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Low SARS-CoV-2 seroprevalence but high perception of risk among healthcare workers at children’s hospital before second pandemic wave in Germany

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World Journal of Pediatrics 2021年第5期17卷 484-494页

作者： Marietta Neumann Annette Aigner Eileen Rossow David Schwarz Maria Marschallek Jorg Steinmann Ralf Stucker ingo koenigs Philippe Stock Department of Paediatrics Altona Children's HospitalUniversitat HamburgAltonaer KinderkrankenhausBleickenallee 3822763 HamburgGermany Corporate Member of Freie Universitat Berlin and Humboldt-Universitat Zu Berlin Institute of Biometry and Clinical Epidermiology BerlinCharite-Universitatsmedizin BerlinBerlinGermany Department of Neonatology and Paediatric Intensive Care Medicine Altona Children's HospitalHamburgGermany Department of Paediatric Surgery Altona Children's HospitalHamburgGermany Labor Dr.Fenner and Colleagues Hamburg.Germany Department of Paediatric Orthopaedics Altona Children's HospitalHamburgGermany Department of Paediatric Surgery University Medical Centre Hamburg Eppendorf(UKE)HamburgGermany Department of Paediatrics Altona Children's HospitalHamburgGermany

Background Healthcare workers are considered a particularly high-risk group during the coronavirus disease 2019(COVID-19)*** workers in paediatries are a unique subgroup:they come into frequent contact with children,who often experience few or no symptoms when infected with severe acute respiratory syndrome coronavirus 2(SARS CoV-2)and,therefore,may transmit the disease to unprotected *** Germany,no studies exist evaluating the risk of COVID-19 to healthcare workers in paediatric *** We tested the staff at a large children's hospital in Germany for immunoglobulin(Ig)G antibodies against the nucle-ocapsid protein of SARS CoV-2 in a period between the first and second epidemic wave in *** used a questionnaire to assess each individual's exposure risk and his/her own perception of having already been infected with *** We recruited 619 participants from all sectors,clinical and non-clinical,constituting 70%of the entire *** seroprevalence of SARS CoV-2 antibodies was 0.325%(95%confidence interval 0.039-I.168).Self-perceived risk of a previ-ous SARS-CoV-2 infection decreased with age(odds ratio,0.81;95%confidence interval,0.70-0.93).Having experienced symptoms more than doubled the odds of a high self-perceived risk(odds ratio,2.18;95%confidence interval,1.59--3.00).There was no significant difference in self perceived risk between men and *** Seroprevalence was low among healtheare workers at a large children's hospital in Germany before the second epidemic wave,and it was far from a level that confers herd ***-perceived risk of infection is often overestimated.

关键词： Health personnel SARS CoV-2 Seroepidemiologic studies Pediatrics

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