... 详细信息

以重庆维普期刊全文数据库中2000～2009年发表于生物技术领域的合著论文作者信息统计数据为数据源,从省级层面运用UCINET和ArcGIS软件分析知识网络的空间结构特征及其演化规律。近十年来生物技术知识网络经历了由萌芽阶段向扩张阶段和成熟阶段转变的过程,知识的扩散方式由接触扩散为主向等级扩散为主转变,知识交流的密集区在空间上相应地经历了由分散到集中到再分散过程,网络节点间地理临近和组织临近的相互作用共同推动着网络空间结构的演化。研究表明:从缩短知识主体的社会距离和优化创新资源的空间配置两个角度,对我国国家创新系统推进生物技术发展提出建议,以提高科技投入产出效率和空间配置效率。

关键词：知识网络演化社会网络分析国家创新系统

A complete compilation of matrix metalloproteinase expression in human malignant gliomas

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World Journal of Clinical Oncology 2012年第5期3卷 67-79页

作者： Carsten Hagemann Jelena Anacker Ralf-ingo Ernestus Giles H Vince Department of Neurosurgery Tumorbiology Laboratory University of Würzburg Josef-Schneider-Str. 11 D-97080 Würzburg Germany Department of Obstetrics and Gynaecology University of Würzburg Josef-Schneider-Str. 4 D-97080 Würzburg Germany

Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy.

关键词： Astrocytic tumor Expression pattern Glioblastoma cell-lines Glioblastoma multiforme Matrix metalloproteinase

Prognostic utility of global longitudinal strain in myocardial infarction

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World Journal of Cardiology 2018年第5期10卷 35-37页

作者： Andreas Schuster Soren J Backhaus Thomas Stiermaier ingo Eitel Department of Cardiology Royal North Shore Hospitalthe Kolling InstituteNothern Clinical SchoolUniversity of SydneySydney 201101Australia Department of Cardiology and Pneumology University Hospital GoettingenGoettingen 37075Germany Medical Clinic II(Cardiology/Angiology/Intensive Care Medicine) University Heart Center LübeckLübeck 23538Germany

Cardiovascular magnetic resonance(CMR) represents the reference standard for cardiac morphology and function assessment. Since introduction in 2009, CMR feature tracking(CMR-FT) has become a frequently used tool in the assessment of myocardial deformation and wall motion on the basis of routinely acquired b-SSFP cine images. Extensive validation has led to excellent intra-and inter-observer as well as inter-study reproducibility. CMR-FT derived myocardial deformation indices such as left ventricular(LV) strain have been shown to be impaired in cardiac diseases such as cardiomyopathies as well as myocardial infarction. Although LV ejection fraction(LVEF) is the routinely and frequently utilized parameter for systolic myocardial function assessment and major adverse clinical event(MACE) prediction, it fails to assess regional differences. Recently, LV strain has emerged as a superior measure for risk assessment and MACE prediction as compared to the established markers e.g., LVEF. This editorial aims to elucidate current discussions in the field of strain assessment in myocardial infarction in the light of recent data from a large prospective multicentre CMR study.

关键词： Feature tracking Myocardial infarction Cardiovascular magnetic resonance Cardiomyopathy Prognosis